SLBP_RNA_bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone RNA hairpin-binding protein RNA-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HE27_LEIBR

TriTrypDb:

LbrM.25.0800 , LBRM2903_250016900

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071204	histone pre-mRNA 3'end processing complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HE27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE27

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0008152	metabolic process	1	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0036002	pre-mRNA binding	5	1
GO:0071207	histone pre-mRNA stem-loop binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.701
CLV_NRD_NRD_1	170	172	PF00675	0.235
CLV_NRD_NRD_1	224	226	PF00675	0.346
CLV_NRD_NRD_1	228	230	PF00675	0.318
CLV_NRD_NRD_1	410	412	PF00675	0.778
CLV_NRD_NRD_1	96	98	PF00675	0.673
CLV_PCSK_FUR_1	168	172	PF00082	0.234
CLV_PCSK_KEX2_1	168	170	PF00082	0.346
CLV_PCSK_KEX2_1	190	192	PF00082	0.346
CLV_PCSK_KEX2_1	217	219	PF00082	0.346
CLV_PCSK_KEX2_1	228	230	PF00082	0.267
CLV_PCSK_KEX2_1	410	412	PF00082	0.800
CLV_PCSK_KEX2_1	96	98	PF00082	0.673
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.346
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.346
CLV_PCSK_SKI1_1	228	232	PF00082	0.346
CLV_PCSK_SKI1_1	300	304	PF00082	0.571
CLV_PCSK_SKI1_1	702	706	PF00082	0.531
CLV_PCSK_SKI1_1	793	797	PF00082	0.679
CLV_PCSK_SKI1_1	88	92	PF00082	0.579
CLV_Separin_Metazoa	266	270	PF03568	0.591
DEG_Nend_UBRbox_3	1	3	PF02207	0.696
DEG_SCF_FBW7_1	787	794	PF00400	0.582
DOC_ANK_TNKS_1	17	24	PF00023	0.556
DOC_ANK_TNKS_1	635	642	PF00023	0.537
DOC_CKS1_1	10	15	PF01111	0.579
DOC_CKS1_1	758	763	PF01111	0.548
DOC_CKS1_1	819	824	PF01111	0.730
DOC_CYCLIN_RxL_1	466	477	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	497	503	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	823	829	PF00134	0.558
DOC_MAPK_gen_1	168	179	PF00069	0.546
DOC_MAPK_gen_1	217	224	PF00069	0.529
DOC_MAPK_gen_1	269	277	PF00069	0.584
DOC_MAPK_gen_1	410	416	PF00069	0.735
DOC_MAPK_MEF2A_6	269	277	PF00069	0.584
DOC_PP1_RVXF_1	173	180	PF00149	0.546
DOC_PP2B_LxvP_1	14	17	PF13499	0.568
DOC_PP2B_LxvP_1	207	210	PF13499	0.546
DOC_PP2B_LxvP_1	497	500	PF13499	0.621
DOC_PP2B_LxvP_1	552	555	PF13499	0.677
DOC_PP4_FxxP_1	91	94	PF00568	0.575
DOC_PP4_MxPP_1	535	538	PF00568	0.516
DOC_USP7_MATH_1	106	110	PF00917	0.588
DOC_USP7_MATH_1	143	147	PF00917	0.641
DOC_USP7_MATH_1	488	492	PF00917	0.685
DOC_USP7_MATH_1	523	527	PF00917	0.626
DOC_USP7_MATH_1	616	620	PF00917	0.631
