Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE52_LEIBR

TriTrypDb:

LbrM.25.1060 , LBRM2903_250019800

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.589
CLV_C14_Caspase3-7	373	377	PF00656	0.355
CLV_C14_Caspase3-7	584	588	PF00656	0.518
CLV_NRD_NRD_1	201	203	PF00675	0.549
CLV_NRD_NRD_1	22	24	PF00675	0.558
CLV_NRD_NRD_1	273	275	PF00675	0.554
CLV_NRD_NRD_1	333	335	PF00675	0.392
CLV_NRD_NRD_1	338	340	PF00675	0.434
CLV_NRD_NRD_1	613	615	PF00675	0.585
CLV_NRD_NRD_1	655	657	PF00675	0.662
CLV_NRD_NRD_1	674	676	PF00675	0.492
CLV_NRD_NRD_1	71	73	PF00675	0.506
CLV_PCSK_FUR_1	614	618	PF00082	0.611
CLV_PCSK_FUR_1	653	657	PF00082	0.655
CLV_PCSK_FUR_1	88	92	PF00082	0.658
CLV_PCSK_KEX2_1	201	203	PF00082	0.546
CLV_PCSK_KEX2_1	214	216	PF00082	0.594
CLV_PCSK_KEX2_1	273	275	PF00082	0.554
CLV_PCSK_KEX2_1	30	32	PF00082	0.546
CLV_PCSK_KEX2_1	333	335	PF00082	0.392
CLV_PCSK_KEX2_1	613	615	PF00082	0.613
CLV_PCSK_KEX2_1	616	618	PF00082	0.591
CLV_PCSK_KEX2_1	655	657	PF00082	0.653
CLV_PCSK_KEX2_1	674	676	PF00082	0.492
CLV_PCSK_KEX2_1	90	92	PF00082	0.595
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.682
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.566
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.649
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.594
CLV_PCSK_PC7_1	86	92	PF00082	0.587
CLV_PCSK_SKI1_1	23	27	PF00082	0.561
CLV_PCSK_SKI1_1	31	35	PF00082	0.531
CLV_PCSK_SKI1_1	334	338	PF00082	0.476
CLV_PCSK_SKI1_1	446	450	PF00082	0.469
CLV_PCSK_SKI1_1	65	69	PF00082	0.551
CLV_PCSK_SKI1_1	795	799	PF00082	0.503
CLV_Separin_Metazoa	327	331	PF03568	0.383
DEG_APCC_DBOX_1	144	152	PF00400	0.625
DEG_APCC_DBOX_1	285	293	PF00400	0.402
DEG_SCF_FBW7_1	1	6	PF00400	0.479
DEG_SCF_TRCP1_1	583	589	PF00400	0.517
DEG_SPOP_SBC_1	155	159	PF00917	0.680
DEG_SPOP_SBC_1	495	499	PF00917	0.804
DOC_CKS1_1	74	79	PF01111	0.678
DOC_CYCLIN_RxL_1	443	453	PF00134	0.451
DOC_CYCLIN_RxL_1	616	626	PF00134	0.649
DOC_MAPK_DCC_7	273	283	PF00069	0.558
DOC_MAPK_gen_1	273	283	PF00069	0.551
DOC_MAPK_gen_1	613	622	PF00069	0.557
DOC_MAPK_HePTP_8	271	283	PF00069	0.544
DOC_MAPK_JIP1_4	520	526	PF00069	0.486
DOC_MAPK_MEF2A_6	274	283	PF00069	0.562
DOC_MAPK_MEF2A_6	520	528	PF00069	0.356
DOC_MAPK_MEF2A_6	613	622	PF00069	0.555
DOC_MAPK_MEF2A_6	748	756	PF00069	0.540
DOC_PP1_RVXF_1	444	451	PF00149	0.561
DOC_PP2B_LxvP_1	754	757	PF13499	0.587
