RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE65_LEIBR

TriTrypDb:

LbrM.25.1190 , LBRM2903_250021500

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0034518	RNA cap binding complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.490
CLV_NRD_NRD_1	128	130	PF00675	0.490
CLV_NRD_NRD_1	179	181	PF00675	0.321
CLV_NRD_NRD_1	315	317	PF00675	0.404
CLV_NRD_NRD_1	366	368	PF00675	0.317
CLV_NRD_NRD_1	373	375	PF00675	0.343
CLV_NRD_NRD_1	438	440	PF00675	0.338
CLV_NRD_NRD_1	48	50	PF00675	0.353
CLV_NRD_NRD_1	94	96	PF00675	0.414
CLV_PCSK_FUR_1	46	50	PF00082	0.368
CLV_PCSK_KEX2_1	181	183	PF00082	0.291
CLV_PCSK_KEX2_1	315	317	PF00082	0.404
CLV_PCSK_KEX2_1	366	368	PF00082	0.320
CLV_PCSK_KEX2_1	373	375	PF00082	0.345
CLV_PCSK_KEX2_1	438	440	PF00082	0.372
CLV_PCSK_KEX2_1	48	50	PF00082	0.376
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.281
CLV_PCSK_PC7_1	177	183	PF00082	0.417
CLV_PCSK_PC7_1	369	375	PF00082	0.417
CLV_PCSK_SKI1_1	172	176	PF00082	0.269
CLV_PCSK_SKI1_1	203	207	PF00082	0.340
CLV_PCSK_SKI1_1	213	217	PF00082	0.322
CLV_PCSK_SKI1_1	279	283	PF00082	0.375
CLV_PCSK_SKI1_1	315	319	PF00082	0.435
CLV_PCSK_SKI1_1	369	373	PF00082	0.368
CLV_PCSK_SKI1_1	451	455	PF00082	0.302
CLV_PCSK_SKI1_1	48	52	PF00082	0.299
CLV_PCSK_SKI1_1	610	614	PF00082	0.385
CLV_PCSK_SKI1_1	78	82	PF00082	0.303
DEG_APCC_DBOX_1	202	210	PF00400	0.303
DEG_APCC_DBOX_1	212	220	PF00400	0.303
DEG_APCC_DBOX_1	609	617	PF00400	0.334
DEG_Nend_UBRbox_1	1	4	PF02207	0.417
DEG_SPOP_SBC_1	402	406	PF00917	0.385
DOC_CKS1_1	537	542	PF01111	0.350
DOC_CYCLIN_RxL_1	200	210	PF00134	0.416
DOC_CYCLIN_RxL_1	43	55	PF00134	0.291
DOC_MAPK_DCC_7	213	221	PF00069	0.193
DOC_MAPK_gen_1	180	190	PF00069	0.303
DOC_MAPK_gen_1	43	52	PF00069	0.417
DOC_MAPK_gen_1	95	102	PF00069	0.350
DOC_MAPK_MEF2A_6	408	416	PF00069	0.381
DOC_MAPK_MEF2A_6	95	104	PF00069	0.335
DOC_PP2B_LxvP_1	420	423	PF13499	0.289
DOC_PP2B_LxvP_1	573	576	PF13499	0.417
DOC_USP7_MATH_1	254	258	PF00917	0.333
DOC_USP7_MATH_1	274	278	PF00917	0.232
DOC_USP7_MATH_1	35	39	PF00917	0.462
DOC_USP7_MATH_1	385	389	PF00917	0.377
DOC_USP7_MATH_1	402	406	PF00917	0.403
DOC_USP7_MATH_1	582	586	PF00917	0.278
DOC_WW_Pin1_4	214	219	PF00397	0.350
DOC_WW_Pin1_4	328	333	PF00397	0.280
DOC_WW_Pin1_4	383	388	PF00397	0.372
DOC_WW_Pin1_4	398	403	PF00397	0.475
DOC_WW_Pin1_4	536	541	PF00397	0.305
DOC_WW_Pin1_4	555	560	PF00397	0.447
DOC_WW_Pin1_4	86	91	PF00397	0.313
LIG_14-3-3_CanoR_1	279	284	PF00244	0.465
LIG_14-3-3_CanoR_1	351	359	PF00244	0.417
LIG_14-3-3_CanoR_1	451	459	PF00244	0.298
LIG_14-3-3_CanoR_1	503	512	PF00244	0.381
LIG_APCC_ABBA_1	60	65	PF00400	0.334
LIG_BRCT_BRCA1_1	289	293	PF00533	0.400
LIG_CtBP_PxDLS_1	138	144	PF00389	0.289
LIG_eIF4E_1	447	453	PF01652	0.417
LIG_FHA_1	134	140	PF00498	0.417
LIG_FHA_1	337	343	PF00498	0.426
LIG_FHA_1	411	417	PF00498	0.362
LIG_FHA_1	428	434	PF00498	0.192
LIG_FHA_1	493	499	PF00498	0.253
LIG_FHA_2	329	335	PF00498	0.274
LIG_FHA_2	388	394	PF00498	0.332
LIG_FHA_2	589	595	PF00498	0.355
LIG_IBAR_NPY_1	118	120	PF08397	0.193
LIG_LIR_Gen_1	263	271	PF02991	0.350
LIG_LIR_Gen_1	3	11	PF02991	0.277
LIG_LIR_Gen_1	41	52	PF02991	0.274
LIG_LIR_Gen_1	461	470	PF02991	0.288
LIG_LIR_Gen_1	568	576	PF02991	0.302
LIG_LIR_Nem_3	114	120	PF02991	0.417
LIG_LIR_Nem_3	159	165	PF02991	0.350
LIG_LIR_Nem_3	227	231	PF02991	0.375
LIG_LIR_Nem_3	263	267	PF02991	0.350
LIG_LIR_Nem_3	291	297	PF02991	0.318
LIG_LIR_Nem_3	3	7	PF02991	0.285
LIG_LIR_Nem_3	41	47	PF02991	0.274
LIG_LIR_Nem_3	461	466	PF02991	0.288
LIG_LIR_Nem_3	568	573	PF02991	0.321
LIG_LYPXL_yS_3	97	100	PF13949	0.368
LIG_NRBOX	46	52	PF00104	0.289
LIG_PCNA_yPIPBox_3	199	213	PF02747	0.404
LIG_Pex14_2	501	505	PF04695	0.303
LIG_PTB_Apo_2	222	229	PF02174	0.193
LIG_PTB_Phospho_1	222	228	PF10480	0.193
LIG_SH2_CRK	264	268	PF00017	0.350
LIG_SH2_CRK	447	451	PF00017	0.429
LIG_SH2_CRK	570	574	PF00017	0.417
LIG_SH2_PTP2	228	231	PF00017	0.334
LIG_SH2_PTP2	604	607	PF00017	0.308
LIG_SH2_SRC	120	123	PF00017	0.303
LIG_SH2_SRC	228	231	PF00017	0.358
LIG_SH2_STAP1	338	342	PF00017	0.350
LIG_SH2_STAP1	570	574	PF00017	0.360
LIG_SH2_STAP1	69	73	PF00017	0.277
LIG_SH2_STAT5	120	123	PF00017	0.200
LIG_SH2_STAT5	162	165	PF00017	0.193
LIG_SH2_STAT5	228	231	PF00017	0.334
LIG_SH2_STAT5	338	341	PF00017	0.422
LIG_SH2_STAT5	421	424	PF00017	0.437
LIG_SH2_STAT5	432	435	PF00017	0.388
LIG_SH2_STAT5	604	607	PF00017	0.349
LIG_SH3_1	107	113	PF00018	0.417
LIG_SH3_2	90	95	PF14604	0.350
LIG_SH3_3	107	113	PF00018	0.313
LIG_SH3_3	381	387	PF00018	0.193
LIG_SH3_3	534	540	PF00018	0.318
LIG_SH3_3	600	606	PF00018	0.394
LIG_SH3_3	87	93	PF00018	0.368
LIG_Sin3_3	462	469	PF02671	0.350
