LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
serine/threonine-protein phosphatase
Species:
Leishmania braziliensis
UniProt:
A4HE75_LEIBR
TriTrypDb:
LbrM.25.1290 , LBRM2903_250022600
Length:
221

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HE75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE75

Function

Biological processes
Term Name Level Count
GO:0000082 G1/S transition of mitotic cell cycle 5 1
GO:0006470 protein dephosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0022402 cell cycle process 2 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044770 cell cycle phase transition 3 1
GO:0044772 mitotic cell cycle phase transition 4 1
GO:0044843 cell cycle G1/S phase transition 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004721 phosphoprotein phosphatase activity 3 10
GO:0004722 protein serine/threonine phosphatase activity 4 10
GO:0016787 hydrolase activity 2 10
GO:0016788 hydrolase activity, acting on ester bonds 3 10
GO:0016791 phosphatase activity 5 10
GO:0017018 myosin phosphatase activity 5 10
GO:0042578 phosphoric ester hydrolase activity 4 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 116 120 PF00656 0.325
CLV_NRD_NRD_1 206 208 PF00675 0.484
CLV_NRD_NRD_1 46 48 PF00675 0.301
CLV_PCSK_KEX2_1 206 208 PF00082 0.484
CLV_PCSK_SKI1_1 196 200 PF00082 0.387
CLV_PCSK_SKI1_1 33 37 PF00082 0.301
DEG_Nend_UBRbox_1 1 3 PF02207 0.244
DOC_CYCLIN_yClb5_NLxxxL_5 180 188 PF00134 0.355
DOC_MAPK_gen_1 16 25 PF00069 0.301
DOC_PP4_FxxP_1 172 175 PF00568 0.351
DOC_USP7_MATH_1 210 214 PF00917 0.530
DOC_WW_Pin1_4 121 126 PF00397 0.301
DOC_WW_Pin1_4 213 218 PF00397 0.539
DOC_WW_Pin1_4 80 85 PF00397 0.301
LIG_14-3-3_CanoR_1 1 7 PF00244 0.367
LIG_14-3-3_CanoR_1 33 42 PF00244 0.301
LIG_AP2alpha_1 58 62 PF02296 0.357
LIG_Clathr_ClatBox_1 187 191 PF01394 0.366
LIG_FHA_1 6 12 PF00498 0.364
LIG_FHA_1 66 72 PF00498 0.357
LIG_FHA_2 161 167 PF00498 0.425
LIG_LIR_Apic_2 109 115 PF02991 0.301
LIG_LIR_Apic_2 170 175 PF02991 0.343
LIG_LIR_Gen_1 56 66 PF02991 0.311
LIG_LIR_Gen_1 87 95 PF02991 0.440
LIG_LIR_Nem_3 36 42 PF02991 0.301
LIG_LIR_Nem_3 56 61 PF02991 0.112
LIG_LIR_Nem_3 63 67 PF02991 0.287
LIG_LIR_Nem_3 87 92 PF02991 0.440
LIG_NRBOX 183 189 PF00104 0.342
LIG_PDZ_Class_2 216 221 PF00595 0.498
LIG_Pex14_2 58 62 PF04695 0.357
LIG_PTB_Apo_2 70 77 PF02174 0.325
LIG_SH2_STAP1 42 46 PF00017 0.301
LIG_SH2_STAT5 177 180 PF00017 0.381
LIG_SH2_STAT5 64 67 PF00017 0.301
LIG_SUMO_SIM_anti_2 7 13 PF11976 0.301
LIG_SUMO_SIM_par_1 166 173 PF11976 0.344
LIG_SUMO_SIM_par_1 186 192 PF11976 0.178
LIG_UBA3_1 11 16 PF00899 0.301
LIG_WRC_WIRS_1 86 91 PF05994 0.440
MOD_CDK_SPK_2 121 126 PF00069 0.301
MOD_CK1_1 213 219 PF00069 0.533
MOD_CK1_1 5 11 PF00069 0.301
MOD_GlcNHglycan 172 175 PF01048 0.351
MOD_GlcNHglycan 50 53 PF01048 0.325
MOD_GSK3_1 29 36 PF00069 0.301
MOD_N-GLC_2 176 178 PF02516 0.357
MOD_N-GLC_2 195 197 PF02516 0.389
MOD_PIKK_1 33 39 PF00454 0.301
MOD_Plk_4 167 173 PF00069 0.334
MOD_Plk_4 7 13 PF00069 0.301
MOD_ProDKin_1 121 127 PF00069 0.301
MOD_ProDKin_1 213 219 PF00069 0.533
MOD_ProDKin_1 80 86 PF00069 0.301
TRG_DiLeu_BaEn_1 7 12 PF01217 0.301
