Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE30_LEIBR

TriTrypDb:

LbrM.25.0830 , LBRM2903_250017200

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.468
CLV_MEL_PAP_1	289	295	PF00089	0.444
CLV_NRD_NRD_1	122	124	PF00675	0.545
CLV_NRD_NRD_1	160	162	PF00675	0.517
CLV_NRD_NRD_1	267	269	PF00675	0.574
CLV_NRD_NRD_1	271	273	PF00675	0.541
CLV_NRD_NRD_1	299	301	PF00675	0.691
CLV_NRD_NRD_1	360	362	PF00675	0.604
CLV_NRD_NRD_1	368	370	PF00675	0.524
CLV_NRD_NRD_1	39	41	PF00675	0.454
CLV_NRD_NRD_1	402	404	PF00675	0.487
CLV_PCSK_FUR_1	119	123	PF00082	0.465
CLV_PCSK_KEX2_1	119	121	PF00082	0.574
CLV_PCSK_KEX2_1	122	124	PF00082	0.530
CLV_PCSK_KEX2_1	160	162	PF00082	0.552
CLV_PCSK_KEX2_1	267	269	PF00082	0.574
CLV_PCSK_KEX2_1	271	273	PF00082	0.541
CLV_PCSK_KEX2_1	299	301	PF00082	0.675
CLV_PCSK_KEX2_1	360	362	PF00082	0.494
CLV_PCSK_KEX2_1	367	369	PF00082	0.406
CLV_PCSK_KEX2_1	39	41	PF00082	0.454
CLV_PCSK_KEX2_1	402	404	PF00082	0.487
CLV_PCSK_PC7_1	267	273	PF00082	0.498
CLV_PCSK_PC7_1	398	404	PF00082	0.494
CLV_PCSK_SKI1_1	39	43	PF00082	0.408
CLV_PCSK_SKI1_1	98	102	PF00082	0.388
DEG_APCC_DBOX_1	291	299	PF00400	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.522
DEG_SCF_FBW7_2	31	37	PF00400	0.400
DOC_CDC14_PxL_1	16	24	PF14671	0.414
DOC_CKS1_1	31	36	PF01111	0.403
DOC_CYCLIN_yClb3_PxF_3	326	334	PF00134	0.482
DOC_MAPK_gen_1	317	327	PF00069	0.625
DOC_MAPK_gen_1	367	375	PF00069	0.383
DOC_MAPK_MEF2A_6	368	377	PF00069	0.378
DOC_USP7_MATH_1	111	115	PF00917	0.543
DOC_USP7_MATH_1	12	16	PF00917	0.590
DOC_USP7_MATH_1	176	180	PF00917	0.498
DOC_USP7_MATH_1	243	247	PF00917	0.498
DOC_USP7_MATH_1	252	256	PF00917	0.485
DOC_USP7_MATH_1	282	286	PF00917	0.543
DOC_USP7_MATH_1	6	10	PF00917	0.592
DOC_WW_Pin1_4	30	35	PF00397	0.411
LIG_14-3-3_CanoR_1	141	147	PF00244	0.459
LIG_14-3-3_CanoR_1	292	296	PF00244	0.503
LIG_14-3-3_CanoR_1	320	326	PF00244	0.510
LIG_14-3-3_CanoR_1	350	359	PF00244	0.371
LIG_Actin_RPEL_3	362	381	PF02755	0.445
LIG_Actin_WH2_2	68	85	PF00022	0.438
LIG_BIR_III_4	164	168	PF00653	0.423
LIG_DLG_GKlike_1	369	377	PF00625	0.429
LIG_FHA_1	185	191	PF00498	0.440
LIG_FHA_1	215	221	PF00498	0.605
LIG_FHA_1	256	262	PF00498	0.701
LIG_FHA_1	322	328	PF00498	0.514
LIG_FHA_1	67	73	PF00498	0.421
LIG_FHA_1	95	101	PF00498	0.414
LIG_LIR_Gen_1	58	66	PF02991	0.396
LIG_LIR_Gen_1	97	105	PF02991	0.439
LIG_LIR_Nem_3	164	169	PF02991	0.523
LIG_LIR_Nem_3	58	64	PF02991	0.403
LIG_LIR_Nem_3	97	102	PF02991	0.408
LIG_NRBOX	194	200	PF00104	0.533
LIG_NRBOX	285	291	PF00104	0.537
LIG_PDZ_Class_2	438	443	PF00595	0.438
LIG_SH2_CRK	196	200	PF00017	0.427
LIG_SH2_CRK	359	363	PF00017	0.424
LIG_SH2_CRK	435	439	PF00017	0.400
LIG_SH2_PTP2	99	102	PF00017	0.331
LIG_SH2_SRC	162	165	PF00017	0.530
LIG_SH2_STAP1	80	84	PF00017	0.344
LIG_SH2_STAT5	196	199	PF00017	0.469
LIG_SH2_STAT5	351	354	PF00017	0.451
LIG_SH2_STAT5	61	64	PF00017	0.367
LIG_SH2_STAT5	99	102	PF00017	0.436
LIG_SH3_3	28	34	PF00018	0.456
LIG_SH3_3	323	329	PF00018	0.772
LIG_SH3_3	50	56	PF00018	0.383
LIG_SUMO_SIM_par_1	18	24	PF11976	0.441
LIG_SUMO_SIM_par_1	383	390	PF11976	0.355
LIG_TRAF2_1	363	366	PF00917	0.473
