39S ribosomal protein L23, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE24_LEIBR

TriTrypDb:

LbrM.25.0770 , LBRM2903_250016600

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4HE24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE24

PDB structure(s): 7aih_N , 7am2_N , 7ane_N

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.550
CLV_NRD_NRD_1	117	119	PF00675	0.410
CLV_NRD_NRD_1	136	138	PF00675	0.286
CLV_NRD_NRD_1	207	209	PF00675	0.427
CLV_PCSK_FUR_1	205	209	PF00082	0.402
CLV_PCSK_KEX2_1	136	138	PF00082	0.453
CLV_PCSK_KEX2_1	207	209	PF00082	0.426
CLV_PCSK_KEX2_1	48	50	PF00082	0.605
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.626
CLV_PCSK_SKI1_1	156	160	PF00082	0.393
CLV_PCSK_SKI1_1	169	173	PF00082	0.389
CLV_PCSK_SKI1_1	207	211	PF00082	0.530
CLV_PCSK_SKI1_1	238	242	PF00082	0.510
DEG_APCC_DBOX_1	155	163	PF00400	0.377
DEG_Nend_UBRbox_1	1	4	PF02207	0.674
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.362
DOC_MAPK_MEF2A_6	148	157	PF00069	0.490
DOC_PP4_FxxP_1	172	175	PF00568	0.365
DOC_PP4_FxxP_1	52	55	PF00568	0.498
DOC_PP4_FxxP_1	91	94	PF00568	0.477
DOC_USP7_MATH_1	40	44	PF00917	0.670
DOC_WW_Pin1_4	135	140	PF00397	0.481
DOC_WW_Pin1_4	228	233	PF00397	0.394
DOC_WW_Pin1_4	243	248	PF00397	0.550
DOC_WW_Pin1_4	3	8	PF00397	0.443
LIG_14-3-3_CanoR_1	25	32	PF00244	0.617
LIG_BRCT_BRCA1_1	146	150	PF00533	0.455
LIG_BRCT_BRCA1_1	233	237	PF00533	0.468
LIG_deltaCOP1_diTrp_1	121	125	PF00928	0.406
LIG_EH1_1	7	15	PF00400	0.448
LIG_FHA_1	16	22	PF00498	0.454
LIG_FHA_1	166	172	PF00498	0.475
LIG_FHA_1	39	45	PF00498	0.628
LIG_LIR_Apic_2	121	126	PF02991	0.392
LIG_LIR_Nem_3	103	109	PF02991	0.406
LIG_LIR_Nem_3	138	144	PF02991	0.355
LIG_LIR_Nem_3	147	153	PF02991	0.492
LIG_LIR_Nem_3	234	240	PF02991	0.476
LIG_MLH1_MIPbox_1	146	150	PF16413	0.492
LIG_Pex14_2	142	146	PF04695	0.357
LIG_REV1ctd_RIR_1	143	150	PF16727	0.356
LIG_SH2_CRK	53	57	PF00017	0.483
LIG_SH2_STAP1	80	84	PF00017	0.334
LIG_SH2_STAT5	141	144	PF00017	0.396
LIG_SH2_STAT5	149	152	PF00017	0.370
LIG_SH2_STAT5	186	189	PF00017	0.361
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.459
LIG_SUMO_SIM_par_1	225	231	PF11976	0.343
LIG_TRAF2_1	179	182	PF00917	0.456
MOD_CDK_SPxxK_3	243	250	PF00069	0.560
MOD_CK1_1	231	237	PF00069	0.463
MOD_CK1_1	35	41	PF00069	0.711
MOD_CK1_1	43	49	PF00069	0.694
MOD_CK1_1	6	12	PF00069	0.545
MOD_CK2_1	176	182	PF00069	0.386
MOD_CMANNOS	75	78	PF00535	0.432
MOD_Cter_Amidation	205	208	PF01082	0.395
MOD_GSK3_1	2	9	PF00069	0.641
MOD_GSK3_1	21	28	PF00069	0.604
MOD_GSK3_1	32	39	PF00069	0.655
MOD_N-GLC_1	164	169	PF02516	0.392
MOD_NEK2_1	63	68	PF00069	0.669
MOD_PKA_2	15	21	PF00069	0.477
MOD_PKA_2	26	32	PF00069	0.526
MOD_Plk_2-3	215	221	PF00069	0.461
MOD_Plk_4	158	164	PF00069	0.369
MOD_Plk_4	231	237	PF00069	0.496
MOD_Plk_4	40	46	PF00069	0.593
MOD_ProDKin_1	135	141	PF00069	0.470
MOD_ProDKin_1	228	234	PF00069	0.396
MOD_ProDKin_1	243	249	PF00069	0.555
MOD_ProDKin_1	3	9	PF00069	0.444
MOD_SUMO_for_1	209	212	PF00179	0.535
MOD_SUMO_rev_2	212	219	PF00179	0.422
MOD_SUMO_rev_2	244	251	PF00179	0.590
TRG_ENDOCYTIC_2	53	56	PF00928	0.488
TRG_ER_diArg_1	102	105	PF00400	0.410
TRG_ER_diArg_1	135	137	PF00400	0.461
TRG_ER_diArg_1	197	200	PF00400	0.399
TRG_ER_diArg_1	204	207	PF00400	0.422
TRG_ER_diArg_1	49	52	PF00400	0.510
TRG_ER_diArg_1	64	67	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z4	Leptomonas seymouri	82%	100%
A0A0S4J3V0	Bodo saltans	58%	100%
A0A1X0P4M1	Trypanosomatidae	75%	100%
A0A3Q8IGI5	Leishmania donovani	88%	100%
A0A422NTM0	Trypanosoma rangeli	68%	100%
A4I1D0	Leishmania infantum	88%	100%
D0A5M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AXG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QA05	Leishmania major	87%	98%