MGT2 magnesium transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

magnesium transporter protein 2

Species:

Leishmania braziliensis

UniProt:

A4HE45_LEIBR

TriTrypDb:

LbrM.25.0980 , LBRM2903_250019100

Length:

413

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HE45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE45

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006811	monoatomic ion transport	4	7
GO:0006812	monoatomic cation transport	5	7
GO:0015693	magnesium ion transport	7	6
GO:0030001	metal ion transport	6	6
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0008324	monoatomic cation transmembrane transporter activity	4	17
GO:0015075	monoatomic ion transmembrane transporter activity	3	17
GO:0015095	magnesium ion transmembrane transporter activity	6	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	17
GO:0022857	transmembrane transporter activity	2	17
GO:0022890	inorganic cation transmembrane transporter activity	4	17
GO:0046873	metal ion transmembrane transporter activity	5	17
GO:0015562	efflux transmembrane transporter activity	3	1
GO:0046583	monoatomic cation efflux transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.409
CLV_NRD_NRD_1	244	246	PF00675	0.269
CLV_NRD_NRD_1	251	253	PF00675	0.269
CLV_NRD_NRD_1	41	43	PF00675	0.462
CLV_NRD_NRD_1	70	72	PF00675	0.334
CLV_PCSK_KEX2_1	165	167	PF00082	0.397
CLV_PCSK_KEX2_1	244	246	PF00082	0.275
CLV_PCSK_KEX2_1	250	252	PF00082	0.278
CLV_PCSK_KEX2_1	70	72	PF00082	0.321
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.310
CLV_PCSK_SKI1_1	165	169	PF00082	0.342
CLV_PCSK_SKI1_1	245	249	PF00082	0.320
CLV_PCSK_SKI1_1	257	261	PF00082	0.292
CLV_PCSK_SKI1_1	292	296	PF00082	0.309
CLV_PCSK_SKI1_1	309	313	PF00082	0.297
CLV_PCSK_SKI1_1	397	401	PF00082	0.452
CLV_PCSK_SKI1_1	71	75	PF00082	0.280
CLV_Separin_Metazoa	172	176	PF03568	0.536
DEG_APCC_DBOX_1	70	78	PF00400	0.480
DOC_CKS1_1	270	275	PF01111	0.596
DOC_CYCLIN_RxL_1	24	35	PF00134	0.638
DOC_MAPK_MEF2A_6	175	183	PF00069	0.492
DOC_MAPK_MEF2A_6	297	305	PF00069	0.478
DOC_PP1_RVXF_1	25	32	PF00149	0.626
DOC_PP2B_LxvP_1	231	234	PF13499	0.511
DOC_USP7_MATH_1	205	209	PF00917	0.589
DOC_USP7_MATH_1	30	34	PF00917	0.564
DOC_USP7_MATH_1	94	98	PF00917	0.580
DOC_WW_Pin1_4	192	197	PF00397	0.580
DOC_WW_Pin1_4	269	274	PF00397	0.571
DOC_WW_Pin1_4	63	68	PF00397	0.597
DOC_WW_Pin1_4	7	12	PF00397	0.726
LIG_14-3-3_CanoR_1	250	260	PF00244	0.493
LIG_14-3-3_CanoR_1	326	336	PF00244	0.536
LIG_APCC_ABBA_1	288	293	PF00400	0.596
LIG_BRCT_BRCA1_1	137	141	PF00533	0.552
LIG_DLG_GKlike_1	252	259	PF00625	0.596
LIG_eIF4E_1	261	267	PF01652	0.511
LIG_FHA_1	153	159	PF00498	0.583
LIG_FHA_1	184	190	PF00498	0.571
LIG_FHA_1	193	199	PF00498	0.565
LIG_FHA_1	214	220	PF00498	0.482
LIG_FHA_1	55	61	PF00498	0.592
LIG_FHA_1	8	14	PF00498	0.756
LIG_FHA_2	122	128	PF00498	0.603
LIG_FHA_2	159	165	PF00498	0.596
LIG_FHA_2	64	70	PF00498	0.563
LIG_FHA_2	84	90	PF00498	0.542
LIG_FHA_2	93	99	PF00498	0.549
LIG_LIR_Gen_1	57	67	PF02991	0.521
LIG_LIR_Nem_3	119	125	PF02991	0.538
LIG_LIR_Nem_3	164	170	PF02991	0.523
LIG_LIR_Nem_3	254	259	PF02991	0.598
LIG_LIR_Nem_3	57	62	PF02991	0.521
LIG_SH2_SRC	109	112	PF00017	0.501
LIG_SH2_STAP1	206	210	PF00017	0.571
LIG_SH2_STAT5	261	264	PF00017	0.426
LIG_SH2_STAT5	28	31	PF00017	0.670
LIG_SH3_3	404	410	PF00018	0.707
LIG_SH3_3	78	84	PF00018	0.571
LIG_SH3_3	88	94	PF00018	0.522
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.498
LIG_SUMO_SIM_anti_2	342	348	PF11976	0.363
LIG_TRAF2_1	66	69	PF00917	0.566
LIG_UBA3_1	158	165	PF00899	0.573
LIG_UBA3_1	259	265	PF00899	0.510
LIG_UBA3_1	284	292	PF00899	0.409
LIG_WRC_WIRS_1	253	258	PF05994	0.571
MOD_CDK_SPxxK_3	269	276	PF00069	0.571
MOD_CDK_SPxxK_3	63	70	PF00069	0.510
MOD_CK1_1	192	198	PF00069	0.529
MOD_CK1_1	328	334	PF00069	0.527
MOD_CK1_1	35	41	PF00069	0.639
MOD_CK1_1	392	398	PF00069	0.498
MOD_CK1_1	82	88	PF00069	0.494
MOD_CK2_1	121	127	PF00069	0.603
MOD_CK2_1	63	69	PF00069	0.519
MOD_GlcNHglycan	330	333	PF01048	0.297
MOD_GlcNHglycan	34	37	PF01048	0.426
MOD_GSK3_1	148	155	PF00069	0.486
MOD_GSK3_1	17	24	PF00069	0.711
MOD_GSK3_1	190	197	PF00069	0.466
MOD_GSK3_1	213	220	PF00069	0.505
MOD_GSK3_1	271	278	PF00069	0.524
MOD_GSK3_1	31	38	PF00069	0.677
MOD_GSK3_1	321	328	PF00069	0.553
MOD_GSK3_1	79	86	PF00069	0.545
MOD_N-GLC_1	134	139	PF02516	0.422
MOD_N-GLC_1	31	36	PF02516	0.493
MOD_NEK2_1	1	6	PF00069	0.783
MOD_NEK2_1	158	163	PF00069	0.504
MOD_NEK2_1	183	188	PF00069	0.556
MOD_NEK2_1	189	194	PF00069	0.556
MOD_NEK2_1	21	26	PF00069	0.690
MOD_NEK2_1	275	280	PF00069	0.489
MOD_NEK2_1	31	36	PF00069	0.544
MOD_NEK2_1	325	330	PF00069	0.506
MOD_NEK2_1	353	358	PF00069	0.369
MOD_NEK2_1	367	372	PF00069	0.273
MOD_NEK2_1	389	394	PF00069	0.451
MOD_PIKK_1	296	302	PF00454	0.472
MOD_PIKK_1	325	331	PF00454	0.522
MOD_PIKK_1	339	345	PF00454	0.420
MOD_PKA_1	251	257	PF00069	0.512
MOD_PKA_2	251	257	PF00069	0.486
MOD_PKA_2	275	281	PF00069	0.481
MOD_PKA_2	325	331	PF00069	0.531
MOD_PKB_1	250	258	PF00069	0.552
MOD_Plk_1	54	60	PF00069	0.553
MOD_Plk_2-3	127	133	PF00069	0.543
MOD_Plk_4	148	154	PF00069	0.497
MOD_Plk_4	17	23	PF00069	0.771
MOD_Plk_4	194	200	PF00069	0.482
MOD_Plk_4	275	281	PF00069	0.481
MOD_Plk_4	35	41	PF00069	0.651
MOD_Plk_4	353	359	PF00069	0.370
MOD_Plk_4	83	89	PF00069	0.521
MOD_ProDKin_1	192	198	PF00069	0.580
MOD_ProDKin_1	269	275	PF00069	0.571
MOD_ProDKin_1	63	69	PF00069	0.597
MOD_ProDKin_1	7	13	PF00069	0.730
MOD_SUMO_rev_2	330	338	PF00179	0.525
TRG_DiLeu_BaEn_1	227	232	PF01217	0.481
TRG_DiLeu_BaEn_3	68	74	PF01217	0.597
TRG_ENDOCYTIC_2	122	125	PF00928	0.514
TRG_ENDOCYTIC_2	28	31	PF00928	0.671
TRG_ER_diArg_1	2	5	PF00400	0.780
TRG_ER_diArg_1	243	245	PF00400	0.468
TRG_ER_diArg_1	249	252	PF00400	0.466
TRG_ER_diArg_1	25	28	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I5	Leptomonas seymouri	73%	100%
A0A1X0NLW5	Trypanosomatidae	43%	96%
A0A1X0NLX5	Trypanosomatidae	37%	100%
A0A1X0NUD3	Trypanosomatidae	30%	100%
A0A3Q8IND2	Leishmania donovani	84%	100%
A0A3R7KXL6	Trypanosoma rangeli	37%	100%
A0A3R7R8A9	Trypanosoma rangeli	45%	97%
A0A3S5IQJ8	Trypanosoma rangeli	26%	100%
A4I1F1	Leishmania infantum	84%	100%
C9ZK17	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZK26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	97%
C9ZWQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	73%
C9ZXP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q9Y4	Leishmania major	84%	100%
V5B7S4	Trypanosoma cruzi	43%	100%
V5D3L0	Trypanosoma cruzi	45%	95%