DOC_PP4_FxxP_1	635	638	PF00568	0.666
DOC_USP7_MATH_1	155	159	PF00917	0.655
DOC_USP7_MATH_1	164	168	PF00917	0.696
DOC_USP7_MATH_1	180	184	PF00917	0.638
DOC_USP7_MATH_1	285	289	PF00917	0.382
DOC_USP7_MATH_1	353	357	PF00917	0.674
DOC_USP7_MATH_1	399	403	PF00917	0.536
DOC_USP7_MATH_1	494	498	PF00917	0.811
DOC_USP7_MATH_1	629	633	PF00917	0.657
DOC_USP7_MATH_1	765	769	PF00917	0.696
DOC_USP7_MATH_1	786	790	PF00917	0.633
DOC_USP7_MATH_1	875	879	PF00917	0.684
DOC_USP7_UBL2_3	24	28	PF12436	0.532
DOC_WW_Pin1_4	151	156	PF00397	0.671
DOC_WW_Pin1_4	200	205	PF00397	0.643
DOC_WW_Pin1_4	242	247	PF00397	0.527
DOC_WW_Pin1_4	281	286	PF00397	0.500
DOC_WW_Pin1_4	41	46	PF00397	0.548
DOC_WW_Pin1_4	504	509	PF00397	0.612
DOC_WW_Pin1_4	588	593	PF00397	0.535
DOC_WW_Pin1_4	710	715	PF00397	0.529
DOC_WW_Pin1_4	73	78	PF00397	0.562
DOC_WW_Pin1_4	928	933	PF00397	0.496
DOC_WW_Pin1_4	95	100	PF00397	0.601
LIG_14-3-3_CanoR_1	145	155	PF00244	0.625
LIG_14-3-3_CanoR_1	173	182	PF00244	0.600
LIG_14-3-3_CanoR_1	219	223	PF00244	0.639
LIG_14-3-3_CanoR_1	286	290	PF00244	0.482
LIG_14-3-3_CanoR_1	451	455	PF00244	0.492
LIG_14-3-3_CanoR_1	630	638	PF00244	0.594
LIG_14-3-3_CanoR_1	65	70	PF00244	0.611
LIG_14-3-3_CanoR_1	663	669	PF00244	0.508
LIG_14-3-3_CanoR_1	801	811	PF00244	0.487
LIG_14-3-3_CanoR_1	893	899	PF00244	0.622
LIG_AP2alpha_1	411	415	PF02296	0.433
LIG_BIR_III_2	385	389	PF00653	0.445
LIG_BRCT_BRCA1_1	506	510	PF00533	0.576
LIG_BRCT_BRCA1_1	631	635	PF00533	0.580
LIG_Clathr_ClatBox_1	622	626	PF01394	0.595
LIG_eIF4E_1	443	449	PF01652	0.453
LIG_FHA_1	128	134	PF00498	0.602
LIG_FHA_1	158	164	PF00498	0.634
LIG_FHA_1	201	207	PF00498	0.689
LIG_FHA_1	295	301	PF00498	0.398
LIG_FHA_1	321	327	PF00498	0.451
LIG_FHA_1	349	355	PF00498	0.638
LIG_FHA_1	373	379	PF00498	0.427
LIG_FHA_1	451	457	PF00498	0.468
LIG_FHA_1	52	58	PF00498	0.647
LIG_FHA_1	676	682	PF00498	0.568
LIG_FHA_1	729	735	PF00498	0.434
LIG_FHA_1	830	836	PF00498	0.618
LIG_FHA_2	368	374	PF00498	0.404
LIG_FHA_2	471	477	PF00498	0.680
LIG_FHA_2	74	80	PF00498	0.697
LIG_FHA_2	835	841	PF00498	0.527
LIG_FHA_2	884	890	PF00498	0.560
LIG_FHA_2	895	901	PF00498	0.469
LIG_GBD_Chelix_1	305	313	PF00786	0.438
LIG_GBD_Chelix_1	522	530	PF00786	0.405
LIG_IRF3_LxIS_1	924	931	PF10401	0.465
LIG_LIR_Apic_2	632	638	PF02991	0.705
LIG_LIR_Apic_2	71	77	PF02991	0.666
LIG_LIR_Gen_1	413	423	PF02991	0.464
LIG_LIR_Gen_1	59	67	PF02991	0.488
