PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE19_LEIBR

TriTrypDb:

LbrM.25.0720 , LBRM2903_250016100

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.482
CLV_NRD_NRD_1	220	222	PF00675	0.599
CLV_NRD_NRD_1	225	227	PF00675	0.594
CLV_NRD_NRD_1	251	253	PF00675	0.613
CLV_NRD_NRD_1	263	265	PF00675	0.645
CLV_NRD_NRD_1	380	382	PF00675	0.762
CLV_NRD_NRD_1	46	48	PF00675	0.420
CLV_PCSK_KEX2_1	167	169	PF00082	0.455
CLV_PCSK_KEX2_1	220	222	PF00082	0.599
CLV_PCSK_KEX2_1	225	227	PF00082	0.594
CLV_PCSK_KEX2_1	251	253	PF00082	0.575
CLV_PCSK_KEX2_1	262	264	PF00082	0.596
CLV_PCSK_KEX2_1	332	334	PF00082	0.544
CLV_PCSK_KEX2_1	380	382	PF00082	0.762
CLV_PCSK_KEX2_1	46	48	PF00082	0.408
CLV_PCSK_KEX2_1	89	91	PF00082	0.570
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.568
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.626
CLV_PCSK_PC7_1	221	227	PF00082	0.606
CLV_PCSK_SKI1_1	168	172	PF00082	0.435
CLV_PCSK_SKI1_1	220	224	PF00082	0.568
CLV_PCSK_SKI1_1	263	267	PF00082	0.606
CLV_PCSK_SKI1_1	31	35	PF00082	0.370
CLV_PCSK_SKI1_1	36	40	PF00082	0.476
CLV_PCSK_SKI1_1	47	51	PF00082	0.438
CLV_PCSK_SKI1_1	78	82	PF00082	0.443
DEG_APCC_DBOX_1	379	387	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DOC_CYCLIN_RxL_1	247	259	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.466
DOC_MAPK_gen_1	167	173	PF00069	0.398
DOC_MAPK_gen_1	78	86	PF00069	0.516
DOC_MAPK_gen_1	88	96	PF00069	0.499
DOC_MAPK_MEF2A_6	183	192	PF00069	0.494
DOC_USP7_MATH_1	114	118	PF00917	0.567
DOC_USP7_MATH_1	337	341	PF00917	0.702
DOC_USP7_MATH_1	344	348	PF00917	0.742
DOC_USP7_UBL2_3	398	402	PF12436	0.695
DOC_WW_Pin1_4	174	179	PF00397	0.517
DOC_WW_Pin1_4	308	313	PF00397	0.708
DOC_WW_Pin1_4	409	414	PF00397	0.551
LIG_14-3-3_CanoR_1	174	178	PF00244	0.438
LIG_14-3-3_CanoR_1	220	228	PF00244	0.650
LIG_14-3-3_CanoR_1	252	258	PF00244	0.553
LIG_14-3-3_CanoR_1	263	273	PF00244	0.509
LIG_14-3-3_CanoR_1	78	84	PF00244	0.502
LIG_APCC_ABBA_1	304	309	PF00400	0.444
LIG_BIR_III_2	7	11	PF00653	0.492
LIG_deltaCOP1_diTrp_1	227	235	PF00928	0.462
LIG_eIF4E_1	165	171	PF01652	0.495
LIG_FHA_1	123	129	PF00498	0.542
LIG_FHA_1	136	142	PF00498	0.623
LIG_FHA_1	183	189	PF00498	0.385
LIG_FHA_1	232	238	PF00498	0.572
LIG_FHA_1	268	274	PF00498	0.537
LIG_FHA_2	159	165	PF00498	0.452
LIG_FHA_2	241	247	PF00498	0.504
LIG_FHA_2	266	272	PF00498	0.434
LIG_FHA_2	311	317	PF00498	0.458
LIG_LIR_Apic_2	227	231	PF02991	0.677
LIG_LIR_Apic_2	234	239	PF02991	0.559
LIG_LIR_Gen_1	166	173	PF02991	0.499
LIG_LIR_Gen_1	305	315	PF02991	0.637
LIG_LIR_Gen_1	82	87	PF02991	0.327
LIG_LIR_Nem_3	117	121	PF02991	0.471
LIG_LIR_Nem_3	152	158	PF02991	0.403
LIG_LIR_Nem_3	161	165	PF02991	0.399
LIG_LIR_Nem_3	166	172	PF02991	0.416
LIG_LIR_Nem_3	305	310	PF02991	0.581
LIG_LIR_Nem_3	82	86	PF02991	0.512
LIG_Pex14_1	44	48	PF04695	0.511
LIG_Pex14_2	158	162	PF04695	0.365
LIG_PTB_Apo_2	229	236	PF02174	0.462
LIG_SH2_CRK	118	122	PF00017	0.380
LIG_SH2_SRC	236	239	PF00017	0.610
LIG_SH2_STAP1	165	169	PF00017	0.358
LIG_SH2_STAT3	317	320	PF00017	0.478
LIG_SH2_STAT5	100	103	PF00017	0.451
LIG_SH2_STAT5	157	160	PF00017	0.356
LIG_SH2_STAT5	169	172	PF00017	0.375
LIG_SH2_STAT5	181	184	PF00017	0.499
LIG_SH2_STAT5	191	194	PF00017	0.463
LIG_SH2_STAT5	236	239	PF00017	0.635
LIG_SH2_STAT5	48	51	PF00017	0.265
