LeishMANIAdb
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Protein transport protein Sec61 subunit gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein transport protein Sec61 subunit gamma
Gene product:
protein transport protein Sec61 gamma subunit, putative
Species:
Leishmania braziliensis
UniProt:
A4HE37_LEIBR
TriTrypDb:
LbrM.25.0900 , LBRM2903_250018100
Length:
69

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 8
GO:0016020 membrane 2 9
GO:0031090 organelle membrane 3 8
GO:0110165 cellular anatomical entity 1 9
GO:0032991 protein-containing complex 1 1
GO:0071256 translocon complex 3 1
GO:0071261 Ssh1 translocon complex 4 1
GO:0098796 membrane protein complex 2 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Expansion

Sequence features

A4HE37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE37

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 8
GO:0006810 transport 3 9
GO:0006886 intracellular protein transport 4 9
GO:0008104 protein localization 4 9
GO:0009987 cellular process 1 9
GO:0015031 protein transport 4 9
GO:0033036 macromolecule localization 2 9
GO:0045184 establishment of protein localization 3 9
GO:0046907 intracellular transport 3 9
GO:0051179 localization 1 9
GO:0051234 establishment of localization 2 9
GO:0051641 cellular localization 2 9
GO:0051649 establishment of localization in cell 3 9
GO:0070727 cellular macromolecule localization 3 9
GO:0071702 organic substance transport 4 9
GO:0071705 nitrogen compound transport 4 9
GO:0031204 post-translational protein targeting to membrane, translocation 5 1
GO:0055085 transmembrane transport 2 1
GO:0065002 intracellular protein transmembrane transport 4 1
GO:0071806 protein transmembrane transport 3 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0008320 protein transmembrane transporter activity 3 9
GO:0022857 transmembrane transporter activity 2 9
GO:0022884 macromolecule transmembrane transporter activity 3 9
GO:0140318 protein transporter activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 23 25 PF00675 0.290
CLV_PCSK_SKI1_1 56 60 PF00082 0.465
DEG_Nend_UBRbox_2 1 3 PF02207 0.580
DOC_CYCLIN_yCln2_LP_2 8 14 PF00134 0.628
DOC_PP1_RVXF_1 54 60 PF00149 0.321
LIG_LIR_Nem_3 6 12 PF02991 0.566
LIG_PDZ_Class_2 64 69 PF00595 0.359
LIG_Pex14_2 50 54 PF04695 0.340
LIG_REV1ctd_RIR_1 51 60 PF16727 0.321
LIG_SH3_3 55 61 PF00018 0.265
LIG_UBA3_1 47 56 PF00899 0.403
LIG_UBA3_1 8 17 PF00899 0.590
TRG_ENDOCYTIC_2 31 34 PF00928 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q9 Leptomonas seymouri 84% 100%
A0A0S4JVU0 Bodo saltans 65% 100%
A0A3S7WZ20 Leishmania donovani 94% 100%
A4I1E3 Leishmania infantum 94% 100%
C9ZJW1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9AXI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P0DI74 Arabidopsis thaliana 54% 100%
P0DI75 Arabidopsis thaliana 54% 100%
P35179 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 86%
P38385 Oryza sativa subsp. japonica 52% 100%
P60058 Canis lupus familiaris 55% 100%
P60059 Homo sapiens 55% 100%
P60060 Mus musculus 55% 100%
Q09827 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 99%
Q19967 Caenorhabditis elegans 55% 100%
Q3T104 Bos taurus 55% 100%
Q4Q9Z2 Leishmania major 94% 100%
Q54JV6 Dictyostelium discoideum 49% 100%
Q66KU2 Xenopus laevis 55% 100%
Q7SZU9 Gadus morhua 51% 100%
Q7T207 Harpagifer antarcticus 55% 100%
Q7Z1B8 Gryllotalpa orientalis 53% 100%
Q8I7D9 Ciona intestinalis 53% 100%
Q962X7 Branchiostoma belcheri 55% 100%
Q9C2D4 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 41% 99%
Q9SMP2 Arabidopsis thaliana 55% 100%
Q9V668 Drosophila melanogaster 53% 100%
Q9VWE9 Drosophila melanogaster 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS