Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE29_LEIBR

TriTrypDb:

LbrM.25.0820 , LBRM2903_250017100

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.454
CLV_C14_Caspase3-7	5	9	PF00656	0.846
CLV_NRD_NRD_1	142	144	PF00675	0.612
CLV_NRD_NRD_1	314	316	PF00675	0.692
CLV_NRD_NRD_1	321	323	PF00675	0.595
CLV_NRD_NRD_1	333	335	PF00675	0.498
CLV_NRD_NRD_1	347	349	PF00675	0.622
CLV_NRD_NRD_1	422	424	PF00675	0.820
CLV_NRD_NRD_1	426	428	PF00675	0.747
CLV_NRD_NRD_1	501	503	PF00675	0.742
CLV_PCSK_FUR_1	418	422	PF00082	0.818
CLV_PCSK_KEX2_1	104	106	PF00082	0.801
CLV_PCSK_KEX2_1	142	144	PF00082	0.612
CLV_PCSK_KEX2_1	314	316	PF00082	0.692
CLV_PCSK_KEX2_1	323	325	PF00082	0.575
CLV_PCSK_KEX2_1	347	349	PF00082	0.840
CLV_PCSK_KEX2_1	420	422	PF00082	0.822
CLV_PCSK_KEX2_1	426	428	PF00082	0.714
CLV_PCSK_KEX2_1	538	540	PF00082	0.731
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.675
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.724
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.822
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.731
CLV_PCSK_PC7_1	418	424	PF00082	0.819
CLV_PCSK_PC7_1	534	540	PF00082	0.711
CLV_PCSK_SKI1_1	123	127	PF00082	0.572
CLV_Separin_Metazoa	234	238	PF03568	0.674
DEG_COP1_1	459	469	PF00400	0.786
DEG_Nend_UBRbox_2	1	3	PF02207	0.607
DEG_SPOP_SBC_1	260	264	PF00917	0.600
DOC_ANK_TNKS_1	141	148	PF00023	0.601
DOC_CKS1_1	410	415	PF01111	0.766
DOC_CKS1_1	496	501	PF01111	0.751
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.575
DOC_PP1_RVXF_1	532	538	PF00149	0.693
DOC_PP2B_LxvP_1	184	187	PF13499	0.585
DOC_PP2B_LxvP_1	371	374	PF13499	0.834
DOC_PP2B_LxvP_1	390	393	PF13499	0.517
DOC_PP4_FxxP_1	280	283	PF00568	0.470
DOC_USP7_MATH_1	169	173	PF00917	0.620
DOC_USP7_MATH_1	190	194	PF00917	0.810
DOC_USP7_MATH_1	270	274	PF00917	0.605
DOC_USP7_MATH_1	30	34	PF00917	0.606
DOC_USP7_MATH_1	336	340	PF00917	0.784
DOC_USP7_MATH_1	401	405	PF00917	0.580
DOC_USP7_MATH_1	438	442	PF00917	0.687
DOC_USP7_MATH_1	454	458	PF00917	0.726
DOC_USP7_MATH_1	460	464	PF00917	0.732
DOC_USP7_MATH_1	469	473	PF00917	0.564
DOC_USP7_MATH_1	64	68	PF00917	0.797
DOC_USP7_MATH_2	435	441	PF00917	0.574
DOC_USP7_UBL2_3	100	104	PF12436	0.597
DOC_USP7_UBL2_3	331	335	PF12436	0.805
DOC_WW_Pin1_4	17	22	PF00397	0.833
DOC_WW_Pin1_4	26	31	PF00397	0.681
DOC_WW_Pin1_4	275	280	PF00397	0.660
DOC_WW_Pin1_4	334	339	PF00397	0.567
DOC_WW_Pin1_4	409	414	PF00397	0.765
DOC_WW_Pin1_4	452	457	PF00397	0.569
