TAP42 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TAP42-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4HE53_LEIBR

TriTrypDb:

LbrM.25.1070 , LBRM2903_250019900

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE53

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	12
GO:0010646	regulation of cell communication	4	12
GO:0023051	regulation of signaling	3	12
GO:0048583	regulation of response to stimulus	3	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0051174	regulation of phosphorus metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019902	phosphatase binding	4	1
GO:0019903	protein phosphatase binding	5	1
GO:0051721	protein phosphatase 2A binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.435
CLV_C14_Caspase3-7	314	318	PF00656	0.478
CLV_NRD_NRD_1	244	246	PF00675	0.266
CLV_NRD_NRD_1	320	322	PF00675	0.298
CLV_PCSK_FUR_1	240	244	PF00082	0.278
CLV_PCSK_KEX2_1	100	102	PF00082	0.278
CLV_PCSK_KEX2_1	242	244	PF00082	0.239
CLV_PCSK_KEX2_1	320	322	PF00082	0.275
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.278
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.239
CLV_PCSK_PC7_1	240	246	PF00082	0.278
CLV_PCSK_SKI1_1	184	188	PF00082	0.320
DEG_MDM2_SWIB_1	52	59	PF02201	0.535
DEG_SPOP_SBC_1	371	375	PF00917	0.460
DOC_CKS1_1	82	87	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.431
DOC_MAPK_gen_1	320	326	PF00069	0.475
DOC_MAPK_MEF2A_6	178	187	PF00069	0.565
DOC_PP1_RVXF_1	182	188	PF00149	0.535
DOC_PP1_RVXF_1	273	279	PF00149	0.432
DOC_USP7_MATH_1	371	375	PF00917	0.477
DOC_WW_Pin1_4	63	68	PF00397	0.456
DOC_WW_Pin1_4	81	86	PF00397	0.345
LIG_14-3-3_CanoR_1	220	226	PF00244	0.539
LIG_14-3-3_CanoR_1	328	332	PF00244	0.460
LIG_14-3-3_CanoR_1	57	62	PF00244	0.535
LIG_APCC_ABBA_1	183	188	PF00400	0.535
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	374	378	PF00533	0.376
LIG_CSL_BTD_1	82	85	PF09270	0.442
LIG_deltaCOP1_diTrp_1	451	457	PF00928	0.498
LIG_DLG_GKlike_1	292	300	PF00625	0.478
LIG_eIF4E_1	86	92	PF01652	0.579
LIG_FHA_1	145	151	PF00498	0.459
LIG_FHA_1	201	207	PF00498	0.474
LIG_FHA_1	24	30	PF00498	0.439
LIG_FHA_1	328	334	PF00498	0.436
LIG_FHA_1	339	345	PF00498	0.477
LIG_FHA_1	401	407	PF00498	0.431
LIG_FHA_1	74	80	PF00498	0.431
LIG_FHA_1	82	88	PF00498	0.456
LIG_FHA_2	258	264	PF00498	0.456
LIG_FHA_2	403	409	PF00498	0.441
LIG_FHA_2	75	81	PF00498	0.498
LIG_HOMEOBOX	187	190	PF00046	0.535
LIG_LIR_Gen_1	124	134	PF02991	0.496
LIG_LIR_Gen_1	156	167	PF02991	0.361
LIG_LIR_Gen_1	179	190	PF02991	0.477
LIG_LIR_Gen_1	330	339	PF02991	0.463
LIG_LIR_Gen_1	408	417	PF02991	0.475
LIG_LIR_Gen_1	51	59	PF02991	0.496
LIG_LIR_Gen_1	90	99	PF02991	0.442
LIG_LIR_LC3C_4	47	50	PF02991	0.376
LIG_LIR_Nem_3	156	162	PF02991	0.385
LIG_LIR_Nem_3	179	185	PF02991	0.461
LIG_LIR_Nem_3	202	207	PF02991	0.438
LIG_LIR_Nem_3	330	334	PF02991	0.463
LIG_LIR_Nem_3	408	412	PF02991	0.478
LIG_LIR_Nem_3	51	55	PF02991	0.528
LIG_LIR_Nem_3	80	86	PF02991	0.442
LIG_LIR_Nem_3	90	95	PF02991	0.442
LIG_Pex14_1	182	186	PF04695	0.442
LIG_Pex14_2	52	56	PF04695	0.481
LIG_RPA_C_Fungi	215	227	PF08784	0.331
LIG_SH2_CRK	331	335	PF00017	0.280
LIG_SH2_STAP1	25	29	PF00017	0.289
LIG_SH2_STAP1	74	78	PF00017	0.412
LIG_SH2_STAT3	387	390	PF00017	0.360
LIG_SH2_STAT5	238	241	PF00017	0.281
