Sec23_trunk domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HE13_LEIBR

TriTrypDb:

LbrM.25.0660 , LBRM2903_250015500

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HE13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.678
CLV_NRD_NRD_1	219	221	PF00675	0.568
CLV_NRD_NRD_1	63	65	PF00675	0.708
CLV_PCSK_KEX2_1	106	108	PF00082	0.678
CLV_PCSK_KEX2_1	218	220	PF00082	0.566
CLV_PCSK_SKI1_1	83	87	PF00082	0.697
CLV_Separin_Metazoa	61	65	PF03568	0.319
DEG_SPOP_SBC_1	93	97	PF00917	0.483
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.416
DOC_PP2B_LxvP_1	12	15	PF13499	0.422
DOC_PP2B_LxvP_1	123	126	PF13499	0.455
DOC_PP2B_LxvP_1	261	264	PF13499	0.639
DOC_USP7_MATH_1	126	130	PF00917	0.516
DOC_USP7_MATH_1	19	23	PF00917	0.474
DOC_USP7_MATH_1	91	95	PF00917	0.484
DOC_WW_Pin1_4	317	322	PF00397	0.705
DOC_WW_Pin1_4	71	76	PF00397	0.417
LIG_Actin_WH2_2	143	160	PF00022	0.307
LIG_FHA_1	142	148	PF00498	0.423
LIG_FHA_1	169	175	PF00498	0.296
LIG_FHA_1	58	64	PF00498	0.439
LIG_LIR_Apic_2	276	280	PF02991	0.770
LIG_LIR_Apic_2	303	307	PF02991	0.670
LIG_LIR_Gen_1	74	82	PF02991	0.293
LIG_LIR_Nem_3	136	141	PF02991	0.452
LIG_LIR_Nem_3	74	79	PF02991	0.290
LIG_PTB_Apo_2	113	120	PF02174	0.404
LIG_Rb_LxCxE_1	21	35	PF01857	0.303
LIG_SH2_CRK	277	281	PF00017	0.848
LIG_SH2_CRK	319	323	PF00017	0.660
LIG_SH2_CRK	76	80	PF00017	0.295
LIG_SH2_GRB2like	295	298	PF00017	0.794
LIG_SH2_GRB2like	331	334	PF00017	0.659
LIG_SH2_NCK_1	304	308	PF00017	0.663
LIG_SH2_NCK_1	319	323	PF00017	0.630
LIG_SH2_SRC	331	334	PF00017	0.740
LIG_SH2_STAT3	231	234	PF00017	0.652
LIG_SH2_STAT3	236	239	PF00017	0.637
LIG_SH2_STAT3	241	244	PF00017	0.625
LIG_SH2_STAT3	246	249	PF00017	0.641
LIG_SH2_STAT3	251	254	PF00017	0.739
LIG_SH2_STAT3	33	36	PF00017	0.443
LIG_SH2_STAT5	76	79	PF00017	0.290
LIG_SUMO_SIM_anti_2	20	28	PF11976	0.401
LIG_UBA3_1	26	34	PF00899	0.296
LIG_WRC_WIRS_1	82	87	PF05994	0.295
MOD_CK1_1	22	28	PF00069	0.386
MOD_CK1_1	334	340	PF00069	0.682
MOD_CK1_1	74	80	PF00069	0.423
MOD_CK1_1	81	87	PF00069	0.402
MOD_CK1_1	94	100	PF00069	0.441
MOD_Cter_Amidation	216	219	PF01082	0.453
MOD_GlcNHglycan	12	15	PF01048	0.747
MOD_GlcNHglycan	152	155	PF01048	0.655
MOD_GlcNHglycan	207	210	PF01048	0.412
MOD_GlcNHglycan	298	301	PF01048	0.567
MOD_GlcNHglycan	325	329	PF01048	0.506
MOD_GlcNHglycan	97	100	PF01048	0.736
MOD_GSK3_1	6	13	PF00069	0.565
MOD_GSK3_1	71	78	PF00069	0.333
MOD_GSK3_1	91	98	PF00069	0.425
MOD_N-GLC_1	134	139	PF02516	0.567
MOD_N-GLC_1	142	147	PF02516	0.507
MOD_N-GLC_1	296	301	PF02516	0.565
MOD_N-GLC_1	332	337	PF02516	0.465
MOD_NEK2_1	10	15	PF00069	0.454
MOD_NEK2_1	141	146	PF00069	0.430
MOD_NEK2_1	205	210	PF00069	0.412
MOD_NEK2_1	92	97	PF00069	0.454
MOD_NEK2_2	75	80	PF00069	0.293
MOD_PIKK_1	32	38	PF00454	0.399
MOD_Plk_1	134	140	PF00069	0.362
MOD_Plk_1	142	148	PF00069	0.330
MOD_Plk_1	168	174	PF00069	0.312
MOD_Plk_1	29	35	PF00069	0.506
MOD_Plk_4	134	140	PF00069	0.391
MOD_Plk_4	19	25	PF00069	0.428
MOD_Plk_4	6	12	PF00069	0.464
MOD_ProDKin_1	317	323	PF00069	0.703
MOD_ProDKin_1	71	77	PF00069	0.414
MOD_SUMO_rev_2	128	134	PF00179	0.406
TRG_ENDOCYTIC_2	76	79	PF00928	0.290
TRG_ER_diArg_1	218	220	PF00400	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IN96	Leishmania donovani	53%	100%
A4I1C0	Leishmania infantum	54%	100%
E9AXF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4QA16	Leishmania major	57%	99%