LIG_SH3_2	111	116	PF14604	0.607
LIG_SH3_3	108	114	PF00018	0.499
LIG_SH3_3	17	23	PF00018	0.438
LIG_TRAF2_1	161	164	PF00917	0.408
LIG_TRAF2_1	177	180	PF00917	0.433
LIG_TRFH_1	235	239	PF08558	0.480
LIG_WRC_WIRS_1	83	88	PF05994	0.338
MOD_CDC14_SPxK_1	417	420	PF00782	0.524
MOD_CDK_SPxK_1	414	420	PF00069	0.549
MOD_CK1_1	133	139	PF00069	0.641
MOD_CK1_1	142	148	PF00069	0.539
MOD_CK1_1	282	288	PF00069	0.518
MOD_CK1_1	82	88	PF00069	0.516
MOD_CK2_1	124	130	PF00069	0.573
MOD_CK2_1	158	164	PF00069	0.410
MOD_CK2_1	174	180	PF00069	0.423
MOD_CK2_1	240	246	PF00069	0.508
MOD_CK2_1	253	259	PF00069	0.498
MOD_CK2_1	265	271	PF00069	0.351
MOD_CK2_1	302	308	PF00069	0.674
MOD_CK2_1	310	316	PF00069	0.700
MOD_CK2_1	366	372	PF00069	0.619
MOD_GlcNHglycan	103	108	PF01048	0.583
MOD_GlcNHglycan	145	148	PF01048	0.455
MOD_GlcNHglycan	194	198	PF01048	0.507
MOD_GlcNHglycan	281	284	PF01048	0.592
MOD_GlcNHglycan	321	324	PF01048	0.605
MOD_GlcNHglycan	347	350	PF01048	0.819
MOD_GlcNHglycan	359	362	PF01048	0.722
MOD_GlcNHglycan	376	379	PF01048	0.821
MOD_GlcNHglycan	388	391	PF01048	0.582
MOD_GlcNHglycan	394	397	PF01048	0.686
MOD_GSK3_1	120	127	PF00069	0.519
MOD_GSK3_1	129	136	PF00069	0.572
MOD_GSK3_1	139	146	PF00069	0.609
MOD_GSK3_1	282	289	PF00069	0.490
MOD_GSK3_1	366	373	PF00069	0.754
MOD_N-GLC_1	133	138	PF02516	0.485
MOD_N-GLC_1	231	236	PF02516	0.539
MOD_N-GLC_1	345	350	PF02516	0.623
MOD_N-GLC_1	374	379	PF02516	0.566
MOD_N-GLC_2	151	153	PF02516	0.545
MOD_NEK2_1	172	177	PF00069	0.476
MOD_NEK2_1	265	270	PF00069	0.448
MOD_NEK2_1	370	375	PF00069	0.711
MOD_NEK2_1	58	63	PF00069	0.421
MOD_NEK2_2	231	236	PF00069	0.459
MOD_NEK2_2	302	307	PF00069	0.439
MOD_PIKK_1	15	21	PF00454	0.470
MOD_PKA_1	220	226	PF00069	0.647
MOD_PKA_2	142	148	PF00069	0.487
MOD_PKA_2	173	179	PF00069	0.498
MOD_PKA_2	220	226	PF00069	0.647
MOD_PKA_2	325	331	PF00069	0.750
MOD_PKB_1	262	270	PF00069	0.511
MOD_PKB_1	324	332	PF00069	0.503
MOD_Plk_1	139	145	PF00069	0.607
MOD_Plk_1	231	237	PF00069	0.459
MOD_Plk_1	366	372	PF00069	0.534
MOD_Plk_2-3	124	130	PF00069	0.527
MOD_Plk_2-3	240	246	PF00069	0.497
MOD_Plk_2-3	366	372	PF00069	0.534
MOD_Plk_4	124	130	PF00069	0.431
MOD_Plk_4	151	157	PF00069	0.543
MOD_Plk_4	231	237	PF00069	0.568
MOD_Plk_4	310	316	PF00069	0.550
MOD_Plk_4	79	85	PF00069	0.497
MOD_ProDKin_1	174	180	PF00069	0.515
MOD_ProDKin_1	308	314	PF00069	0.705
MOD_ProDKin_1	409	415	PF00069	0.547
MOD_SUMO_rev_2	327	334	PF00179	0.549
TRG_DiLeu_BaEn_1	124	129	PF01217	0.426
TRG_ENDOCYTIC_2	118	121	PF00928	0.387
TRG_ENDOCYTIC_2	155	158	PF00928	0.379
TRG_ENDOCYTIC_2	169	172	PF00928	0.363
TRG_ER_diArg_1	167	169	PF00400	0.518
TRG_ER_diArg_1	220	222	PF00400	0.600
TRG_ER_diArg_1	250	252	PF00400	0.627
TRG_ER_diArg_1	262	264	PF00400	0.645
TRG_ER_diArg_1	380	382	PF00400	0.761
TRG_ER_diArg_1	46	48	PF00400	0.427
TRG_ER_diArg_1	71	74	PF00400	0.394
TRG_ER_diArg_1	75	78	PF00400	0.569
TRG_NLS_MonoExtC_3	87	93	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI8	Leptomonas seymouri	50%	100%
A0A1X0P4C2	Trypanosomatidae	31%	100%
A0A3S7WYY8	Leishmania donovani	68%	100%
A0A422MPP3	Trypanosoma rangeli	36%	100%
A4I1C6	Leishmania infantum	68%	100%
E9AXG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QA10	Leishmania major	64%	100%
V5BXG5	Trypanosoma cruzi	33%	100%