LIG_TRAF2_1	419	422	PF00917	0.327
LIG_TRAF2_1	427	430	PF00917	0.304
LIG_TYR_ITSM	95	102	PF00017	0.348
LIG_WRC_WIRS_1	405	410	PF05994	0.351
LIG_WRC_WIRS_1	61	66	PF05994	0.376
MOD_CK1_1	15	21	PF00069	0.580
MOD_CK1_1	214	220	PF00069	0.653
MOD_CK1_1	255	261	PF00069	0.545
MOD_CK1_1	29	35	PF00069	0.413
MOD_CK1_1	291	297	PF00069	0.569
MOD_CK1_1	321	327	PF00069	0.542
MOD_CK1_1	65	71	PF00069	0.413
MOD_CK2_1	111	117	PF00069	0.534
MOD_CK2_1	147	153	PF00069	0.594
MOD_CK2_1	291	297	PF00069	0.500
MOD_CK2_1	360	366	PF00069	0.471
MOD_GlcNHglycan	174	177	PF01048	0.669
MOD_GlcNHglycan	221	224	PF01048	0.564
MOD_GlcNHglycan	28	31	PF01048	0.435
MOD_GlcNHglycan	303	306	PF01048	0.572
MOD_GlcNHglycan	308	311	PF01048	0.656
MOD_GlcNHglycan	64	67	PF01048	0.411
MOD_GlcNHglycan	7	11	PF01048	0.554
MOD_GSK3_1	11	18	PF00069	0.673
MOD_GSK3_1	152	159	PF00069	0.497
MOD_GSK3_1	172	179	PF00069	0.470
MOD_GSK3_1	2	9	PF00069	0.633
MOD_GSK3_1	211	218	PF00069	0.659
MOD_GSK3_1	237	244	PF00069	0.612
MOD_GSK3_1	253	260	PF00069	0.512
MOD_GSK3_1	26	33	PF00069	0.363
MOD_GSK3_1	316	323	PF00069	0.616
MOD_GSK3_1	369	376	PF00069	0.360
MOD_GSK3_1	60	67	PF00069	0.428
MOD_GSK3_1	90	97	PF00069	0.526
MOD_N-GLC_1	103	108	PF02516	0.452
MOD_N-GLC_1	147	152	PF02516	0.418
MOD_NEK2_1	172	177	PF00069	0.665
MOD_NEK2_1	21	26	PF00069	0.611
MOD_NEK2_1	237	242	PF00069	0.467
MOD_NEK2_1	257	262	PF00069	0.452
MOD_NEK2_1	301	306	PF00069	0.555
MOD_NEK2_1	373	378	PF00069	0.416
MOD_NEK2_1	404	409	PF00069	0.375
MOD_NEK2_1	64	69	PF00069	0.402
MOD_NEK2_1	88	93	PF00069	0.428
MOD_NEK2_2	266	271	PF00069	0.524
MOD_NEK2_2	329	334	PF00069	0.470
MOD_OFUCOSY	274	280	PF10250	0.535
MOD_PIKK_1	211	217	PF00454	0.625
MOD_PIKK_1	360	366	PF00454	0.402
MOD_PIKK_1	387	393	PF00454	0.446
MOD_PKA_1	360	366	PF00069	0.427
MOD_PKA_2	266	272	PF00069	0.556
MOD_PKA_2	291	297	PF00069	0.551
MOD_PKA_2	316	322	PF00069	0.633
MOD_PKA_2	352	358	PF00069	0.405
MOD_PKA_2	360	366	PF00069	0.399
MOD_PKB_1	367	375	PF00069	0.383
MOD_Plk_1	12	18	PF00069	0.563
MOD_Plk_1	147	153	PF00069	0.527
MOD_Plk_1	237	243	PF00069	0.468
MOD_Plk_1	282	288	PF00069	0.505
MOD_Plk_4	142	148	PF00069	0.466
MOD_Plk_4	369	375	PF00069	0.375
MOD_ProDKin_1	30	36	PF00069	0.408
MOD_SUMO_rev_2	429	434	PF00179	0.441
TRG_DiLeu_BaEn_1	400	405	PF01217	0.474
TRG_DiLeu_BaEn_1	429	434	PF01217	0.451
TRG_DiLeu_BaEn_4	429	435	PF01217	0.454
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.420
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.511
TRG_ENDOCYTIC_2	166	169	PF00928	0.521
TRG_ENDOCYTIC_2	196	199	PF00928	0.425
TRG_ENDOCYTIC_2	359	362	PF00928	0.423
TRG_ENDOCYTIC_2	61	64	PF00928	0.379
TRG_ENDOCYTIC_2	99	102	PF00928	0.436
TRG_ER_diArg_1	119	122	PF00400	0.566
TRG_ER_diArg_1	160	162	PF00400	0.517
TRG_ER_diArg_1	298	300	PF00400	0.683
TRG_ER_diArg_1	359	361	PF00400	0.385
TRG_ER_diArg_1	367	369	PF00400	0.397
TRG_ER_diArg_1	38	40	PF00400	0.408
TRG_ER_diArg_1	402	404	PF00400	0.487
TRG_NES_CRM1_1	284	297	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU1	Leptomonas seymouri	39%	100%
E9AXH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q9Z9	Leishmania major	69%	100%