LMBR1-like membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HE60_LEIBR

TriTrypDb:

LbrM.25.1140 , LBRM2903_250020900

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HE60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	468	470	PF00675	0.357
CLV_PCSK_KEX2_1	467	469	PF00082	0.363
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.413
CLV_PCSK_SKI1_1	219	223	PF00082	0.206
CLV_PCSK_SKI1_1	304	308	PF00082	0.316
CLV_PCSK_SKI1_1	374	378	PF00082	0.226
CLV_PCSK_SKI1_1	85	89	PF00082	0.162
DEG_Nend_Nbox_1	1	3	PF02207	0.358
DOC_CKS1_1	78	83	PF01111	0.148
DOC_MAPK_gen_1	113	120	PF00069	0.348
DOC_MAPK_gen_1	264	272	PF00069	0.528
DOC_MAPK_gen_1	466	476	PF00069	0.604
DOC_MAPK_MEF2A_6	177	186	PF00069	0.233
DOC_MAPK_MEF2A_6	243	250	PF00069	0.449
DOC_MAPK_MEF2A_6	41	50	PF00069	0.271
DOC_PP1_RVXF_1	372	379	PF00149	0.426
DOC_PP1_RVXF_1	83	90	PF00149	0.148
DOC_PP4_FxxP_1	56	59	PF00568	0.162
DOC_USP7_MATH_1	411	415	PF00917	0.197
DOC_USP7_MATH_1	51	55	PF00917	0.355
DOC_USP7_UBL2_3	222	226	PF12436	0.528
DOC_WW_Pin1_4	294	299	PF00397	0.523
DOC_WW_Pin1_4	62	67	PF00397	0.315
DOC_WW_Pin1_4	77	82	PF00397	0.315
LIG_Actin_WH2_2	420	438	PF00022	0.279
LIG_CaM_IQ_9	251	266	PF13499	0.606
LIG_Clathr_ClatBox_1	57	61	PF01394	0.199
LIG_EH1_1	394	402	PF00400	0.349
LIG_eIF4E_1	205	211	PF01652	0.182
LIG_FHA_1	125	131	PF00498	0.273
LIG_FHA_1	177	183	PF00498	0.240
LIG_FHA_1	186	192	PF00498	0.192
LIG_FHA_1	19	25	PF00498	0.224
LIG_FHA_1	223	229	PF00498	0.428
LIG_FHA_1	334	340	PF00498	0.274
LIG_GBD_Chelix_1	7	15	PF00786	0.367
LIG_LIR_Apic_2	54	59	PF02991	0.162
LIG_LIR_Gen_1	21	28	PF02991	0.345
LIG_LIR_Gen_1	33	44	PF02991	0.482
LIG_LIR_Gen_1	403	412	PF02991	0.339
LIG_LIR_Gen_1	417	424	PF02991	0.345
LIG_LIR_Nem_3	149	155	PF02991	0.270
LIG_LIR_Nem_3	21	26	PF02991	0.345
LIG_LIR_Nem_3	297	302	PF02991	0.494
LIG_LIR_Nem_3	33	39	PF02991	0.482
LIG_LIR_Nem_3	403	408	PF02991	0.298
LIG_LIR_Nem_3	414	418	PF02991	0.222
LIG_NRBOX	333	339	PF00104	0.315
LIG_Pex14_1	199	203	PF04695	0.243
LIG_Pex14_2	101	105	PF04695	0.316
LIG_Pex14_2	197	201	PF04695	0.319
LIG_Pex14_2	358	362	PF04695	0.243
LIG_Pex14_2	56	60	PF04695	0.162
LIG_PTB_Apo_2	272	279	PF02174	0.526
LIG_PTB_Phospho_1	272	278	PF10480	0.526
LIG_SH2_CRK	302	306	PF00017	0.434
LIG_SH2_CRK	405	409	PF00017	0.349
LIG_SH2_CRK	418	422	PF00017	0.352
LIG_SH2_GRB2like	291	294	PF00017	0.432
LIG_SH2_NCK_1	291	295	PF00017	0.538
LIG_SH2_NCK_1	405	409	PF00017	0.395
LIG_SH2_PTP2	23	26	PF00017	0.286
LIG_SH2_SRC	23	26	PF00017	0.286
LIG_SH2_STAP1	187	191	PF00017	0.307
LIG_SH2_STAP1	405	409	PF00017	0.395
LIG_SH2_STAT5	171	174	PF00017	0.294
LIG_SH2_STAT5	187	190	PF00017	0.152
LIG_SH2_STAT5	23	26	PF00017	0.256
LIG_SH2_STAT5	27	30	PF00017	0.415
LIG_SH2_STAT5	278	281	PF00017	0.521
LIG_SH2_STAT5	291	294	PF00017	0.547
LIG_SH2_STAT5	359	362	PF00017	0.243
LIG_SH2_STAT5	38	41	PF00017	0.415
LIG_SH3_3	108	114	PF00018	0.431
LIG_SH3_3	94	100	PF00018	0.285
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.202
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.331
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.271
