BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE69_LEIBR

TriTrypDb:

LbrM.25.1230 , LBRM2903_250021900

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.418
CLV_MEL_PAP_1	170	176	PF00089	0.415
CLV_NRD_NRD_1	134	136	PF00675	0.700
CLV_NRD_NRD_1	147	149	PF00675	0.302
CLV_NRD_NRD_1	253	255	PF00675	0.520
CLV_NRD_NRD_1	258	260	PF00675	0.548
CLV_NRD_NRD_1	355	357	PF00675	0.632
CLV_NRD_NRD_1	377	379	PF00675	0.479
CLV_NRD_NRD_1	62	64	PF00675	0.495
CLV_PCSK_KEX2_1	134	136	PF00082	0.700
CLV_PCSK_KEX2_1	149	151	PF00082	0.339
CLV_PCSK_KEX2_1	183	185	PF00082	0.650
CLV_PCSK_KEX2_1	252	254	PF00082	0.521
CLV_PCSK_KEX2_1	307	309	PF00082	0.580
CLV_PCSK_KEX2_1	355	357	PF00082	0.632
CLV_PCSK_KEX2_1	376	378	PF00082	0.482
CLV_PCSK_KEX2_1	62	64	PF00082	0.495
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.339
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.487
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.580
CLV_PCSK_PC7_1	373	379	PF00082	0.569
CLV_PCSK_SKI1_1	149	153	PF00082	0.292
CLV_PCSK_SKI1_1	237	241	PF00082	0.385
CLV_PCSK_SKI1_1	254	258	PF00082	0.324
CLV_PCSK_SKI1_1	308	312	PF00082	0.570
CLV_PCSK_SKI1_1	49	53	PF00082	0.406
CLV_PCSK_SKI1_1	80	84	PF00082	0.433
DEG_COP1_1	413	423	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.490
DEG_SCF_FBW7_1	277	283	PF00400	0.690
DEG_SCF_FBW7_2	492	499	PF00400	0.477
DOC_CKS1_1	277	282	PF01111	0.690
DOC_CKS1_1	420	425	PF01111	0.493
DOC_CKS1_1	449	454	PF01111	0.502
DOC_CKS1_1	457	462	PF01111	0.496
DOC_CYCLIN_RxL_1	146	156	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.464
DOC_MAPK_gen_1	411	417	PF00069	0.506
DOC_PP2B_LxvP_1	397	400	PF13499	0.477
DOC_PP4_MxPP_1	187	190	PF00568	0.487
DOC_SPAK_OSR1_1	173	177	PF12202	0.450
DOC_USP7_MATH_1	15	19	PF00917	0.507
DOC_USP7_MATH_1	206	210	PF00917	0.603
DOC_USP7_MATH_1	213	217	PF00917	0.634
DOC_USP7_MATH_1	267	271	PF00917	0.645
DOC_USP7_MATH_1	323	327	PF00917	0.593
DOC_USP7_MATH_1	439	443	PF00917	0.660
DOC_USP7_MATH_1	91	95	PF00917	0.414
DOC_WW_Pin1_4	105	110	PF00397	0.531
DOC_WW_Pin1_4	114	119	PF00397	0.715
DOC_WW_Pin1_4	123	128	PF00397	0.733
DOC_WW_Pin1_4	168	173	PF00397	0.615
DOC_WW_Pin1_4	176	181	PF00397	0.662
DOC_WW_Pin1_4	199	204	PF00397	0.703
DOC_WW_Pin1_4	214	219	PF00397	0.649
DOC_WW_Pin1_4	220	225	PF00397	0.633
DOC_WW_Pin1_4	273	278	PF00397	0.698
DOC_WW_Pin1_4	280	285	PF00397	0.656
DOC_WW_Pin1_4	287	292	PF00397	0.547
DOC_WW_Pin1_4	341	346	PF00397	0.446
DOC_WW_Pin1_4	405	410	PF00397	0.598
DOC_WW_Pin1_4	419	424	PF00397	0.666
DOC_WW_Pin1_4	430	435	PF00397	0.640
DOC_WW_Pin1_4	448	453	PF00397	0.715
DOC_WW_Pin1_4	456	461	PF00397	0.626
DOC_WW_Pin1_4	492	497	PF00397	0.472
DOC_WW_Pin1_4	87	92	PF00397	0.471
LIG_14-3-3_CanoR_1	134	140	PF00244	0.669
LIG_14-3-3_CanoR_1	173	177	PF00244	0.608
LIG_14-3-3_CanoR_1	214	218	PF00244	0.684
LIG_14-3-3_CanoR_1	289	299	PF00244	0.770
LIG_14-3-3_CanoR_1	308	317	PF00244	0.378
LIG_Actin_WH2_2	178	196	PF00022	0.491
