S5A_REDUCTASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 23

Species:

Leishmania braziliensis

UniProt:

A4HE76_LEIBR

TriTrypDb:

LbrM.25.1300 , LBRM2903_250022800

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HE76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE76

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.197
CLV_NRD_NRD_1	175	177	PF00675	0.498
CLV_NRD_NRD_1	31	33	PF00675	0.333
CLV_PCSK_SKI1_1	50	54	PF00082	0.294
CLV_PCSK_SKI1_1	62	66	PF00082	0.280
DOC_ANK_TNKS_1	18	25	PF00023	0.542
DOC_CYCLIN_RxL_1	97	106	PF00134	0.346
DOC_MAPK_gen_1	29	37	PF00069	0.548
DOC_MAPK_gen_1	50	60	PF00069	0.500
DOC_MAPK_MEF2A_6	108	115	PF00069	0.363
DOC_PP1_RVXF_1	48	55	PF00149	0.490
DOC_PP1_RVXF_1	98	105	PF00149	0.332
DOC_PP4_FxxP_1	104	107	PF00568	0.313
DOC_PP4_FxxP_1	223	226	PF00568	0.197
DOC_USP7_MATH_1	118	122	PF00917	0.213
DOC_USP7_MATH_1	204	208	PF00917	0.255
DOC_USP7_UBL2_3	177	181	PF12436	0.184
LIG_APCC_ABBAyCdc20_2	100	106	PF00400	0.275
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_BRCT_BRCA1_1	201	205	PF00533	0.298
LIG_BRCT_BRCA1_1	41	45	PF00533	0.546
LIG_BRCT_BRCA1_1	75	79	PF00533	0.586
LIG_FHA_1	118	124	PF00498	0.240
LIG_FHA_1	63	69	PF00498	0.565
LIG_FHA_2	161	167	PF00498	0.476
LIG_LIR_Apic_2	221	226	PF02991	0.197
LIG_LIR_Gen_1	120	129	PF02991	0.281
LIG_LIR_Gen_1	210	219	PF02991	0.396
LIG_LIR_Gen_1	85	93	PF02991	0.278
LIG_LIR_Nem_3	120	125	PF02991	0.297
LIG_LIR_Nem_3	167	173	PF02991	0.269
LIG_LIR_Nem_3	202	206	PF02991	0.319
LIG_LIR_Nem_3	210	216	PF02991	0.298
LIG_LIR_Nem_3	218	223	PF02991	0.450
LIG_LIR_Nem_3	240	244	PF02991	0.444
LIG_LIR_Nem_3	85	89	PF02991	0.278
LIG_NRP_CendR_1	254	256	PF00754	0.270
LIG_Pex14_1	130	134	PF04695	0.279
LIG_Pex14_1	220	224	PF04695	0.279
LIG_PTB_Apo_2	187	194	PF02174	0.289
LIG_PTB_Phospho_1	187	193	PF10480	0.336
LIG_REV1ctd_RIR_1	182	190	PF16727	0.242
LIG_SH2_CRK	134	138	PF00017	0.462
LIG_SH2_CRK	86	90	PF00017	0.279
LIG_SH2_STAT5	170	173	PF00017	0.273
LIG_SH2_STAT5	193	196	PF00017	0.242
LIG_SH2_STAT5	86	89	PF00017	0.279
LIG_SH2_STAT5	98	101	PF00017	0.362
LIG_SH3_3	12	18	PF00018	0.594
LIG_SH3_3	122	128	PF00018	0.279
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.210
LIG_SUMO_SIM_anti_2	210	218	PF11976	0.355
LIG_SUMO_SIM_par_1	210	218	PF11976	0.355
LIG_SUMO_SIM_par_1	64	70	PF11976	0.416
LIG_TYR_ITIM	132	137	PF00017	0.314
LIG_WRC_WIRS_1	119	124	PF05994	0.197
LIG_WRC_WIRS_1	200	205	PF05994	0.242
MOD_CK1_1	207	213	PF00069	0.321
MOD_GlcNHglycan	1	4	PF01048	0.582
MOD_GlcNHglycan	10	13	PF01048	0.481
MOD_GlcNHglycan	206	209	PF01048	0.518
MOD_GlcNHglycan	69	72	PF01048	0.344
MOD_GlcNHglycan	75	78	PF01048	0.288
MOD_GlcNHglycan	79	82	PF01048	0.248
MOD_GSK3_1	160	167	PF00069	0.288
MOD_GSK3_1	204	211	PF00069	0.336
MOD_GSK3_1	73	80	PF00069	0.499
MOD_N-GLC_1	77	82	PF02516	0.242
MOD_NEK2_1	185	190	PF00069	0.322
MOD_NEK2_1	67	72	PF00069	0.525
MOD_NEK2_1	73	78	PF00069	0.464
MOD_NEK2_1	79	84	PF00069	0.215
MOD_NEK2_1	89	94	PF00069	0.187
MOD_PIKK_1	164	170	PF00454	0.197
MOD_PKA_2	138	144	PF00069	0.434
MOD_PKA_2	233	239	PF00069	0.554
MOD_Plk_4	118	124	PF00069	0.221
MOD_Plk_4	149	155	PF00069	0.337
MOD_Plk_4	209	215	PF00069	0.351
MOD_Plk_4	22	28	PF00069	0.608
MOD_Plk_4	224	230	PF00069	0.349
MOD_Plk_4	62	68	PF00069	0.471
MOD_SUMO_rev_2	106	114	PF00179	0.309
MOD_SUMO_rev_2	236	243	PF00179	0.446
TRG_DiLeu_BaEn_1	175	180	PF01217	0.298
TRG_ENDOCYTIC_2	129	132	PF00928	0.279
TRG_ENDOCYTIC_2	134	137	PF00928	0.493
TRG_ENDOCYTIC_2	170	173	PF00928	0.242
TRG_ENDOCYTIC_2	200	203	PF00928	0.242
TRG_ENDOCYTIC_2	86	89	PF00928	0.279
TRG_ER_diArg_1	253	256	PF00400	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H2	Leptomonas seymouri	65%	98%
A0A0S4JBK7	Bodo saltans	56%	100%
A0A3R7KQ16	Trypanosoma rangeli	57%	100%
A0A3S7WZ53	Leishmania donovani	82%	100%
A4I1J0	Leishmania infantum	82%	100%
C9ZJX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AXM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q9U7	Leishmania major	81%	100%
V5B3K3	Trypanosoma cruzi	56%	89%