Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE39_LEIBR

TriTrypDb:

LbrM.25.0920 , LBRM2903_250018400

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE39

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.517
CLV_C14_Caspase3-7	261	265	PF00656	0.443
CLV_C14_Caspase3-7	651	655	PF00656	0.505
CLV_C14_Caspase3-7	853	857	PF00656	0.626
CLV_NRD_NRD_1	120	122	PF00675	0.408
CLV_NRD_NRD_1	208	210	PF00675	0.451
CLV_NRD_NRD_1	279	281	PF00675	0.424
CLV_NRD_NRD_1	513	515	PF00675	0.366
CLV_NRD_NRD_1	590	592	PF00675	0.711
CLV_NRD_NRD_1	632	634	PF00675	0.498
CLV_NRD_NRD_1	671	673	PF00675	0.758
CLV_PCSK_KEX2_1	120	122	PF00082	0.383
CLV_PCSK_KEX2_1	208	210	PF00082	0.451
CLV_PCSK_KEX2_1	22	24	PF00082	0.478
CLV_PCSK_KEX2_1	270	272	PF00082	0.425
CLV_PCSK_KEX2_1	279	281	PF00082	0.429
CLV_PCSK_KEX2_1	512	514	PF00082	0.394
CLV_PCSK_KEX2_1	632	634	PF00082	0.498
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.478
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.408
CLV_PCSK_SKI1_1	200	204	PF00082	0.355
CLV_PCSK_SKI1_1	271	275	PF00082	0.391
CLV_PCSK_SKI1_1	432	436	PF00082	0.497
CLV_PCSK_SKI1_1	491	495	PF00082	0.317
CLV_PCSK_SKI1_1	514	518	PF00082	0.308
CLV_PCSK_SKI1_1	632	636	PF00082	0.507
CLV_PCSK_SKI1_1	802	806	PF00082	0.461
DEG_APCC_DBOX_1	819	827	PF00400	0.505
DEG_COP1_1	293	302	PF00400	0.466
DEG_SPOP_SBC_1	501	505	PF00917	0.638
DOC_CYCLIN_RxL_1	117	128	PF00134	0.417
DOC_CYCLIN_RxL_1	196	205	PF00134	0.332
DOC_MAPK_gen_1	120	127	PF00069	0.425
DOC_MAPK_gen_1	591	598	PF00069	0.510
DOC_MAPK_MEF2A_6	338	346	PF00069	0.484
DOC_PP1_RVXF_1	121	128	PF00149	0.282
DOC_PP1_RVXF_1	198	204	PF00149	0.394
DOC_PP1_RVXF_1	489	496	PF00149	0.318
DOC_PP4_FxxP_1	495	498	PF00568	0.456
DOC_PP4_FxxP_1	80	83	PF00568	0.470
DOC_USP7_MATH_1	135	139	PF00917	0.566
DOC_USP7_MATH_1	144	148	PF00917	0.392
DOC_USP7_MATH_1	255	259	PF00917	0.657
DOC_USP7_MATH_1	29	33	PF00917	0.590
DOC_USP7_MATH_1	300	304	PF00917	0.685
DOC_USP7_MATH_1	483	487	PF00917	0.554
DOC_USP7_MATH_1	501	505	PF00917	0.573
DOC_USP7_MATH_1	780	784	PF00917	0.555
DOC_WW_Pin1_4	25	30	PF00397	0.505
DOC_WW_Pin1_4	280	285	PF00397	0.490
DOC_WW_Pin1_4	306	311	PF00397	0.618
DOC_WW_Pin1_4	494	499	PF00397	0.632
DOC_WW_Pin1_4	591	596	PF00397	0.735
DOC_WW_Pin1_4	655	660	PF00397	0.493
DOC_WW_Pin1_4	692	697	PF00397	0.487
DOC_WW_Pin1_4	698	703	PF00397	0.570
DOC_WW_Pin1_4	84	89	PF00397	0.475
LIG_14-3-3_CanoR_1	123	128	PF00244	0.503
LIG_14-3-3_CanoR_1	378	382	PF00244	0.467
LIG_14-3-3_CanoR_1	438	447	PF00244	0.595
LIG_14-3-3_CanoR_1	451	461	PF00244	0.454
