Cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin

Gene product:

cyclin

Species:

Leishmania braziliensis

UniProt:

A4HE79_LEIBR

TriTrypDb:

LbrM.25.1330 , LBRM2903_250023100

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1902554	serine/threonine protein kinase complex	6	2
GO:1902911	protein kinase complex	5	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4HE79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE79

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	2
GO:0001932	regulation of protein phosphorylation	7	2
GO:0009987	cellular process	1	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0022402	cell cycle process	2	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031399	regulation of protein modification process	6	2
GO:0042325	regulation of phosphorylation	7	2
GO:0043549	regulation of kinase activity	5	2
GO:0044770	cell cycle phase transition	3	2
GO:0044772	mitotic cell cycle phase transition	4	2
GO:0045859	regulation of protein kinase activity	6	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051338	regulation of transferase activity	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0071900	regulation of protein serine/threonine kinase activity	7	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903047	mitotic cell cycle process	3	2
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	2

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	2
GO:0019207	kinase regulator activity	3	2
GO:0019887	protein kinase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.173
CLV_NRD_NRD_1	299	301	PF00675	0.281
CLV_NRD_NRD_1	88	90	PF00675	0.411
CLV_PCSK_KEX2_1	299	301	PF00082	0.281
CLV_PCSK_SKI1_1	119	123	PF00082	0.370
CLV_PCSK_SKI1_1	207	211	PF00082	0.349
CLV_PCSK_SKI1_1	89	93	PF00082	0.287
DEG_APCC_DBOX_1	127	135	PF00400	0.281
DEG_Nend_UBRbox_3	1	3	PF02207	0.462
DOC_CKS1_1	42	47	PF01111	0.525
DOC_MAPK_gen_1	128	136	PF00069	0.295
DOC_PP1_RVXF_1	117	124	PF00149	0.360
DOC_PP4_FxxP_1	184	187	PF00568	0.318
DOC_USP7_MATH_1	316	320	PF00917	0.373
DOC_WW_Pin1_4	200	205	PF00397	0.275
DOC_WW_Pin1_4	41	46	PF00397	0.635
LIG_14-3-3_CanoR_1	181	187	PF00244	0.301
LIG_14-3-3_CanoR_1	207	212	PF00244	0.345
LIG_14-3-3_CanoR_1	244	254	PF00244	0.173
LIG_14-3-3_CanoR_1	299	307	PF00244	0.273
LIG_14-3-3_CanoR_1	50	60	PF00244	0.397
LIG_14-3-3_CanoR_1	69	78	PF00244	0.154
LIG_14-3-3_CanoR_1	80	88	PF00244	0.377
LIG_APCC_ABBA_1	103	108	PF00400	0.281
LIG_BIR_III_2	250	254	PF00653	0.173
LIG_BRCT_BRCA1_1	106	110	PF00533	0.173
LIG_CSL_BTD_1	148	151	PF09270	0.281
LIG_FHA_1	107	113	PF00498	0.321
LIG_FHA_1	135	141	PF00498	0.251
LIG_FHA_1	164	170	PF00498	0.223
LIG_FHA_1	187	193	PF00498	0.332
LIG_FHA_1	276	282	PF00498	0.299
LIG_FHA_1	283	289	PF00498	0.280
LIG_FHA_1	60	66	PF00498	0.378
LIG_FHA_2	150	156	PF00498	0.330
LIG_FHA_2	163	169	PF00498	0.276
LIG_FHA_2	245	251	PF00498	0.262
LIG_LIR_Gen_1	108	117	PF02991	0.281
LIG_LIR_Gen_1	118	127	PF02991	0.281
LIG_LIR_Gen_1	173	182	PF02991	0.372
LIG_LIR_Gen_1	210	218	PF02991	0.336
LIG_LIR_Gen_1	304	315	PF02991	0.351
