Putative cytochrome c oxidase VII

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome oxidase subunit VII

Species:

Leishmania braziliensis

UniProt:

A4HE57_LEIBR

TriTrypDb:

LbrM.25.1110 , LBRM2903_250020300

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HE57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE57

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	63	69	PF00089	0.403
CLV_NRD_NRD_1	116	118	PF00675	0.565
CLV_NRD_NRD_1	158	160	PF00675	0.611
CLV_PCSK_KEX2_1	36	38	PF00082	0.305
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.303
CLV_PCSK_SKI1_1	37	41	PF00082	0.384
DOC_MAPK_gen_1	77	87	PF00069	0.574
DOC_MAPK_MEF2A_6	77	86	PF00069	0.570
DOC_PP4_FxxP_1	161	164	PF00568	0.405
DOC_PP4_FxxP_1	40	43	PF00568	0.587
DOC_PP4_FxxP_1	49	52	PF00568	0.533
DOC_USP7_MATH_1	91	95	PF00917	0.189
DOC_USP7_UBL2_3	118	122	PF12436	0.370
DOC_WW_Pin1_4	128	133	PF00397	0.372
LIG_14-3-3_CanoR_1	117	121	PF00244	0.479
LIG_14-3-3_CanoR_1	30	36	PF00244	0.585
LIG_14-3-3_CanoR_1	66	72	PF00244	0.608
LIG_EH_1	22	26	PF12763	0.590
LIG_EH1_1	80	88	PF00400	0.478
LIG_FHA_2	11	17	PF00498	0.541
LIG_LIR_Apic_2	38	43	PF02991	0.537
LIG_LIR_Gen_1	131	139	PF02991	0.379
LIG_LIR_Gen_1	92	103	PF02991	0.344
LIG_LIR_Nem_3	28	32	PF02991	0.579
LIG_LIR_Nem_3	92	98	PF02991	0.295
LIG_PDZ_Class_2	160	165	PF00595	0.408
LIG_Pex14_2	25	29	PF04695	0.629
LIG_SH2_SRC	162	165	PF00017	0.412
LIG_SH2_STAP1	142	146	PF00017	0.371
LIG_SH2_STAP1	27	31	PF00017	0.658
LIG_SH2_STAT5	162	165	PF00017	0.446
LIG_SH3_3	36	42	PF00018	0.641
LIG_SH3_3	4	10	PF00018	0.634
LIG_SH3_3	76	82	PF00018	0.587
LIG_TRAF2_2	52	57	PF00917	0.548
LIG_UBA3_1	62	70	PF00899	0.508
LIG_UBA3_1	97	102	PF00899	0.331
MOD_CK2_1	10	16	PF00069	0.544
MOD_GlcNHglycan	98	101	PF01048	0.402
MOD_GSK3_1	112	119	PF00069	0.463
MOD_N-GLC_1	128	133	PF02516	0.572
MOD_NEK2_1	150	155	PF00069	0.488
MOD_NEK2_1	25	30	PF00069	0.666
MOD_NEK2_2	31	36	PF00069	0.537
MOD_PKA_2	116	122	PF00069	0.474
MOD_PKA_2	65	71	PF00069	0.599
MOD_Plk_4	104	110	PF00069	0.445
MOD_Plk_4	58	64	PF00069	0.576
MOD_Plk_4	91	97	PF00069	0.237
MOD_ProDKin_1	128	134	PF00069	0.371
MOD_SUMO_for_1	35	38	PF00179	0.661
TRG_ER_diArg_1	17	20	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGN0	Leptomonas seymouri	88%	100%
A0A0S4IVN1	Bodo saltans	68%	100%
A0A1X0NLX0	Trypanosomatidae	70%	100%
A0A1X0NML5	Trypanosomatidae	68%	100%
A0A3Q8IDG0	Leishmania donovani	94%	100%
A0A3R7LCN3	Trypanosoma rangeli	70%	100%
A4I1F5	Leishmania infantum	94%	100%
C9ZK13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AXJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9Y0	Leishmania major	95%	100%