TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE43_LEIBR

TriTrypDb:

LbrM.25.0960 , LBRM2903_250018900

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.558
CLV_C14_Caspase3-7	36	40	PF00656	0.536
CLV_C14_Caspase3-7	53	57	PF00656	0.540
CLV_C14_Caspase3-7	610	614	PF00656	0.617
CLV_NRD_NRD_1	102	104	PF00675	0.769
CLV_NRD_NRD_1	298	300	PF00675	0.547
CLV_NRD_NRD_1	307	309	PF00675	0.492
CLV_NRD_NRD_1	334	336	PF00675	0.684
CLV_NRD_NRD_1	358	360	PF00675	0.626
CLV_NRD_NRD_1	644	646	PF00675	0.599
CLV_NRD_NRD_1	652	654	PF00675	0.498
CLV_NRD_NRD_1	739	741	PF00675	0.633
CLV_PCSK_FUR_1	332	336	PF00082	0.715
CLV_PCSK_KEX2_1	102	104	PF00082	0.769
CLV_PCSK_KEX2_1	297	299	PF00082	0.548
CLV_PCSK_KEX2_1	307	309	PF00082	0.490
CLV_PCSK_KEX2_1	334	336	PF00082	0.684
CLV_PCSK_KEX2_1	358	360	PF00082	0.643
CLV_PCSK_KEX2_1	387	389	PF00082	0.752
CLV_PCSK_KEX2_1	527	529	PF00082	0.539
CLV_PCSK_KEX2_1	644	646	PF00082	0.599
CLV_PCSK_KEX2_1	652	654	PF00082	0.498
CLV_PCSK_KEX2_1	724	726	PF00082	0.475
CLV_PCSK_KEX2_1	870	872	PF00082	0.571
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.643
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.752
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.539
CLV_PCSK_PC1ET2_1	724	726	PF00082	0.440
CLV_PCSK_PC1ET2_1	870	872	PF00082	0.571
CLV_PCSK_SKI1_1	146	150	PF00082	0.555
CLV_PCSK_SKI1_1	180	184	PF00082	0.595
CLV_PCSK_SKI1_1	298	302	PF00082	0.549
CLV_PCSK_SKI1_1	388	392	PF00082	0.751
CLV_PCSK_SKI1_1	466	470	PF00082	0.622
CLV_PCSK_SKI1_1	524	528	PF00082	0.567
CLV_PCSK_SKI1_1	630	634	PF00082	0.624
CLV_PCSK_SKI1_1	658	662	PF00082	0.551
CLV_PCSK_SKI1_1	762	766	PF00082	0.588
DEG_SCF_FBW7_1	86	93	PF00400	0.587
DEG_SCF_FBW7_2	42	48	PF00400	0.575
DOC_CKS1_1	112	117	PF01111	0.589
DOC_CKS1_1	389	394	PF01111	0.601
DOC_CKS1_1	42	47	PF01111	0.574
DOC_CKS1_1	474	479	PF01111	0.562
DOC_CKS1_1	553	558	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.610
DOC_MAPK_DCC_7	596	605	PF00069	0.447
DOC_MAPK_gen_1	503	513	PF00069	0.532
DOC_MAPK_gen_1	740	751	PF00069	0.446
DOC_MAPK_gen_1	774	782	PF00069	0.443
DOC_MAPK_MEF2A_6	506	515	PF00069	0.381
DOC_PP1_RVXF_1	643	650	PF00149	0.595
DOC_PP2B_LxvP_1	390	393	PF13499	0.569
DOC_SPAK_OSR1_1	245	249	PF12202	0.639
DOC_USP7_MATH_1	173	177	PF00917	0.650
DOC_USP7_MATH_1	238	242	PF00917	0.573
DOC_USP7_MATH_1	375	379	PF00917	0.751
DOC_USP7_MATH_1	520	524	PF00917	0.375
DOC_USP7_MATH_1	778	782	PF00917	0.600
DOC_USP7_MATH_1	830	834	PF00917	0.678
DOC_USP7_MATH_1	838	842	PF00917	0.736
DOC_USP7_MATH_2	163	169	PF00917	0.538
DOC_USP7_MATH_2	477	483	PF00917	0.426
DOC_USP7_UBL2_3	281	285	PF12436	0.548
DOC_USP7_UBL2_3	737	741	PF12436	0.420
DOC_WW_Pin1_4	111	116	PF00397	0.765
DOC_WW_Pin1_4	13	18	PF00397	0.734
DOC_WW_Pin1_4	183	188	PF00397	0.563
DOC_WW_Pin1_4	251	256	PF00397	0.587
DOC_WW_Pin1_4	283	288	PF00397	0.530
DOC_WW_Pin1_4	371	376	PF00397	0.808
DOC_WW_Pin1_4	388	393	PF00397	0.787
DOC_WW_Pin1_4	404	409	PF00397	0.631
DOC_WW_Pin1_4	41	46	PF00397	0.571
DOC_WW_Pin1_4	453	458	PF00397	0.638
DOC_WW_Pin1_4	473	478	PF00397	0.520
DOC_WW_Pin1_4	552	557	PF00397	0.579
DOC_WW_Pin1_4	559	564	PF00397	0.666
DOC_WW_Pin1_4	568	573	PF00397	0.635
DOC_WW_Pin1_4	824	829	PF00397	0.702
DOC_WW_Pin1_4	834	839	PF00397	0.613
DOC_WW_Pin1_4	848	853	PF00397	0.587
DOC_WW_Pin1_4	86	91	PF00397	0.747
LIG_14-3-3_CanoR_1	107	115	PF00244	0.733
LIG_14-3-3_CanoR_1	223	228	PF00244	0.685
LIG_14-3-3_CanoR_1	334	344	PF00244	0.565
LIG_14-3-3_CanoR_1	369	375	PF00244	0.733
LIG_14-3-3_CanoR_1	431	436	PF00244	0.538
LIG_14-3-3_CanoR_1	557	562	PF00244	0.706
LIG_14-3-3_CanoR_1	567	574	PF00244	0.630
LIG_14-3-3_CanoR_1	601	606	PF00244	0.639
LIG_14-3-3_CanoR_1	820	830	PF00244	0.690
LIG_14-3-3_CanoR_1	871	881	PF00244	0.605
LIG_14-3-3_CanoR_1	95	100	PF00244	0.657
LIG_BRCT_BRCA1_1	153	157	PF00533	0.737
LIG_BRCT_BRCA1_1	167	171	PF00533	0.570
LIG_BRCT_BRCA1_1	225	229	PF00533	0.719
LIG_BRCT_BRCA1_1	39	43	PF00533	0.566
LIG_FHA_1	112	118	PF00498	0.694
LIG_FHA_1	127	133	PF00498	0.681
LIG_FHA_1	164	170	PF00498	0.614
LIG_FHA_1	193	199	PF00498	0.605
LIG_FHA_1	746	752	PF00498	0.436
LIG_FHA_1	91	97	PF00498	0.625
LIG_FHA_2	334	340	PF00498	0.694
LIG_FHA_2	399	405	PF00498	0.654
LIG_FHA_2	42	48	PF00498	0.726
LIG_FHA_2	474	480	PF00498	0.543
LIG_FHA_2	679	685	PF00498	0.531
LIG_Integrin_RGD_1	118	120	PF01839	0.657
LIG_LIR_Apic_2	109	115	PF02991	0.590
LIG_LIR_Apic_2	450	454	PF02991	0.538
LIG_LIR_Nem_3	40	46	PF02991	0.633
LIG_LIR_Nem_3	862	868	PF02991	0.719
LIG_PCNA_yPIPBox_3	415	429	PF02747	0.552
LIG_PTB_Apo_2	142	149	PF02174	0.568
LIG_SH2_CRK	112	116	PF00017	0.588
LIG_SH2_CRK	688	692	PF00017	0.640
LIG_SH2_STAP1	591	595	PF00017	0.598