LIG_LIR_Gen_1	62	72	PF02991	0.257
LIG_LIR_Nem_3	108	114	PF02991	0.296
LIG_LIR_Nem_3	118	123	PF02991	0.298
LIG_LIR_Nem_3	173	177	PF02991	0.311
LIG_LIR_Nem_3	210	214	PF02991	0.327
LIG_LIR_Nem_3	304	310	PF02991	0.309
LIG_LIR_Nem_3	314	318	PF02991	0.393
LIG_LIR_Nem_3	62	67	PF02991	0.360
LIG_LYPXL_yS_3	221	224	PF13949	0.370
LIG_PDZ_Class_1	317	322	PF00595	0.521
LIG_SH2_CRK	124	128	PF00017	0.370
LIG_SH2_CRK	307	311	PF00017	0.323
LIG_SH2_NCK_1	307	311	PF00017	0.360
LIG_SH2_STAP1	307	311	PF00017	0.365
LIG_SH2_STAP1	72	76	PF00017	0.402
LIG_SH2_STAT5	111	114	PF00017	0.310
LIG_SH2_STAT5	164	167	PF00017	0.334
LIG_SH2_STAT5	63	66	PF00017	0.297
LIG_Sin3_3	233	240	PF02671	0.272
LIG_SUMO_SIM_par_1	94	102	PF11976	0.340
LIG_TYR_ITSM	107	114	PF00017	0.311
LIG_UBA3_1	96	104	PF00899	0.249
MOD_CDK_SPK_2	41	46	PF00069	0.444
MOD_CDK_SPxxK_3	200	207	PF00069	0.173
MOD_CK1_1	25	31	PF00069	0.546
MOD_CK1_1	290	296	PF00069	0.301
MOD_CK1_1	82	88	PF00069	0.351
MOD_CK2_1	162	168	PF00069	0.281
MOD_CK2_1	300	306	PF00069	0.374
MOD_GlcNHglycan	215	218	PF01048	0.253
MOD_GlcNHglycan	289	292	PF01048	0.397
MOD_GlcNHglycan	8	11	PF01048	0.529
MOD_GSK3_1	182	189	PF00069	0.334
MOD_GSK3_1	196	203	PF00069	0.317
MOD_GSK3_1	51	58	PF00069	0.455
MOD_N-GLC_1	245	250	PF02516	0.390
MOD_N-GLC_1	25	30	PF02516	0.610
MOD_N-GLC_2	154	156	PF02516	0.360
MOD_NEK2_1	1	6	PF00069	0.603
MOD_NEK2_1	182	187	PF00069	0.335
MOD_NEK2_1	196	201	PF00069	0.281
MOD_NEK2_1	213	218	PF00069	0.242
MOD_NEK2_1	317	322	PF00069	0.512
MOD_OFUCOSY	194	200	PF10250	0.272
MOD_PIKK_1	245	251	PF00454	0.461
MOD_PIKK_1	282	288	PF00454	0.383
MOD_PKA_1	300	306	PF00069	0.311
MOD_PKA_2	79	85	PF00069	0.377
MOD_Plk_4	106	112	PF00069	0.302
MOD_Plk_4	207	213	PF00069	0.360
MOD_Plk_4	59	65	PF00069	0.257
MOD_ProDKin_1	200	206	PF00069	0.275
MOD_ProDKin_1	41	47	PF00069	0.632
MOD_SUMO_for_1	143	146	PF00179	0.266
MOD_SUMO_rev_2	98	105	PF00179	0.385
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.276
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.352
TRG_ENDOCYTIC_2	111	114	PF00928	0.287
TRG_ENDOCYTIC_2	221	224	PF00928	0.275
TRG_ENDOCYTIC_2	307	310	PF00928	0.323
TRG_ER_diArg_1	298	300	PF00400	0.281
TRG_NES_CRM1_1	94	108	PF08389	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P242	Leptomonas seymouri	36%	76%
A0A0N1PCH1	Leptomonas seymouri	71%	100%
A0A0S4JB51	Bodo saltans	50%	93%
A0A0S4JDL7	Bodo saltans	37%	98%
A0A1X0NNN9	Trypanosomatidae	56%	96%
A0A1X0NS93	Trypanosomatidae	36%	80%
A0A3S7X632	Leishmania donovani	39%	100%
A0A422N0Z8	Trypanosoma rangeli	52%	96%
A0A422P2X2	Trypanosoma rangeli	35%	85%
A0MEB5	Arabidopsis thaliana	33%	98%
A2YH60	Oryza sativa subsp. indica	32%	77%
A4HKX7	Leishmania braziliensis	39%	100%
A4I1J3	Leishmania infantum	85%	100%
A4I8F7	Leishmania infantum	39%	100%
E9AXM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B3B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O48790	Arabidopsis thaliana	32%	83%
O77689	Bos taurus	28%	81%
O93229	Rana japonica	31%	82%
O95067	Homo sapiens	29%	81%
P04962	Spisula solidissima	34%	76%
P07818	Arbacia punctulata	33%	79%
