Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PRP38 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HE72_LEIBR

TriTrypDb:

LbrM.25.1260 , LBRM2903_250022200

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0071011	precatalytic spliceosome	4	2

Expansion

Sequence features

A4HE72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE72

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008380	RNA splicing	7	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.525
CLV_C14_Caspase3-7	484	488	PF00656	0.639
CLV_C14_Caspase3-7	585	589	PF00656	0.748
CLV_NRD_NRD_1	114	116	PF00675	0.545
CLV_NRD_NRD_1	122	124	PF00675	0.553
CLV_NRD_NRD_1	366	368	PF00675	0.392
CLV_NRD_NRD_1	539	541	PF00675	0.625
CLV_NRD_NRD_1	634	636	PF00675	0.663
CLV_NRD_NRD_1	650	652	PF00675	0.531
CLV_NRD_NRD_1	654	656	PF00675	0.354
CLV_NRD_NRD_1	96	98	PF00675	0.498
CLV_PCSK_KEX2_1	114	116	PF00082	0.545
CLV_PCSK_KEX2_1	122	124	PF00082	0.553
CLV_PCSK_KEX2_1	261	263	PF00082	0.539
CLV_PCSK_KEX2_1	366	368	PF00082	0.392
CLV_PCSK_KEX2_1	537	539	PF00082	0.635
CLV_PCSK_KEX2_1	612	614	PF00082	0.646
CLV_PCSK_KEX2_1	634	636	PF00082	0.658
CLV_PCSK_KEX2_1	650	652	PF00082	0.531
CLV_PCSK_KEX2_1	96	98	PF00082	0.498
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.539
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.667
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.686
CLV_PCSK_SKI1_1	129	133	PF00082	0.674
CLV_PCSK_SKI1_1	228	232	PF00082	0.305
CLV_PCSK_SKI1_1	262	266	PF00082	0.439
CLV_PCSK_SKI1_1	302	306	PF00082	0.592
CLV_PCSK_SKI1_1	315	319	PF00082	0.495
CLV_PCSK_SKI1_1	417	421	PF00082	0.506
CLV_PCSK_SKI1_1	651	655	PF00082	0.573
CLV_Separin_Metazoa	263	267	PF03568	0.488
DEG_Nend_UBRbox_2	1	3	PF02207	0.650
DEG_SPOP_SBC_1	177	181	PF00917	0.603
DEG_SPOP_SBC_1	192	196	PF00917	0.686
DEG_SPOP_SBC_1	199	203	PF00917	0.600
DEG_SPOP_SBC_1	54	58	PF00917	0.566
DOC_ANK_TNKS_1	460	467	PF00023	0.660
DOC_ANK_TNKS_1	552	559	PF00023	0.515
DOC_CKS1_1	389	394	PF01111	0.452
DOC_CYCLIN_RxL_1	259	267	PF00134	0.504
DOC_CYCLIN_RxL_1	413	424	PF00134	0.519
DOC_MAPK_gen_1	366	376	PF00069	0.354
DOC_MAPK_gen_1	634	645	PF00069	0.628
DOC_MAPK_MEF2A_6	367	376	PF00069	0.366
DOC_MAPK_MEF2A_6	638	647	PF00069	0.634
DOC_MAPK_NFAT4_5	638	646	PF00069	0.630
DOC_MAPK_RevD_3	524	540	PF00069	0.722
DOC_PP2B_LxvP_1	13	16	PF13499	0.396
DOC_PP4_FxxP_1	389	392	PF00568	0.384
DOC_PP4_FxxP_1	6	9	PF00568	0.499
DOC_USP7_MATH_1	177	181	PF00917	0.609
DOC_USP7_MATH_1	191	195	PF00917	0.693
DOC_USP7_MATH_1	197	201	PF00917	0.499
DOC_USP7_MATH_1	296	300	PF00917	0.394
DOC_USP7_MATH_1	473	477	PF00917	0.749
DOC_USP7_MATH_1	48	52	PF00917	0.758
DOC_USP7_MATH_1	486	490	PF00917	0.744
