Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HE58_LEIBR

TriTrypDb:

LbrM.25.1120 , LBRM2903_250020400 , LBRM2903_250020500

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.545
CLV_C14_Caspase3-7	550	554	PF00656	0.693
CLV_C14_Caspase3-7	562	566	PF00656	0.597
CLV_NRD_NRD_1	12	14	PF00675	0.485
CLV_NRD_NRD_1	202	204	PF00675	0.680
CLV_NRD_NRD_1	270	272	PF00675	0.550
CLV_PCSK_FUR_1	200	204	PF00082	0.679
CLV_PCSK_KEX2_1	12	14	PF00082	0.485
CLV_PCSK_KEX2_1	202	204	PF00082	0.680
CLV_PCSK_SKI1_1	107	111	PF00082	0.529
CLV_PCSK_SKI1_1	167	171	PF00082	0.500
CLV_PCSK_SKI1_1	188	192	PF00082	0.481
CLV_PCSK_SKI1_1	368	372	PF00082	0.550
CLV_PCSK_SKI1_1	555	559	PF00082	0.694
DEG_SCF_FBW7_1	556	562	PF00400	0.548
DEG_SCF_FBW7_2	375	380	PF00400	0.585
DOC_CDC14_PxL_1	208	216	PF14671	0.529
DOC_CKS1_1	53	58	PF01111	0.483
DOC_CKS1_1	556	561	PF01111	0.545
DOC_CYCLIN_yClb3_PxF_3	263	271	PF00134	0.533
DOC_PP2B_PxIxI_1	388	394	PF00149	0.568
DOC_PP4_FxxP_1	238	241	PF00568	0.694
DOC_USP7_MATH_1	103	107	PF00917	0.614
DOC_USP7_MATH_1	176	180	PF00917	0.604
DOC_USP7_MATH_1	261	265	PF00917	0.607
DOC_USP7_MATH_1	375	379	PF00917	0.511
DOC_USP7_MATH_1	435	439	PF00917	0.674
DOC_USP7_MATH_1	445	449	PF00917	0.614
DOC_USP7_MATH_1	559	563	PF00917	0.697
DOC_USP7_MATH_1	8	12	PF00917	0.488
DOC_USP7_UBL2_3	188	192	PF12436	0.481
DOC_WW_Pin1_4	118	123	PF00397	0.515
DOC_WW_Pin1_4	143	148	PF00397	0.637
DOC_WW_Pin1_4	262	267	PF00397	0.674
DOC_WW_Pin1_4	306	311	PF00397	0.660
DOC_WW_Pin1_4	371	376	PF00397	0.678
DOC_WW_Pin1_4	439	444	PF00397	0.687
DOC_WW_Pin1_4	52	57	PF00397	0.490
DOC_WW_Pin1_4	542	547	PF00397	0.657
DOC_WW_Pin1_4	555	560	PF00397	0.542
LIG_14-3-3_CanoR_1	131	135	PF00244	0.540
LIG_14-3-3_CanoR_1	271	276	PF00244	0.544
LIG_Actin_WH2_2	490	508	PF00022	0.500
LIG_BIR_III_2	420	424	PF00653	0.652
LIG_BRCT_BRCA1_1	264	268	PF00533	0.533
LIG_EVH1_2	457	461	PF00568	0.674
LIG_FHA_1	115	121	PF00498	0.496
LIG_FHA_1	240	246	PF00498	0.566
LIG_FHA_1	26	32	PF00498	0.494
LIG_FHA_1	319	325	PF00498	0.510
LIG_FHA_1	365	371	PF00498	0.544
LIG_FHA_1	5	11	PF00498	0.511
LIG_FHA_1	514	520	PF00498	0.578
LIG_FHA_1	543	549	PF00498	0.638
LIG_FHA_1	96	102	PF00498	0.514
LIG_FHA_2	242	248	PF00498	0.764
LIG_FHA_2	280	286	PF00498	0.540
LIG_FHA_2	303	309	PF00498	0.545
LIG_FHA_2	361	367	PF00498	0.533