LIG_LIR_Gen_1	636	646	PF02991	0.640
LIG_LIR_Gen_1	703	714	PF02991	0.485
LIG_LIR_Gen_1	812	823	PF02991	0.446
LIG_LIR_Nem_3	221	227	PF02991	0.658
LIG_LIR_Nem_3	315	320	PF02991	0.430
LIG_LIR_Nem_3	413	417	PF02991	0.456
LIG_LIR_Nem_3	59	64	PF02991	0.474
LIG_LIR_Nem_3	626	631	PF02991	0.530
LIG_LIR_Nem_3	636	642	PF02991	0.544
LIG_LIR_Nem_3	703	709	PF02991	0.484
LIG_LIR_Nem_3	812	818	PF02991	0.442
LIG_LIR_Nem_3	824	830	PF02991	0.488
LIG_PCNA_yPIPBox_3	902	916	PF02747	0.453
LIG_Pex14_2	33	37	PF04695	0.539
LIG_Pex14_2	411	415	PF04695	0.433
LIG_Pex14_2	635	639	PF04695	0.616
LIG_PTB_Apo_2	404	411	PF02174	0.535
LIG_PTB_Apo_2	601	608	PF02174	0.666
LIG_PTB_Phospho_1	404	410	PF10480	0.533
LIG_PTB_Phospho_1	601	607	PF10480	0.668
LIG_REV1ctd_RIR_1	447	455	PF16727	0.512
LIG_SH2_CRK	800	804	PF00017	0.545
LIG_SH2_NCK_1	369	373	PF00017	0.601
LIG_SH2_STAP1	443	447	PF00017	0.450
LIG_SH2_STAT3	147	150	PF00017	0.428
LIG_SH2_STAT5	147	150	PF00017	0.625
LIG_SH2_STAT5	36	39	PF00017	0.541
LIG_SH2_STAT5	369	372	PF00017	0.575
LIG_SH2_STAT5	382	385	PF00017	0.393
LIG_SH2_STAT5	410	413	PF00017	0.581
LIG_SH2_STAT5	447	450	PF00017	0.442
LIG_SH2_STAT5	452	455	PF00017	0.483
LIG_SH3_3	210	216	PF00018	0.700
LIG_SH3_3	243	249	PF00018	0.546
LIG_SH3_3	297	303	PF00018	0.401
LIG_SH3_3	515	521	PF00018	0.534
LIG_SH3_3	744	750	PF00018	0.524
LIG_SH3_3	91	97	PF00018	0.619
LIG_SH3_3	926	932	PF00018	0.487
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.438
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.378
LIG_SUMO_SIM_anti_2	321	330	PF11976	0.434
LIG_SUMO_SIM_par_1	232	238	PF11976	0.596
LIG_SUMO_SIM_par_1	296	302	PF11976	0.487
LIG_TRAF2_2	99	104	PF00917	0.557
LIG_TRFH_1	41	45	PF08558	0.609
LIG_TYR_ITIM	798	803	PF00017	0.551
LIG_UBA3_1	250	256	PF00899	0.623
LIG_UBA3_1	289	293	PF00899	0.399
LIG_WRC_WIRS_1	58	63	PF05994	0.455
MOD_CDK_SPK_2	281	286	PF00069	0.500
MOD_CDK_SPxxK_3	200	207	PF00069	0.683
MOD_CDK_SPxxK_3	41	48	PF00069	0.642
MOD_CDK_SPxxK_3	73	80	PF00069	0.683
MOD_CDK_SPxxK_3	928	935	PF00069	0.497
MOD_CK1_1	154	160	PF00069	0.709
MOD_CK1_1	284	290	PF00069	0.357
MOD_CK1_1	318	324	PF00069	0.345
MOD_CK1_1	356	362	PF00069	0.690
MOD_CK1_1	497	503	PF00069	0.745
MOD_CK1_1	586	592	PF00069	0.593
MOD_CK1_1	684	690	PF00069	0.781
MOD_CK1_1	755	761	PF00069	0.701
MOD_CK1_1	880	886	PF00069	0.609
MOD_CK2_1	318	324	PF00069	0.450