LIG_14-3-3_CanoR_1	513	519	PF00244	0.419
LIG_14-3-3_CanoR_1	591	595	PF00244	0.746
LIG_14-3-3_CanoR_1	608	613	PF00244	0.513
LIG_14-3-3_CanoR_1	715	719	PF00244	0.449
LIG_14-3-3_CanoR_1	802	808	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	686	690	PF00533	0.513
LIG_CtBP_PxDLS_1	507	511	PF00389	0.470
LIG_eIF4E_1	722	728	PF01652	0.351
LIG_eIF4E_1	93	99	PF01652	0.295
LIG_FHA_1	10	16	PF00498	0.616
LIG_FHA_1	196	202	PF00498	0.451
LIG_FHA_1	483	489	PF00498	0.443
LIG_FHA_1	546	552	PF00498	0.444
LIG_FHA_1	677	683	PF00498	0.686
LIG_FHA_1	731	737	PF00498	0.449
LIG_FHA_1	84	90	PF00498	0.518
LIG_FHA_2	225	231	PF00498	0.338
LIG_FHA_2	257	263	PF00498	0.493
LIG_FHA_2	3	9	PF00498	0.503
LIG_FHA_2	45	51	PF00498	0.519
LIG_FHA_2	487	493	PF00498	0.419
LIG_FHA_2	515	521	PF00498	0.426
LIG_FHA_2	699	705	PF00498	0.415
LIG_FHA_2	741	747	PF00498	0.532
LIG_FHA_2	838	844	PF00498	0.625
LIG_FHA_2	857	863	PF00498	0.611
LIG_GBD_Chelix_1	528	536	PF00786	0.359
LIG_IRF3_LxIS_1	94	100	PF10401	0.290
LIG_LIR_Apic_2	380	384	PF02991	0.508
LIG_LIR_Apic_2	492	498	PF02991	0.420
LIG_LIR_Gen_1	215	222	PF02991	0.591
LIG_LIR_Gen_1	485	495	PF02991	0.473
LIG_LIR_Gen_1	517	526	PF02991	0.316
LIG_LIR_Gen_1	548	558	PF02991	0.395
LIG_LIR_Gen_1	721	730	PF02991	0.361
LIG_LIR_Gen_1	858	867	PF02991	0.574
LIG_LIR_Nem_3	205	210	PF02991	0.451
LIG_LIR_Nem_3	215	220	PF02991	0.577
LIG_LIR_Nem_3	283	288	PF02991	0.525
LIG_LIR_Nem_3	327	333	PF02991	0.612
LIG_LIR_Nem_3	485	490	PF02991	0.613
LIG_LIR_Nem_3	517	522	PF02991	0.307
LIG_LIR_Nem_3	548	553	PF02991	0.394
LIG_LIR_Nem_3	646	652	PF02991	0.510
LIG_LIR_Nem_3	721	725	PF02991	0.351
LIG_LIR_Nem_3	870	875	PF02991	0.516
LIG_MAD2	286	294	PF02301	0.512
LIG_MYND_1	791	795	PF01753	0.477
LIG_NRBOX	147	153	PF00104	0.407
LIG_NRBOX	489	495	PF00104	0.453
LIG_PDZ_Class_2	871	876	PF00595	0.520
LIG_Pex14_1	285	289	PF04695	0.468
LIG_Pex14_2	495	499	PF04695	0.405
LIG_Pex14_2	634	638	PF04695	0.512
LIG_SH2_CRK	339	343	PF00017	0.518
LIG_SH2_CRK	694	698	PF00017	0.402
LIG_SH2_CRK	722	726	PF00017	0.344
LIG_SH2_CRK	787	791	PF00017	0.521
LIG_SH2_NCK_1	217	221	PF00017	0.514
LIG_SH2_NCK_1	722	726	PF00017	0.302
LIG_SH2_PTP2	487	490	PF00017	0.465
LIG_SH2_STAP1	393	397	PF00017	0.537
LIG_SH2_STAT3	667	670	PF00017	0.507
LIG_SH2_STAT5	393	396	PF00017	0.564
LIG_SH2_STAT5	466	469	PF00017	0.456
LIG_SH2_STAT5	487	490	PF00017	0.486
LIG_SH2_STAT5	534	537	PF00017	0.437
LIG_SH2_STAT5	667	670	PF00017	0.649
LIG_SH2_STAT5	93	96	PF00017	0.440
LIG_SH3_1	788	794	PF00018	0.478
LIG_SH3_2	574	579	PF14604	0.549
LIG_SH3_3	179	185	PF00018	0.523
LIG_SH3_3	40	46	PF00018	0.757
LIG_SH3_3	401	407	PF00018	0.491
LIG_SH3_3	442	448	PF00018	0.438
LIG_SH3_3	560	566	PF00018	0.461
LIG_SH3_3	571	577	PF00018	0.531
LIG_SH3_3	788	794	PF00018	0.485
LIG_SUMO_SIM_par_1	466	472	PF11976	0.489
LIG_TRAF2_1	259	262	PF00917	0.668
LIG_TRAF2_1	318	321	PF00917	0.521
LIG_TRAF2_1	4	7	PF00917	0.504
LIG_TRAF2_1	434	437	PF00917	0.593
LIG_TRAF2_1	859	862	PF00917	0.652
LIG_TYR_ITIM	287	292	PF00017	0.499
LIG_UBA3_1	141	146	PF00899	0.290
LIG_WRC_WIRS_1	124	129	PF05994	0.292
MOD_CDC14_SPxK_1	283	286	PF00782	0.532
MOD_CDK_SPK_2	655	660	PF00069	0.493
MOD_CDK_SPxK_1	280	286	PF00069	0.529
MOD_CK1_1	18	24	PF00069	0.489
MOD_CK1_1	2	8	PF00069	0.517
MOD_CK1_1	215	221	PF00069	0.554
MOD_CK1_1	231	237	PF00069	0.328
MOD_CK1_1	454	460	PF00069	0.712
MOD_CK1_1	474	480	PF00069	0.414
MOD_CK1_1	486	492	PF00069	0.496
MOD_CK1_1	497	503	PF00069	0.540
MOD_CK1_1	58	64	PF00069	0.569
MOD_CK1_1	594	600	PF00069	0.730
MOD_CK1_1	767	773	PF00069	0.672
MOD_CK1_1	837	843	PF00069	0.575
MOD_CK1_1	9	15	PF00069	0.492
MOD_CK2_1	1	7	PF00069	0.519
MOD_CK2_1	224	230	PF00069	0.393
MOD_CK2_1	255	261	PF00069	0.662
MOD_CK2_1	44	50	PF00069	0.520
MOD_CK2_1	500	506	PF00069	0.535
MOD_CK2_1	514	520	PF00069	0.392
MOD_CK2_1	608	614	PF00069	0.776
MOD_CK2_1	698	704	PF00069	0.406
MOD_CK2_1	740	746	PF00069	0.564
MOD_CK2_1	837	843	PF00069	0.575
MOD_CK2_1	856	862	PF00069	0.576
MOD_CMANNOS	211	214	PF00535	0.458
MOD_Cter_Amidation	589	592	PF01082	0.531
MOD_Cter_Amidation	670	673	PF01082	0.601
MOD_GlcNHglycan	204	207	PF01048	0.321
MOD_GlcNHglycan	233	236	PF01048	0.395
MOD_GlcNHglycan	436	441	PF01048	0.637
MOD_GlcNHglycan	471	474	PF01048	0.545
MOD_GlcNHglycan	499	502	PF01048	0.737
MOD_GlcNHglycan	584	587	PF01048	0.820
MOD_GlcNHglycan	601	604	PF01048	0.517
MOD_GlcNHglycan	769	772	PF01048	0.671
MOD_GlcNHglycan	782	785	PF01048	0.588
MOD_GlcNHglycan	99	102	PF01048	0.477
MOD_GSK3_1	140	147	PF00069	0.372
MOD_GSK3_1	2	9	PF00069	0.511
MOD_GSK3_1	224	231	PF00069	0.536
MOD_GSK3_1	25	32	PF00069	0.563
MOD_GSK3_1	428	435	PF00069	0.532
MOD_GSK3_1	471	478	PF00069	0.531
MOD_GSK3_1	482	489	PF00069	0.513
MOD_GSK3_1	497	504	PF00069	0.754
MOD_GSK3_1	536	543	PF00069	0.564
MOD_GSK3_1	545	552	PF00069	0.431
MOD_GSK3_1	590	597	PF00069	0.793
MOD_GSK3_1	692	699	PF00069	0.357
MOD_GSK3_1	714	721	PF00069	0.405
MOD_GSK3_1	763	770	PF00069	0.719
MOD_GSK3_1	803	810	PF00069	0.483
MOD_GSK3_1	822	829	PF00069	0.479
MOD_GSK3_1	834	841	PF00069	0.469
MOD_N-GLC_1	280	285	PF02516	0.354
MOD_N-GLC_1	514	519	PF02516	0.502
