Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE54_LEIBR

TriTrypDb:

LbrM.25.1080 , LBRM2903_250020000

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.709
CLV_NRD_NRD_1	115	117	PF00675	0.425
CLV_NRD_NRD_1	123	125	PF00675	0.467
CLV_NRD_NRD_1	191	193	PF00675	0.747
CLV_NRD_NRD_1	219	221	PF00675	0.716
CLV_NRD_NRD_1	41	43	PF00675	0.600
CLV_PCSK_KEX2_1	115	117	PF00082	0.425
CLV_PCSK_KEX2_1	218	220	PF00082	0.611
CLV_PCSK_KEX2_1	41	43	PF00082	0.600
CLV_PCSK_SKI1_1	116	120	PF00082	0.431
CLV_PCSK_SKI1_1	193	197	PF00082	0.456
CLV_PCSK_SKI1_1	70	74	PF00082	0.581
DEG_Nend_UBRbox_1	1	4	PF02207	0.671
DOC_ANK_TNKS_1	218	225	PF00023	0.695
DOC_MAPK_MEF2A_6	103	110	PF00069	0.476
DOC_MAPK_MEF2A_6	206	215	PF00069	0.644
DOC_USP7_MATH_1	118	122	PF00917	0.443
DOC_USP7_MATH_1	94	98	PF00917	0.506
DOC_USP7_MATH_1	99	103	PF00917	0.453
DOC_USP7_UBL2_3	190	194	PF12436	0.613
DOC_WW_Pin1_4	139	144	PF00397	0.575
DOC_WW_Pin1_4	17	22	PF00397	0.487
DOC_WW_Pin1_4	194	199	PF00397	0.652
LIG_14-3-3_CanoR_1	149	159	PF00244	0.740
LIG_14-3-3_CanoR_1	2	9	PF00244	0.585
LIG_14-3-3_CanoR_1	42	52	PF00244	0.609
LIG_14-3-3_CanoR_1	54	59	PF00244	0.532
LIG_14-3-3_CterR_2	226	229	PF00244	0.733
LIG_BRCT_BRCA1_1	96	100	PF00533	0.616
LIG_deltaCOP1_diTrp_1	128	134	PF00928	0.439
LIG_FHA_1	136	142	PF00498	0.567
LIG_FHA_1	210	216	PF00498	0.656
LIG_FHA_2	168	174	PF00498	0.604
LIG_LIR_Gen_1	85	94	PF02991	0.603
LIG_LIR_Nem_3	197	202	PF02991	0.626
LIG_LIR_Nem_3	85	91	PF02991	0.426
LIG_Pex14_1	130	134	PF04695	0.427
LIG_SH2_CRK	9	13	PF00017	0.590
LIG_SH2_STAP1	9	13	PF00017	0.597
LIG_WW_3	20	24	PF00397	0.467
MOD_CDK_SPxK_1	17	23	PF00069	0.570
MOD_CK2_1	194	200	PF00069	0.637
MOD_GlcNHglycan	70	73	PF01048	0.583
MOD_GSK3_1	106	113	PF00069	0.461
MOD_GSK3_1	135	142	PF00069	0.520
MOD_GSK3_1	24	31	PF00069	0.691
MOD_NEK2_1	1	6	PF00069	0.602
MOD_NEK2_1	106	111	PF00069	0.455
MOD_NEK2_1	126	131	PF00069	0.246
MOD_NEK2_1	24	29	PF00069	0.613
MOD_NEK2_1	68	73	PF00069	0.548
MOD_NEK2_1	83	88	PF00069	0.368
MOD_PIKK_1	161	167	PF00454	0.731
MOD_PIKK_1	43	49	PF00454	0.586
MOD_PKA_2	1	7	PF00069	0.632
MOD_Plk_2-3	209	215	PF00069	0.650
MOD_Plk_4	83	89	PF00069	0.378
MOD_ProDKin_1	139	145	PF00069	0.573
MOD_ProDKin_1	17	23	PF00069	0.490
MOD_ProDKin_1	194	200	PF00069	0.647
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.528
TRG_ENDOCYTIC_2	9	12	PF00928	0.665
TRG_ER_diArg_1	114	116	PF00400	0.424
TRG_ER_diArg_1	217	220	PF00400	0.704
TRG_ER_diArg_1	40	42	PF00400	0.531
TRG_NLS_MonoExtN_4	190	196	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H8	Leptomonas seymouri	63%	100%
A0A1X0NMP7	Trypanosomatidae	45%	88%
A0A3Q8ICI7	Leishmania donovani	78%	97%
A4I1I2	Leishmania infantum	78%	97%
C9ZJY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9AXL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
Q4Q9V5	Leishmania major	78%	100%
V5D3X1	Trypanosoma cruzi	45%	92%