Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HE36_LEIBR

TriTrypDb:

LbrM.25.0890 , LBRM2903_250018000

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE36

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.666
CLV_NRD_NRD_1	139	141	PF00675	0.515
CLV_NRD_NRD_1	159	161	PF00675	0.515
CLV_NRD_NRD_1	289	291	PF00675	0.613
CLV_PCSK_KEX2_1	139	141	PF00082	0.515
CLV_PCSK_KEX2_1	159	161	PF00082	0.515
CLV_PCSK_KEX2_1	248	250	PF00082	0.465
CLV_PCSK_KEX2_1	289	291	PF00082	0.613
CLV_PCSK_KEX2_1	80	82	PF00082	0.684
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.465
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.684
CLV_PCSK_SKI1_1	291	295	PF00082	0.676
CLV_PCSK_SKI1_1	311	315	PF00082	0.449
CLV_PCSK_SKI1_1	381	385	PF00082	0.385
CLV_PCSK_SKI1_1	49	53	PF00082	0.421
CLV_PCSK_SKI1_1	60	64	PF00082	0.292
DEG_APCC_DBOX_1	8	16	PF00400	0.514
DEG_MDM2_SWIB_1	364	372	PF02201	0.344
DEG_Nend_Nbox_1	1	3	PF02207	0.724
DOC_CDC14_PxL_1	347	355	PF14671	0.328
DOC_MAPK_gen_1	159	167	PF00069	0.532
DOC_MAPK_gen_1	266	273	PF00069	0.686
DOC_PP1_RVXF_1	58	64	PF00149	0.397
DOC_PP4_FxxP_1	395	398	PF00568	0.366
DOC_USP7_MATH_1	383	387	PF00917	0.223
DOC_USP7_MATH_1	418	422	PF00917	0.643
DOC_USP7_MATH_2	94	100	PF00917	0.461
DOC_WW_Pin1_4	170	175	PF00397	0.492
DOC_WW_Pin1_4	178	183	PF00397	0.574
DOC_WW_Pin1_4	373	378	PF00397	0.328
DOC_WW_Pin1_4	90	95	PF00397	0.456
DOC_WW_Pin1_4	99	104	PF00397	0.458
LIG_14-3-3_CanoR_1	214	222	PF00244	0.408
LIG_BRCT_BRCA1_1	390	394	PF00533	0.328
LIG_FHA_1	171	177	PF00498	0.693
LIG_FHA_1	312	318	PF00498	0.367
LIG_FHA_1	323	329	PF00498	0.277
LIG_FHA_1	367	373	PF00498	0.363
LIG_FHA_2	233	239	PF00498	0.375
LIG_FHA_2	317	323	PF00498	0.367
LIG_FHA_2	48	54	PF00498	0.548
LIG_HCF-1_HBM_1	36	39	PF13415	0.515
LIG_LIR_Gen_1	150	157	PF02991	0.502
LIG_LIR_Gen_1	346	353	PF02991	0.370
LIG_LIR_Gen_1	36	47	PF02991	0.499
LIG_LIR_Gen_1	50	58	PF02991	0.502
LIG_LIR_Nem_3	104	109	PF02991	0.414
LIG_LIR_Nem_3	240	245	PF02991	0.415
LIG_LIR_Nem_3	346	350	PF02991	0.352
LIG_LIR_Nem_3	36	42	PF02991	0.494
LIG_LIR_Nem_3	391	397	PF02991	0.328
LIG_LIR_Nem_3	50	55	PF02991	0.508
LIG_LYPXL_yS_3	258	261	PF13949	0.448
LIG_MYND_3	350	354	PF01753	0.413
LIG_Pex14_2	190	194	PF04695	0.506
LIG_Pex14_2	364	368	PF04695	0.328
LIG_SH2_CRK	110	114	PF00017	0.453
LIG_SH2_CRK	347	351	PF00017	0.444
LIG_SH2_CRK	39	43	PF00017	0.355
LIG_SH2_NCK_1	347	351	PF00017	0.358
LIG_SH2_STAP1	202	206	PF00017	0.413
LIG_SH2_STAT3	142	145	PF00017	0.531
LIG_SH2_STAT5	112	115	PF00017	0.460
LIG_SH2_STAT5	153	156	PF00017	0.469
LIG_SH2_STAT5	206	209	PF00017	0.481
LIG_SH2_STAT5	241	244	PF00017	0.450
LIG_SH2_STAT5	347	350	PF00017	0.274
LIG_SH2_STAT5	39	42	PF00017	0.347
LIG_SH2_STAT5	66	69	PF00017	0.393
LIG_SH3_3	129	135	PF00018	0.462
LIG_SH3_3	221	227	PF00018	0.510
LIG_SUMO_SIM_anti_2	324	330	PF11976	0.328
LIG_SUMO_SIM_par_1	324	330	PF11976	0.449
LIG_TYR_ITIM	199	204	PF00017	0.278
LIG_WRC_WIRS_1	242	247	PF05994	0.538
MOD_CDK_SPxK_1	373	379	PF00069	0.328
MOD_CK1_1	155	161	PF00069	0.492
MOD_CK1_1	172	178	PF00069	0.525
MOD_CK1_1	20	26	PF00069	0.446
MOD_CK1_1	324	330	PF00069	0.344
MOD_CK1_1	388	394	PF00069	0.333
MOD_CK1_1	99	105	PF00069	0.453
MOD_CK2_1	232	238	PF00069	0.394
MOD_CK2_1	90	96	PF00069	0.467
MOD_GlcNHglycan	103	106	PF01048	0.482
MOD_GlcNHglycan	115	118	PF01048	0.448
MOD_GlcNHglycan	24	27	PF01048	0.547
MOD_GlcNHglycan	277	280	PF01048	0.672
MOD_GSK3_1	148	155	PF00069	0.555
MOD_GSK3_1	172	179	PF00069	0.693
MOD_GSK3_1	20	27	PF00069	0.470
MOD_GSK3_1	384	391	PF00069	0.385
MOD_N-GLC_1	170	175	PF02516	0.581
MOD_N-GLC_1	20	25	PF02516	0.454
MOD_N-GLC_1	87	92	PF02516	0.547
MOD_NEK2_1	2	7	PF00069	0.575
MOD_NEK2_1	204	209	PF00069	0.491
MOD_NEK2_1	298	303	PF00069	0.777
MOD_NEK2_1	30	35	PF00069	0.435
MOD_NEK2_2	241	246	PF00069	0.532
MOD_PIKK_1	327	333	PF00454	0.449
MOD_PIKK_1	87	93	PF00454	0.574
MOD_PKA_2	2	8	PF00069	0.564
MOD_PKA_2	222	228	PF00069	0.529
MOD_PKA_2	388	394	PF00069	0.328
MOD_Plk_1	311	317	PF00069	0.374
MOD_Plk_1	321	327	PF00069	0.276
MOD_Plk_1	87	93	PF00069	0.586
MOD_Plk_2-3	232	238	PF00069	0.529
MOD_Plk_4	152	158	PF00069	0.513
MOD_Plk_4	388	394	PF00069	0.328
MOD_Plk_4	418	424	PF00069	0.614
MOD_Plk_4	47	53	PF00069	0.463
MOD_Plk_4	8	14	PF00069	0.443
MOD_ProDKin_1	170	176	PF00069	0.502
MOD_ProDKin_1	178	184	PF00069	0.570
MOD_ProDKin_1	373	379	PF00069	0.328
MOD_ProDKin_1	90	96	PF00069	0.451
MOD_ProDKin_1	99	105	PF00069	0.458
MOD_SUMO_rev_2	188	197	PF00179	0.524
MOD_SUMO_rev_2	305	313	PF00179	0.438
MOD_SUMO_rev_2	338	346	PF00179	0.344
TRG_AP2beta_CARGO_1	240	249	PF09066	0.516
TRG_DiLeu_BaEn_1	354	359	PF01217	0.413
TRG_DiLeu_BaEn_4	149	155	PF01217	0.558
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.494
TRG_ENDOCYTIC_2	110	113	PF00928	0.458
TRG_ENDOCYTIC_2	153	156	PF00928	0.486
TRG_ENDOCYTIC_2	201	204	PF00928	0.399
TRG_ENDOCYTIC_2	258	261	PF00928	0.432
TRG_ENDOCYTIC_2	347	350	PF00928	0.363
TRG_ENDOCYTIC_2	39	42	PF00928	0.347
TRG_ER_diArg_1	138	140	PF00400	0.497
TRG_ER_diArg_1	288	290	PF00400	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U5	Leptomonas seymouri	81%	99%
A0A0S4JVQ8	Bodo saltans	46%	100%
A0A1X0NLX7	Trypanosomatidae	57%	100%
A0A3Q8IBQ1	Leishmania donovani	93%	100%
A0A422NXL7	Trypanosoma rangeli	63%	100%
A4I1E2	Leishmania infantum	93%	100%
C9ZJV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AXH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9Z3	Leishmania major	92%	100%
V5BGC6	Trypanosoma cruzi	65%	100%