BESS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HE12_LEIBR

TriTrypDb:

LbrM.25.0650 , LBRM2903_250015400

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.368
CLV_NRD_NRD_1	37	39	PF00675	0.590
CLV_PCSK_SKI1_1	135	139	PF00082	0.578
CLV_PCSK_SKI1_1	151	155	PF00082	0.424
CLV_PCSK_SKI1_1	206	210	PF00082	0.343
DEG_SPOP_SBC_1	126	130	PF00917	0.363
DEG_SPOP_SBC_1	61	65	PF00917	0.523
DOC_CKS1_1	146	151	PF01111	0.491
DOC_CKS1_1	44	49	PF01111	0.485
DOC_CYCLIN_RxL_1	265	275	PF00134	0.504
DOC_PP1_RVXF_1	204	211	PF00149	0.381
DOC_PP2B_LxvP_1	100	103	PF13499	0.550
DOC_PP2B_LxvP_1	123	126	PF13499	0.515
DOC_PP2B_LxvP_1	191	194	PF13499	0.351
DOC_PP4_FxxP_1	209	212	PF00568	0.505
DOC_USP7_MATH_1	10	14	PF00917	0.772
DOC_USP7_MATH_1	127	131	PF00917	0.450
DOC_USP7_MATH_1	149	153	PF00917	0.714
DOC_USP7_MATH_1	178	182	PF00917	0.650
DOC_USP7_MATH_1	233	237	PF00917	0.672
DOC_USP7_MATH_1	254	258	PF00917	0.657
DOC_USP7_MATH_1	51	55	PF00917	0.597
DOC_USP7_MATH_1	67	71	PF00917	0.671
DOC_USP7_MATH_1	74	78	PF00917	0.497
DOC_WW_Pin1_4	145	150	PF00397	0.485
DOC_WW_Pin1_4	152	157	PF00397	0.397
DOC_WW_Pin1_4	174	179	PF00397	0.793
DOC_WW_Pin1_4	252	257	PF00397	0.514
DOC_WW_Pin1_4	312	317	PF00397	0.486
DOC_WW_Pin1_4	43	48	PF00397	0.504
LIG_AP2alpha_2	163	165	PF02296	0.383
LIG_FHA_1	126	132	PF00498	0.343
LIG_FHA_1	56	62	PF00498	0.587
LIG_FHA_1	63	69	PF00498	0.658
LIG_FHA_2	190	196	PF00498	0.361
LIG_GBD_Chelix_1	300	308	PF00786	0.480
LIG_IBAR_NPY_1	375	377	PF08397	0.509
LIG_LIR_Apic_2	342	347	PF02991	0.538
LIG_LIR_Nem_3	46	52	PF02991	0.492
LIG_SH2_CRK	344	348	PF00017	0.531
LIG_SH2_CRK	364	368	PF00017	0.620
LIG_SH2_GRB2like	335	338	PF00017	0.655
LIG_SH2_NCK_1	344	348	PF00017	0.553
LIG_SH2_NCK_1	359	363	PF00017	0.635
LIG_SH2_NCK_1	364	368	PF00017	0.748
LIG_SH2_SRC	276	279	PF00017	0.404
LIG_SH2_STAT3	380	383	PF00017	0.552
LIG_SH2_STAT5	45	48	PF00017	0.544
LIG_SH3_1	344	350	PF00018	0.522
LIG_SH3_3	344	350	PF00018	0.524
LIG_SH3_3	376	382	PF00018	0.604
LIG_SH3_3	44	50	PF00018	0.521
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.661
LIG_SUMO_SIM_par_1	157	163	PF11976	0.516
LIG_SUMO_SIM_par_1	189	196	PF11976	0.611
LIG_SUMO_SIM_par_1	269	275	PF11976	0.392
MOD_CDK_SPxK_1	145	151	PF00069	0.489
MOD_CK1_1	152	158	PF00069	0.472
MOD_CK1_1	179	185	PF00069	0.669
MOD_CK1_1	189	195	PF00069	0.442
MOD_CK1_1	200	206	PF00069	0.360
MOD_CK1_1	4	10	PF00069	0.644
MOD_CK2_1	10	16	PF00069	0.754
MOD_GlcNHglycan	150	154	PF01048	0.548
MOD_GlcNHglycan	167	170	PF01048	0.739
MOD_GlcNHglycan	178	181	PF01048	0.528
MOD_GlcNHglycan	256	259	PF01048	0.592
MOD_GlcNHglycan	372	375	PF01048	0.557
MOD_GlcNHglycan	53	56	PF01048	0.719
MOD_GlcNHglycan	76	79	PF01048	0.515
MOD_GSK3_1	1	8	PF00069	0.807
MOD_GSK3_1	145	152	PF00069	0.556
MOD_GSK3_1	174	181	PF00069	0.587
MOD_GSK3_1	189	196	PF00069	0.482
MOD_GSK3_1	223	230	PF00069	0.556
MOD_GSK3_1	272	279	PF00069	0.355
MOD_GSK3_1	314	321	PF00069	0.532
MOD_GSK3_1	51	58	PF00069	0.616
MOD_N-GLC_1	174	179	PF02516	0.515
MOD_N-GLC_1	339	344	PF02516	0.690
MOD_N-GLC_1	72	77	PF02516	0.586
MOD_N-GLC_2	117	119	PF02516	0.415
MOD_N-GLC_2	92	94	PF02516	0.378
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	165	170	PF00069	0.554
MOD_NEK2_1	186	191	PF00069	0.401
MOD_NEK2_1	197	202	PF00069	0.369
MOD_NMyristoyl	1	7	PF02799	0.615
MOD_PIKK_1	5	11	PF00454	0.784
MOD_Plk_1	149	155	PF00069	0.468
MOD_Plk_4	186	192	PF00069	0.662
MOD_Plk_4	193	199	PF00069	0.461
MOD_ProDKin_1	145	151	PF00069	0.489
MOD_ProDKin_1	152	158	PF00069	0.384
MOD_ProDKin_1	174	180	PF00069	0.793
MOD_ProDKin_1	252	258	PF00069	0.511
MOD_ProDKin_1	312	318	PF00069	0.493
MOD_ProDKin_1	43	49	PF00069	0.499
TRG_ER_diArg_1	144	147	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V9	Leptomonas seymouri	35%	93%
A0A3Q8ICF2	Leishmania donovani	58%	91%
A4I1B9	Leishmania infantum	58%	91%
E9AXF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	92%
Q4QA17	Leishmania major	58%	100%