ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HE28_LEIBR

TriTrypDb:

LbrM.25.0810 , LBRM2903_250017000

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.491
CLV_PCSK_SKI1_1	163	167	PF00082	0.413
DEG_APCC_DBOX_1	236	244	PF00400	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.465
DEG_ODPH_VHL_1	3	15	PF01847	0.301
DEG_SPOP_SBC_1	102	106	PF00917	0.438
DOC_CDC14_PxL_1	1	9	PF14671	0.499
DOC_CKS1_1	95	100	PF01111	0.530
DOC_CYCLIN_RxL_1	158	168	PF00134	0.391
DOC_PP2B_LxvP_1	2	5	PF13499	0.390
DOC_PP4_FxxP_1	95	98	PF00568	0.444
DOC_USP7_MATH_1	101	105	PF00917	0.669
DOC_USP7_MATH_1	123	127	PF00917	0.641
DOC_USP7_MATH_1	175	179	PF00917	0.308
DOC_USP7_MATH_1	209	213	PF00917	0.501
DOC_WW_Pin1_4	145	150	PF00397	0.246
DOC_WW_Pin1_4	26	31	PF00397	0.455
DOC_WW_Pin1_4	94	99	PF00397	0.448
LIG_14-3-3_CanoR_1	41	45	PF00244	0.320
LIG_14-3-3_CanoR_1	63	68	PF00244	0.268
LIG_14-3-3_CterR_2	256	260	PF00244	0.393
LIG_EH1_1	193	201	PF00400	0.366
LIG_eIF4E_1	40	46	PF01652	0.447
LIG_FHA_2	180	186	PF00498	0.317
LIG_LIR_Gen_1	225	235	PF02991	0.543
LIG_LIR_Nem_3	225	230	PF02991	0.549
LIG_RPA_C_Fungi	58	70	PF08784	0.164
LIG_SH2_NCK_1	35	39	PF00017	0.377
LIG_SH2_PTP2	227	230	PF00017	0.507
LIG_SH2_SRC	227	230	PF00017	0.620
LIG_SH2_STAT5	227	230	PF00017	0.574
LIG_SH2_STAT5	35	38	PF00017	0.404
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.294
MOD_CK1_1	119	125	PF00069	0.573
MOD_CK1_1	126	132	PF00069	0.456
MOD_CK2_1	247	253	PF00069	0.474
MOD_GlcNHglycan	121	124	PF01048	0.528
MOD_GlcNHglycan	155	158	PF01048	0.423
MOD_GlcNHglycan	21	24	PF01048	0.443
MOD_GlcNHglycan	211	214	PF01048	0.633
MOD_GlcNHglycan	99	102	PF01048	0.518
MOD_GSK3_1	108	115	PF00069	0.528
MOD_GSK3_1	117	124	PF00069	0.643
MOD_GSK3_1	175	182	PF00069	0.352
MOD_GSK3_1	59	66	PF00069	0.394
MOD_GSK3_1	97	104	PF00069	0.460
MOD_N-GLC_1	19	24	PF02516	0.419
MOD_N-GLC_1	200	205	PF02516	0.421
MOD_N-GLC_1	247	252	PF02516	0.558
MOD_N-GLC_1	33	38	PF02516	0.456
MOD_NEK2_1	116	121	PF00069	0.532
MOD_NEK2_1	165	170	PF00069	0.344
MOD_NEK2_1	200	205	PF00069	0.398
MOD_NEK2_1	247	252	PF00069	0.445
MOD_NEK2_1	59	64	PF00069	0.360
MOD_PIKK_1	117	123	PF00454	0.429
MOD_PIKK_1	217	223	PF00454	0.619
MOD_PKA_2	175	181	PF00069	0.322
MOD_PKA_2	40	46	PF00069	0.301
MOD_Plk_1	19	25	PF00069	0.483
MOD_Plk_1	200	206	PF00069	0.432
MOD_Plk_1	247	253	PF00069	0.471
MOD_Plk_4	123	129	PF00069	0.632
MOD_Plk_4	40	46	PF00069	0.246
MOD_ProDKin_1	145	151	PF00069	0.246
MOD_ProDKin_1	26	32	PF00069	0.450
MOD_ProDKin_1	94	100	PF00069	0.464
TRG_ENDOCYTIC_2	227	230	PF00928	0.554
TRG_ER_diArg_1	237	240	PF00400	0.449
TRG_NES_CRM1_1	185	198	PF08389	0.322
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I922	Leptomonas seymouri	63%	100%
A0A0S4IRG3	Bodo saltans	30%	100%
A0A1X0NNH1	Trypanosomatidae	38%	100%
A0A3Q8ICG2	Leishmania donovani	82%	99%
A0A422NXA4	Trypanosoma rangeli	38%	100%
A4I1D4	Leishmania infantum	82%	99%
C9ZKX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AXH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QA01	Leishmania major	81%	100%
Q6P6B7	Homo sapiens	28%	72%
V5BBP8	Trypanosoma cruzi	38%	100%