RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE44_LEIBR

TriTrypDb:

LbrM.25.0970 , LBRM2903_250019000

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE44

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.405
CLV_NRD_NRD_1	300	302	PF00675	0.669
CLV_NRD_NRD_1	357	359	PF00675	0.526
CLV_NRD_NRD_1	439	441	PF00675	0.680
CLV_PCSK_FUR_1	153	157	PF00082	0.532
CLV_PCSK_KEX2_1	155	157	PF00082	0.464
CLV_PCSK_KEX2_1	300	302	PF00082	0.669
CLV_PCSK_KEX2_1	357	359	PF00082	0.665
CLV_PCSK_KEX2_1	439	441	PF00082	0.634
CLV_PCSK_KEX2_1	80	82	PF00082	0.624
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.665
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.532
CLV_PCSK_SKI1_1	201	205	PF00082	0.552
CLV_PCSK_SKI1_1	238	242	PF00082	0.684
CLV_PCSK_SKI1_1	81	85	PF00082	0.617
DEG_APCC_DBOX_1	226	234	PF00400	0.535
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.427
DOC_MAPK_gen_1	153	161	PF00069	0.397
DOC_MAPK_gen_1	6	15	PF00069	0.523
DOC_MAPK_MEF2A_6	153	161	PF00069	0.464
DOC_PP2B_LxvP_1	88	91	PF13499	0.467
DOC_USP7_MATH_1	179	183	PF00917	0.658
DOC_USP7_MATH_1	255	259	PF00917	0.728
DOC_USP7_MATH_1	368	372	PF00917	0.741
DOC_USP7_MATH_1	394	398	PF00917	0.584
DOC_USP7_MATH_1	74	78	PF00917	0.642
DOC_USP7_UBL2_3	45	49	PF12436	0.618
DOC_USP7_UBL2_3	7	11	PF12436	0.615
DOC_WW_Pin1_4	246	251	PF00397	0.628
DOC_WW_Pin1_4	258	263	PF00397	0.559
DOC_WW_Pin1_4	269	274	PF00397	0.655
DOC_WW_Pin1_4	304	309	PF00397	0.652
LIG_14-3-3_CanoR_1	100	109	PF00244	0.439
LIG_14-3-3_CanoR_1	300	308	PF00244	0.677
LIG_14-3-3_CanoR_1	9	14	PF00244	0.592
LIG_14-3-3_CterR_2	439	441	PF00244	0.634
LIG_BIR_III_4	184	188	PF00653	0.563
LIG_BRCT_BRCA1_1	128	132	PF00533	0.374
LIG_BRCT_BRCA1_1	46	50	PF00533	0.391
LIG_deltaCOP1_diTrp_1	29	35	PF00928	0.658
LIG_EH_1	319	323	PF12763	0.655
LIG_FHA_1	10	16	PF00498	0.524
LIG_FHA_1	117	123	PF00498	0.427
LIG_FHA_1	140	146	PF00498	0.439
LIG_FHA_1	71	77	PF00498	0.681
LIG_FHA_2	101	107	PF00498	0.291
LIG_FHA_2	82	88	PF00498	0.592
LIG_Integrin_isoDGR_2	285	287	PF01839	0.515
LIG_Integrin_isoDGR_2	380	382	PF01839	0.735
LIG_LIR_Gen_1	105	116	PF02991	0.539
LIG_LIR_Gen_1	129	140	PF02991	0.353
LIG_LIR_Gen_1	278	284	PF02991	0.528
LIG_LIR_Gen_1	56	65	PF02991	0.590
LIG_LIR_Nem_3	105	111	PF02991	0.536
LIG_LIR_Nem_3	129	135	PF02991	0.339
LIG_LIR_Nem_3	278	282	PF02991	0.625
LIG_LIR_Nem_3	433	438	PF02991	0.647
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.558
LIG_Pex14_2	108	112	PF04695	0.329
LIG_Pex14_2	92	96	PF04695	0.431
LIG_PTB_Apo_2	415	422	PF02174	0.516
LIG_PTB_Phospho_1	415	421	PF10480	0.518
LIG_SH2_PTP2	158	161	PF00017	0.412
LIG_SH2_SRC	421	424	PF00017	0.499
LIG_SH2_STAT5	158	161	PF00017	0.412
LIG_SH2_STAT5	22	25	PF00017	0.519
LIG_SH2_STAT5	401	404	PF00017	0.519
LIG_SH3_1	420	426	PF00018	0.655
LIG_SH3_3	210	216	PF00018	0.664
LIG_SH3_3	302	308	PF00018	0.675
LIG_SH3_3	420	426	PF00018	0.673
LIG_SUMO_SIM_par_1	141	146	PF11976	0.564
LIG_TRAF2_1	103	106	PF00917	0.443
MOD_CK1_1	234	240	PF00069	0.473
MOD_CK1_1	249	255	PF00069	0.678
MOD_CK1_1	258	264	PF00069	0.601
MOD_CK1_1	397	403	PF00069	0.551
MOD_CK1_1	58	64	PF00069	0.686
MOD_CK1_1	70	76	PF00069	0.592
MOD_CK2_1	100	106	PF00069	0.427
MOD_Cter_Amidation	153	156	PF01082	0.433
MOD_GlcNHglycan	136	139	PF01048	0.449
MOD_GlcNHglycan	242	245	PF01048	0.747
MOD_GlcNHglycan	251	254	PF01048	0.741
MOD_GlcNHglycan	257	260	PF01048	0.725
MOD_GlcNHglycan	302	305	PF01048	0.789
MOD_GlcNHglycan	370	373	PF01048	0.745
MOD_GlcNHglycan	374	377	PF01048	0.743
MOD_GlcNHglycan	405	409	PF01048	0.549
MOD_GlcNHglycan	412	416	PF01048	0.738
MOD_GSK3_1	139	146	PF00069	0.464
MOD_GSK3_1	219	226	PF00069	0.604
MOD_GSK3_1	251	258	PF00069	0.600
MOD_GSK3_1	300	307	PF00069	0.705
MOD_GSK3_1	353	360	PF00069	0.714
MOD_GSK3_1	368	375	PF00069	0.765
MOD_GSK3_1	70	77	PF00069	0.578
MOD_N-GLC_1	100	105	PF02516	0.421
MOD_N-GLC_1	269	274	PF02516	0.500
MOD_N-GLC_1	368	373	PF02516	0.824
MOD_N-GLC_1	61	66	PF02516	0.663
MOD_NEK2_1	147	152	PF00069	0.402
MOD_NEK2_1	240	245	PF00069	0.725
MOD_NEK2_1	299	304	PF00069	0.809
MOD_PIKK_1	160	166	PF00454	0.547
MOD_PKA_1	300	306	PF00069	0.743
MOD_PKA_1	357	363	PF00069	0.626
MOD_PKA_2	172	178	PF00069	0.627
MOD_PKA_2	299	305	PF00069	0.728
MOD_PKA_2	357	363	PF00069	0.654
MOD_PKA_2	58	64	PF00069	0.436
MOD_Plk_1	147	153	PF00069	0.407
MOD_Plk_1	277	283	PF00069	0.713
MOD_Plk_1	350	356	PF00069	0.650
MOD_Plk_1	397	403	PF00069	0.612
MOD_Plk_1	55	61	PF00069	0.588
MOD_Plk_2-3	229	235	PF00069	0.432
MOD_Plk_4	107	113	PF00069	0.554
MOD_ProDKin_1	246	252	PF00069	0.627
MOD_ProDKin_1	258	264	PF00069	0.559
MOD_ProDKin_1	269	275	PF00069	0.657
MOD_ProDKin_1	304	310	PF00069	0.648
MOD_SUMO_for_1	338	341	PF00179	0.675
MOD_SUMO_rev_2	39	47	PF00179	0.424
MOD_SUMO_rev_2	77	82	PF00179	0.431
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.395
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.560
TRG_ENDOCYTIC_2	158	161	PF00928	0.412
TRG_ENDOCYTIC_2	57	60	PF00928	0.586
TRG_ER_diArg_1	153	156	PF00400	0.546
TRG_ER_diArg_1	299	301	PF00400	0.677
TRG_ER_diArg_1	438	440	PF00400	0.570
TRG_NLS_MonoExtN_4	4	10	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F7	Leptomonas seymouri	65%	100%
A0A0S4IKR5	Bodo saltans	34%	100%
A0A1X0NLV4	Trypanosomatidae	44%	100%
A0A3S7WZ21	Leishmania donovani	84%	98%
A4I1F0	Leishmania infantum	84%	98%
C9ZJX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AXI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q9Y5	Leishmania major	81%	100%
V5BKV0	Trypanosoma cruzi	49%	100%