LIG_BRCT_BRCA1_1	170	174	PF00533	0.399
LIG_BRCT_BRCA1_1	19	23	PF00533	0.514
LIG_BRCT_BRCA1_1	5	9	PF00533	0.542
LIG_CaM_IQ_9	365	380	PF13499	0.568
LIG_FHA_1	344	350	PF00498	0.559
LIG_FHA_1	381	387	PF00498	0.466
LIG_FHA_1	449	455	PF00498	0.647
LIG_FHA_1	457	463	PF00498	0.549
LIG_FHA_1	68	74	PF00498	0.486
LIG_FHA_2	206	212	PF00498	0.682
LIG_FHA_2	316	322	PF00498	0.513
LIG_FHA_2	475	481	PF00498	0.705
LIG_GSK3_LRP6_1	273	279	PF00069	0.525
LIG_Integrin_RGD_1	37	39	PF01839	0.557
LIG_Integrin_RGD_1	468	470	PF01839	0.542
LIG_LIR_Gen_1	153	162	PF02991	0.435
LIG_LIR_Gen_1	298	306	PF02991	0.593
LIG_LIR_Gen_1	488	498	PF02991	0.560
LIG_LIR_Gen_1	6	16	PF02991	0.502
LIG_LIR_Gen_1	68	77	PF02991	0.307
LIG_LIR_Nem_3	153	157	PF02991	0.443
LIG_LIR_Nem_3	20	26	PF02991	0.538
LIG_LIR_Nem_3	232	238	PF02991	0.348
LIG_LIR_Nem_3	298	302	PF02991	0.615
LIG_LIR_Nem_3	488	494	PF02991	0.481
LIG_LIR_Nem_3	6	12	PF02991	0.504
LIG_LIR_Nem_3	68	74	PF02991	0.303
LIG_PCNA_yPIPBox_3	148	162	PF02747	0.279
LIG_Pex14_2	12	16	PF04695	0.509
LIG_Pex14_2	191	195	PF04695	0.507
LIG_Pex14_2	235	239	PF04695	0.298
LIG_Pex14_2	5	9	PF04695	0.550
LIG_REV1ctd_RIR_1	232	241	PF16727	0.349
LIG_SH2_CRK	162	166	PF00017	0.394
LIG_SH2_CRK	71	75	PF00017	0.464
LIG_SH2_STAP1	71	75	PF00017	0.350
LIG_SH2_STAT3	26	29	PF00017	0.333
LIG_SH2_STAT5	238	241	PF00017	0.324
LIG_SH2_STAT5	26	29	PF00017	0.517
LIG_SH3_3	137	143	PF00018	0.652
LIG_SH3_3	212	218	PF00018	0.639
LIG_SH3_3	271	277	PF00018	0.718
LIG_SH3_3	415	421	PF00018	0.679
LIG_SH3_3	446	452	PF00018	0.705
LIG_SH3_3	454	460	PF00018	0.707
LIG_SH3_3	71	77	PF00018	0.472
LIG_SUMO_SIM_par_1	162	168	PF11976	0.288
LIG_SUMO_SIM_par_1	416	422	PF11976	0.496
LIG_SUMO_SIM_par_1	451	459	PF11976	0.515
LIG_TRAF2_1	385	388	PF00917	0.391
LIG_TYR_ITIM	152	157	PF00017	0.448
MOD_CDK_SPK_2	168	173	PF00069	0.524
MOD_CDK_SPK_2	220	225	PF00069	0.492
MOD_CDK_SPxK_1	405	411	PF00069	0.517
MOD_CDK_SPxxK_3	105	112	PF00069	0.592
MOD_CDK_SPxxK_3	123	130	PF00069	0.498
MOD_CDK_SPxxK_3	176	183	PF00069	0.667
MOD_CDK_SPxxK_3	405	412	PF00069	0.629
MOD_CK1_1	108	114	PF00069	0.515
MOD_CK1_1	202	208	PF00069	0.627
MOD_CK1_1	216	222	PF00069	0.783
MOD_CK1_1	262	268	PF00069	0.664
MOD_CK1_1	276	282	PF00069	0.676
MOD_CK1_1	290	296	PF00069	0.478
MOD_CK1_1	3	9	PF00069	0.579
MOD_CK1_1	442	448	PF00069	0.638
MOD_CK1_1	473	479	PF00069	0.685
MOD_CK1_1	90	96	PF00069	0.423
MOD_CK2_1	108	114	PF00069	0.726
MOD_CK2_1	205	211	PF00069	0.632
MOD_CK2_1	323	329	PF00069	0.552
MOD_CK2_1	334	340	PF00069	0.564
MOD_CK2_1	381	387	PF00069	0.420
MOD_DYRK1A_RPxSP_1	214	218	PF00069	0.520
MOD_GlcNHglycan	135	138	PF01048	0.576
MOD_GlcNHglycan	176	179	PF01048	0.757
MOD_GlcNHglycan	19	22	PF01048	0.485
MOD_GlcNHglycan	204	207	PF01048	0.650
MOD_GlcNHglycan	208	211	PF01048	0.552
MOD_GlcNHglycan	219	222	PF01048	0.759
MOD_GlcNHglycan	261	264	PF01048	0.569
MOD_GlcNHglycan	265	268	PF01048	0.559
MOD_GlcNHglycan	292	295	PF01048	0.549