LIG_SH2_STAT5	25	28	PF00017	0.425
LIG_SH2_STAT5	331	334	PF00017	0.266
LIG_SH2_STAT5	86	89	PF00017	0.322
LIG_SH3_3	341	347	PF00018	0.288
LIG_SH3_3	358	364	PF00018	0.213
LIG_TRAF2_1	171	174	PF00917	0.296
LIG_TRAF2_1	256	259	PF00917	0.411
LIG_UBA3_1	91	100	PF00899	0.265
MOD_CK1_1	110	116	PF00069	0.653
MOD_CK1_1	2	8	PF00069	0.597
MOD_CK1_1	33	39	PF00069	0.371
MOD_CK2_1	121	127	PF00069	0.700
MOD_CK2_1	168	174	PF00069	0.224
MOD_CK2_1	253	259	PF00069	0.437
MOD_CK2_1	276	282	PF00069	0.276
MOD_CK2_1	287	293	PF00069	0.246
MOD_CK2_1	402	408	PF00069	0.280
MOD_CK2_1	74	80	PF00069	0.344
MOD_CMANNOS	454	457	PF00535	0.360
MOD_GlcNHglycan	109	112	PF01048	0.610
MOD_GlcNHglycan	114	117	PF01048	0.685
MOD_GlcNHglycan	123	126	PF01048	0.776
MOD_GlcNHglycan	152	155	PF01048	0.630
MOD_GlcNHglycan	357	360	PF01048	0.423
MOD_GlcNHglycan	451	454	PF01048	0.360
MOD_GSK3_1	107	114	PF00069	0.676
MOD_GSK3_1	135	142	PF00069	0.705
MOD_GSK3_1	146	153	PF00069	0.747
MOD_GSK3_1	17	24	PF00069	0.375
MOD_GSK3_1	221	228	PF00069	0.312
MOD_GSK3_1	253	260	PF00069	0.300
MOD_GSK3_1	288	295	PF00069	0.408
MOD_GSK3_1	29	36	PF00069	0.236
MOD_GSK3_1	355	362	PF00069	0.357
MOD_N-GLC_1	30	35	PF02516	0.414
MOD_NEK2_1	176	181	PF00069	0.266
MOD_NEK2_1	21	26	PF00069	0.443
MOD_NEK2_1	218	223	PF00069	0.412
MOD_NEK2_1	225	230	PF00069	0.389
MOD_NEK2_1	257	262	PF00069	0.242
MOD_NEK2_1	276	281	PF00069	0.330
MOD_NEK2_1	287	292	PF00069	0.321
MOD_NEK2_1	30	35	PF00069	0.325
MOD_NEK2_1	338	343	PF00069	0.189
MOD_NEK2_2	155	160	PF00069	0.400
MOD_NEK2_2	402	407	PF00069	0.189
MOD_PIKK_1	115	121	PF00454	0.538
MOD_PIKK_1	210	216	PF00454	0.290
MOD_PK_1	57	63	PF00069	0.189
MOD_PKA_2	135	141	PF00069	0.753
MOD_PKA_2	225	231	PF00069	0.216
MOD_PKA_2	304	310	PF00069	0.265
MOD_PKA_2	327	333	PF00069	0.298
MOD_PKA_2	350	356	PF00069	0.276
MOD_Plk_1	155	161	PF00069	0.451
MOD_Plk_1	264	270	PF00069	0.420
MOD_Plk_1	292	298	PF00069	0.331
MOD_Plk_1	30	36	PF00069	0.428
MOD_Plk_1	322	328	PF00069	0.283
MOD_Plk_1	37	43	PF00069	0.316
MOD_Plk_2-3	197	203	PF00069	0.289
MOD_Plk_2-3	253	259	PF00069	0.189
MOD_Plk_4	234	240	PF00069	0.192
MOD_Plk_4	292	298	PF00069	0.352
MOD_Plk_4	329	335	PF00069	0.266
MOD_Plk_4	372	378	PF00069	0.299
MOD_Plk_4	44	50	PF00069	0.189
MOD_Plk_4	57	63	PF00069	0.240
MOD_ProDKin_1	63	69	PF00069	0.300
MOD_ProDKin_1	81	87	PF00069	0.145
MOD_SUMO_for_1	229	232	PF00179	0.331
MOD_SUMO_rev_2	232	237	PF00179	0.411
TRG_DiLeu_BaEn_4	165	171	PF01217	0.589
TRG_DiLeu_BaEn_4	252	258	PF01217	0.380
TRG_DiLeu_BaEn_4	263	269	PF01217	0.348
TRG_DiLeu_BaEn_4	433	439	PF01217	0.281
TRG_ENDOCYTIC_2	126	129	PF00928	0.496
TRG_ENDOCYTIC_2	331	334	PF00928	0.280
TRG_ER_diArg_1	243	245	PF00400	0.301
TRG_ER_diArg_1	268	271	PF00400	0.287
TRG_ER_diArg_1	319	321	PF00400	0.360
TRG_NES_CRM1_1	93	107	PF08389	0.189
TRG_NLS_MonoCore_2	241	246	PF00514	0.300
TRG_NLS_MonoExtN_4	240	246	PF00514	0.309
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB4	Leptomonas seymouri	70%	100%
A0A0S4JC44	Bodo saltans	36%	100%
A0A1X0NM51	Trypanosomatidae	46%	100%
A0A3R7MA47	Trypanosoma rangeli	42%	100%
A0A3S7WZ42	Leishmania donovani	84%	100%
A4I1I1	Leishmania infantum	84%	100%
C9ZJY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9V6	Leishmania major	84%	100%
V5AN63	Trypanosoma cruzi	41%	100%