TRG_ENDOCYTIC_2 3 6 PF00928 0.369
TRG_ENDOCYTIC_2 64 67 PF00928 0.301
TRG_ER_diArg_1 205 207 PF00400 0.461
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.301

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7S7 Leptomonas seymouri 42% 73%
A0A0N1IBK9 Leptomonas seymouri 60% 72%
A0A0N1P9X9 Leptomonas seymouri 60% 72%
A0A0N1PCC5 Leptomonas seymouri 50% 72%
A0A0N1PDK9 Leptomonas seymouri 99% 70%
A0A0S4ILF8 Bodo saltans 61% 73%
A0A0S4JEA1 Bodo saltans 36% 100%
A0A0S4JJ96 Bodo saltans 42% 70%
A0A0S4JJH3 Bodo saltans 41% 70%
A0A0S4KGD7 Bodo saltans 85% 74%
A0A0S4KKU2 Bodo saltans 50% 72%
A0A1X0NNN6 Trypanosomatidae 83% 66%
A0A1X0NS37 Trypanosomatidae 67% 80%
A0A1X0NS65 Trypanosomatidae 58% 73%
A0A1X0NYR5 Trypanosomatidae 43% 73%
A0A1X0P982 Trypanosomatidae 43% 67%
A0A1X0PA67 Trypanosomatidae 41% 75%
A0A1X0PAK9 Trypanosomatidae 42% 74%
A0A1X0PBJ2 Trypanosomatidae 47% 72%
A0A3Q8IFB2 Leishmania donovani 41% 74%
A0A3Q8IH18 Leishmania donovani 60% 72%
A0A3Q8IHY7 Leishmania donovani 41% 87%
A0A3R7MFZ7 Trypanosoma rangeli 44% 67%
A0A3R7N275 Trypanosoma rangeli 42% 73%
A0A3R7NP99 Trypanosoma rangeli 49% 72%
A0A3S7WZ39 Leishmania donovani 100% 70%
A0A3S7X190 Leishmania donovani 41% 73%
A0A3S7X1Y0 Leishmania donovani 61% 72%
A0A3S7X7I6 Leishmania donovani 40% 73%
A0A3S7X7J8 Leishmania donovani 44% 75%
A0A3S7X7K2 Leishmania donovani 40% 73%
A0A3S7X8K6 Leishmania donovani 50% 72%
A0A422N8P1 Trypanosoma rangeli 42% 78%
A0A422NKG0 Trypanosoma rangeli 63% 72%
A0A422NYN7 Trypanosoma rangeli 57% 73%
A0C1E4 Paramecium tetraurelia 61% 72%
A0CCD2 Paramecium tetraurelia 61% 72%
A0CNL9 Paramecium tetraurelia 59% 70%
A0DJ90 Paramecium tetraurelia 58% 73%
A2X2G3 Oryza sativa subsp. indica 71% 72%
A2XN40 Oryza sativa subsp. indica 74% 72%
A2YEB4 Oryza sativa subsp. indica 71% 72%
A3C4N5 Oryza sativa subsp. japonica 75% 70%
A4HAI7 Leishmania braziliensis 40% 100%
A4HAI8 Leishmania braziliensis 39% 100%
A4HAI9 Leishmania braziliensis 40% 100%
A4HAJ8 Leishmania braziliensis 44% 100%
A4HBE2 Leishmania braziliensis 50% 100%
A4HGA9 Leishmania braziliensis 41% 73%
A4HGX0 Leishmania braziliensis 61% 81%
A4HKU9 Leishmania braziliensis 60% 72%
A4I1H6 Leishmania infantum 100% 70%
A4I3E3 Leishmania infantum 41% 73%
A4I400 Leishmania infantum 61% 72%
A4I8C8 Leishmania infantum 60% 72%
A4I9P2 Leishmania infantum 44% 75%
A4IAJ0 Leishmania infantum 50% 72%
A6H772 Bos taurus 62% 72%
A8WGP3 Danio rerio 63% 71%
A8XE00 Caenorhabditis briggsae 59% 66%
A9JRC7 Danio rerio 62% 72%
C9ZJZ6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 86% 68%
C9ZN02 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 68%
C9ZN04 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZN06 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 75%
D0A805 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 73%
D0A970 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 72%
D0AAU4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 73%
E9AHS8 Leishmania infantum 40% 78%
E9AHS9 Leishmania infantum 40% 73%
E9AHT0 Leishmania infantum 41% 74%
E9AHT1 Leishmania infantum 40% 73%
E9AXL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 70%