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.334
LIG_SUMO_SIM_anti_2	551	556	PF11976	0.193
LIG_TRAF2_1	232	235	PF00917	0.417
LIG_TRAF2_1	489	492	PF00917	0.350
LIG_TRAF2_1	563	566	PF00917	0.299
LIG_TRFH_1	13	17	PF08558	0.289
LIG_TYR_ITIM	42	47	PF00017	0.417
LIG_UBA3_1	14	23	PF00899	0.417
LIG_UBA3_1	59	67	PF00899	0.417
LIG_WRC_WIRS_1	1	6	PF05994	0.334
MOD_CDK_SPxxK_3	328	335	PF00069	0.274
MOD_CDK_SPxxK_3	555	562	PF00069	0.350
MOD_CK1_1	248	254	PF00069	0.397
MOD_CK1_1	308	314	PF00069	0.472
MOD_CK1_1	383	389	PF00069	0.339
MOD_CK1_1	401	407	PF00069	0.398
MOD_CK1_1	410	416	PF00069	0.355
MOD_CK1_1	504	510	PF00069	0.395
MOD_CK1_1	542	548	PF00069	0.203
MOD_CK1_1	568	574	PF00069	0.417
MOD_CK1_1	585	591	PF00069	0.145
MOD_CK2_1	204	210	PF00069	0.385
MOD_CK2_1	229	235	PF00069	0.308
MOD_CK2_1	328	334	PF00069	0.274
MOD_CK2_1	73	79	PF00069	0.289
MOD_Cter_Amidation	313	316	PF01082	0.350
MOD_Cter_Amidation	436	439	PF01082	0.426
MOD_Cter_Amidation	93	96	PF01082	0.350
MOD_GlcNHglycan	189	193	PF01048	0.402
MOD_GlcNHglycan	231	234	PF01048	0.481
MOD_GlcNHglycan	32	35	PF01048	0.402
MOD_GlcNHglycan	353	356	PF01048	0.443
MOD_GlcNHglycan	387	390	PF01048	0.313
MOD_GlcNHglycan	409	412	PF01048	0.354
MOD_GlcNHglycan	454	457	PF01048	0.325
MOD_GlcNHglycan	460	463	PF01048	0.336
MOD_GlcNHglycan	483	486	PF01048	0.308
MOD_GlcNHglycan	506	509	PF01048	0.378
MOD_GlcNHglycan	55	58	PF01048	0.301
MOD_GlcNHglycan	555	558	PF01048	0.424
MOD_GlcNHglycan	7	10	PF01048	0.364
MOD_GSK3_1	188	195	PF00069	0.343
MOD_GSK3_1	205	212	PF00069	0.235
MOD_GSK3_1	30	37	PF00069	0.295
MOD_GSK3_1	383	390	PF00069	0.477
MOD_GSK3_1	398	405	PF00069	0.251
MOD_GSK3_1	454	461	PF00069	0.400
MOD_GSK3_1	515	522	PF00069	0.350
MOD_GSK3_1	565	572	PF00069	0.441
MOD_N-GLC_1	172	177	PF02516	0.193
MOD_N-GLC_1	224	229	PF02516	0.193
MOD_N-GLC_1	398	403	PF02516	0.193
MOD_N-GLC_2	350	352	PF02516	0.417
MOD_NEK2_1	133	138	PF00069	0.329
MOD_NEK2_1	163	168	PF00069	0.335
MOD_NEK2_1	362	367	PF00069	0.435
MOD_NEK2_1	452	457	PF00069	0.334
MOD_NEK2_1	458	463	PF00069	0.341
MOD_NEK2_1	501	506	PF00069	0.350
MOD_NEK2_1	569	574	PF00069	0.464
MOD_OFUCOSY	161	167	PF10250	0.334
MOD_OFUCOSY	244	249	PF10250	0.193
MOD_PIKK_1	172	178	PF00454	0.426
MOD_PIKK_1	274	280	PF00454	0.205
MOD_PIKK_1	336	342	PF00454	0.428
MOD_PIKK_1	596	602	PF00454	0.417