MOD_CK2_1	367	373	PF00069	0.567
MOD_CK2_1	470	476	PF00069	0.561
MOD_CK2_1	822	828	PF00069	0.588
MOD_CK2_1	883	889	PF00069	0.559
MOD_CK2_1	894	900	PF00069	0.485
MOD_Cter_Amidation	21	24	PF01082	0.658
MOD_GlcNHglycan	166	169	PF01048	0.610
MOD_GlcNHglycan	182	185	PF01048	0.621
MOD_GlcNHglycan	209	212	PF01048	0.691
MOD_GlcNHglycan	224	227	PF01048	0.509
MOD_GlcNHglycan	263	266	PF01048	0.484
MOD_GlcNHglycan	317	320	PF01048	0.351
MOD_GlcNHglycan	350	354	PF01048	0.698
MOD_GlcNHglycan	355	358	PF01048	0.660
MOD_GlcNHglycan	484	487	PF01048	0.552
MOD_GlcNHglycan	54	57	PF01048	0.610
MOD_GlcNHglycan	583	586	PF01048	0.696
MOD_GlcNHglycan	664	667	PF01048	0.568
MOD_GlcNHglycan	769	772	PF01048	0.712
MOD_GlcNHglycan	788	791	PF01048	0.640
MOD_GlcNHglycan	839	844	PF01048	0.752
MOD_GlcNHglycan	873	876	PF01048	0.633
MOD_GlcNHglycan	877	880	PF01048	0.631
MOD_GlcNHglycan	882	885	PF01048	0.630
MOD_GSK3_1	128	135	PF00069	0.629
MOD_GSK3_1	151	158	PF00069	0.540
MOD_GSK3_1	218	225	PF00069	0.590
MOD_GSK3_1	281	288	PF00069	0.508
MOD_GSK3_1	349	356	PF00069	0.696
MOD_GSK3_1	450	457	PF00069	0.411
MOD_GSK3_1	494	501	PF00069	0.705
MOD_GSK3_1	52	59	PF00069	0.552
MOD_GSK3_1	581	588	PF00069	0.643
MOD_GSK3_1	629	636	PF00069	0.629
MOD_GSK3_1	683	690	PF00069	0.761
MOD_GSK3_1	701	708	PF00069	0.460
MOD_GSK3_1	765	772	PF00069	0.666
MOD_GSK3_1	80	87	PF00069	0.694
MOD_GSK3_1	830	837	PF00069	0.512
MOD_GSK3_1	871	878	PF00069	0.660
MOD_N-GLC_1	138	143	PF02516	0.421
MOD_N-GLC_1	315	320	PF02516	0.349
MOD_NEK2_1	128	133	PF00069	0.575
MOD_NEK2_1	137	142	PF00069	0.574
MOD_NEK2_1	156	161	PF00069	0.477
MOD_NEK2_1	222	227	PF00069	0.552
MOD_NEK2_1	235	240	PF00069	0.545
MOD_NEK2_1	26	31	PF00069	0.562
MOD_NEK2_1	305	310	PF00069	0.440
MOD_NEK2_1	450	455	PF00069	0.467
MOD_NEK2_1	683	688	PF00069	0.506
MOD_NEK2_1	727	732	PF00069	0.537
MOD_NEK2_1	752	757	PF00069	0.715
MOD_NEK2_1	802	807	PF00069	0.473
MOD_NEK2_2	249	254	PF00069	0.633
MOD_PIKK_1	146	152	PF00454	0.518
MOD_PIKK_1	359	365	PF00454	0.614
MOD_PIKK_1	629	635	PF00454	0.582
MOD_PIKK_1	97	103	PF00454	0.733
MOD_PKA_1	655	661	PF00069	0.496
MOD_PKA_2	164	170	PF00069	0.662
MOD_PKA_2	172	178	PF00069	0.593
MOD_PKA_2	218	224	PF00069	0.695
MOD_PKA_2	285	291	PF00069	0.515
MOD_PKA_2	450	456	PF00069	0.477
MOD_PKA_2	482	488	PF00069	0.552
MOD_PKA_2	52	58	PF00069	0.597
MOD_PKA_2	581	587	PF00069	0.648
MOD_PKA_2	600	606	PF00069	0.578
