Frataxin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

frataxin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HE41_LEIBR

TriTrypDb:

LbrM.25.0940 , LBRM2903_250018600

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7

Expansion

Sequence features

A4HE41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE41

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0016226	iron-sulfur cluster assembly	4	10
GO:0022607	cellular component assembly	4	10
GO:0031163	metallo-sulfur cluster assembly	5	10
GO:0042592	homeostatic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0048878	chemical homeostasis	4	10
GO:0050801	monoatomic ion homeostasis	5	10
GO:0055065	obsolete metal ion homeostasis	7	10
GO:0055072	obsolete iron ion homeostasis	9	10
GO:0055076	obsolete transition metal ion homeostasis	8	10
GO:0055080	monoatomic cation homeostasis	6	10
GO:0065007	biological regulation	1	10
GO:0065008	regulation of biological quality	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0098771	inorganic ion homeostasis	6	10
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006778	porphyrin-containing compound metabolic process	5	7
GO:0006779	porphyrin-containing compound biosynthetic process	6	7
GO:0006783	heme biosynthetic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006810	transport	3	7
GO:0006811	monoatomic ion transport	4	7
GO:0006873	intracellular monoatomic ion homeostasis	4	7
GO:0006875	obsolete intracellular metal ion homeostasis	6	7
GO:0006879	intracellular iron ion homeostasis	8	7
GO:0009058	biosynthetic process	2	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0018282	metal incorporation into metallo-sulfur cluster	5	1
GO:0018283	iron incorporation into metallo-sulfur cluster	5	1
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0019538	protein metabolic process	3	1
GO:0019725	cellular homeostasis	2	7
GO:0030003	intracellular monoatomic cation homeostasis	5	7
GO:0033013	tetrapyrrole metabolic process	4	7
GO:0033014	tetrapyrrole biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0036211	protein modification process	4	1
GO:0042168	heme metabolic process	3	7
GO:0042440	pigment metabolic process	2	7
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046148	pigment biosynthetic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0055082	intracellular chemical homeostasis	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005506	iron ion binding	6	10
GO:0008199	ferric iron binding	7	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0003824	catalytic activity	1	7
GO:0004322	ferroxidase activity	5	7
GO:0008198	ferrous iron binding	7	1
GO:0016491	oxidoreductase activity	2	7
GO:0016530	metallochaperone activity	2	1
GO:0016722	oxidoreductase activity, acting on metal ions	3	7
GO:0016724	oxidoreductase activity, acting on metal ions, oxygen as acceptor	4	7
GO:0034986	iron chaperone activity	3	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1
GO:0140104	molecular carrier activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.457
CLV_NRD_NRD_1	47	49	PF00675	0.571
CLV_PCSK_KEX2_1	47	49	PF00082	0.571
CLV_PCSK_SKI1_1	120	124	PF00082	0.196
CLV_PCSK_SKI1_1	9	13	PF00082	0.490
DEG_APCC_DBOX_1	8	16	PF00400	0.598
DEG_Nend_UBRbox_1	1	4	PF02207	0.447
DEG_SPOP_SBC_1	16	20	PF00917	0.582
DOC_MAPK_gen_1	2	12	PF00069	0.478
DOC_MAPK_HePTP_8	124	136	PF00069	0.429
DOC_MAPK_MEF2A_6	127	136	PF00069	0.429
DOC_PP1_RVXF_1	156	162	PF00149	0.531
DOC_USP7_MATH_1	97	101	PF00917	0.505
DOC_WW_Pin1_4	135	140	PF00397	0.443
LIG_14-3-3_CanoR_1	158	162	PF00244	0.388
LIG_FHA_2	80	86	PF00498	0.446
LIG_FHA_2	91	97	PF00498	0.446
LIG_GBD_Chelix_1	170	178	PF00786	0.302
LIG_LIR_Gen_1	73	83	PF02991	0.284
LIG_LIR_Nem_3	73	78	PF02991	0.494
LIG_PDZ_Class_2	183	188	PF00595	0.597
LIG_SH2_CRK	146	150	PF00017	0.429
LIG_SH2_CRK	28	32	PF00017	0.528
LIG_SH2_CRK	67	71	PF00017	0.620
LIG_SH2_NCK_1	146	150	PF00017	0.472
LIG_SH2_NCK_1	28	32	PF00017	0.418
LIG_SUMO_SIM_anti_2	85	93	PF11976	0.502
LIG_SUMO_SIM_par_1	111	117	PF11976	0.449
LIG_SUMO_SIM_par_1	147	152	PF11976	0.481
LIG_SUMO_SIM_par_1	85	93	PF11976	0.502
LIG_TYR_ITIM	65	70	PF00017	0.622
LIG_UBA3_1	178	187	PF00899	0.183
LIG_UBA3_1	87	94	PF00899	0.373
MOD_CK1_1	138	144	PF00069	0.284
MOD_CK1_1	160	166	PF00069	0.423
MOD_CK1_1	36	42	PF00069	0.633
MOD_CK1_1	56	62	PF00069	0.690
MOD_GlcNHglycan	140	143	PF01048	0.289
MOD_GlcNHglycan	40	43	PF01048	0.714
MOD_GlcNHglycan	99	102	PF01048	0.355
MOD_GSK3_1	134	141	PF00069	0.282
MOD_GSK3_1	16	23	PF00069	0.580
MOD_GSK3_1	26	33	PF00069	0.645
MOD_GSK3_1	49	56	PF00069	0.618
MOD_N-GLC_1	31	36	PF02516	0.578
MOD_NEK2_1	134	139	PF00069	0.270
MOD_NEK2_1	15	20	PF00069	0.594
MOD_NEK2_1	30	35	PF00069	0.573
MOD_NEK2_1	38	43	PF00069	0.598
MOD_NEK2_1	90	95	PF00069	0.373
MOD_PIKK_1	149	155	PF00454	0.390
MOD_PKA_2	157	163	PF00069	0.207
MOD_Plk_1	56	62	PF00069	0.517
MOD_Plk_4	26	32	PF00069	0.555
MOD_Plk_4	33	39	PF00069	0.608
MOD_ProDKin_1	135	141	PF00069	0.290
MOD_SUMO_rev_2	180	188	PF00179	0.352
MOD_SUMO_rev_2	73	80	PF00179	0.437
MOD_SUMO_rev_2	86	95	PF00179	0.299
TRG_DiLeu_BaEn_1	86	91	PF01217	0.373
TRG_DiLeu_BaEn_2	118	124	PF01217	0.271
TRG_ENDOCYTIC_2	146	149	PF00928	0.270
TRG_ENDOCYTIC_2	28	31	PF00928	0.527
TRG_ENDOCYTIC_2	67	70	PF00928	0.616
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I091	Leptomonas seymouri	63%	96%
A0A0S4ITQ9	Bodo saltans	44%	100%
A0A1X0NLP7	Trypanosomatidae	57%	100%
A0A422NXL2	Trypanosoma rangeli	50%	100%
A4I1E7	Leishmania infantum	79%	99%
E9AXI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
I7HD01	Leishmania donovani	79%	99%
O74831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q4Q9Y8	Leishmania major	77%	100%