Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HE25_LEIBR

TriTrypDb:

LbrM.25.0780 , LBRM2903_250016700

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HE25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.407
CLV_C14_Caspase3-7	46	50	PF00656	0.401
CLV_NRD_NRD_1	130	132	PF00675	0.705
CLV_NRD_NRD_1	163	165	PF00675	0.697
CLV_NRD_NRD_1	244	246	PF00675	0.269
CLV_PCSK_KEX2_1	163	165	PF00082	0.720
CLV_PCSK_KEX2_1	244	246	PF00082	0.304
CLV_PCSK_SKI1_1	134	138	PF00082	0.617
DEG_APCC_DBOX_1	244	252	PF00400	0.472
DOC_CKS1_1	232	237	PF01111	0.606
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.414
DOC_MAPK_gen_1	244	251	PF00069	0.469
DOC_PP4_FxxP_1	216	219	PF00568	0.699
DOC_PP4_FxxP_1	236	239	PF00568	0.600
DOC_USP7_MATH_1	154	158	PF00917	0.463
DOC_USP7_MATH_1	188	192	PF00917	0.391
DOC_USP7_MATH_1	257	261	PF00917	0.377
DOC_USP7_MATH_1	315	319	PF00917	0.450
DOC_USP7_UBL2_3	83	87	PF12436	0.642
DOC_WW_Pin1_4	119	124	PF00397	0.493
DOC_WW_Pin1_4	215	220	PF00397	0.703
DOC_WW_Pin1_4	231	236	PF00397	0.641
DOC_WW_Pin1_4	290	295	PF00397	0.438
LIG_14-3-3_CanoR_1	300	307	PF00244	0.509
LIG_14-3-3_CanoR_1	34	38	PF00244	0.409
LIG_14-3-3_CanoR_1	9	13	PF00244	0.516
LIG_CaM_NSCaTE_8	261	268	PF13499	0.424
LIG_FHA_1	110	116	PF00498	0.338
LIG_FHA_1	15	21	PF00498	0.223
LIG_FHA_1	95	101	PF00498	0.227
LIG_FHA_2	232	238	PF00498	0.604
LIG_LIR_Apic_2	215	219	PF02991	0.599
LIG_LIR_Apic_2	234	239	PF02991	0.672
LIG_LIR_Gen_1	13	22	PF02991	0.363
LIG_LIR_Gen_1	191	202	PF02991	0.417
LIG_LIR_Gen_1	36	43	PF02991	0.482
LIG_LIR_Gen_1	60	69	PF02991	0.263
LIG_LIR_LC3C_4	60	65	PF02991	0.214
LIG_LIR_Nem_3	13	18	PF02991	0.363
LIG_LIR_Nem_3	157	162	PF02991	0.430
LIG_LIR_Nem_3	191	197	PF02991	0.434
LIG_LIR_Nem_3	237	243	PF02991	0.650
LIG_LIR_Nem_3	259	264	PF02991	0.256
LIG_LIR_Nem_3	36	40	PF02991	0.478
LIG_LIR_Nem_3	60	64	PF02991	0.269
LIG_NRBOX	110	116	PF00104	0.361
LIG_Pex14_2	236	240	PF04695	0.630
LIG_SH2_CRK	61	65	PF00017	0.227
LIG_SH2_STAP1	144	148	PF00017	0.467
LIG_SH2_STAP1	15	19	PF00017	0.304
LIG_SH2_STAT5	102	105	PF00017	0.304
LIG_SH2_STAT5	144	147	PF00017	0.467
LIG_SH2_STAT5	26	29	PF00017	0.372
LIG_SH3_1	226	232	PF00018	0.609
LIG_SH3_3	226	232	PF00018	0.720
LIG_SUMO_SIM_anti_2	247	252	PF11976	0.227
LIG_SUMO_SIM_par_1	16	23	PF11976	0.298
LIG_SUMO_SIM_par_1	247	252	PF11976	0.223
LIG_SUMO_SIM_par_1	60	67	PF11976	0.214
LIG_TYR_ITIM	192	197	PF00017	0.465
LIG_WRC_WIRS_1	15	20	PF05994	0.227
MOD_CDK_SPK_2	290	295	PF00069	0.438
MOD_CK1_1	11	17	PF00069	0.227
MOD_CK1_1	215	221	PF00069	0.603
MOD_CK1_1	274	280	PF00069	0.480
MOD_CK1_1	302	308	PF00069	0.497
MOD_CK2_1	231	237	PF00069	0.602
MOD_CK2_1	33	39	PF00069	0.420
MOD_DYRK1A_RPxSP_1	119	123	PF00069	0.398
MOD_GlcNHglycan	146	149	PF01048	0.681
MOD_GlcNHglycan	151	154	PF01048	0.656
MOD_GlcNHglycan	184	187	PF01048	0.650
MOD_GlcNHglycan	273	276	PF01048	0.700
MOD_GlcNHglycan	283	286	PF01048	0.725
MOD_GlcNHglycan	301	304	PF01048	0.725
MOD_GlcNHglycan	311	314	PF01048	0.659
MOD_GlcNHglycan	317	320	PF01048	0.626
MOD_GlcNHglycan	55	58	PF01048	0.654
MOD_GlcNHglycan	83	86	PF01048	0.442
MOD_GSK3_1	142	149	PF00069	0.442
MOD_GSK3_1	173	180	PF00069	0.442
MOD_GSK3_1	267	274	PF00069	0.415
MOD_NEK2_1	1	6	PF00069	0.600
MOD_NEK2_1	109	114	PF00069	0.392
MOD_NEK2_1	249	254	PF00069	0.323
MOD_NEK2_1	256	261	PF00069	0.367
MOD_NEK2_1	266	271	PF00069	0.521
MOD_NEK2_1	53	58	PF00069	0.387
MOD_NEK2_1	70	75	PF00069	0.304
MOD_NEK2_1	94	99	PF00069	0.300
MOD_OFUCOSY	92	98	PF10250	0.227
MOD_PIKK_1	26	32	PF00454	0.414
MOD_PIKK_1	274	280	PF00454	0.463
MOD_PIKK_1	41	47	PF00454	0.365
MOD_PKA_2	289	295	PF00069	0.491
MOD_PKA_2	299	305	PF00069	0.479
MOD_PKA_2	33	39	PF00069	0.413
MOD_PKA_2	8	14	PF00069	0.414
MOD_Plk_4	14	20	PF00069	0.288
MOD_Plk_4	33	39	PF00069	0.490
MOD_ProDKin_1	119	125	PF00069	0.495
MOD_ProDKin_1	215	221	PF00069	0.705
MOD_ProDKin_1	231	237	PF00069	0.634
MOD_ProDKin_1	290	296	PF00069	0.438
TRG_ENDOCYTIC_2	102	105	PF00928	0.304
TRG_ENDOCYTIC_2	106	109	PF00928	0.304
TRG_ENDOCYTIC_2	15	18	PF00928	0.304
TRG_ENDOCYTIC_2	194	197	PF00928	0.421
TRG_ENDOCYTIC_2	61	64	PF00928	0.304
TRG_ER_diArg_1	162	164	PF00400	0.438
TRG_ER_diArg_1	243	245	PF00400	0.657
TRG_ER_diLys_1	325	328	PF00400	0.486
TRG_NLS_MonoExtC_3	130	135	PF00514	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE40	Leptomonas seymouri	39%	98%
A0A3Q8ICA7	Leishmania donovani	58%	96%
A4I1D1	Leishmania infantum	58%	96%
E9AXG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%
Q4QA04	Leishmania major	57%	100%