MOD_PKA_2	629	635	PF00069	0.549
MOD_PKA_2	655	661	PF00069	0.606
MOD_PKA_2	662	668	PF00069	0.586
MOD_PKA_2	786	792	PF00069	0.537
MOD_PKA_2	79	85	PF00069	0.553
MOD_PKA_2	803	809	PF00069	0.616
MOD_PKA_2	894	900	PF00069	0.607
MOD_PKB_1	653	661	PF00069	0.495
MOD_Plk_1	103	109	PF00069	0.496
MOD_Plk_1	349	355	PF00069	0.628
MOD_Plk_1	684	690	PF00069	0.767
MOD_Plk_1	702	708	PF00069	0.568
MOD_Plk_1	823	829	PF00069	0.411
MOD_Plk_1	853	859	PF00069	0.555
MOD_Plk_1	919	925	PF00069	0.516
MOD_Plk_4	128	134	PF00069	0.510
MOD_Plk_4	229	235	PF00069	0.537
MOD_Plk_4	285	291	PF00069	0.510
MOD_Plk_4	364	370	PF00069	0.649
MOD_Plk_4	684	690	PF00069	0.756
MOD_Plk_4	705	711	PF00069	0.509
MOD_Plk_4	728	734	PF00069	0.516
MOD_ProDKin_1	151	157	PF00069	0.675
MOD_ProDKin_1	200	206	PF00069	0.649
MOD_ProDKin_1	242	248	PF00069	0.526
MOD_ProDKin_1	281	287	PF00069	0.491
MOD_ProDKin_1	41	47	PF00069	0.548
MOD_ProDKin_1	504	510	PF00069	0.611
MOD_ProDKin_1	588	594	PF00069	0.533
MOD_ProDKin_1	710	716	PF00069	0.520
MOD_ProDKin_1	73	79	PF00069	0.566
MOD_ProDKin_1	928	934	PF00069	0.496
MOD_ProDKin_1	95	101	PF00069	0.595
MOD_SUMO_for_1	37	40	PF00179	0.607
MOD_SUMO_for_1	514	517	PF00179	0.623
TRG_DiLeu_BaEn_1	324	329	PF01217	0.443
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.470
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.663
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.496
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.628
TRG_ENDOCYTIC_2	447	450	PF00928	0.442
TRG_ENDOCYTIC_2	599	602	PF00928	0.602
TRG_ENDOCYTIC_2	607	610	PF00928	0.507
TRG_ENDOCYTIC_2	800	803	PF00928	0.546
TRG_ER_diArg_1	200	202	PF00400	0.537
TRG_ER_diArg_1	272	274	PF00400	0.579
TRG_ER_diArg_1	332	334	PF00400	0.390
TRG_ER_diArg_1	613	615	PF00400	0.577
TRG_ER_diArg_1	617	620	PF00400	0.529
TRG_ER_diArg_1	653	656	PF00400	0.726
TRG_NES_CRM1_1	900	914	PF08389	0.502
TRG_NLS_MonoExtC_3	26	31	PF00514	0.529
TRG_NLS_MonoExtN_4	24	31	PF00514	0.531
TRG_NLS_MonoExtN_4	613	620	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ93	Leptomonas seymouri	60%	100%
A0A1X0NM18	Trypanosomatidae	37%	100%
A0A3Q8IFB6	Leishmania donovani	81%	98%
A0A422P200	Trypanosoma rangeli	39%	100%
A4I1I0	Leishmania infantum	81%	98%
C9ZJY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AXL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4Q9V7	Leishmania major	82%	100%