DNL-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNL zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HE15_LEIBR

TriTrypDb:

LbrM.25.0680 , LBRM2903_250015700

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE15

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0031647	regulation of protein stability	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050821	protein stabilization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0005515	protein binding	2	1
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	42	44	PF00675	0.658
CLV_PCSK_KEX2_1	147	149	PF00082	0.405
CLV_PCSK_KEX2_1	42	44	PF00082	0.658
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.405
CLV_PCSK_SKI1_1	144	148	PF00082	0.405
CLV_PCSK_SKI1_1	169	173	PF00082	0.405
DEG_SPOP_SBC_1	72	76	PF00917	0.574
DOC_CYCLIN_RxL_1	166	174	PF00134	0.405
DOC_MAPK_gen_1	191	200	PF00069	0.573
DOC_PP2B_LxvP_1	109	112	PF13499	0.569
DOC_USP7_MATH_1	2	6	PF00917	0.579
DOC_USP7_MATH_1	57	61	PF00917	0.577
DOC_USP7_MATH_1	71	75	PF00917	0.551
DOC_USP7_MATH_1	83	87	PF00917	0.606
DOC_USP7_UBL2_3	147	151	PF12436	0.405
DOC_WW_Pin1_4	61	66	PF00397	0.731
DOC_WW_Pin1_4	95	100	PF00397	0.595
LIG_14-3-3_CanoR_1	10	19	PF00244	0.581
LIG_14-3-3_CanoR_1	24	32	PF00244	0.579
LIG_14-3-3_CanoR_1	42	50	PF00244	0.594
LIG_14-3-3_CanoR_1	58	65	PF00244	0.613
LIG_EH1_1	31	39	PF00400	0.472
LIG_FHA_1	153	159	PF00498	0.459
LIG_FHA_1	45	51	PF00498	0.574
LIG_FHA_2	182	188	PF00498	0.405
LIG_FHA_2	201	207	PF00498	0.552
LIG_FHA_2	86	92	PF00498	0.624
LIG_LIR_Gen_1	195	204	PF02991	0.587
LIG_LIR_Gen_1	206	215	PF02991	0.549
LIG_LIR_Gen_1	9	19	PF02991	0.501
LIG_LIR_Nem_3	142	146	PF02991	0.405
LIG_LIR_Nem_3	195	200	PF02991	0.569
LIG_LIR_Nem_3	204	210	PF02991	0.560
LIG_LIR_Nem_3	9	15	PF02991	0.503
LIG_SH2_CRK	143	147	PF00017	0.405
LIG_SH2_CRK	207	211	PF00017	0.662
LIG_SH2_STAT5	154	157	PF00017	0.405
LIG_SH3_3	158	164	PF00018	0.405
LIG_SH3_3	207	213	PF00018	0.663
LIG_SUMO_SIM_par_1	157	162	PF11976	0.447
LIG_TRAF2_1	89	92	PF00917	0.471
MOD_CK1_1	33	39	PF00069	0.682
MOD_CK1_1	46	52	PF00069	0.601
MOD_CK1_1	86	92	PF00069	0.618
MOD_CK2_1	181	187	PF00069	0.405
MOD_CK2_1	85	91	PF00069	0.614
MOD_GlcNHglycan	12	15	PF01048	0.582
MOD_GlcNHglycan	68	72	PF01048	0.639
MOD_GlcNHglycan	85	88	PF01048	0.483
MOD_GSK3_1	2	9	PF00069	0.694
MOD_GSK3_1	24	31	PF00069	0.564
MOD_GSK3_1	44	51	PF00069	0.580
MOD_GSK3_1	57	64	PF00069	0.636
MOD_GSK3_1	67	74	PF00069	0.586
MOD_GSK3_1	81	88	PF00069	0.658
MOD_N-GLC_1	52	57	PF02516	0.537
MOD_NEK2_1	120	125	PF00069	0.550
MOD_NEK2_1	179	184	PF00069	0.417
MOD_NEK2_1	32	37	PF00069	0.634
MOD_PIKK_1	57	63	PF00454	0.583
MOD_PKA_1	147	153	PF00069	0.405
MOD_PKA_2	147	153	PF00069	0.405
MOD_PKA_2	2	8	PF00069	0.599
MOD_PKA_2	57	63	PF00069	0.559
MOD_Plk_1	114	120	PF00069	0.732
MOD_Plk_4	115	121	PF00069	0.615
MOD_Plk_4	193	199	PF00069	0.622
MOD_Plk_4	33	39	PF00069	0.555
MOD_ProDKin_1	61	67	PF00069	0.730
MOD_ProDKin_1	95	101	PF00069	0.583
MOD_SUMO_for_1	192	195	PF00179	0.405
TRG_DiLeu_BaEn_3	91	97	PF01217	0.456
TRG_ENDOCYTIC_2	143	146	PF00928	0.405
TRG_ENDOCYTIC_2	207	210	PF00928	0.663
TRG_ER_diArg_1	23	26	PF00400	0.520
TRG_ER_diArg_1	42	44	PF00400	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDE1	Leishmania donovani	78%	91%
A4I1C2	Leishmania infantum	78%	91%
E9AXF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	91%
Q4QA14	Leishmania major	77%	100%