P13350	Xenopus laevis	29%	81%
P13351	Xenopus laevis	30%	82%
P13952	Spisula solidissima	35%	75%
P14635	Homo sapiens	31%	74%
P15206	Marthasterias glacialis	31%	83%
P18606	Xenopus laevis	34%	77%
P20248	Homo sapiens	35%	75%
P24860	Mus musculus	31%	75%
P24861	Patella vulgata	32%	76%
P24862	Patella vulgata	32%	79%
P24868	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	68%
P24870	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	75%
P24871	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	70%
P25010	Daucus carota	32%	94%
P25011	Glycine max	35%	71%
P25012	Glycine max	37%	100%
P30183	Arabidopsis thaliana	34%	75%
P30274	Bos taurus	35%	75%
P30276	Mus musculus	29%	81%
P30278	Medicago sativa	30%	98%
P30283	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	74%
P30284	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	67%
P32943	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	85%
P34800	Antirrhinum majus	32%	68%
P34801	Antirrhinum majus	35%	73%
P37881	Mesocricetus auratus	34%	76%
P37882	Mesocricetus auratus	31%	75%
P37883	Mesocricetus auratus	29%	81%
P42524	Dictyostelium discoideum	35%	74%
P43449	Gallus gallus	33%	82%
P46277	Medicago sativa subsp. varia	32%	75%
P46278	Medicago sativa subsp. varia	30%	74%
P47827	Xenopus laevis	36%	78%
P51943	Mus musculus	34%	76%
P51986	Hydra viridissima	32%	77%
P51987	Hydra viridissima	32%	82%
P51988	Hydra vulgaris	32%	89%
P78396	Homo sapiens	36%	69%
Q01J96	Oryza sativa subsp. indica	34%	76%
Q08301	Cricetulus griseus	32%	75%
Q0D9C7	Oryza sativa subsp. japonica	32%	77%
Q0DH40	Oryza sativa subsp. japonica	31%	72%
Q0DJR9	Oryza sativa subsp. japonica	36%	90%
Q0JIF2	Oryza sativa subsp. japonica	34%	72%
Q0JPA4	Oryza sativa subsp. japonica	32%	68%
Q10654	Caenorhabditis elegans	26%	84%
Q10Q62	Oryza sativa subsp. japonica	28%	79%
Q147G5	Arabidopsis thaliana	36%	74%
Q2QN26	Oryza sativa subsp. japonica	34%	84%
Q38819	Arabidopsis thaliana	34%	72%
Q39067	Arabidopsis thaliana	37%	72%
Q39068	Arabidopsis thaliana	32%	75%
Q39069	Arabidopsis thaliana	36%	78%
Q39070	Arabidopsis thaliana	33%	75%
Q39071	Arabidopsis thaliana	37%	73%
Q3ECW2	Arabidopsis thaliana	32%	87%
Q4Q4U0	Leishmania major	39%	100%
Q4Q9U4	Leishmania major	85%	100%
Q4R7A8	Macaca fascicularis	29%	81%
Q5A0A9	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	66%
Q60FX9	Anguilla japonica	30%	82%
Q61456	Mus musculus	36%	76%
Q6AY13	Rattus norvegicus	36%	76%
Q7XSJ6	Oryza sativa subsp. japonica	34%	77%
Q8MUA0	Leishmania donovani	85%	100%
Q92161	Carassius auratus	35%	82%
Q92162	Carassius auratus	35%	81%
Q9C6A9	Arabidopsis thaliana	33%	87%
Q9C6Y3	Arabidopsis thaliana	37%	70%
Q9DG96	Oryzias luzonensis	31%	83%
Q9DG99	Oryzias javanicus	30%	84%
Q9DGA0	Oryzias javanicus	31%	80%
Q9DGA3	Oryzias curvinotus	30%	83%
Q9DGA4	Oryzias curvinotus	32%	80%
Q9FMH5	Arabidopsis thaliana	31%	91%
Q9FVX0	Arabidopsis thaliana	33%	73%
Q9IBG0	Oryzias latipes	31%	83%
Q9IBG1	Oryzias latipes	30%	80%
Q9LDM4	Arabidopsis thaliana	33%	75%
Q9SFW6	Arabidopsis thaliana	32%	75%
V5BLA1	Trypanosoma cruzi	37%	85%