LIG_SUMO_SIM_par_1	178	185	PF11976	0.358
LIG_SUMO_SIM_par_1	398	404	PF11976	0.291
LIG_SUMO_SIM_par_1	48	54	PF11976	0.323
LIG_SUMO_SIM_par_1	8	14	PF11976	0.266
LIG_TYR_ITIM	300	305	PF00017	0.498
LIG_TYR_ITSM	19	26	PF00017	0.395
LIG_TYR_ITSM	401	408	PF00017	0.395
LIG_UBA3_1	136	145	PF00899	0.162
LIG_WRC_WIRS_1	325	330	PF05994	0.282
LIG_WRC_WIRS_1	412	417	PF05994	0.297
MOD_CK1_1	175	181	PF00069	0.249
MOD_CK1_1	185	191	PF00069	0.233
MOD_GlcNHglycan	228	231	PF01048	0.213
MOD_GlcNHglycan	31	36	PF01048	0.284
MOD_GSK3_1	163	170	PF00069	0.254
MOD_GSK3_1	172	179	PF00069	0.227
MOD_GSK3_1	222	229	PF00069	0.488
MOD_GSK3_1	27	34	PF00069	0.460
MOD_GSK3_1	62	69	PF00069	0.330
MOD_N-GLC_1	164	169	PF02516	0.382
MOD_N-GLC_1	395	400	PF02516	0.357
MOD_N-GLC_1	74	79	PF02516	0.381
MOD_NEK2_1	124	129	PF00069	0.292
MOD_NEK2_1	262	267	PF00069	0.613
MOD_NEK2_1	333	338	PF00069	0.266
MOD_NEK2_1	360	365	PF00069	0.368
MOD_NEK2_1	395	400	PF00069	0.320
MOD_NEK2_1	401	406	PF00069	0.281
MOD_NEK2_1	450	455	PF00069	0.316
MOD_NEK2_2	51	56	PF00069	0.162
MOD_PKA_2	255	261	PF00069	0.560
MOD_PKA_2	263	269	PF00069	0.555
MOD_Plk_1	148	154	PF00069	0.307
MOD_Plk_1	164	170	PF00069	0.239
MOD_Plk_1	395	401	PF00069	0.387
MOD_Plk_1	74	80	PF00069	0.201
MOD_Plk_4	11	17	PF00069	0.340
MOD_Plk_4	124	130	PF00069	0.306
MOD_Plk_4	18	24	PF00069	0.357
MOD_Plk_4	182	188	PF00069	0.226
MOD_Plk_4	228	234	PF00069	0.492
MOD_Plk_4	333	339	PF00069	0.258
MOD_Plk_4	385	391	PF00069	0.413
MOD_Plk_4	395	401	PF00069	0.189
MOD_Plk_4	450	456	PF00069	0.271
MOD_Plk_4	51	57	PF00069	0.387
MOD_Plk_4	66	72	PF00069	0.206
MOD_ProDKin_1	294	300	PF00069	0.523
MOD_ProDKin_1	62	68	PF00069	0.315
MOD_ProDKin_1	77	83	PF00069	0.315
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.148
TRG_ENDOCYTIC_2	144	147	PF00928	0.173
TRG_ENDOCYTIC_2	155	158	PF00928	0.136
TRG_ENDOCYTIC_2	23	26	PF00928	0.271
TRG_ENDOCYTIC_2	302	305	PF00928	0.434
TRG_ENDOCYTIC_2	325	328	PF00928	0.240
TRG_ENDOCYTIC_2	353	356	PF00928	0.243
TRG_ENDOCYTIC_2	405	408	PF00928	0.368
TRG_ENDOCYTIC_2	418	421	PF00928	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRR8	Leptomonas seymouri	73%	100%
A0A0N1I533	Leptomonas seymouri	24%	100%
A0A0S4IQ17	Bodo saltans	46%	100%
A0A0S4JTI8	Bodo saltans	34%	94%
A0A1X0NKT2	Trypanosomatidae	33%	100%
A0A1X0NM00	Trypanosomatidae	54%	100%
A0A3Q8IGK4	Leishmania donovani	80%	100%
A0A3S5H7Y2	Leishmania donovani	23%	100%
A0A422P212	Trypanosoma rangeli	55%	100%
A4HM51	Leishmania braziliensis	24%	100%
A4I1F8	Leishmania infantum	80%	100%
A4IAR3	Leishmania infantum	23%	100%
C9ZK11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A2E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D8TFA8	Selaginella moellendorffii	27%	100%
E9AEI9	Leishmania major	23%	95%
E9AXJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B5Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4Q9X7	Leishmania major	79%	100%
Q54BI3	Dictyostelium discoideum	30%	95%
Q54QP7	Dictyostelium discoideum	31%	95%
Q658I5	Oryza sativa subsp. japonica	28%	94%
Q9M028	Arabidopsis thaliana	29%	94%
Q9SR93	Arabidopsis thaliana	29%	94%