LIG_SH2_STAP1	619	623	PF00017	0.568
LIG_SH2_STAP1	688	692	PF00017	0.608
LIG_SH2_STAP1	712	716	PF00017	0.554
LIG_SH2_STAP1	747	751	PF00017	0.568
LIG_SH2_STAP1	793	797	PF00017	0.398
LIG_SH2_STAT3	580	583	PF00017	0.615
LIG_SH2_STAT5	580	583	PF00017	0.615
LIG_SH2_STAT5	747	750	PF00017	0.399
LIG_SH3_1	451	457	PF00018	0.685
LIG_SH3_3	403	409	PF00018	0.601
LIG_SH3_3	426	432	PF00018	0.538
LIG_SH3_3	451	457	PF00018	0.685
LIG_SH3_3	75	81	PF00018	0.755
LIG_SH3_3	8	14	PF00018	0.645
LIG_SH3_3	98	104	PF00018	0.581
LIG_SH3_4	256	263	PF00018	0.585
LIG_SUMO_SIM_anti_2	262	271	PF11976	0.547
LIG_SUMO_SIM_anti_2	476	484	PF11976	0.541
LIG_SUMO_SIM_par_1	476	484	PF11976	0.424
LIG_SUMO_SIM_par_1	601	608	PF11976	0.642
LIG_TRAF2_1	182	185	PF00917	0.661
LIG_TRAF2_1	757	760	PF00917	0.660
LIG_WW_3	99	103	PF00397	0.760
MOD_CDK_SPK_2	111	116	PF00069	0.765
MOD_CDK_SPK_2	251	256	PF00069	0.543
MOD_CDK_SPK_2	552	557	PF00069	0.520
MOD_CDK_SPK_2	824	829	PF00069	0.641
MOD_CDK_SPK_2	834	839	PF00069	0.726
MOD_CDK_SPK_2	848	853	PF00069	0.587
MOD_CDK_SPK_2	86	91	PF00069	0.763
MOD_CDK_SPxK_1	371	377	PF00069	0.575
MOD_CDK_SPxxK_3	111	118	PF00069	0.670
MOD_CDK_SPxxK_3	552	559	PF00069	0.510
MOD_CDK_SPxxK_3	848	855	PF00069	0.576
MOD_CK1_1	106	112	PF00069	0.825
MOD_CK1_1	135	141	PF00069	0.685
MOD_CK1_1	144	150	PF00069	0.686
MOD_CK1_1	151	157	PF00069	0.684
MOD_CK1_1	219	225	PF00069	0.547
MOD_CK1_1	241	247	PF00069	0.774
MOD_CK1_1	262	268	PF00069	0.565
MOD_CK1_1	333	339	PF00069	0.749
MOD_CK1_1	378	384	PF00069	0.771
MOD_CK1_1	436	442	PF00069	0.687
MOD_CK1_1	546	552	PF00069	0.525
MOD_CK1_1	604	610	PF00069	0.725
MOD_CK1_1	824	830	PF00069	0.730
MOD_CK2_1	262	268	PF00069	0.603
MOD_CK2_1	289	295	PF00069	0.594
MOD_CK2_1	333	339	PF00069	0.618
MOD_CK2_1	398	404	PF00069	0.684
MOD_CK2_1	407	413	PF00069	0.647
MOD_CK2_1	46	52	PF00069	0.738
MOD_CK2_1	473	479	PF00069	0.554
MOD_CK2_1	604	610	PF00069	0.705
MOD_CK2_1	726	732	PF00069	0.622
MOD_CK2_1	754	760	PF00069	0.587
MOD_CK2_1	778	784	PF00069	0.577
MOD_DYRK1A_RPxSP_1	834	838	PF00069	0.750
MOD_GlcNHglycan	218	221	PF01048	0.569
MOD_GlcNHglycan	236	239	PF01048	0.521
MOD_GlcNHglycan	240	243	PF01048	0.575
MOD_GlcNHglycan	27	30	PF01048	0.748
MOD_GlcNHglycan	381	384	PF01048	0.712
MOD_GlcNHglycan	393	396	PF01048	0.843
MOD_GlcNHglycan	409	412	PF01048	0.580