LIG_FHA_2	53	59	PF00498	0.476
LIG_FHA_2	548	554	PF00498	0.695
LIG_FHA_2	67	73	PF00498	0.425
LIG_LIR_Apic_2	235	241	PF02991	0.683
LIG_LIR_Gen_1	464	475	PF02991	0.670
LIG_LIR_Gen_1	492	501	PF02991	0.545
LIG_LIR_Gen_1	69	77	PF02991	0.616
LIG_LIR_Nem_3	464	470	PF02991	0.652
LIG_LIR_Nem_3	492	497	PF02991	0.545
LIG_LIR_Nem_3	499	504	PF02991	0.395
LIG_LIR_Nem_3	69	74	PF02991	0.595
LIG_NRBOX	58	64	PF00104	0.447
LIG_NRP_CendR_1	569	570	PF00754	0.704
LIG_PROFILIN_1	452	458	PF00235	0.534
LIG_PTAP_UEV_1	146	151	PF05743	0.678
LIG_SH2_CRK	335	339	PF00017	0.604
LIG_SH2_CRK	480	484	PF00017	0.502
LIG_SH2_PTP2	386	389	PF00017	0.622
LIG_SH2_SRC	386	389	PF00017	0.622
LIG_SH2_STAT3	61	64	PF00017	0.454
LIG_SH2_STAT5	18	21	PF00017	0.453
LIG_SH2_STAT5	218	221	PF00017	0.561
LIG_SH2_STAT5	224	227	PF00017	0.456
LIG_SH2_STAT5	29	32	PF00017	0.405
LIG_SH2_STAT5	386	389	PF00017	0.622
LIG_SH2_STAT5	467	470	PF00017	0.487
LIG_SH2_STAT5	504	507	PF00017	0.463
LIG_SH2_STAT5	61	64	PF00017	0.454
LIG_SH3_1	335	341	PF00018	0.516
LIG_SH3_2	454	459	PF14604	0.680
LIG_SH3_3	119	125	PF00018	0.512
LIG_SH3_3	144	150	PF00018	0.685
LIG_SH3_3	198	204	PF00018	0.619
LIG_SH3_3	206	212	PF00018	0.567
LIG_SH3_3	260	266	PF00018	0.708
LIG_SH3_3	335	341	PF00018	0.634
LIG_SH3_3	413	419	PF00018	0.798
LIG_SH3_3	449	455	PF00018	0.686
LIG_SH3_3	50	56	PF00018	0.511
LIG_SH3_3	553	559	PF00018	0.605
LIG_SUMO_SIM_par_1	545	553	PF11976	0.548
LIG_TRAF2_1	39	42	PF00917	0.351
MOD_CK1_1	108	114	PF00069	0.649
MOD_CK1_1	121	127	PF00069	0.548
MOD_CK1_1	216	222	PF00069	0.563
MOD_CK1_1	264	270	PF00069	0.583
MOD_CK1_1	309	315	PF00069	0.683
MOD_CK1_1	323	329	PF00069	0.480
MOD_CK1_1	346	352	PF00069	0.645
MOD_CK1_1	439	445	PF00069	0.668
MOD_CK1_1	80	86	PF00069	0.504
MOD_CK1_1	90	96	PF00069	0.507
MOD_CK2_1	279	285	PF00069	0.544
MOD_CK2_1	36	42	PF00069	0.388
MOD_CK2_1	52	58	PF00069	0.455
MOD_CK2_1	66	72	PF00069	0.397
MOD_DYRK1A_RPxSP_1	555	559	PF00069	0.547
MOD_GlcNHglycan	139	142	PF01048	0.673
MOD_GlcNHglycan	296	299	PF01048	0.679
MOD_GlcNHglycan	311	314	PF01048	0.562
MOD_GlcNHglycan	351	354	PF01048	0.660
MOD_GlcNHglycan	38	41	PF01048	0.354
MOD_GlcNHglycan	413	416	PF01048	0.606
MOD_GlcNHglycan	77	80	PF01048	0.607
MOD_GlcNHglycan	83	86	PF01048	0.643
MOD_GlcNHglycan	93	96	PF01048	0.557
MOD_GSK3_1	103	110	PF00069	0.571
MOD_GSK3_1	111	118	PF00069	0.531
MOD_GSK3_1	129	136	PF00069	0.535
MOD_GSK3_1	145	152	PF00069	0.610
MOD_GSK3_1	165	172	PF00069	0.511
MOD_GSK3_1	213	220	PF00069	0.539
MOD_GSK3_1	262	269	PF00069	0.647
MOD_GSK3_1	279	286	PF00069	0.571
MOD_GSK3_1	302	309	PF00069	0.603
MOD_GSK3_1	340	347	PF00069	0.535
MOD_GSK3_1	349	356	PF00069	0.544
MOD_GSK3_1	360	367	PF00069	0.604
MOD_GSK3_1	371	378	PF00069	0.617
MOD_GSK3_1	4	11	PF00069	0.524
MOD_GSK3_1	435	442	PF00069	0.677
MOD_GSK3_1	492	499	PF00069	0.656
MOD_GSK3_1	555	562	PF00069	0.696
MOD_GSK3_1	66	73	PF00069	0.405
MOD_GSK3_1	77	84	PF00069	0.550
MOD_GSK3_1	87	94	PF00069	0.568
MOD_GSK3_1	95	102	PF00069	0.497
MOD_N-GLC_1	118	123	PF02516	0.515
MOD_N-GLC_1	66	71	PF02516	0.508
MOD_NEK2_1	109	114	PF00069	0.504
MOD_NEK2_1	129	134	PF00069	0.507
MOD_NEK2_1	184	189	PF00069	0.605
MOD_NEK2_1	214	219	PF00069	0.539
MOD_NEK2_1	270	275	PF00069	0.546
MOD_NEK2_1	344	349	PF00069	0.555
MOD_NEK2_1	403	408	PF00069	0.586
MOD_NEK2_1	461	466	PF00069	0.584
MOD_NEK2_1	547	552	PF00069	0.549
MOD_NEK2_1	77	82	PF00069	0.502
MOD_NEK2_1	91	96	PF00069	0.487
MOD_NEK2_2	18	23	PF00069	0.428
MOD_NEK2_2	266	271	PF00069	0.536
MOD_PIKK_1	252	258	PF00454	0.657
MOD_PIKK_1	445	451	PF00454	0.554
MOD_PIKK_1	563	569	PF00454	0.554
MOD_PKA_1	191	197	PF00069	0.515
MOD_PKA_1	271	277	PF00069	0.544
MOD_PKA_2	130	136	PF00069	0.539
MOD_PKA_2	270	276	PF00069	0.544
MOD_PKA_2	411	417	PF00069	0.775
MOD_Plk_1	436	442	PF00069	0.660
MOD_Plk_4	323	329	PF00069	0.603
MOD_ProDKin_1	118	124	PF00069	0.517
MOD_ProDKin_1	143	149	PF00069	0.636
MOD_ProDKin_1	262	268	PF00069	0.677
MOD_ProDKin_1	306	312	PF00069	0.660
MOD_ProDKin_1	371	377	PF00069	0.672
MOD_ProDKin_1	439	445	PF00069	0.686
MOD_ProDKin_1	52	58	PF00069	0.482
MOD_ProDKin_1	542	548	PF00069	0.657
MOD_ProDKin_1	555	561	PF00069	0.542
MOD_SUMO_rev_2	464	473	PF00179	0.510
TRG_DiLeu_BaEn_1	58	63	PF01217	0.441
TRG_DiLeu_BaEn_2	179	185	PF01217	0.599
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.550
TRG_ENDOCYTIC_2	467	470	PF00928	0.487
TRG_ENDOCYTIC_2	480	483	PF00928	0.385
TRG_ER_diArg_1	12	14	PF00400	0.485
TRG_ER_diArg_1	199	202	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID95	Leishmania donovani	70%	100%
A4I1F6	Leishmania infantum	70%	100%
E9AXJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q9X9	Leishmania major	71%	94%