Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE51_LEIBR

TriTrypDb:

LbrM.25.1050 , LBRM2903_250019700

Length:

2580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A4HE51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0008285	negative regulation of cell population proliferation	5	7
GO:0042127	regulation of cell population proliferation	4	7
GO:0048519	negative regulation of biological process	3	7
GO:0048523	negative regulation of cellular process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1369	1373	PF00656	0.487
CLV_C14_Caspase3-7	1755	1759	PF00656	0.347
CLV_C14_Caspase3-7	2268	2272	PF00656	0.503
CLV_C14_Caspase3-7	2296	2300	PF00656	0.404
CLV_C14_Caspase3-7	2350	2354	PF00656	0.388
CLV_C14_Caspase3-7	2357	2361	PF00656	0.368
CLV_C14_Caspase3-7	2427	2431	PF00656	0.377
CLV_C14_Caspase3-7	409	413	PF00656	0.636
CLV_C14_Caspase3-7	640	644	PF00656	0.664
CLV_C14_Caspase3-7	763	767	PF00656	0.666

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5U7	Leptomonas seymouri	48%	99%
A0A3Q8ICD6	Leishmania donovani	75%	100%
A4I1H9	Leishmania infantum	75%	99%
E9AXL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q9V8	Leishmania major	73%	100%

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