Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE73_LEIBR

TriTrypDb:

LbrM.25.1270 , LBRM2903_250022400

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.653
CLV_NRD_NRD_1	245	247	PF00675	0.317
CLV_NRD_NRD_1	3	5	PF00675	0.650
CLV_PCSK_KEX2_1	245	247	PF00082	0.317
CLV_PCSK_SKI1_1	246	250	PF00082	0.289
CLV_PCSK_SKI1_1	59	63	PF00082	0.426
DEG_SPOP_SBC_1	153	157	PF00917	0.498
DEG_SPOP_SBC_1	47	51	PF00917	0.677
DOC_CDC14_PxL_1	96	104	PF14671	0.476
DOC_USP7_MATH_1	153	157	PF00917	0.704
DOC_USP7_MATH_1	174	178	PF00917	0.686
DOC_USP7_MATH_1	3	7	PF00917	0.623
DOC_USP7_MATH_1	8	12	PF00917	0.523
DOC_WW_Pin1_4	126	131	PF00397	0.527
DOC_WW_Pin1_4	137	142	PF00397	0.527
DOC_WW_Pin1_4	180	185	PF00397	0.640
DOC_WW_Pin1_4	249	254	PF00397	0.262
LIG_Actin_WH2_2	96	113	PF00022	0.296
LIG_BRCT_BRCA1_1	5	9	PF00533	0.674
LIG_FHA_1	104	110	PF00498	0.394
LIG_FHA_1	164	170	PF00498	0.490
LIG_FHA_1	48	54	PF00498	0.518
LIG_FHA_2	118	124	PF00498	0.491
LIG_FHA_2	226	232	PF00498	0.293
LIG_FHA_2	53	59	PF00498	0.392
LIG_Integrin_RGD_1	236	238	PF01839	0.377
LIG_LIR_Gen_1	85	93	PF02991	0.528
LIG_PDZ_Class_3	256	261	PF00595	0.590
LIG_SH2_CRK	32	36	PF00017	0.502
LIG_SH2_GRB2like	54	57	PF00017	0.491
LIG_SH2_NCK_1	32	36	PF00017	0.502
LIG_SH2_SRC	198	201	PF00017	0.348
LIG_SH2_STAT5	198	201	PF00017	0.323
LIG_SH2_STAT5	54	57	PF00017	0.426
LIG_SH3_3	247	253	PF00018	0.283
LIG_TRAF2_1	113	116	PF00917	0.323
LIG_TRAF2_1	55	58	PF00917	0.456
LIG_TYR_ITIM	30	35	PF00017	0.497
MOD_CK1_1	156	162	PF00069	0.757
MOD_CK1_1	163	169	PF00069	0.645
MOD_CK1_1	82	88	PF00069	0.632
MOD_CK2_1	101	107	PF00069	0.427
MOD_CK2_1	117	123	PF00069	0.539
MOD_CK2_1	52	58	PF00069	0.423
MOD_CK2_1	61	67	PF00069	0.394
MOD_GlcNHglycan	10	13	PF01048	0.680
MOD_GlcNHglycan	103	106	PF01048	0.442
MOD_GlcNHglycan	156	159	PF01048	0.777
MOD_GlcNHglycan	170	173	PF01048	0.698
MOD_GlcNHglycan	70	73	PF01048	0.673
MOD_GlcNHglycan	81	84	PF01048	0.581
MOD_GSK3_1	152	159	PF00069	0.713
MOD_GSK3_1	175	182	PF00069	0.764
MOD_GSK3_1	31	38	PF00069	0.642
MOD_GSK3_1	43	50	PF00069	0.631
MOD_GSK3_1	75	82	PF00069	0.560
MOD_N-GLC_1	36	41	PF02516	0.570
MOD_N-GLC_1	75	80	PF02516	0.545
MOD_N-GLC_2	162	164	PF02516	0.617
MOD_NEK2_1	61	66	PF00069	0.419
MOD_NEK2_1	68	73	PF00069	0.515
MOD_NEK2_2	117	122	PF00069	0.490
MOD_PIKK_1	61	67	PF00454	0.409
MOD_PKA_2	3	9	PF00069	0.626
MOD_PKA_2	88	94	PF00069	0.514
MOD_Plk_4	98	104	PF00069	0.452
MOD_ProDKin_1	126	132	PF00069	0.536
MOD_ProDKin_1	137	143	PF00069	0.526
MOD_ProDKin_1	180	186	PF00069	0.363
MOD_ProDKin_1	249	255	PF00069	0.262
TRG_DiLeu_BaEn_2	56	62	PF01217	0.498
TRG_DiLeu_BaEn_3	194	200	PF01217	0.317
TRG_DiLeu_BaEn_4	57	63	PF01217	0.432
TRG_ENDOCYTIC_2	32	35	PF00928	0.503
TRG_ER_diArg_1	244	246	PF00400	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL9	Leptomonas seymouri	51%	97%
A0A1X0NMN4	Trypanosomatidae	32%	100%
A0A3Q8IBS1	Leishmania donovani	80%	100%
A4I1H5	Leishmania infantum	79%	100%
C9ZJZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AXK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q9W2	Leishmania major	77%	97%