DOC_WW_Pin1_4	465	470	PF00397	0.514
DOC_WW_Pin1_4	495	500	PF00397	0.741
LIG_14-3-3_CanoR_1	173	181	PF00244	0.785
LIG_14-3-3_CanoR_1	324	330	PF00244	0.629
LIG_14-3-3_CanoR_1	421	428	PF00244	0.733
LIG_14-3-3_CanoR_1	439	447	PF00244	0.614
LIG_14-3-3_CanoR_1	507	515	PF00244	0.747
LIG_Actin_WH2_2	223	239	PF00022	0.513
LIG_BIR_III_4	351	355	PF00653	0.600
LIG_deltaCOP1_diTrp_1	375	385	PF00928	0.825
LIG_FHA_1	181	187	PF00498	0.843
LIG_FHA_1	5	11	PF00498	0.596
LIG_FHA_1	522	528	PF00498	0.444
LIG_FHA_2	212	218	PF00498	0.491
LIG_FHA_2	363	369	PF00498	0.594
LIG_FHA_2	496	502	PF00498	0.748
LIG_LIR_Apic_2	278	283	PF02991	0.493
LIG_LIR_Gen_1	205	216	PF02991	0.476
LIG_LIR_Gen_1	375	385	PF02991	0.586
LIG_LIR_Gen_1	521	530	PF02991	0.695
LIG_LIR_Nem_3	205	211	PF02991	0.482
LIG_LIR_Nem_3	375	381	PF02991	0.586
LIG_LIR_Nem_3	412	417	PF02991	0.767
LIG_LIR_Nem_3	521	526	PF02991	0.705
LIG_MYND_1	275	279	PF01753	0.562
LIG_SH2_CRK	523	527	PF00017	0.694
LIG_SH2_SRC	299	302	PF00017	0.664
LIG_SH2_STAP1	307	311	PF00017	0.695
LIG_SH2_STAP1	505	509	PF00017	0.743
LIG_SH2_STAP1	523	527	PF00017	0.397
LIG_SH2_STAT5	299	302	PF00017	0.664
LIG_SH2_STAT5	508	511	PF00017	0.746
LIG_SH2_STAT5	523	526	PF00017	0.454
LIG_SH3_1	335	341	PF00018	0.569
LIG_SH3_2	138	143	PF14604	0.592
LIG_SH3_3	135	141	PF00018	0.617
LIG_SH3_3	264	270	PF00018	0.652
LIG_SH3_3	282	288	PF00018	0.700
LIG_SH3_3	335	341	PF00018	0.569
LIG_SH3_3	376	382	PF00018	0.821
LIG_SH3_3	463	469	PF00018	0.707
LIG_SH3_3	472	478	PF00018	0.773
LIG_SH3_3	481	487	PF00018	0.616
LIG_SH3_3	490	496	PF00018	0.513
LIG_Sin3_3	490	497	PF02671	0.799
LIG_TRAF2_1	200	203	PF00917	0.778
LIG_TRAF2_1	365	368	PF00917	0.673
LIG_TRAF2_1	498	501	PF00917	0.748
LIG_UBA3_1	286	291	PF00899	0.684
MOD_CDK_SPxK_1	409	415	PF00069	0.767
MOD_CDK_SPxxK_3	495	502	PF00069	0.755
MOD_CK1_1	171	177	PF00069	0.784
MOD_CK1_1	193	199	PF00069	0.621
MOD_CK1_1	22	28	PF00069	0.747
MOD_CK1_1	262	268	PF00069	0.601
MOD_CK1_1	339	345	PF00069	0.841
MOD_CK1_1	403	409	PF00069	0.565
MOD_CK2_1	149	155	PF00069	0.854
MOD_CK2_1	250	256	PF00069	0.680
MOD_CK2_1	362	368	PF00069	0.730
MOD_CK2_1	39	45	PF00069	0.604
MOD_CK2_1	495	501	PF00069	0.758
MOD_CK2_1	6	12	PF00069	0.852
MOD_CMANNOS	411	414	PF00535	0.799
MOD_Cter_Amidation	332	335	PF01082	0.806
MOD_GlcNHglycan	190	193	PF01048	0.796
MOD_GlcNHglycan	195	198	PF01048	0.726
MOD_GlcNHglycan	252	255	PF01048	0.654
MOD_GlcNHglycan	272	275	PF01048	0.502
MOD_GlcNHglycan	338	341	PF01048	0.745
MOD_GlcNHglycan	356	360	PF01048	0.632
MOD_GlcNHglycan	423	426	PF01048	0.661
MOD_GlcNHglycan	440	443	PF01048	0.703
MOD_GlcNHglycan	452	455	PF01048	0.583
MOD_GlcNHglycan	462	465	PF01048	0.564
MOD_GlcNHglycan	488	491	PF01048	0.809
MOD_GlcNHglycan	511	514	PF01048	0.753
MOD_GlcNHglycan	62	65	PF01048	0.718
MOD_GSK3_1	15	22	PF00069	0.799
MOD_GSK3_1	169	176	PF00069	0.781
MOD_GSK3_1	25	32	PF00069	0.687
MOD_GSK3_1	261	268	PF00069	0.685
MOD_GSK3_1	275	282	PF00069	0.707
MOD_GSK3_1	426	433	PF00069	0.780
MOD_GSK3_1	450	457	PF00069	0.789
MOD_GSK3_1	465	472	PF00069	0.568
MOD_GSK3_1	521	528	PF00069	0.448
MOD_GSK3_1	60	67	PF00069	0.740
MOD_GSK3_1	81	88	PF00069	0.806
MOD_GSK3_1	90	97	PF00069	0.692
MOD_N-GLC_1	112	117	PF02516	0.710
MOD_N-GLC_1	90	95	PF02516	0.601
MOD_NEK2_1	223	228	PF00069	0.676
MOD_NEK2_1	525	530	PF00069	0.683
MOD_NEK2_1	69	74	PF00069	0.590
MOD_NEK2_2	30	35	PF00069	0.603
MOD_PIKK_1	265	271	PF00454	0.840
MOD_PK_1	19	25	PF00069	0.601
MOD_PKA_1	421	427	PF00069	0.819
MOD_PKA_2	169	175	PF00069	0.739
MOD_PKA_2	325	331	PF00069	0.615
MOD_PKA_2	421	427	PF00069	0.819
MOD_PKA_2	438	444	PF00069	0.547
MOD_PKA_2	45	51	PF00069	0.759
MOD_PKB_1	173	181	PF00069	0.839
MOD_Plk_1	112	118	PF00069	0.709
MOD_Plk_1	64	70	PF00069	0.839
MOD_Plk_2-3	6	12	PF00069	0.813
MOD_Plk_4	223	229	PF00069	0.681
MOD_Plk_4	521	527	PF00069	0.447
MOD_Plk_4	65	71	PF00069	0.839
MOD_ProDKin_1	17	23	PF00069	0.833
MOD_ProDKin_1	26	32	PF00069	0.682
MOD_ProDKin_1	275	281	PF00069	0.644
MOD_ProDKin_1	334	340	PF00069	0.569
MOD_ProDKin_1	409	415	PF00069	0.767
MOD_ProDKin_1	452	458	PF00069	0.570
MOD_ProDKin_1	465	471	PF00069	0.514
MOD_ProDKin_1	495	501	PF00069	0.738
MOD_SUMO_for_1	125	128	PF00179	0.602
MOD_SUMO_for_1	200	203	PF00179	0.680
MOD_SUMO_rev_2	253	263	PF00179	0.590
MOD_SUMO_rev_2	356	366	PF00179	0.725
TRG_DiLeu_BaEn_1	156	161	PF01217	0.568
TRG_DiLeu_BaEn_1	65	70	PF01217	0.839
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.697
TRG_ENDOCYTIC_2	523	526	PF00928	0.702
TRG_ER_diArg_1	141	143	PF00400	0.593
TRG_ER_diArg_1	313	315	PF00400	0.688
TRG_ER_diArg_1	421	423	PF00400	0.826
TRG_ER_diArg_1	426	428	PF00400	0.731
TRG_NLS_MonoExtC_3	321	326	PF00514	0.721
TRG_NLS_MonoExtN_4	322	327	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8INB5	Leishmania donovani	67%	92%
A4I1D5	Leishmania infantum	67%	92%
E9AXH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	80%
Q4QA00	Leishmania major	68%	100%