MOD_GlcNHglycan	469	472	PF01048	0.534
MOD_GlcNHglycan	534	537	PF01048	0.383
MOD_GlcNHglycan	56	59	PF01048	0.585
MOD_GlcNHglycan	568	571	PF01048	0.556
MOD_GlcNHglycan	666	669	PF01048	0.707
MOD_GlcNHglycan	729	732	PF01048	0.716
MOD_GlcNHglycan	756	759	PF01048	0.650
MOD_GlcNHglycan	783	787	PF01048	0.632
MOD_GlcNHglycan	823	826	PF01048	0.535
MOD_GlcNHglycan	842	845	PF01048	0.596
MOD_GSK3_1	122	129	PF00069	0.570
MOD_GSK3_1	144	151	PF00069	0.728
MOD_GSK3_1	161	168	PF00069	0.517
MOD_GSK3_1	218	225	PF00069	0.544
MOD_GSK3_1	230	237	PF00069	0.573
MOD_GSK3_1	289	296	PF00069	0.501
MOD_GSK3_1	33	40	PF00069	0.600
MOD_GSK3_1	330	337	PF00069	0.586
MOD_GSK3_1	367	374	PF00069	0.823
MOD_GSK3_1	375	382	PF00069	0.730
MOD_GSK3_1	431	438	PF00069	0.713
MOD_GSK3_1	528	535	PF00069	0.436
MOD_GSK3_1	555	562	PF00069	0.722
MOD_GSK3_1	568	575	PF00069	0.588
MOD_GSK3_1	660	667	PF00069	0.750
MOD_GSK3_1	714	721	PF00069	0.392
MOD_GSK3_1	727	734	PF00069	0.472
MOD_GSK3_1	778	785	PF00069	0.484
MOD_GSK3_1	830	837	PF00069	0.732
MOD_GSK3_1	838	845	PF00069	0.684
MOD_GSK3_1	86	93	PF00069	0.653
MOD_GSK3_1	866	873	PF00069	0.559
MOD_N-GLC_1	144	149	PF02516	0.578
MOD_N-GLC_1	151	156	PF02516	0.559
MOD_N-GLC_1	234	239	PF02516	0.647
MOD_N-GLC_1	375	380	PF02516	0.750
MOD_N-GLC_1	857	862	PF02516	0.602
MOD_NEK2_1	148	153	PF00069	0.544
MOD_NEK2_1	467	472	PF00069	0.533
MOD_NEK2_1	718	723	PF00069	0.582
MOD_NEK2_1	736	741	PF00069	0.425
MOD_NEK2_1	821	826	PF00069	0.578
MOD_PIKK_1	106	112	PF00454	0.672
MOD_PIKK_1	146	152	PF00454	0.663
MOD_PIKK_1	37	43	PF00454	0.620
MOD_PIKK_1	46	52	PF00454	0.580
MOD_PIKK_1	660	666	PF00454	0.694
MOD_PK_1	601	607	PF00069	0.642
MOD_PKA_1	334	340	PF00069	0.694
MOD_PKA_1	652	658	PF00069	0.649
MOD_PKA_1	870	876	PF00069	0.574
MOD_PKA_2	106	112	PF00069	0.726
MOD_PKA_2	135	141	PF00069	0.570
MOD_PKA_2	222	228	PF00069	0.690
MOD_PKA_2	244	250	PF00069	0.657
MOD_PKA_2	333	339	PF00069	0.784
MOD_PKA_2	378	384	PF00069	0.602
MOD_PKA_2	566	572	PF00069	0.606
MOD_PKA_2	652	658	PF00069	0.649
MOD_PKA_2	838	844	PF00069	0.760
MOD_PKA_2	866	872	PF00069	0.733
MOD_PKA_2	90	96	PF00069	0.626
MOD_PKB_1	332	340	PF00069	0.700
MOD_Plk_1	144	150	PF00069	0.672
MOD_Plk_1	151	157	PF00069	0.709
MOD_Plk_1	173	179	PF00069	0.630
MOD_Plk_1	268	274	PF00069	0.607
MOD_Plk_1	313	319	PF00069	0.624
MOD_Plk_1	46	52	PF00069	0.588
