Dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HE38_LEIBR

TriTrypDb:

LbrM.25.0910 , LBRM2903_250018200

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE38

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0036094	small molecule binding	2	16
GO:0050661	NADP binding	4	16
GO:0051287	NAD binding	4	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0008679	2-hydroxy-3-oxopropionate reductase activity	5	5
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	6
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	6
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.534
CLV_NRD_NRD_1	129	131	PF00675	0.292
CLV_NRD_NRD_1	236	238	PF00675	0.278
CLV_NRD_NRD_1	354	356	PF00675	0.543
CLV_NRD_NRD_1	89	91	PF00675	0.368
CLV_PCSK_KEX2_1	129	131	PF00082	0.273
CLV_PCSK_KEX2_1	236	238	PF00082	0.278
CLV_PCSK_KEX2_1	5	7	PF00082	0.337
CLV_PCSK_KEX2_1	89	91	PF00082	0.249
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.337
CLV_PCSK_PC7_1	85	91	PF00082	0.173
CLV_PCSK_SKI1_1	144	148	PF00082	0.405
CLV_PCSK_SKI1_1	341	345	PF00082	0.684
CLV_PCSK_SKI1_1	89	93	PF00082	0.235
DEG_SPOP_SBC_1	389	393	PF00917	0.566
DOC_CKS1_1	411	416	PF01111	0.504
DOC_CYCLIN_RxL_1	21	32	PF00134	0.251
DOC_MAPK_gen_1	129	135	PF00069	0.371
DOC_MAPK_gen_1	29	38	PF00069	0.235
DOC_MAPK_gen_1	5	12	PF00069	0.297
DOC_MAPK_HePTP_8	26	38	PF00069	0.235
DOC_MAPK_MEF2A_6	29	38	PF00069	0.235
DOC_MAPK_MEF2A_6	5	12	PF00069	0.318
DOC_MAPK_MEF2A_6	73	82	PF00069	0.235
DOC_MAPK_NFAT4_5	31	39	PF00069	0.251
DOC_PP1_RVXF_1	22	29	PF00149	0.235
DOC_PP2B_LxvP_1	135	138	PF13499	0.284
DOC_USP7_MATH_1	181	185	PF00917	0.267
DOC_USP7_MATH_1	307	311	PF00917	0.417
DOC_USP7_MATH_1	388	392	PF00917	0.761
DOC_USP7_MATH_1	397	401	PF00917	0.638
DOC_WW_Pin1_4	139	144	PF00397	0.235
DOC_WW_Pin1_4	163	168	PF00397	0.367
DOC_WW_Pin1_4	341	346	PF00397	0.613
DOC_WW_Pin1_4	364	369	PF00397	0.536
DOC_WW_Pin1_4	410	415	PF00397	0.596
LIG_14-3-3_CanoR_1	355	361	PF00244	0.612
LIG_14-3-3_CanoR_1	67	72	PF00244	0.251
LIG_APCC_ABBA_1	169	174	PF00400	0.235
LIG_APCC_ABBAyCdc20_2	130	136	PF00400	0.367
LIG_BRCT_BRCA1_1	165	169	PF00533	0.325
LIG_CaM_IQ_9	33	49	PF13499	0.235
LIG_FHA_1	21	27	PF00498	0.308
LIG_FHA_1	352	358	PF00498	0.559
LIG_FHA_1	377	383	PF00498	0.462
LIG_FHA_2	111	117	PF00498	0.235
LIG_FHA_2	239	245	PF00498	0.367
LIG_FHA_2	421	427	PF00498	0.587
LIG_LIR_Gen_1	216	225	PF02991	0.308
LIG_LIR_Gen_1	32	43	PF02991	0.251
LIG_LIR_Gen_1	72	82	PF02991	0.301
LIG_LIR_Nem_3	166	172	PF02991	0.368
LIG_LIR_Nem_3	216	221	PF02991	0.308
LIG_LIR_Nem_3	291	297	PF02991	0.431
LIG_LIR_Nem_3	32	38	PF02991	0.285
LIG_LIR_Nem_3	72	77	PF02991	0.280
LIG_SH2_CRK	218	222	PF00017	0.308
LIG_SH2_SRC	323	326	PF00017	0.477
LIG_SH2_STAP1	172	176	PF00017	0.235
LIG_SH2_STAT5	161	164	PF00017	0.234
LIG_SH2_STAT5	323	326	PF00017	0.361
LIG_SH2_STAT5	35	38	PF00017	0.274
LIG_SH3_3	152	158	PF00018	0.403
LIG_SH3_3	243	249	PF00018	0.431
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.374
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.235
LIG_SUMO_SIM_par_1	76	81	PF11976	0.238
LIG_TRAF2_1	329	332	PF00917	0.318