E9AZN0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 73%
E9B090 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 72%
E9B387 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 72%
E9B4P8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 74%
E9B4P9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 72%
E9B4Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 74%
E9B4Q1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 73%
E9B4Q6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 75%
E9B5L4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 72%
G5EGK8 Caenorhabditis elegans 72% 69%
O00743 Homo sapiens 53% 72%
O02658 Caenorhabditis elegans 44% 72%
O04856 Nicotiana tabacum 46% 70%
O04857 Nicotiana tabacum 45% 71%
O04858 Nicotiana tabacum 44% 73%
O04860 Nicotiana tabacum 73% 70%
O04951 Arabidopsis thaliana 71% 72%
O15757 Dictyostelium discoideum 44% 69%
O76932 Drosophila melanogaster 60% 72%
O82733 Arabidopsis thaliana 49% 67%
O82734 Arabidopsis thaliana 47% 68%
P0C5D7 Oryza sativa subsp. indica 75% 70%
P11084 Oryctolagus cuniculus 62% 72%
P11493 Sus scrofa 74% 75%
P11611 Oryctolagus cuniculus 74% 72%
P11612 Drosophila melanogaster 43% 70%
P12982 Drosophila melanogaster 48% 73%
P13681 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 68%
P20604 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 52% 71%
P20654 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 46% 68%
P22198 Zea mays 45% 70%
P23635 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 72% 72%
P23636 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 72% 69%
P23696 Drosophila melanogaster 73% 72%
P23777 Brassica napus 47% 87%
P23778 Brassica napus 74% 72%
P23880 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 69%
P30366 Arabidopsis thaliana 45% 69%
P32345 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 56% 72%
P32598 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 45% 71%
P36614 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 55% 72%
P36873 Homo sapiens 47% 68%
P36874 Xenopus laevis 47% 68%
P48461 Drosophila melanogaster 48% 68%
P48462 Drosophila melanogaster 47% 67%
P48463 Gallus gallus 74% 72%
P48480 Acetabularia peniculus 45% 69%
P48481 Acetabularia peniculus 46% 69%
P48482 Arabidopsis thaliana 47% 71%
P48483 Arabidopsis thaliana 49% 69%
P48484 Arabidopsis thaliana 46% 69%
P48485 Arabidopsis thaliana 46% 71%
P48486 Arabidopsis thaliana 44% 69%
P48487 Brassica oleracea 44% 70%
P48488 Medicago sativa subsp. varia 45% 69%
P48489 Oryza sativa subsp. japonica 46% 69%
P48490 Phaseolus vulgaris 47% 70%
P48528 Arabidopsis thaliana 66% 72%
P48529 Arabidopsis thaliana 66% 72%
P48577 Acetabularia peniculus 72% 72%
P48578 Arabidopsis thaliana 76% 71%
P48579 Helianthus annuus 71% 72%
P48580 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 74% 68%
P48726 Paramecium tetraurelia 59% 70%
P48727 Caenorhabditis elegans 48% 66%
P49576 Paramecium tetraurelia 58% 73%
P60510 Homo sapiens 62% 72%
P61287 Bos taurus 47% 68%
P61292 Sus scrofa 47% 68%
P62136 Homo sapiens 49% 67%
P62137 Mus musculus 49% 67%
P62138 Rattus norvegicus 49% 67%
P62139 Oryctolagus cuniculus 49% 67%
