GPN-loop GTPase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GPN-loop GTPase 3

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE55_LEIBR

TriTrypDb:

LbrM.25.1090 , LBRM2903_250020100

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE55

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016787	hydrolase activity	2	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	26	30	PF00082	0.449
DEG_APCC_KENBOX_2	28	32	PF00400	0.650
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DOC_PP2B_PxIxI_1	12	18	PF00149	0.650
DOC_PP4_FxxP_1	10	13	PF00568	0.650
LIG_BRCT_BRCA1_1	24	28	PF00533	0.650
LIG_FHA_1	92	98	PF00498	0.650
LIG_FHA_2	17	23	PF00498	0.650
LIG_LIR_Gen_1	11	18	PF02991	0.650
LIG_LIR_Gen_1	41	52	PF02991	0.650
LIG_LIR_Gen_1	66	76	PF02991	0.650
LIG_LIR_Nem_3	11	17	PF02991	0.650
LIG_LIR_Nem_3	41	47	PF02991	0.650
LIG_LIR_Nem_3	66	71	PF02991	0.650
LIG_LIR_Nem_3	72	76	PF02991	0.574
LIG_Pex14_2	10	14	PF04695	0.650
LIG_SH2_STAT5	83	86	PF00017	0.650
LIG_SUMO_SIM_par_1	74	80	PF11976	0.650
LIG_WRC_WIRS_1	70	75	PF05994	0.650
LIG_WW_3	50	54	PF00397	0.650
MOD_CK1_1	3	9	PF00069	0.650
MOD_GSK3_1	82	89	PF00069	0.650
MOD_N-GLC_2	86	88	PF02516	0.449
MOD_NEK2_1	2	7	PF00069	0.650
MOD_NEK2_1	45	50	PF00069	0.650
MOD_NEK2_1	91	96	PF00069	0.650
MOD_PKB_1	53	61	PF00069	0.650
MOD_Plk_1	45	51	PF00069	0.650
MOD_Plk_1	91	97	PF00069	0.650
MOD_Plk_4	3	9	PF00069	0.650
MOD_Plk_4	86	92	PF00069	0.650
TRG_ENDOCYTIC_2	44	47	PF00928	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4PF70	USTMA	28%	40%
Q54NK8	DICDI	34%	39%
Q54TE7	DICDI	31%	35%