DOC_USP7_MATH_1	589	593	PF00917	0.663
DOC_USP7_MATH_1	607	611	PF00917	0.625
DOC_USP7_MATH_2	164	170	PF00917	0.497
DOC_WW_Pin1_4	193	198	PF00397	0.774
DOC_WW_Pin1_4	335	340	PF00397	0.397
DOC_WW_Pin1_4	35	40	PF00397	0.644
DOC_WW_Pin1_4	388	393	PF00397	0.454
DOC_WW_Pin1_4	42	47	PF00397	0.775
DOC_WW_Pin1_4	469	474	PF00397	0.614
LIG_14-3-3_CanoR_1	282	288	PF00244	0.554
LIG_14-3-3_CanoR_1	290	298	PF00244	0.546
LIG_14-3-3_CanoR_1	349	355	PF00244	0.462
LIG_14-3-3_CanoR_1	378	382	PF00244	0.376
LIG_14-3-3_CanoR_1	71	76	PF00244	0.557
LIG_Actin_WH2_2	215	230	PF00022	0.529
LIG_APCC_ABBA_1	574	579	PF00400	0.719
LIG_BIR_III_4	588	592	PF00653	0.766
LIG_BRCT_BRCA1_1	479	483	PF00533	0.754
LIG_Clathr_ClatBox_1	575	579	PF01394	0.760
LIG_CSL_BTD_1	428	431	PF09270	0.417
LIG_CtBP_PxDLS_1	116	122	PF00389	0.458
LIG_eIF4E_1	259	265	PF01652	0.331
LIG_FHA_1	157	163	PF00498	0.630
LIG_FHA_1	205	211	PF00498	0.478
LIG_FHA_1	282	288	PF00498	0.525
LIG_FHA_1	389	395	PF00498	0.379
LIG_FHA_1	609	615	PF00498	0.555
LIG_FHA_1	642	648	PF00498	0.600
LIG_FHA_1	90	96	PF00498	0.446
LIG_FHA_2	303	309	PF00498	0.575
LIG_FHA_2	351	357	PF00498	0.399
LIG_FHA_2	36	42	PF00498	0.718
LIG_FHA_2	419	425	PF00498	0.519
LIG_FHA_2	482	488	PF00498	0.777
LIG_GBD_Chelix_1	342	350	PF00786	0.475
LIG_LIR_Apic_2	5	9	PF02991	0.553
LIG_LIR_Gen_1	207	213	PF02991	0.495
LIG_LIR_Gen_1	384	394	PF02991	0.477
LIG_LIR_Gen_1	658	664	PF02991	0.586
LIG_LIR_Nem_3	207	211	PF02991	0.500
LIG_LIR_Nem_3	274	279	PF02991	0.408
LIG_LIR_Nem_3	384	389	PF02991	0.475
LIG_LIR_Nem_3	427	432	PF02991	0.510
LIG_LIR_Nem_3	507	513	PF02991	0.604
LIG_LIR_Nem_3	658	664	PF02991	0.683
LIG_PAM2_1	267	279	PF00658	0.520
LIG_PCNA_PIPBox_1	354	363	PF02747	0.498
LIG_PCNA_yPIPBox_3	417	430	PF02747	0.503
LIG_PDZ_Class_2	659	664	PF00595	0.566
LIG_PTB_Apo_2	82	89	PF02174	0.560
LIG_PTB_Phospho_1	82	88	PF10480	0.555
LIG_Rb_LxCxE_1	396	416	PF01857	0.479
LIG_SH2_CRK	327	331	PF00017	0.443
LIG_SH2_NCK_1	379	383	PF00017	0.376
LIG_SH2_STAT5	208	211	PF00017	0.483
LIG_SH2_STAT5	212	215	PF00017	0.459
LIG_SH2_STAT5	243	246	PF00017	0.538
LIG_SH2_STAT5	320	323	PF00017	0.394
LIG_SH2_STAT5	375	378	PF00017	0.383
LIG_SH2_STAT5	379	382	PF00017	0.359
LIG_SH2_STAT5	386	389	PF00017	0.324
LIG_SH2_STAT5	661	664	PF00017	0.593
LIG_SH3_3	141	147	PF00018	0.529
LIG_SH3_3	438	444	PF00018	0.518
LIG_SH3_3	523	529	PF00018	0.595
LIG_SUMO_SIM_anti_2	559	568	PF11976	0.739
LIG_SUMO_SIM_anti_2	644	649	PF11976	0.593
LIG_TRFH_1	379	383	PF08558	0.476
LIG_TYR_ITIM	325	330	PF00017	0.405
MOD_CK1_1	135	141	PF00069	0.649
MOD_CK1_1	180	186	PF00069	0.677
MOD_CK1_1	195	201	PF00069	0.658
MOD_CK1_1	204	210	PF00069	0.522
MOD_CK1_1	281	287	PF00069	0.493