DOC_WW_Pin1_4	104	109	PF00397	0.732
DOC_WW_Pin1_4	160	165	PF00397	0.544
DOC_WW_Pin1_4	205	210	PF00397	0.546
DOC_WW_Pin1_4	30	35	PF00397	0.674
DOC_WW_Pin1_4	327	332	PF00397	0.598
DOC_WW_Pin1_4	403	408	PF00397	0.749
DOC_WW_Pin1_4	416	421	PF00397	0.593
DOC_WW_Pin1_4	437	442	PF00397	0.608
DOC_WW_Pin1_4	45	50	PF00397	0.536
DOC_WW_Pin1_4	481	486	PF00397	0.652
DOC_WW_Pin1_4	503	508	PF00397	0.726
DOC_WW_Pin1_4	598	603	PF00397	0.519
DOC_WW_Pin1_4	624	629	PF00397	0.680
DOC_WW_Pin1_4	644	649	PF00397	0.490
DOC_WW_Pin1_4	732	737	PF00397	0.585
DOC_WW_Pin1_4	757	762	PF00397	0.549
DOC_WW_Pin1_4	764	769	PF00397	0.516
DOC_WW_Pin1_4	787	792	PF00397	0.681
DOC_WW_Pin1_4	818	823	PF00397	0.703
DOC_WW_Pin1_4	9	14	PF00397	0.582
LIG_14-3-3_CanoR_1	359	364	PF00244	0.558
LIG_14-3-3_CanoR_1	469	474	PF00244	0.799
LIG_14-3-3_CanoR_1	702	711	PF00244	0.588
LIG_14-3-3_CanoR_1	9	13	PF00244	0.583
LIG_Actin_WH2_2	185	202	PF00022	0.546
LIG_Actin_WH2_2	286	302	PF00022	0.579
LIG_APCC_ABBA_1	26	31	PF00400	0.537
LIG_BRCT_BRCA1_1	838	842	PF00533	0.522
LIG_deltaCOP1_diTrp_1	663	669	PF00928	0.505
LIG_EVH1_2	499	503	PF00568	0.701
LIG_FHA_1	277	283	PF00498	0.401
LIG_FHA_1	34	40	PF00498	0.528
LIG_FHA_1	378	384	PF00498	0.527
LIG_FHA_1	491	497	PF00498	0.719
LIG_FHA_1	624	630	PF00498	0.682
LIG_FHA_1	703	709	PF00498	0.524
LIG_FHA_1	745	751	PF00498	0.668
LIG_FHA_1	775	781	PF00498	0.527
LIG_FHA_1	9	15	PF00498	0.582
LIG_FHA_2	815	821	PF00498	0.576
LIG_IRF3_LxIS_1	832	839	PF10401	0.520
LIG_LIR_Apic_2	89	94	PF02991	0.575
LIG_LIR_Gen_1	183	194	PF02991	0.546
LIG_LIR_Gen_1	22	30	PF02991	0.594
LIG_LIR_Gen_1	235	243	PF02991	0.649
LIG_LIR_Gen_1	306	317	PF02991	0.566
LIG_LIR_Gen_1	450	457	PF02991	0.556
LIG_LIR_Gen_1	657	664	PF02991	0.579
LIG_LIR_Gen_1	667	677	PF02991	0.647
LIG_LIR_Nem_3	235	239	PF02991	0.615
LIG_LIR_Nem_3	306	312	PF02991	0.559
LIG_LIR_Nem_3	35	40	PF02991	0.536
LIG_LIR_Nem_3	450	454	PF02991	0.601
LIG_LIR_Nem_3	655	659	PF02991	0.505
LIG_MYND_1	83	87	PF01753	0.562
LIG_Pex14_1	665	669	PF04695	0.506
LIG_Pex14_2	234	238	PF04695	0.640
LIG_SH2_GRB2like	186	189	PF00017	0.546
LIG_SH2_PTP2	236	239	PF00017	0.564
LIG_SH2_STAT3	113	116	PF00017	0.569
LIG_SH2_STAT5	181	184	PF00017	0.546
LIG_SH2_STAT5	186	189	PF00017	0.509
LIG_SH2_STAT5	236	239	PF00017	0.672
LIG_SH2_STAT5	25	28	PF00017	0.552
LIG_SH2_STAT5	656	659	PF00017	0.504
LIG_SH3_2	412	417	PF14604	0.579
LIG_SH3_3	151	157	PF00018	0.556
LIG_SH3_3	203	209	PF00018	0.546
LIG_SH3_3	406	412	PF00018	0.715
LIG_SH3_3	48	54	PF00018	0.690
LIG_SH3_3	482	488	PF00018	0.625
LIG_SH3_3	493	499	PF00018	0.687
LIG_SH3_3	516	522	PF00018	0.579
LIG_SH3_3	527	533	PF00018	0.516
LIG_SH3_3	535	541	PF00018	0.518
LIG_SH3_3	547	553	PF00018	0.466
LIG_SH3_3	573	579	PF00018	0.709
LIG_SH3_3	730	736	PF00018	0.591
LIG_SH3_3	755	761	PF00018	0.625
LIG_SH3_3	824	830	PF00018	0.636
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.562
LIG_SUMO_SIM_par_1	491	498	PF11976	0.562
LIG_SUMO_SIM_par_1	785	790	PF11976	0.538
LIG_TRAF2_1	294	297	PF00917	0.585
LIG_WW_2	412	415	PF00397	0.726
MOD_CDC14_SPxK_1	408	411	PF00782	0.732
MOD_CDK_SPK_2	405	410	PF00069	0.745
MOD_CDK_SPxK_1	405	411	PF00069	0.729
MOD_CDK_SPxK_1	787	793	PF00069	0.680
MOD_CDK_SPxK_1	9	15	PF00069	0.582
MOD_CDK_SPxxK_3	403	410	PF00069	0.728
MOD_CDK_SPxxK_3	818	825	PF00069	0.734
MOD_CK1_1	128	134	PF00069	0.588
MOD_CK1_1	311	317	PF00069	0.563
MOD_CK1_1	319	325	PF00069	0.521
MOD_CK1_1	435	441	PF00069	0.583
MOD_CK1_1	443	449	PF00069	0.539
MOD_CK1_1	474	480	PF00069	0.568
MOD_CK1_1	506	512	PF00069	0.657
MOD_CK1_1	608	614	PF00069	0.609
MOD_CK1_1	757	763	PF00069	0.579
MOD_CK2_1	160	166	PF00069	0.654
MOD_CK2_1	205	211	PF00069	0.434
MOD_CK2_1	327	333	PF00069	0.599
MOD_DYRK1A_RPxSP_1	732	736	PF00069	0.558
MOD_GlcNHglycan	123	126	PF01048	0.734
MOD_GlcNHglycan	127	130	PF01048	0.678
MOD_GlcNHglycan	200	203	PF01048	0.346
MOD_GlcNHglycan	285	288	PF01048	0.600
MOD_GlcNHglycan	318	321	PF01048	0.681
MOD_GlcNHglycan	342	345	PF01048	0.637
MOD_GlcNHglycan	384	387	PF01048	0.722
MOD_GlcNHglycan	437	440	PF01048	0.618
MOD_GlcNHglycan	463	466	PF01048	0.674
MOD_GlcNHglycan	473	476	PF01048	0.552
MOD_GlcNHglycan	503	506	PF01048	0.621
MOD_GlcNHglycan	525	528	PF01048	0.732
MOD_GlcNHglycan	558	561	PF01048	0.544
MOD_GlcNHglycan	607	610	PF01048	0.588
MOD_GlcNHglycan	674	677	PF01048	0.680
MOD_GlcNHglycan	693	696	PF01048	0.490
MOD_GlcNHglycan	702	705	PF01048	0.618
MOD_GlcNHglycan	715	718	PF01048	0.554
MOD_GlcNHglycan	753	757	PF01048	0.556
MOD_GlcNHglycan	768	771	PF01048	0.591
MOD_GSK3_1	121	128	PF00069	0.605
MOD_GSK3_1	180	187	PF00069	0.546
MOD_GSK3_1	378	385	PF00069	0.626
MOD_GSK3_1	41	48	PF00069	0.619
MOD_GSK3_1	433	440	PF00069	0.587
MOD_GSK3_1	443	450	PF00069	0.530
MOD_GSK3_1	469	476	PF00069	0.623
MOD_GSK3_1	499	506	PF00069	0.560
MOD_GSK3_1	52	59	PF00069	0.593
MOD_GSK3_1	616	623	PF00069	0.517
MOD_GSK3_1	696	703	PF00069	0.618
MOD_GSK3_1	760	767	PF00069	0.540
MOD_GSK3_1	787	794	PF00069	0.587
MOD_GSK3_1	814	821	PF00069	0.711
MOD_N-GLC_1	213	218	PF02516	0.234
MOD_N-GLC_1	432	437	PF02516	0.563
MOD_N-GLC_1	644	649	PF02516	0.538
MOD_NEK2_1	198	203	PF00069	0.568