P62140 Homo sapiens 47% 68%
P62141 Mus musculus 47% 68%
P62142 Rattus norvegicus 47% 68%
P62143 Oryctolagus cuniculus 47% 68%
P62207 Gallus gallus 47% 68%
P62714 Homo sapiens 74% 72%
P62715 Mus musculus 74% 72%
P62716 Rattus norvegicus 74% 72%
P63087 Mus musculus 47% 68%
P63088 Rattus norvegicus 47% 68%
P63330 Mus musculus 73% 72%
P63331 Rattus norvegicus 73% 72%
P67774 Bos taurus 73% 72%
P67775 Homo sapiens 73% 72%
P67776 Sus scrofa 73% 72%
P67777 Oryctolagus cuniculus 73% 72%
P91420 Caenorhabditis elegans 43% 72%
P97470 Mus musculus 62% 72%
Q05547 Drosophila melanogaster 47% 73%
Q06009 Medicago sativa 75% 71%
Q07098 Arabidopsis thaliana 71% 72%
Q07099 Arabidopsis thaliana 71% 72%
Q07100 Arabidopsis thaliana 76% 71%
Q09496 Caenorhabditis elegans 50% 67%
Q0DBD3 Oryza sativa subsp. japonica 71% 72%
Q0E2S4 Oryza sativa subsp. japonica 71% 72%
Q0P594 Bos taurus 74% 72%
Q10298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 55% 72%
Q10BT5 Oryza sativa subsp. japonica 74% 72%
Q27497 Caenorhabditis elegans 48% 67%
Q27884 Drosophila melanogaster 50% 73%
Q3SWW9 Bos taurus 47% 68%
Q3T0E7 Bos taurus 49% 67%
Q4Q2C2 Leishmania major 50% 100%
Q4Q3C0 Leishmania major 45% 100%
Q4Q3C5 Leishmania major 40% 100%
Q4Q3C6 Leishmania major 41% 100%
Q4Q3C7 Leishmania major 40% 100%
Q4Q3C8 Leishmania major 40% 100%
Q4Q4W8 Leishmania major 61% 100%
Q4Q7Z5 Leishmania major 61% 100%
Q4Q8K1 Leishmania major 41% 100%
Q4Q9W1 Leishmania major 100% 100%
Q54RD6 Dictyostelium discoideum 54% 71%
Q59KY8 Candida albicans (strain SC5314 / ATCC MYA-2876) 52% 70%
Q5BJ92 Rattus norvegicus 61% 72%
Q5I085 Xenopus tropicalis 47% 68%
Q5R6K8 Pongo abelii 62% 72%
Q5R740 Pongo abelii 47% 68%
Q61JR3 Caenorhabditis briggsae 48% 67%
Q627N3 Caenorhabditis briggsae 48% 66%
Q64620 Rattus norvegicus 53% 72%
Q6BFF6 Paramecium tetraurelia 59% 70%
Q6CNT6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 58% 72%
Q6FM81 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 55% 72%
Q6GQL2 Xenopus laevis 47% 68%
Q6IP91 Xenopus laevis 62% 72%
Q6NVU2 Xenopus tropicalis 47% 68%
Q6P861 Xenopus tropicalis 62% 72%
Q74ZR2 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 58% 71%
Q7SZ10 Xenopus laevis 47% 68%
Q8LSN3 Pisum sativum 53% 73%
Q8MJ46 Canis lupus familiaris 47% 68%
Q8MJ47 Canis lupus familiaris 47% 68%
Q8WMS6 Canis lupus familiaris 49% 67%
Q8X178 Blumeria hordei 73% 67%
Q9CQR6 Mus musculus 53% 72%
Q9HFQ2 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 75% 67%
Q9LHE7 Arabidopsis thaliana 54% 73%
Q9M9W3 Arabidopsis thaliana 47% 69%
Q9SX52 Arabidopsis thaliana 53% 73%
Q9U9A3 Dictyostelium discoideum 54% 72%
Q9UW86 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 46% 72%
Q9XGH7 Nicotiana tabacum 74% 71%
Q9XTT8 Caenorhabditis elegans 59% 69%
Q9XW79 Caenorhabditis elegans 60% 66%
Q9XZE5 Dictyostelium discoideum 73% 72%
Q9Y0B7 Dictyostelium discoideum 61% 72%
Q9ZSE4 Hevea brasiliensis 71% 72%
V5AUW3 Trypanosoma cruzi 44% 67%
V5BKU4 Trypanosoma cruzi 42% 73%
V5DAX7 Trypanosoma cruzi 41% 96%
V5DCW3 Trypanosoma cruzi 63% 72%
V5DMS5 Trypanosoma cruzi 51% 72%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS