Modification methylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

modification methylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HE63_LEIBR

TriTrypDb:

LbrM.25.1170 , LBRM2903_250021300

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE63

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	5	6
GO:0008168	methyltransferase activity	4	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0009008	DNA-methyltransferase activity	4	6
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.757
CLV_C14_Caspase3-7	221	225	PF00656	0.814
CLV_C14_Caspase3-7	426	430	PF00656	0.532
CLV_C14_Caspase3-7	743	747	PF00656	0.563
CLV_C14_Caspase3-7	794	798	PF00656	0.607
CLV_NRD_NRD_1	120	122	PF00675	0.819
CLV_NRD_NRD_1	245	247	PF00675	0.667
CLV_NRD_NRD_1	266	268	PF00675	0.682
CLV_NRD_NRD_1	35	37	PF00675	0.627
CLV_NRD_NRD_1	556	558	PF00675	0.323
CLV_NRD_NRD_1	679	681	PF00675	0.327
CLV_NRD_NRD_1	76	78	PF00675	0.797
CLV_NRD_NRD_1	841	843	PF00675	0.476
CLV_PCSK_KEX2_1	119	121	PF00082	0.823
CLV_PCSK_KEX2_1	245	247	PF00082	0.667
CLV_PCSK_KEX2_1	266	268	PF00082	0.682
CLV_PCSK_KEX2_1	35	37	PF00082	0.727
CLV_PCSK_KEX2_1	558	560	PF00082	0.322
CLV_PCSK_KEX2_1	679	681	PF00082	0.327
CLV_PCSK_KEX2_1	841	843	PF00082	0.595
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.645
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.379
CLV_PCSK_SKI1_1	207	211	PF00082	0.681
CLV_PCSK_SKI1_1	267	271	PF00082	0.661
CLV_PCSK_SKI1_1	35	39	PF00082	0.627
CLV_PCSK_SKI1_1	350	354	PF00082	0.325
CLV_PCSK_SKI1_1	41	45	PF00082	0.635
CLV_PCSK_SKI1_1	602	606	PF00082	0.281
CLV_PCSK_SKI1_1	700	704	PF00082	0.319
CLV_Separin_Metazoa	484	488	PF03568	0.517
DEG_APCC_DBOX_1	340	348	PF00400	0.517
DEG_APCC_DBOX_1	93	101	PF00400	0.671
DEG_SCF_FBW7_1	397	402	PF00400	0.574
DEG_SPOP_SBC_1	399	403	PF00917	0.563
DOC_CYCLIN_RxL_1	697	705	PF00134	0.556
DOC_MAPK_MEF2A_6	188	197	PF00069	0.498
DOC_PP1_RVXF_1	556	563	PF00149	0.556
DOC_PP2B_LxvP_1	177	180	PF13499	0.649
DOC_PP2B_LxvP_1	379	382	PF13499	0.630
DOC_PP2B_LxvP_1	528	531	PF13499	0.426
DOC_PP4_FxxP_1	357	360	PF00568	0.556
DOC_PP4_FxxP_1	586	589	PF00568	0.533
DOC_PP4_FxxP_1	783	786	PF00568	0.556
DOC_USP7_MATH_1	149	153	PF00917	0.769
DOC_USP7_MATH_1	164	168	PF00917	0.450
DOC_USP7_MATH_1	212	216	PF00917	0.612
DOC_USP7_MATH_1	284	288	PF00917	0.647
DOC_USP7_MATH_1	399	403	PF00917	0.627
DOC_USP7_MATH_1	411	415	PF00917	0.692
DOC_USP7_MATH_1	461	465	PF00917	0.517
DOC_USP7_MATH_1	524	528	PF00917	0.514
DOC_USP7_MATH_1	619	623	PF00917	0.493
DOC_USP7_MATH_1	659	663	PF00917	0.607
DOC_USP7_MATH_1	752	756	PF00917	0.556
DOC_USP7_MATH_1	833	837	PF00917	0.628
DOC_WW_Pin1_4	208	213	PF00397	0.516
DOC_WW_Pin1_4	295	300	PF00397	0.641
DOC_WW_Pin1_4	308	313	PF00397	0.545
DOC_WW_Pin1_4	395	400	PF00397	0.583
DOC_WW_Pin1_4	550	555	PF00397	0.517
DOC_WW_Pin1_4	581	586	PF00397	0.447
DOC_WW_Pin1_4	615	620	PF00397	0.607
DOC_WW_Pin1_4	655	660	PF00397	0.543
DOC_WW_Pin1_4	717	722	PF00397	0.502
LIG_14-3-3_CanoR_1	408	416	PF00244	0.533
LIG_14-3-3_CanoR_1	522	531	PF00244	0.555
LIG_14-3-3_CanoR_1	597	604	PF00244	0.426
LIG_14-3-3_CanoR_1	61	67	PF00244	0.550
LIG_14-3-3_CanoR_1	679	685	PF00244	0.534
LIG_14-3-3_CanoR_1	698	703	PF00244	0.546
LIG_14-3-3_CanoR_1	707	711	PF00244	0.480
LIG_Actin_WH2_2	24	40	PF00022	0.597
LIG_Actin_WH2_2	724	741	PF00022	0.579
LIG_APCC_ABBAyCdc20_2	478	484	PF00400	0.517
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BIR_III_1	1	5	PF00653	0.552
LIG_BIR_III_3	1	5	PF00653	0.669
LIG_BIR_III_4	470	474	PF00653	0.607
LIG_BRCT_BRCA1_1	330	334	PF00533	0.511
LIG_Clathr_ClatBox_1	505	509	PF01394	0.607
LIG_deltaCOP1_diTrp_1	477	482	PF00928	0.556
LIG_DLG_GKlike_1	575	583	PF00625	0.524
LIG_EVH1_2	763	767	PF00568	0.517
LIG_FHA_1	128	134	PF00498	0.534
LIG_FHA_1	137	143	PF00498	0.682
LIG_FHA_1	266	272	PF00498	0.629
LIG_FHA_1	296	302	PF00498	0.546
LIG_FHA_1	32	38	PF00498	0.482
LIG_FHA_1	450	456	PF00498	0.565
LIG_FHA_1	493	499	PF00498	0.556
LIG_FHA_1	523	529	PF00498	0.502
LIG_FHA_1	603	609	PF00498	0.426
LIG_FHA_1	787	793	PF00498	0.544
LIG_FHA_2	102	108	PF00498	0.690
LIG_FHA_2	161	167	PF00498	0.654
LIG_FHA_2	219	225	PF00498	0.770
LIG_FHA_2	327	333	PF00498	0.376
LIG_FHA_2	42	48	PF00498	0.759
LIG_FHA_2	530	536	PF00498	0.607
LIG_FHA_2	722	728	PF00498	0.556
LIG_GBD_Chelix_1	728	736	PF00786	0.226
LIG_LIR_Apic_2	356	360	PF02991	0.556
LIG_LIR_Apic_2	584	589	PF02991	0.426
LIG_LIR_Apic_2	780	786	PF02991	0.556
LIG_LIR_Gen_1	171	181	PF02991	0.639
LIG_LIR_Gen_1	329	337	PF02991	0.520
LIG_LIR_Gen_1	49	58	PF02991	0.793
LIG_LIR_Gen_1	541	552	PF02991	0.477
LIG_LIR_Nem_3	171	176	PF02991	0.632
LIG_LIR_Nem_3	329	333	PF02991	0.510
LIG_LIR_Nem_3	477	483	PF02991	0.556
LIG_LIR_Nem_3	49	54	PF02991	0.756
LIG_LIR_Nem_3	541	547	PF02991	0.477
LIG_LIR_Nem_3	617	623	PF02991	0.558
LIG_LIR_Nem_3	708	713	PF02991	0.493
LIG_LYPXL_SIV_4	619	627	PF13949	0.607
LIG_NRBOX	205	211	PF00104	0.644
LIG_PCNA_yPIPBox_3	725	739	PF02747	0.592
LIG_Pex14_2	330	334	PF04695	0.517
LIG_Pex14_2	353	357	PF04695	0.556
LIG_PTB_Apo_2	444	451	PF02174	0.426
LIG_REV1ctd_RIR_1	560	570	PF16727	0.556
LIG_REV1ctd_RIR_1	765	775	PF16727	0.556
LIG_SH2_CRK	192	196	PF00017	0.561
LIG_SH2_CRK	620	624	PF00017	0.556
LIG_SH2_CRK	815	819	PF00017	0.517
LIG_SH2_PTP2	544	547	PF00017	0.484
LIG_SH2_STAP1	181	185	PF00017	0.483
LIG_SH2_STAP1	540	544	PF00017	0.426
LIG_SH2_STAP1	713	717	PF00017	0.492
LIG_SH2_STAT3	540	543	PF00017	0.579
LIG_SH2_STAT5	240	243	PF00017	0.753
LIG_SH2_STAT5	544	547	PF00017	0.498
LIG_SH2_STAT5	561	564	PF00017	0.504
LIG_SH2_STAT5	837	840	PF00017	0.461
LIG_SH2_STAT5	99	102	PF00017	0.530
LIG_SH3_3	247	253	PF00018	0.660
LIG_SH3_3	61	67	PF00018	0.550
LIG_SH3_3	715	721	PF00018	0.442
LIG_SH3_3	757	763	PF00018	0.545
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.715
LIG_SUMO_SIM_par_1	503	509	PF11976	0.607
LIG_TRAF2_1	622	625	PF00917	0.426
LIG_TRFH_1	581	585	PF08558	0.426
LIG_TYR_ITIM	481	486	PF00017	0.517
LIG_TYR_ITIM	542	547	PF00017	0.484
LIG_WRC_WIRS_1	134	139	PF05994	0.507
LIG_WRC_WIRS_1	327	332	PF05994	0.501
MOD_CDC14_SPxK_1	618	621	PF00782	0.607
MOD_CDK_SPxK_1	615	621	PF00069	0.607
MOD_CDK_SPxxK_3	550	557	PF00069	0.517
MOD_CK1_1	136	142	PF00069	0.752
MOD_CK1_1	152	158	PF00069	0.564
MOD_CK1_1	220	226	PF00069	0.712
MOD_CK1_1	285	291	PF00069	0.727
MOD_CK1_1	3	9	PF00069	0.707
MOD_CK1_1	317	323	PF00069	0.542
MOD_CK1_1	400	406	PF00069	0.569
MOD_CK1_1	584	590	PF00069	0.426
MOD_CK1_1	615	621	PF00069	0.568
MOD_CK1_1	660	666	PF00069	0.506
MOD_CK1_1	705	711	PF00069	0.492
MOD_CK2_1	101	107	PF00069	0.680
MOD_CK2_1	326	332	PF00069	0.376
MOD_CK2_1	339	345	PF00069	0.517
MOD_CK2_1	619	625	PF00069	0.426
MOD_CK2_1	716	722	PF00069	0.559
MOD_Cter_Amidation	117	120	PF01082	0.671
MOD_GlcNHglycan	123	126	PF01048	0.802
MOD_GlcNHglycan	151	154	PF01048	0.730
MOD_GlcNHglycan	259	262	PF01048	0.613
MOD_GlcNHglycan	341	344	PF01048	0.407
MOD_GlcNHglycan	404	407	PF01048	0.777
MOD_GlcNHglycan	413	416	PF01048	0.654
MOD_GlcNHglycan	568	571	PF01048	0.336
MOD_GlcNHglycan	64	67	PF01048	0.780
MOD_GlcNHglycan	652	655	PF01048	0.371
MOD_GlcNHglycan	662	665	PF01048	0.325
MOD_GlcNHglycan	753	757	PF01048	0.226
MOD_GlcNHglycan	794	797	PF01048	0.371
MOD_GlcNHglycan	810	813	PF01048	0.341
MOD_GlcNHglycan	83	86	PF01048	0.537
MOD_GSK3_1	123	130	PF00069	0.768
MOD_GSK3_1	132	139	PF00069	0.735
MOD_GSK3_1	149	156	PF00069	0.565
MOD_GSK3_1	160	167	PF00069	0.670
MOD_GSK3_1	2	9	PF00069	0.672
MOD_GSK3_1	208	215	PF00069	0.741
MOD_GSK3_1	216	223	PF00069	0.645
MOD_GSK3_1	393	400	PF00069	0.632
MOD_GSK3_1	407	414	PF00069	0.681
MOD_GSK3_1	420	427	PF00069	0.545
MOD_GSK3_1	575	582	PF00069	0.426
MOD_GSK3_1	615	622	PF00069	0.560
MOD_GSK3_1	629	636	PF00069	0.531
MOD_GSK3_1	655	662	PF00069	0.555
MOD_GSK3_1	698	705	PF00069	0.517
MOD_GSK3_1	717	724	PF00069	0.517
MOD_GSK3_1	787	794	PF00069	0.598
MOD_N-GLC_1	382	387	PF02516	0.517
MOD_N-GLC_1	41	46	PF02516	0.628
MOD_N-GLC_1	440	445	PF02516	0.226
MOD_N-GLC_1	633	638	PF02516	0.226
MOD_NEK2_1	111	116	PF00069	0.556
MOD_NEK2_1	133	138	PF00069	0.558
MOD_NEK2_1	142	147	PF00069	0.542
MOD_NEK2_1	232	237	PF00069	0.765
MOD_NEK2_1	265	270	PF00069	0.611
MOD_NEK2_1	31	36	PF00069	0.658
MOD_NEK2_1	339	344	PF00069	0.607
MOD_NEK2_1	428	433	PF00069	0.523
MOD_NEK2_1	579	584	PF00069	0.493
MOD_NEK2_1	668	673	PF00069	0.508
MOD_NEK2_1	702	707	PF00069	0.498
MOD_NEK2_1	93	98	PF00069	0.697
MOD_PIKK_1	112	118	PF00454	0.807
MOD_PIKK_1	314	320	PF00454	0.531
MOD_PIKK_1	489	495	PF00454	0.426
MOD_PIKK_1	721	727	PF00454	0.607
MOD_PIKK_1	787	793	PF00454	0.566
MOD_PKA_2	100	106	PF00069	0.670
MOD_PKA_2	265	271	PF00069	0.613
MOD_PKA_2	31	37	PF00069	0.477
MOD_PKA_2	407	413	PF00069	0.535
MOD_PKA_2	596	602	PF00069	0.426
MOD_PKA_2	678	684	PF00069	0.534
MOD_PKA_2	706	712	PF00069	0.517
MOD_PKA_2	93	99	PF00069	0.742
MOD_PKB_1	520	528	PF00069	0.454
MOD_Plk_1	232	238	PF00069	0.515
MOD_Plk_1	382	388	PF00069	0.522
MOD_Plk_1	575	581	PF00069	0.426
MOD_Plk_1	633	639	PF00069	0.579
MOD_Plk_1	787	793	PF00069	0.535
MOD_Plk_2-3	424	430	PF00069	0.531
MOD_Plk_4	172	178	PF00069	0.645
MOD_Plk_4	833	839	PF00069	0.635
MOD_Plk_4	93	99	PF00069	0.784
MOD_ProDKin_1	208	214	PF00069	0.519
MOD_ProDKin_1	295	301	PF00069	0.642
MOD_ProDKin_1	308	314	PF00069	0.547
MOD_ProDKin_1	395	401	PF00069	0.580
MOD_ProDKin_1	550	556	PF00069	0.517
MOD_ProDKin_1	581	587	PF00069	0.447
MOD_ProDKin_1	615	621	PF00069	0.607
MOD_ProDKin_1	655	661	PF00069	0.543
MOD_ProDKin_1	717	723	PF00069	0.502
TRG_DiLeu_BaEn_1	172	177	PF01217	0.672
TRG_DiLeu_BaEn_1	205	210	PF01217	0.641
TRG_DiLeu_BaEn_1	780	785	PF01217	0.607
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.516
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.545
TRG_ENDOCYTIC_2	192	195	PF00928	0.563
TRG_ENDOCYTIC_2	483	486	PF00928	0.517
TRG_ENDOCYTIC_2	544	547	PF00928	0.484
TRG_ENDOCYTIC_2	620	623	PF00928	0.531
TRG_ENDOCYTIC_2	713	716	PF00928	0.517
TRG_ENDOCYTIC_2	815	818	PF00928	0.517
TRG_ER_diArg_1	244	246	PF00400	0.664
TRG_ER_diArg_1	265	267	PF00400	0.682
TRG_ER_diArg_1	35	37	PF00400	0.741
TRG_ER_diArg_1	557	560	PF00400	0.519
TRG_ER_diArg_1	678	680	PF00400	0.527
TRG_NLS_MonoExtN_4	554	561	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE0	Leptomonas seymouri	48%	100%
A0A3S5H7E7	Leishmania donovani	74%	100%
A4I1G3	Leishmania infantum	74%	100%
C9ZK08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AXJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q9X3	Leishmania major	74%	99%