MOD_CDK_SPK_2	139	144	PF00069	0.235
MOD_CDK_SPxxK_3	163	170	PF00069	0.367
MOD_CK1_1	228	234	PF00069	0.269
MOD_CK1_1	256	262	PF00069	0.348
MOD_CK1_1	391	397	PF00069	0.614
MOD_CK1_1	69	75	PF00069	0.274
MOD_CK2_1	392	398	PF00069	0.711
MOD_GlcNHglycan	139	142	PF01048	0.284
MOD_GlcNHglycan	183	186	PF01048	0.256
MOD_GlcNHglycan	255	258	PF01048	0.432
MOD_GlcNHglycan	309	312	PF01048	0.522
MOD_GlcNHglycan	31	34	PF01048	0.285
MOD_GlcNHglycan	351	354	PF01048	0.592
MOD_GlcNHglycan	358	361	PF01048	0.597
MOD_GlcNHglycan	371	374	PF01048	0.580
MOD_GlcNHglycan	52	56	PF01048	0.389
MOD_GSK3_1	225	232	PF00069	0.236
MOD_GSK3_1	252	259	PF00069	0.375
MOD_GSK3_1	351	358	PF00069	0.595
MOD_GSK3_1	37	44	PF00069	0.279
MOD_GSK3_1	378	385	PF00069	0.605
MOD_GSK3_1	388	395	PF00069	0.669
MOD_GSK3_1	399	406	PF00069	0.579
MOD_GSK3_1	409	416	PF00069	0.552
MOD_LATS_1	39	45	PF00433	0.273
MOD_LATS_1	65	71	PF00433	0.235
MOD_N-GLC_1	181	186	PF02516	0.267
MOD_N-GLC_1	349	354	PF02516	0.668
MOD_NEK2_1	195	200	PF00069	0.367
MOD_NEK2_1	225	230	PF00069	0.235
MOD_NEK2_1	270	275	PF00069	0.379
MOD_NEK2_1	297	302	PF00069	0.392
MOD_NEK2_1	382	387	PF00069	0.671
MOD_PIKK_1	189	195	PF00454	0.235
MOD_PIKK_1	399	405	PF00454	0.789
MOD_PIKK_1	413	419	PF00454	0.572
MOD_PKA_1	355	361	PF00069	0.474
MOD_PKA_2	66	72	PF00069	0.273
MOD_Plk_1	110	116	PF00069	0.284
MOD_Plk_1	225	231	PF00069	0.235
MOD_Plk_1	270	276	PF00069	0.394
MOD_Plk_1	297	303	PF00069	0.448
MOD_Plk_1	420	426	PF00069	0.510
MOD_Plk_2-3	111	117	PF00069	0.235
MOD_Plk_4	230	236	PF00069	0.262
MOD_ProDKin_1	139	145	PF00069	0.235
MOD_ProDKin_1	163	169	PF00069	0.367
MOD_ProDKin_1	341	347	PF00069	0.609
MOD_ProDKin_1	364	370	PF00069	0.532
MOD_ProDKin_1	410	416	PF00069	0.594
MOD_SUMO_for_1	275	278	PF00179	0.560
TRG_DiLeu_BaEn_1	265	270	PF01217	0.440
TRG_ENDOCYTIC_2	218	221	PF00928	0.314
TRG_ENDOCYTIC_2	35	38	PF00928	0.278
TRG_ENDOCYTIC_2	68	71	PF00928	0.256
TRG_ER_diArg_1	235	237	PF00400	0.278
TRG_ER_diArg_1	89	91	PF00400	0.173
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VA68	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
A0A0N0P3F4	Leptomonas seymouri	72%	100%
A0A0S4IU65	Bodo saltans	26%	100%
A0A0S4J121	Bodo saltans	23%	100%
A0A0S4JYX1	Bodo saltans	66%	100%
A0A1X0NMG5	Trypanosomatidae	68%	100%
A0A3Q8IFE7	Leishmania donovani	28%	100%
A0A3S7WYZ8	Leishmania donovani	88%	100%
A0A422NXA0	Trypanosoma rangeli	71%	100%
A4HHW2	Leishmania braziliensis	29%	100%
A4I1E4	Leishmania infantum	88%	100%
A4I512	Leishmania infantum	28%	100%
C9ZJW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AXI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
E9B0E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O34969	Bacillus subtilis (strain 168)	25%	100%
P0ABQ2	Escherichia coli (strain K12)	27%	100%
P0ABQ3	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P29266	Rattus norvegicus	25%	100%
Q0KBC7	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	26%	100%
Q0QLF5	Eubacterium barkeri	23%	100%
Q46888	Escherichia coli (strain K12)	24%	100%
Q4Q7T9	Leishmania major	28%	100%
Q4Q9Z1	Leishmania major	87%	100%
Q5R5E7	Pongo abelii	27%	100%