MOD_N-GLC_2	674	676	PF02516	0.498
MOD_N-GLC_2	799	801	PF02516	0.424
MOD_NEK2_1	202	207	PF00069	0.403
MOD_NEK2_1	311	316	PF00069	0.595
MOD_NEK2_1	475	480	PF00069	0.653
MOD_NEK2_1	499	504	PF00069	0.471
MOD_NEK2_1	55	60	PF00069	0.517
MOD_NEK2_1	752	757	PF00069	0.626
MOD_NEK2_1	762	767	PF00069	0.744
MOD_NEK2_1	807	812	PF00069	0.507
MOD_NEK2_1	819	824	PF00069	0.316
MOD_NEK2_1	97	102	PF00069	0.377
MOD_NEK2_2	212	217	PF00069	0.468
MOD_OFUCOSY	382	389	PF10250	0.521
MOD_PIKK_1	135	141	PF00454	0.482
MOD_PIKK_1	15	21	PF00454	0.464
MOD_PIKK_1	264	270	PF00454	0.375
MOD_PIKK_1	666	672	PF00454	0.570
MOD_PIKK_1	753	759	PF00454	0.527
MOD_PIKK_1	807	813	PF00454	0.521
MOD_PKA_1	432	438	PF00069	0.498
MOD_PKA_2	377	383	PF00069	0.471
MOD_PKA_2	55	61	PF00069	0.515
MOD_PKA_2	590	596	PF00069	0.717
MOD_PKA_2	607	613	PF00069	0.510
MOD_PKA_2	714	720	PF00069	0.499
MOD_PKA_2	819	825	PF00069	0.466
MOD_PKB_1	121	129	PF00069	0.281
MOD_PKB_1	512	520	PF00069	0.317
MOD_Plk_1	224	230	PF00069	0.393
MOD_Plk_1	514	520	PF00069	0.497
MOD_Plk_1	645	651	PF00069	0.692
MOD_Plk_2-3	856	862	PF00069	0.723
MOD_Plk_4	410	416	PF00069	0.517
MOD_Plk_4	483	489	PF00069	0.503
MOD_Plk_4	506	512	PF00069	0.470
MOD_ProDKin_1	25	31	PF00069	0.507
MOD_ProDKin_1	280	286	PF00069	0.494
MOD_ProDKin_1	306	312	PF00069	0.618
MOD_ProDKin_1	494	500	PF00069	0.642
MOD_ProDKin_1	591	597	PF00069	0.731
MOD_ProDKin_1	655	661	PF00069	0.493
MOD_ProDKin_1	692	698	PF00069	0.491
MOD_ProDKin_1	84	90	PF00069	0.468
MOD_SUMO_rev_2	231	241	PF00179	0.307
TRG_DiLeu_BaEn_1	10	15	PF01217	0.476
TRG_DiLeu_BaEn_4	6	12	PF01217	0.491
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.418
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.394
TRG_ENDOCYTIC_2	207	210	PF00928	0.344
TRG_ENDOCYTIC_2	217	220	PF00928	0.545
TRG_ENDOCYTIC_2	289	292	PF00928	0.537
TRG_ENDOCYTIC_2	339	342	PF00928	0.520
TRG_ENDOCYTIC_2	487	490	PF00928	0.581
TRG_ENDOCYTIC_2	519	522	PF00928	0.303
TRG_ENDOCYTIC_2	722	725	PF00928	0.385
TRG_ENDOCYTIC_2	738	741	PF00928	0.325
TRG_ENDOCYTIC_2	860	863	PF00928	0.555
TRG_ER_diArg_1	119	121	PF00400	0.500
TRG_ER_diArg_1	207	209	PF00400	0.451
TRG_ER_diArg_1	511	514	PF00400	0.408
TRG_ER_diArg_1	632	634	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUQ4	Leptomonas seymouri	38%	100%
A0A3R7LA44	Trypanosoma rangeli	25%	100%
A0A3S7WZ43	Leishmania donovani	66%	100%
A4I1E5	Leishmania infantum	63%	100%
C9ZJW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AXI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q9Z0	Leishmania major	67%	96%