Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE40_LEIBR

TriTrypDb:

LbrM.25.0930 , LBRM2903_250018500

Length:

909

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.549
CLV_MEL_PAP_1	399	405	PF00089	0.649
CLV_NRD_NRD_1	158	160	PF00675	0.578
CLV_NRD_NRD_1	183	185	PF00675	0.722
CLV_NRD_NRD_1	29	31	PF00675	0.584
CLV_NRD_NRD_1	526	528	PF00675	0.534
CLV_NRD_NRD_1	541	543	PF00675	0.489
CLV_NRD_NRD_1	584	586	PF00675	0.714
CLV_NRD_NRD_1	713	715	PF00675	0.738
CLV_NRD_NRD_1	826	828	PF00675	0.747
CLV_PCSK_KEX2_1	183	185	PF00082	0.722
CLV_PCSK_KEX2_1	29	31	PF00082	0.642
CLV_PCSK_KEX2_1	317	319	PF00082	0.545
CLV_PCSK_KEX2_1	526	528	PF00082	0.534
CLV_PCSK_KEX2_1	541	543	PF00082	0.489
CLV_PCSK_KEX2_1	583	585	PF00082	0.607
CLV_PCSK_KEX2_1	713	715	PF00082	0.748
CLV_PCSK_KEX2_1	825	827	PF00082	0.818
CLV_PCSK_KEX2_1	877	879	PF00082	0.837
CLV_PCSK_KEX2_1	901	903	PF00082	0.515
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.634
CLV_PCSK_PC1ET2_1	877	879	PF00082	0.837
CLV_PCSK_PC1ET2_1	901	903	PF00082	0.442
CLV_PCSK_SKI1_1	160	164	PF00082	0.672
CLV_PCSK_SKI1_1	339	343	PF00082	0.464
CLV_PCSK_SKI1_1	346	350	PF00082	0.439
CLV_PCSK_SKI1_1	417	421	PF00082	0.629
CLV_PCSK_SKI1_1	533	537	PF00082	0.446
CLV_PCSK_SKI1_1	739	743	PF00082	0.678
CLV_PCSK_SKI1_1	901	905	PF00082	0.479
CLV_Separin_Metazoa	373	377	PF03568	0.433
DEG_SPOP_SBC_1	16	20	PF00917	0.686
DEG_SPOP_SBC_1	637	641	PF00917	0.632
DEG_SPOP_SBC_1	671	675	PF00917	0.600
DEG_SPOP_SBC_1	80	84	PF00917	0.608
DOC_ANK_TNKS_1	582	589	PF00023	0.472
DOC_ANK_TNKS_1	712	719	PF00023	0.574
DOC_CKS1_1	114	119	PF01111	0.689
DOC_CKS1_1	164	169	PF01111	0.579
DOC_CKS1_1	610	615	PF01111	0.533
DOC_CKS1_1	720	725	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.611
DOC_CYCLIN_yCln2_LP_2	610	616	PF00134	0.779
DOC_MAPK_DCC_7	30	40	PF00069	0.567
DOC_MAPK_gen_1	204	210	PF00069	0.646
DOC_MAPK_gen_1	339	347	PF00069	0.459
DOC_MAPK_gen_1	417	426	PF00069	0.530
DOC_MAPK_MEF2A_6	417	426	PF00069	0.530
DOC_PIKK_1	60	68	PF02985	0.577
DOC_PP2B_LxvP_1	208	211	PF13499	0.719
DOC_PP2B_LxvP_1	68	71	PF13499	0.578
DOC_PP2B_PxIxI_1	35	41	PF00149	0.567
DOC_PP4_MxPP_1	458	461	PF00568	0.590
DOC_USP7_MATH_1	104	108	PF00917	0.694
DOC_USP7_MATH_1	121	125	PF00917	0.525
DOC_USP7_MATH_1	135	139	PF00917	0.615
DOC_USP7_MATH_1	16	20	PF00917	0.684
DOC_USP7_MATH_1	174	178	PF00917	0.604
DOC_USP7_MATH_1	186	190	PF00917	0.611
DOC_USP7_MATH_1	219	223	PF00917	0.734
DOC_USP7_MATH_1	238	242	PF00917	0.763
DOC_USP7_MATH_1	275	279	PF00917	0.430
DOC_USP7_MATH_1	383	387	PF00917	0.581
DOC_USP7_MATH_1	522	526	PF00917	0.714
DOC_USP7_MATH_1	549	553	PF00917	0.425
DOC_USP7_MATH_1	637	641	PF00917	0.630
DOC_USP7_MATH_1	691	695	PF00917	0.773
DOC_USP7_MATH_1	716	720	PF00917	0.733
DOC_USP7_MATH_1	776	780	PF00917	0.632
DOC_USP7_MATH_1	792	796	PF00917	0.732
DOC_USP7_MATH_1	80	84	PF00917	0.608
DOC_USP7_UBL2_3	342	346	PF12436	0.501
DOC_WW_Pin1_4	100	105	PF00397	0.601
DOC_WW_Pin1_4	113	118	PF00397	0.524
DOC_WW_Pin1_4	12	17	PF00397	0.581
DOC_WW_Pin1_4	126	131	PF00397	0.561
DOC_WW_Pin1_4	163	168	PF00397	0.762
DOC_WW_Pin1_4	170	175	PF00397	0.727
DOC_WW_Pin1_4	182	187	PF00397	0.611
DOC_WW_Pin1_4	217	222	PF00397	0.614
DOC_WW_Pin1_4	252	257	PF00397	0.707
DOC_WW_Pin1_4	410	415	PF00397	0.663
DOC_WW_Pin1_4	442	447	PF00397	0.680
DOC_WW_Pin1_4	451	456	PF00397	0.680
DOC_WW_Pin1_4	515	520	PF00397	0.512
DOC_WW_Pin1_4	609	614	PF00397	0.737
DOC_WW_Pin1_4	719	724	PF00397	0.728
DOC_WW_Pin1_4	81	86	PF00397	0.709
DOC_WW_Pin1_4	94	99	PF00397	0.564
LIG_14-3-3_CanoR_1	111	117	PF00244	0.580
LIG_14-3-3_CanoR_1	159	167	PF00244	0.609
LIG_14-3-3_CanoR_1	190	196	PF00244	0.582
LIG_14-3-3_CanoR_1	260	268	PF00244	0.768
LIG_14-3-3_CanoR_1	494	502	PF00244	0.708
LIG_14-3-3_CanoR_1	708	712	PF00244	0.575
LIG_14-3-3_CanoR_1	832	839	PF00244	0.685
LIG_CSL_BTD_1	101	104	PF09270	0.572
LIG_eIF4E_1	335	341	PF01652	0.361
LIG_FHA_1	144	150	PF00498	0.661
LIG_FHA_1	159	165	PF00498	0.655
LIG_FHA_1	204	210	PF00498	0.619
LIG_FHA_1	281	287	PF00498	0.416
LIG_FHA_1	383	389	PF00498	0.580
LIG_FHA_1	657	663	PF00498	0.700
LIG_FHA_1	67	73	PF00498	0.574
LIG_FHA_1	750	756	PF00498	0.658
LIG_FHA_1	848	854	PF00498	0.481
LIG_FHA_2	460	466	PF00498	0.599
LIG_FHA_2	488	494	PF00498	0.779
LIG_FHA_2	572	578	PF00498	0.623
LIG_FHA_2	610	616	PF00498	0.526
LIG_FHA_2	698	704	PF00498	0.569
LIG_Integrin_RGD_1	485	487	PF01839	0.558
LIG_LIR_Apic_2	625	631	PF02991	0.793
LIG_LIR_Gen_1	382	392	PF02991	0.596
LIG_LIR_Gen_1	447	458	PF02991	0.697
LIG_LIR_Gen_1	779	786	PF02991	0.659
LIG_LIR_Nem_3	22	28	PF02991	0.702
LIG_LIR_Nem_3	382	387	PF02991	0.585
LIG_LIR_Nem_3	779	785	PF02991	0.659
LIG_LYPXL_SIV_4	528	536	PF13949	0.557
LIG_NRBOX	618	624	PF00104	0.623
LIG_NRBOX	851	857	PF00104	0.594
LIG_Rb_pABgroove_1	296	304	PF01858	0.538
LIG_SH2_CRK	25	29	PF00017	0.591
LIG_SH2_CRK	335	339	PF00017	0.613
LIG_SH2_CRK	384	388	PF00017	0.586
LIG_SH2_CRK	628	632	PF00017	0.814
LIG_SH2_CRK	782	786	PF00017	0.590
LIG_SH2_GRB2like	557	560	PF00017	0.681
LIG_SH2_PTP2	351	354	PF00017	0.517
LIG_SH2_SRC	529	532	PF00017	0.412
LIG_SH2_STAP1	276	280	PF00017	0.570
LIG_SH2_STAP1	384	388	PF00017	0.586
LIG_SH2_STAP1	557	561	PF00017	0.577
LIG_SH2_STAP1	782	786	PF00017	0.724
LIG_SH2_STAT5	351	354	PF00017	0.517
LIG_SH2_STAT5	384	387	PF00017	0.586
LIG_SH2_STAT5	706	709	PF00017	0.586
LIG_SH3_1	29	35	PF00018	0.572
LIG_SH3_1	877	883	PF00018	0.576
LIG_SH3_3	117	123	PF00018	0.671
LIG_SH3_3	128	134	PF00018	0.569