MOD_NEK2_1	390	395	PF00069	0.538
MOD_NEK2_1	41	46	PF00069	0.692
MOD_NEK2_1	463	468	PF00069	0.703
MOD_NEK2_1	471	476	PF00069	0.778
MOD_NEK2_1	501	506	PF00069	0.621
MOD_NEK2_1	60	65	PF00069	0.531
MOD_NEK2_1	629	634	PF00069	0.531
MOD_NEK2_1	744	749	PF00069	0.537
MOD_NEK2_1	780	785	PF00069	0.685
MOD_NEK2_1	836	841	PF00069	0.532
MOD_NEK2_2	308	313	PF00069	0.552
MOD_NEK2_2	791	796	PF00069	0.574
MOD_PIKK_1	41	47	PF00454	0.536
MOD_PIKK_1	463	469	PF00454	0.723
MOD_PIKK_1	577	583	PF00454	0.554
MOD_PIKK_1	60	66	PF00454	0.638
MOD_PIKK_1	654	660	PF00454	0.665
MOD_PIKK_1	702	708	PF00454	0.530
MOD_PIKK_1	780	786	PF00454	0.686
MOD_PIKK_1	814	820	PF00454	0.595
MOD_PK_1	782	788	PF00069	0.534
MOD_PKA_2	143	149	PF00069	0.561
MOD_PKA_2	358	364	PF00069	0.559
MOD_PKA_2	400	406	PF00069	0.562
MOD_PKA_2	691	697	PF00069	0.677
MOD_PKA_2	713	719	PF00069	0.679
MOD_PKA_2	8	14	PF00069	0.582
MOD_PKB_1	135	143	PF00069	0.559
MOD_Plk_1	135	141	PF00069	0.558
MOD_Plk_1	432	438	PF00069	0.564
MOD_Plk_1	791	797	PF00069	0.575
MOD_Plk_4	21	27	PF00069	0.554
MOD_Plk_4	56	62	PF00069	0.560
MOD_Plk_4	782	788	PF00069	0.549
MOD_ProDKin_1	104	110	PF00069	0.733
MOD_ProDKin_1	160	166	PF00069	0.535
MOD_ProDKin_1	205	211	PF00069	0.546
MOD_ProDKin_1	30	36	PF00069	0.672
MOD_ProDKin_1	327	333	PF00069	0.599
MOD_ProDKin_1	403	409	PF00069	0.745
MOD_ProDKin_1	416	422	PF00069	0.594
MOD_ProDKin_1	437	443	PF00069	0.608
MOD_ProDKin_1	45	51	PF00069	0.535
MOD_ProDKin_1	481	487	PF00069	0.651
MOD_ProDKin_1	503	509	PF00069	0.727
MOD_ProDKin_1	598	604	PF00069	0.518
MOD_ProDKin_1	624	630	PF00069	0.682
MOD_ProDKin_1	644	650	PF00069	0.488
MOD_ProDKin_1	732	738	PF00069	0.584
MOD_ProDKin_1	757	763	PF00069	0.549
MOD_ProDKin_1	764	770	PF00069	0.515
MOD_ProDKin_1	787	793	PF00069	0.680
MOD_ProDKin_1	818	824	PF00069	0.705
MOD_ProDKin_1	9	15	PF00069	0.582
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.546
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.502
TRG_ENDOCYTIC_2	186	189	PF00928	0.546
TRG_ENDOCYTIC_2	236	239	PF00928	0.630
TRG_ENDOCYTIC_2	25	28	PF00928	0.552
TRG_ENDOCYTIC_2	309	312	PF00928	0.543
TRG_ENDOCYTIC_2	562	565	PF00928	0.700
TRG_ENDOCYTIC_2	659	662	PF00928	0.499
TRG_ER_diArg_1	168	171	PF00400	0.546
TRG_ER_diArg_1	227	229	PF00400	0.546
TRG_ER_diArg_1	409	411	PF00400	0.733
TRG_NLS_MonoExtC_3	224	229	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF88	Leishmania donovani	63%	99%
A4I1D3	Leishmania infantum	62%	99%
E9AXH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	97%
Q4QA02	Leishmania major	63%	100%