LeishMANIAdb
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Complex 1 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Complex 1 protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HE34_LEIBR
TriTrypDb:
LbrM.25.0870 , LBRM2903_250017700 *
Length:
162

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0005929 cilium 4 1
GO:0020023 kinetoplast 2 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HE34
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE34

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 91 95 PF00656 0.572
CLV_NRD_NRD_1 121 123 PF00675 0.538
CLV_NRD_NRD_1 159 161 PF00675 0.536
CLV_PCSK_KEX2_1 121 123 PF00082 0.565
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.581
DEG_APCC_DBOX_1 129 137 PF00400 0.563
DEG_Nend_Nbox_1 1 3 PF02207 0.661
DOC_MAPK_gen_1 48 58 PF00069 0.521
DOC_MAPK_MEF2A_6 51 58 PF00069 0.521
DOC_MAPK_MEF2A_6 93 102 PF00069 0.525
DOC_MAPK_NFAT4_5 51 59 PF00069 0.523
DOC_PP2B_LxvP_1 21 24 PF13499 0.585
DOC_PP2B_LxvP_1 59 62 PF13499 0.578
DOC_PP4_FxxP_1 4 7 PF00568 0.427
DOC_SPAK_OSR1_1 77 81 PF12202 0.528
DOC_USP7_MATH_1 101 105 PF00917 0.536
DOC_USP7_UBL2_3 147 151 PF12436 0.643
LIG_14-3-3_CanoR_1 45 51 PF00244 0.647
LIG_CaM_IQ_9 99 115 PF13499 0.533
LIG_FHA_1 154 160 PF00498 0.645
LIG_LIR_Gen_1 76 86 PF02991 0.517
LIG_LIR_Nem_3 152 157 PF02991 0.521
LIG_LIR_Nem_3 76 81 PF02991 0.516
LIG_SH2_GRB2like 153 156 PF00017 0.519
LIG_SH2_STAT5 157 160 PF00017 0.563
LIG_SH3_3 35 41 PF00018 0.558
LIG_SH3_3 55 61 PF00018 0.532
LIG_SH3_CIN85_PxpxPR_1 125 130 PF14604 0.568
LIG_UBA3_1 79 85 PF00899 0.422
MOD_GlcNHglycan 4 7 PF01048 0.679
MOD_GlcNHglycan 62 65 PF01048 0.580
MOD_GSK3_1 101 108 PF00069 0.505
MOD_GSK3_1 11 18 PF00069 0.576
MOD_NEK2_1 11 16 PF00069 0.641
MOD_NEK2_1 139 144 PF00069 0.568
MOD_NEK2_1 2 7 PF00069 0.594
MOD_PIKK_1 139 145 PF00454 0.431
MOD_Plk_1 105 111 PF00069 0.514
MOD_Plk_1 139 145 PF00069 0.431
MOD_Plk_4 11 17 PF00069 0.645
MOD_Plk_4 153 159 PF00069 0.511
TRG_NLS_MonoExtC_3 120 125 PF00514 0.550
TRG_Pf-PMV_PEXEL_1 113 118 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILI5 Leptomonas seymouri 85% 100%
A0A0S4JY75 Bodo saltans 72% 100%
A0A1X0NLU6 Trypanosomatidae 83% 96%
A0A3R7MRN4 Trypanosoma rangeli 79% 100%
A0A3S7WYZ6 Leishmania donovani 91% 100%
A4I1E0 Leishmania infantum 91% 100%
C9ZJV6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
E9AXH7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q9Z5 Leishmania major 92% 100%
V5AWD4 Trypanosoma cruzi 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS