Prefoldin subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit 4

Gene product:

prefoldin subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HE17_LEIBR

TriTrypDb:

LbrM.25.0700 , LBRM2903_250015900

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE17

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.275
CLV_NRD_NRD_1	36	38	PF00675	0.199
CLV_PCSK_KEX2_1	29	31	PF00082	0.267
CLV_PCSK_KEX2_1	36	38	PF00082	0.253
CLV_PCSK_SKI1_1	36	40	PF00082	0.276
CLV_PCSK_SKI1_1	62	66	PF00082	0.305
DOC_CYCLIN_RxL_1	30	44	PF00134	0.532
DOC_MAPK_MEF2A_6	6	13	PF00069	0.594
LIG_FHA_1	40	46	PF00498	0.412
LIG_FHA_2	12	18	PF00498	0.408
LIG_LIR_Gen_1	67	77	PF02991	0.483
LIG_LIR_Nem_3	67	72	PF02991	0.483
LIG_Pex14_2	65	69	PF04695	0.453
LIG_SH2_STAT5	122	125	PF00017	0.425
LIG_SH2_STAT5	63	66	PF00017	0.453
LIG_SUMO_SIM_par_1	8	14	PF11976	0.531
MOD_CK2_1	87	93	PF00069	0.411
MOD_N-GLC_2	20	22	PF02516	0.418
MOD_NEK2_1	1	6	PF00069	0.603
MOD_PIKK_1	116	122	PF00454	0.324
MOD_Plk_1	11	17	PF00069	0.481
MOD_SUMO_rev_2	12	21	PF00179	0.284
MOD_SUMO_rev_2	54	64	PF00179	0.418
MOD_SUMO_rev_2	93	102	PF00179	0.360
TRG_ENDOCYTIC_2	114	117	PF00928	0.306
TRG_ER_diArg_1	29	31	PF00400	0.300
TRG_ER_diArg_1	36	38	PF00400	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU3	Leptomonas seymouri	84%	98%
A0A0S4J0Y8	Bodo saltans	47%	100%
A0A1X0P5G6	Trypanosomatidae	52%	100%
A0A3Q8ID97	Leishmania donovani	90%	99%
A0A3S5IQX3	Trypanosoma rangeli	47%	100%
A4I1C4	Leishmania infantum	90%	99%
D0A5L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
P53900	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	98%
Q2TBR6	Bos taurus	30%	94%
Q4QA12	Leishmania major	88%	100%
Q54TB7	Dictyostelium discoideum	34%	95%
Q9M4B5	Arabidopsis thaliana	38%	98%
Q9M4C4	Avena fatua	38%	100%
Q9NQP4	Homo sapiens	30%	94%
Q9VRL3	Drosophila melanogaster	30%	91%