Putative serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein kinase (fragment), putative

Species:

Leishmania braziliensis

UniProt:

A4HE48_LEIBR

TriTrypDb:

LbrM.25.1010 , LBRM2903_250022600

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE48

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	2
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	3
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0005488	binding	1	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0017018	myosin phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	127	131	PF00082	0.424
CLV_PCSK_SKI1_1	44	48	PF00082	0.356
DEG_APCC_KENBOX_2	48	52	PF00400	0.378
DEG_SPOP_SBC_1	10	14	PF00917	0.452
DOC_CYCLIN_RxL_1	127	138	PF00134	0.425
DOC_MAPK_gen_1	123	131	PF00069	0.414
DOC_PP1_RVXF_1	131	138	PF00149	0.642
DOC_USP7_MATH_1	9	13	PF00917	0.451
DOC_USP7_UBL2_3	126	130	PF12436	0.425
LIG_14-3-3_CanoR_1	57	63	PF00244	0.203
LIG_14-3-3_CanoR_1	97	103	PF00244	0.196
LIG_BRCT_BRCA1_1	116	120	PF00533	0.203
LIG_FHA_1	102	108	PF00498	0.155
LIG_FHA_1	13	19	PF00498	0.502
LIG_FHA_1	130	136	PF00498	0.426
LIG_FHA_1	84	90	PF00498	0.410
LIG_LIR_Gen_1	85	95	PF02991	0.198
LIG_LIR_Nem_3	117	122	PF02991	0.317
LIG_LIR_Nem_3	96	102	PF02991	0.232
LIG_MLH1_MIPbox_1	116	120	PF16413	0.203
LIG_REV1ctd_RIR_1	118	127	PF16727	0.198
LIG_SH2_STAT3	24	27	PF00017	0.300
LIG_SH2_STAT5	119	122	PF00017	0.217
LIG_SH2_STAT5	24	27	PF00017	0.300
LIG_SH2_STAT5	88	91	PF00017	0.294
LIG_SH2_STAT5	94	97	PF00017	0.291
LIG_SH3_3	53	59	PF00018	0.384
LIG_SUMO_SIM_anti_2	103	109	PF11976	0.196
LIG_SUMO_SIM_par_1	12	20	PF11976	0.376
LIG_UBA3_1	107	112	PF00899	0.203
LIG_UBA3_1	73	78	PF00899	0.196
MOD_CK1_1	101	107	PF00069	0.196
MOD_CK1_1	12	18	PF00069	0.391
MOD_GlcNHglycan	5	8	PF01048	0.464
MOD_GSK3_1	125	132	PF00069	0.419
MOD_Plk_4	103	109	PF00069	0.203
TRG_DiLeu_BaEn_1	103	108	PF01217	0.314
TRG_ENDOCYTIC_2	119	122	PF00928	0.150
TRG_ENDOCYTIC_2	88	91	PF00928	0.196
TRG_ENDOCYTIC_2	99	102	PF00928	0.196
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9I2	Trypanosomatidae	42%	83%