MOD_GlcNHglycan	325	328	PF01048	0.527
MOD_GlcNHglycan	334	339	PF01048	0.632
MOD_GlcNHglycan	352	355	PF01048	0.385
MOD_GlcNHglycan	383	386	PF01048	0.552
MOD_GlcNHglycan	403	406	PF01048	0.730
MOD_GlcNHglycan	444	447	PF01048	0.709
MOD_GlcNHglycan	477	480	PF01048	0.723
MOD_GlcNHglycan	482	485	PF01048	0.647
MOD_GlcNHglycan	93	96	PF01048	0.465
MOD_GSK3_1	114	121	PF00069	0.799
MOD_GSK3_1	168	175	PF00069	0.591
MOD_GSK3_1	202	209	PF00069	0.659
MOD_GSK3_1	213	220	PF00069	0.668
MOD_GSK3_1	258	265	PF00069	0.603
MOD_GSK3_1	272	279	PF00069	0.731
MOD_GSK3_1	3	10	PF00069	0.523
MOD_GSK3_1	311	318	PF00069	0.436
MOD_GSK3_1	401	408	PF00069	0.549
MOD_GSK3_1	430	437	PF00069	0.740
MOD_GSK3_1	469	476	PF00069	0.716
MOD_GSK3_1	87	94	PF00069	0.425
MOD_N-GLC_1	341	346	PF02516	0.494
MOD_NEK2_1	174	179	PF00069	0.587
MOD_NEK2_1	56	61	PF00069	0.453
MOD_PIKK_1	247	253	PF00454	0.448
MOD_PIKK_1	267	273	PF00454	0.598
MOD_PIKK_1	3	9	PF00454	0.548
MOD_PIKK_1	471	477	PF00454	0.519
MOD_PKA_1	259	265	PF00069	0.431
MOD_PKA_2	133	139	PF00069	0.678
MOD_PKA_2	172	178	PF00069	0.627
MOD_PKA_2	213	219	PF00069	0.723
MOD_PKA_2	258	264	PF00069	0.545
MOD_Plk_1	413	419	PF00069	0.695
MOD_Plk_1	487	493	PF00069	0.598
MOD_Plk_1	67	73	PF00069	0.549
MOD_Plk_4	360	366	PF00069	0.439
MOD_Plk_4	413	419	PF00069	0.514
MOD_Plk_4	487	493	PF00069	0.704
MOD_Plk_4	56	62	PF00069	0.376
MOD_ProDKin_1	105	111	PF00069	0.535
MOD_ProDKin_1	114	120	PF00069	0.715
MOD_ProDKin_1	123	129	PF00069	0.731
MOD_ProDKin_1	168	174	PF00069	0.625
MOD_ProDKin_1	176	182	PF00069	0.664
MOD_ProDKin_1	199	205	PF00069	0.706
MOD_ProDKin_1	214	220	PF00069	0.650
MOD_ProDKin_1	273	279	PF00069	0.699
MOD_ProDKin_1	280	286	PF00069	0.655
MOD_ProDKin_1	287	293	PF00069	0.542
MOD_ProDKin_1	341	347	PF00069	0.446
MOD_ProDKin_1	405	411	PF00069	0.590
MOD_ProDKin_1	419	425	PF00069	0.665
MOD_ProDKin_1	430	436	PF00069	0.640
MOD_ProDKin_1	448	454	PF00069	0.720
MOD_ProDKin_1	456	462	PF00069	0.629
MOD_ProDKin_1	492	498	PF00069	0.474
MOD_ProDKin_1	87	93	PF00069	0.465
MOD_SUMO_for_1	16	19	PF00179	0.507
MOD_SUMO_rev_2	197	203	PF00179	0.539
MOD_SUMO_rev_2	290	299	PF00179	0.479
TRG_AP2beta_CARGO_1	236	246	PF09066	0.308
TRG_DiLeu_BaEn_2	18	24	PF01217	0.505
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.379
TRG_ENDOCYTIC_2	154	157	PF00928	0.473
TRG_ENDOCYTIC_2	162	165	PF00928	0.367
TRG_ENDOCYTIC_2	71	74	PF00928	0.306
TRG_ER_diArg_1	148	151	PF00400	0.360
TRG_ER_diArg_1	252	254	PF00400	0.527
TRG_ER_diArg_1	376	378	PF00400	0.521
TRG_ER_diArg_1	61	63	PF00400	0.500
TRG_NLS_Bipartite_1	134	152	PF00514	0.393
TRG_NLS_MonoExtC_3	147	153	PF00514	0.291
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC05	Leptomonas seymouri	44%	92%
A0A1X0NLY0	Trypanosomatidae	28%	100%
A0A3R7NU60	Trypanosoma rangeli	27%	100%
A0A3S7WZ41	Leishmania donovani	68%	98%
A4I1H1	Leishmania infantum	67%	98%
E9AXK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q4Q9W6	Leishmania major	67%	100%