MOD_Plk_1	658	664	PF00069	0.560
MOD_Plk_1	712	718	PF00069	0.560
MOD_Plk_1	731	737	PF00069	0.445
MOD_Plk_2-3	268	274	PF00069	0.537
MOD_Plk_2-3	33	39	PF00069	0.561
MOD_Plk_2-3	479	485	PF00069	0.417
MOD_Plk_2-3	732	738	PF00069	0.441
MOD_Plk_4	165	171	PF00069	0.645
MOD_Plk_4	173	179	PF00069	0.578
MOD_Plk_4	262	268	PF00069	0.550
MOD_Plk_4	447	453	PF00069	0.543
MOD_Plk_4	601	607	PF00069	0.642
MOD_Plk_4	793	799	PF00069	0.380
MOD_ProDKin_1	111	117	PF00069	0.765
MOD_ProDKin_1	13	19	PF00069	0.736
MOD_ProDKin_1	183	189	PF00069	0.563
MOD_ProDKin_1	251	257	PF00069	0.587
MOD_ProDKin_1	283	289	PF00069	0.531
MOD_ProDKin_1	371	377	PF00069	0.811
MOD_ProDKin_1	388	394	PF00069	0.789
MOD_ProDKin_1	404	410	PF00069	0.632
MOD_ProDKin_1	41	47	PF00069	0.574
MOD_ProDKin_1	453	459	PF00069	0.638
MOD_ProDKin_1	473	479	PF00069	0.515
MOD_ProDKin_1	552	558	PF00069	0.583
MOD_ProDKin_1	559	565	PF00069	0.667
MOD_ProDKin_1	568	574	PF00069	0.635
MOD_ProDKin_1	824	830	PF00069	0.704
MOD_ProDKin_1	834	840	PF00069	0.614
MOD_ProDKin_1	848	854	PF00069	0.590
MOD_ProDKin_1	86	92	PF00069	0.745
MOD_SUMO_for_1	182	185	PF00179	0.573
MOD_SUMO_rev_2	410	417	PF00179	0.625
MOD_SUMO_rev_2	463	468	PF00179	0.523
TRG_DiLeu_BaEn_1	339	344	PF01217	0.489
TRG_DiLeu_BaEn_1	636	641	PF01217	0.581
TRG_DiLeu_BaEn_2	462	468	PF01217	0.698
TRG_DiLeu_BaEn_4	184	190	PF01217	0.561
TRG_DiLeu_LyEn_5	760	765	PF01217	0.435
TRG_ENDOCYTIC_2	590	593	PF00928	0.600
TRG_ENDOCYTIC_2	688	691	PF00928	0.645
TRG_ER_diArg_1	101	103	PF00400	0.666
TRG_ER_diArg_1	115	118	PF00400	0.597
TRG_ER_diArg_1	297	299	PF00400	0.457
TRG_ER_diArg_1	319	322	PF00400	0.584
TRG_ER_diArg_1	331	334	PF00400	0.672
TRG_ER_diArg_1	441	444	PF00400	0.542
TRG_ER_diArg_1	505	508	PF00400	0.555
TRG_ER_diArg_1	556	559	PF00400	0.642
TRG_ER_diArg_1	643	645	PF00400	0.507
TRG_ER_diArg_1	651	653	PF00400	0.591
TRG_ER_diArg_1	772	775	PF00400	0.421
TRG_ER_diArg_1	852	855	PF00400	0.579
TRG_NLS_Bipartite_1	723	744	PF00514	0.435
TRG_NLS_MonoExtC_3	739	744	PF00514	0.413
TRG_NLS_MonoExtN_4	737	744	PF00514	0.417
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	762	766	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICH3	Leishmania donovani	62%	100%
A4I1E9	Leishmania infantum	62%	100%
E9AXI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q9Y6	Leishmania major	59%	98%