LIG_SH3_3	29	35	PF00018	0.718
LIG_SH3_3	327	333	PF00018	0.376
LIG_SH3_3	717	723	PF00018	0.570
LIG_SH3_3	877	883	PF00018	0.664
LIG_SH3_3	92	98	PF00018	0.703
LIG_SUMO_SIM_anti_2	577	583	PF11976	0.460
LIG_SUMO_SIM_par_1	168	173	PF11976	0.592
LIG_SUMO_SIM_par_1	612	618	PF11976	0.502
LIG_TRAF2_1	518	521	PF00917	0.524
LIG_TRAF2_1	528	531	PF00917	0.435
LIG_TRFH_1	55	59	PF08558	0.572
LIG_TYR_ITIM	780	785	PF00017	0.686
LIG_WW_3	129	133	PF00397	0.573
MOD_CDC14_SPxK_1	103	106	PF00782	0.593
MOD_CDC14_SPxK_1	129	132	PF00782	0.567
MOD_CDC14_SPxK_1	97	100	PF00782	0.638
MOD_CDK_SPK_2	81	86	PF00069	0.604
MOD_CDK_SPxK_1	126	132	PF00069	0.577
MOD_CDK_SPxK_1	94	100	PF00069	0.644
MOD_CDK_SPxxK_3	410	417	PF00069	0.532
MOD_CK1_1	138	144	PF00069	0.668
MOD_CK1_1	15	21	PF00069	0.697
MOD_CK1_1	173	179	PF00069	0.673
MOD_CK1_1	189	195	PF00069	0.674
MOD_CK1_1	243	249	PF00069	0.816
MOD_CK1_1	454	460	PF00069	0.730
MOD_CK1_1	641	647	PF00069	0.775
MOD_CK1_1	719	725	PF00069	0.665
MOD_CK1_1	754	760	PF00069	0.790
MOD_CK1_1	771	777	PF00069	0.490
MOD_CK2_1	17	23	PF00069	0.655
MOD_CK2_1	487	493	PF00069	0.779
MOD_CK2_1	515	521	PF00069	0.645
MOD_CK2_1	571	577	PF00069	0.650
MOD_GlcNHglycan	117	120	PF01048	0.592
MOD_GlcNHglycan	151	154	PF01048	0.695
MOD_GlcNHglycan	217	220	PF01048	0.732
MOD_GlcNHglycan	223	226	PF01048	0.735
MOD_GlcNHglycan	408	411	PF01048	0.626
MOD_GlcNHglycan	430	433	PF01048	0.582
MOD_GlcNHglycan	49	52	PF01048	0.563
MOD_GlcNHglycan	677	680	PF01048	0.646
MOD_GlcNHglycan	693	696	PF01048	0.723
MOD_GlcNHglycan	729	732	PF01048	0.712
MOD_GlcNHglycan	770	773	PF01048	0.614
MOD_GlcNHglycan	804	808	PF01048	0.697
MOD_GSK3_1	12	19	PF00069	0.635
MOD_GSK3_1	126	133	PF00069	0.678
MOD_GSK3_1	154	161	PF00069	0.578
MOD_GSK3_1	168	175	PF00069	0.539
MOD_GSK3_1	182	189	PF00069	0.539
MOD_GSK3_1	190	197	PF00069	0.696
MOD_GSK3_1	200	207	PF00069	0.701
MOD_GSK3_1	213	220	PF00069	0.735
MOD_GSK3_1	240	247	PF00069	0.659
MOD_GSK3_1	3	10	PF00069	0.748
MOD_GSK3_1	406	413	PF00069	0.617
MOD_GSK3_1	438	445	PF00069	0.779
MOD_GSK3_1	459	466	PF00069	0.749
MOD_GSK3_1	47	54	PF00069	0.562
MOD_GSK3_1	502	509	PF00069	0.772
MOD_GSK3_1	594	601	PF00069	0.804
MOD_GSK3_1	637	644	PF00069	0.757
MOD_GSK3_1	671	678	PF00069	0.645
MOD_GSK3_1	691	698	PF00069	0.643
MOD_GSK3_1	749	756	PF00069	0.679
MOD_GSK3_1	764	771	PF00069	0.737
MOD_GSK3_1	786	793	PF00069	0.617
MOD_GSK3_1	813	820	PF00069	0.721
MOD_GSK3_1	821	828	PF00069	0.816
MOD_GSK3_1	96	103	PF00069	0.697
MOD_LATS_1	830	836	PF00433	0.583
MOD_N-GLC_1	149	154	PF02516	0.584
MOD_N-GLC_1	214	219	PF02516	0.585
MOD_N-GLC_1	308	313	PF02516	0.637
MOD_N-GLC_1	637	642	PF02516	0.602
MOD_N-GLC_1	66	71	PF02516	0.580
MOD_N-GLC_1	675	680	PF02516	0.706
MOD_NEK2_1	214	219	PF00069	0.585
MOD_NEK2_1	334	339	PF00069	0.615
MOD_NEK2_1	354	359	PF00069	0.623
MOD_NEK2_1	47	52	PF00069	0.559
MOD_NEK2_1	5	10	PF00069	0.711
MOD_NEK2_1	786	791	PF00069	0.803
MOD_NEK2_1	886	891	PF00069	0.593
MOD_NEK2_2	716	721	PF00069	0.572
MOD_PIKK_1	240	246	PF00454	0.662
MOD_PIKK_1	438	444	PF00454	0.783
MOD_PIKK_1	494	500	PF00454	0.569
MOD_PIKK_1	513	519	PF00454	0.490
MOD_PIKK_1	586	592	PF00454	0.517
MOD_PIKK_1	866	872	PF00454	0.603
MOD_PKA_1	204	210	PF00069	0.574
MOD_PKA_1	768	774	PF00069	0.569
MOD_PKA_1	825	831	PF00069	0.685
MOD_PKA_2	105	111	PF00069	0.669
MOD_PKA_2	158	164	PF00069	0.608
MOD_PKA_2	189	195	PF00069	0.634
MOD_PKA_2	401	407	PF00069	0.629
MOD_PKA_2	707	713	PF00069	0.693
MOD_PKA_2	825	831	PF00069	0.765
MOD_Plk_1	308	314	PF00069	0.636
MOD_Plk_1	571	577	PF00069	0.543
MOD_Plk_1	66	72	PF00069	0.579
MOD_Plk_1	886	892	PF00069	0.536
MOD_Plk_2-3	487	493	PF00069	0.565
MOD_Plk_4	191	197	PF00069	0.579
MOD_Plk_4	204	210	PF00069	0.504
MOD_Plk_4	383	389	PF00069	0.622
MOD_Plk_4	91	97	PF00069	0.589
MOD_ProDKin_1	113	119	PF00069	0.524
MOD_ProDKin_1	12	18	PF00069	0.580
MOD_ProDKin_1	126	132	PF00069	0.567
MOD_ProDKin_1	163	169	PF00069	0.763
MOD_ProDKin_1	170	176	PF00069	0.729
MOD_ProDKin_1	182	188	PF00069	0.609
MOD_ProDKin_1	217	223	PF00069	0.616
MOD_ProDKin_1	252	258	PF00069	0.707
MOD_ProDKin_1	410	416	PF00069	0.663
MOD_ProDKin_1	442	448	PF00069	0.680
MOD_ProDKin_1	451	457	PF00069	0.685
MOD_ProDKin_1	515	521	PF00069	0.509
MOD_ProDKin_1	609	615	PF00069	0.727
MOD_ProDKin_1	719	725	PF00069	0.726
MOD_ProDKin_1	81	87	PF00069	0.708
MOD_ProDKin_1	94	100	PF00069	0.565
MOD_SUMO_for_1	341	344	PF00179	0.509
MOD_SUMO_for_1	575	578	PF00179	0.669
MOD_SUMO_rev_2	314	319	PF00179	0.632
TRG_DiLeu_BaEn_1	373	378	PF01217	0.588
TRG_DiLeu_BaEn_1	577	582	PF01217	0.453
TRG_DiLeu_BaEn_1	618	623	PF01217	0.472
TRG_DiLeu_BaEn_1	851	856	PF01217	0.466
TRG_DiLeu_BaEn_4	577	583	PF01217	0.456
TRG_DiLeu_LyEn_5	373	378	PF01217	0.433
TRG_ENDOCYTIC_2	25	28	PF00928	0.703
TRG_ENDOCYTIC_2	302	305	PF00928	0.503
TRG_ENDOCYTIC_2	335	338	PF00928	0.510
TRG_ENDOCYTIC_2	351	354	PF00928	0.489
TRG_ENDOCYTIC_2	384	387	PF00928	0.586
TRG_ENDOCYTIC_2	529	532	PF00928	0.563
TRG_ENDOCYTIC_2	782	785	PF00928	0.672
TRG_ER_diArg_1	259	262	PF00400	0.550
TRG_ER_diArg_1	28	30	PF00400	0.597
TRG_ER_diArg_1	541	543	PF00400	0.585
TRG_ER_diArg_1	582	585	PF00400	0.691
TRG_ER_diArg_1	825	827	PF00400	0.669
TRG_NES_CRM1_1	353	368	PF08389	0.611
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T6	Leptomonas seymouri	36%	100%
A0A3Q8ICB6	Leishmania donovani	61%	100%
A4I1E6	Leishmania infantum	56%	94%
E9AXI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q9Y9	Leishmania major	60%	98%