MOD_CK1_1	457	463	PF00069	0.563
MOD_CK1_1	60	66	PF00069	0.740
MOD_CK2_1	302	308	PF00069	0.542
MOD_CK2_1	35	41	PF00069	0.697
MOD_CK2_1	509	515	PF00069	0.688
MOD_Cter_Amidation	648	651	PF01082	0.646
MOD_GlcNHglycan	139	142	PF01048	0.706
MOD_GlcNHglycan	188	191	PF01048	0.685
MOD_GlcNHglycan	197	200	PF01048	0.537
MOD_GlcNHglycan	203	206	PF01048	0.412
MOD_GlcNHglycan	293	296	PF01048	0.584
MOD_GlcNHglycan	298	301	PF01048	0.635
MOD_GlcNHglycan	41	45	PF01048	0.706
MOD_GlcNHglycan	487	491	PF01048	0.700
MOD_GlcNHglycan	549	552	PF01048	0.597
MOD_GlcNHglycan	590	594	PF01048	0.737
MOD_GlcNHglycan	621	625	PF01048	0.794
MOD_GlcNHglycan	77	80	PF01048	0.551
MOD_GSK3_1	132	139	PF00069	0.680
MOD_GSK3_1	166	173	PF00069	0.541
MOD_GSK3_1	176	183	PF00069	0.413
MOD_GSK3_1	191	198	PF00069	0.751
MOD_GSK3_1	200	207	PF00069	0.598
MOD_GSK3_1	469	476	PF00069	0.680
MOD_GSK3_1	477	484	PF00069	0.604
MOD_GSK3_1	53	60	PF00069	0.752
MOD_GSK3_1	67	74	PF00069	0.644
MOD_N-GLC_2	324	326	PF02516	0.292
MOD_NEK2_1	170	175	PF00069	0.508
MOD_NEK2_1	186	191	PF00069	0.727
MOD_NEK2_1	244	249	PF00069	0.629
MOD_NEK2_1	264	269	PF00069	0.479
MOD_NEK2_1	448	453	PF00069	0.535
MOD_NEK2_1	547	552	PF00069	0.668
MOD_NEK2_1	641	646	PF00069	0.585
MOD_PIKK_1	253	259	PF00454	0.541
MOD_PIKK_1	454	460	PF00454	0.405
MOD_PIKK_1	477	483	PF00454	0.604
MOD_PKA_2	281	287	PF00069	0.514
MOD_PKA_2	291	297	PF00069	0.506
MOD_PKA_2	377	383	PF00069	0.437
MOD_Plk_4	204	210	PF00069	0.544
MOD_Plk_4	643	649	PF00069	0.592
MOD_ProDKin_1	193	199	PF00069	0.772
MOD_ProDKin_1	335	341	PF00069	0.391
MOD_ProDKin_1	35	41	PF00069	0.645
MOD_ProDKin_1	388	394	PF00069	0.452
MOD_ProDKin_1	42	48	PF00069	0.774
MOD_ProDKin_1	469	475	PF00069	0.611
TRG_DiLeu_BaEn_3	335	341	PF01217	0.491
TRG_DiLeu_BaEn_4	165	171	PF01217	0.356
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.498
TRG_ENDOCYTIC_2	208	211	PF00928	0.495
TRG_ENDOCYTIC_2	327	330	PF00928	0.355
TRG_ENDOCYTIC_2	386	389	PF00928	0.472
TRG_ENDOCYTIC_2	661	664	PF00928	0.693
TRG_ER_diArg_1	113	115	PF00400	0.554
TRG_ER_diArg_1	122	124	PF00400	0.547
TRG_ER_diArg_1	365	367	PF00400	0.443
TRG_ER_diArg_1	538	540	PF00400	0.676
TRG_ER_diArg_1	634	636	PF00400	0.658
TRG_ER_diArg_1	95	97	PF00400	0.493
TRG_NLS_MonoCore_2	536	541	PF00514	0.661
TRG_NLS_MonoExtN_4	609	616	PF00514	0.702
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP9	Leptomonas seymouri	61%	100%
A0A1X0NM33	Trypanosomatidae	32%	100%
A0A3Q8IDC3	Leishmania donovani	83%	100%
A0A422P1Y9	Trypanosoma rangeli	34%	100%
A4I1H4	Leishmania infantum	83%	100%
C9ZJZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AXK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9W3	Leishmania major	83%	99%