MOD_PK_1	548	554	PF00069	0.193
MOD_PKA_1	373	379	PF00069	0.420
MOD_PKA_2	373	379	PF00069	0.420
MOD_PKA_2	588	594	PF00069	0.195
MOD_Plk_1	224	230	PF00069	0.327
MOD_Plk_1	288	294	PF00069	0.303
MOD_Plk_1	305	311	PF00069	0.278
MOD_Plk_1	380	386	PF00069	0.323
MOD_Plk_1	427	433	PF00069	0.302
MOD_Plk_1	565	571	PF00069	0.310
MOD_Plk_4	224	230	PF00069	0.390
MOD_Plk_4	263	269	PF00069	0.247
MOD_Plk_4	279	285	PF00069	0.296
MOD_Plk_4	454	460	PF00069	0.417
MOD_Plk_4	565	571	PF00069	0.371
MOD_ProDKin_1	214	220	PF00069	0.350
MOD_ProDKin_1	328	334	PF00069	0.280
MOD_ProDKin_1	383	389	PF00069	0.372
MOD_ProDKin_1	398	404	PF00069	0.475
MOD_ProDKin_1	536	542	PF00069	0.305
MOD_ProDKin_1	555	561	PF00069	0.447
MOD_ProDKin_1	86	92	PF00069	0.313
MOD_SUMO_rev_2	388	396	PF00179	0.193
TRG_DiLeu_BaEn_1	313	318	PF01217	0.303
TRG_DiLeu_BaEn_4	234	240	PF01217	0.350
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.368
TRG_DiLeu_LyEn_5	313	318	PF01217	0.193
TRG_ENDOCYTIC_2	120	123	PF00928	0.410
TRG_ENDOCYTIC_2	162	165	PF00928	0.193
TRG_ENDOCYTIC_2	228	231	PF00928	0.334
TRG_ENDOCYTIC_2	264	267	PF00928	0.350
TRG_ENDOCYTIC_2	44	47	PF00928	0.274
TRG_ENDOCYTIC_2	447	450	PF00928	0.432
TRG_ENDOCYTIC_2	479	482	PF00928	0.368
TRG_ENDOCYTIC_2	570	573	PF00928	0.417
TRG_ENDOCYTIC_2	604	607	PF00928	0.327
TRG_ENDOCYTIC_2	97	100	PF00928	0.334
TRG_ER_diArg_1	100	103	PF00400	0.329
TRG_ER_diArg_1	143	146	PF00400	0.289
TRG_ER_diArg_1	179	182	PF00400	0.287
TRG_ER_diArg_1	315	317	PF00400	0.350
TRG_ER_diArg_1	318	321	PF00400	0.337
TRG_ER_diArg_1	366	369	PF00400	0.318
TRG_ER_diArg_1	372	374	PF00400	0.348
TRG_ER_diArg_1	438	441	PF00400	0.417
TRG_ER_diArg_1	46	49	PF00400	0.351
TRG_NLS_MonoCore_2	180	185	PF00514	0.289
TRG_NLS_MonoExtC_3	179	184	PF00514	0.310
TRG_NLS_MonoExtN_4	177	184	PF00514	0.343
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.221

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II50	Leptomonas seymouri	58%	95%
A0A0S4J8F6	Bodo saltans	32%	100%
A0A1X0NNM1	Trypanosomatidae	38%	100%
A0A3Q8IDG9	Leishmania donovani	81%	100%
A0A422P1X4	Trypanosoma rangeli	43%	100%
A4I1G5	Leishmania infantum	81%	100%
C9ZK06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AXK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q9X1	Leishmania major	81%	98%
V5D8Y9	Trypanosoma cruzi	42%	100%