Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE11_LEIBR

TriTrypDb:

LbrM.25.0640 , LBRM2903_250015300

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE11

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.435
CLV_NRD_NRD_1	185	187	PF00675	0.530
CLV_NRD_NRD_1	272	274	PF00675	0.415
CLV_PCSK_KEX2_1	185	187	PF00082	0.437
CLV_PCSK_KEX2_1	247	249	PF00082	0.570
CLV_PCSK_KEX2_1	271	273	PF00082	0.423
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.570
CLV_PCSK_SKI1_1	90	94	PF00082	0.484
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DEG_SCF_FBW7_1	22	29	PF00400	0.493
DEG_SPOP_SBC_1	174	178	PF00917	0.450
DOC_CYCLIN_RxL_1	183	192	PF00134	0.511
DOC_CYCLIN_RxL_1	87	95	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.395
DOC_PP1_RVXF_1	184	191	PF00149	0.516
DOC_USP7_MATH_1	120	124	PF00917	0.570
DOC_USP7_MATH_1	166	170	PF00917	0.562
DOC_USP7_MATH_1	172	176	PF00917	0.504
DOC_USP7_MATH_1	5	9	PF00917	0.557
DOC_USP7_MATH_1	57	61	PF00917	0.574
DOC_WW_Pin1_4	122	127	PF00397	0.676
DOC_WW_Pin1_4	168	173	PF00397	0.708
DOC_WW_Pin1_4	177	182	PF00397	0.472
DOC_WW_Pin1_4	22	27	PF00397	0.479
DOC_WW_Pin1_4	61	66	PF00397	0.655
LIG_14-3-3_CanoR_1	179	185	PF00244	0.515
LIG_14-3-3_CanoR_1	287	296	PF00244	0.366
LIG_Actin_WH2_2	204	222	PF00022	0.516
LIG_BIR_III_4	309	313	PF00653	0.326
LIG_BRCT_BRCA1_1	123	127	PF00533	0.622
LIG_BRCT_BRCA1_1	39	43	PF00533	0.452
LIG_CaM_NSCaTE_8	227	234	PF13499	0.435
LIG_Clathr_ClatBox_1	208	212	PF01394	0.394
LIG_Clathr_ClatBox_1	305	309	PF01394	0.421
LIG_eIF4E_1	203	209	PF01652	0.364
LIG_eIF4E_1	44	50	PF01652	0.398
LIG_FHA_1	156	162	PF00498	0.399
LIG_FHA_1	290	296	PF00498	0.413
LIG_FHA_1	44	50	PF00498	0.475
LIG_FHA_2	143	149	PF00498	0.457
LIG_HCF-1_HBM_1	200	203	PF13415	0.366
LIG_LIR_Gen_1	124	135	PF02991	0.468
LIG_LIR_Gen_1	138	147	PF02991	0.349
LIG_LIR_Nem_3	124	130	PF02991	0.486
LIG_LIR_Nem_3	138	143	PF02991	0.358
LIG_LIR_Nem_3	145	149	PF02991	0.350
LIG_LIR_Nem_3	169	173	PF02991	0.470
LIG_LIR_Nem_3	197	202	PF02991	0.513
LIG_MYND_1	345	349	PF01753	0.504
LIG_NRBOX	204	210	PF00104	0.403
LIG_NRBOX	88	94	PF00104	0.411
LIG_OCRL_FandH_1	8	20	PF00620	0.332
LIG_Pex14_1	199	203	PF04695	0.302
LIG_SH2_CRK	75	79	PF00017	0.418
LIG_SH2_STAP1	44	48	PF00017	0.478
LIG_SH2_STAT3	80	83	PF00017	0.427
LIG_SH2_STAT5	146	149	PF00017	0.390
LIG_SH2_STAT5	203	206	PF00017	0.362
LIG_SH2_STAT5	80	83	PF00017	0.427
LIG_SH3_3	1	7	PF00018	0.411
LIG_SH3_3	116	122	PF00018	0.468
LIG_SH3_3	125	131	PF00018	0.395
LIG_SH3_3	234	240	PF00018	0.524
LIG_SH3_3	49	55	PF00018	0.430
LIG_SH3_3	81	87	PF00018	0.354
LIG_SUMO_SIM_par_1	280	286	PF11976	0.261
LIG_SUMO_SIM_par_1	304	309	PF11976	0.405
LIG_Vh1_VBS_1	281	299	PF01044	0.254
MOD_CDC14_SPxK_1	64	67	PF00782	0.575
MOD_CDK_SPxK_1	22	28	PF00069	0.486
MOD_CDK_SPxK_1	61	67	PF00069	0.582
MOD_CK1_1	112	118	PF00069	0.629
MOD_CK1_1	175	181	PF00069	0.532
MOD_CK1_1	324	330	PF00069	0.478
MOD_CK1_1	33	39	PF00069	0.671
MOD_CK1_1	60	66	PF00069	0.498
MOD_CK2_1	142	148	PF00069	0.338
MOD_CK2_1	194	200	PF00069	0.343
MOD_GlcNHglycan	114	117	PF01048	0.664
MOD_GlcNHglycan	234	237	PF01048	0.440
MOD_GlcNHglycan	318	322	PF01048	0.557
MOD_GlcNHglycan	323	326	PF01048	0.578
MOD_GlcNHglycan	59	62	PF01048	0.749
MOD_GSK3_1	155	162	PF00069	0.519
MOD_GSK3_1	168	175	PF00069	0.560
MOD_GSK3_1	211	218	PF00069	0.493
MOD_GSK3_1	22	29	PF00069	0.627
MOD_GSK3_1	30	37	PF00069	0.677
MOD_GSK3_1	317	324	PF00069	0.474
MOD_GSK3_1	39	46	PF00069	0.468
MOD_GSK3_1	57	64	PF00069	0.632
MOD_N-GLC_1	22	27	PF02516	0.479
MOD_N-GLC_1	321	326	PF02516	0.465
MOD_NEK2_1	153	158	PF00069	0.663
MOD_NEK2_1	211	216	PF00069	0.446
MOD_NEK2_1	288	293	PF00069	0.342
MOD_NEK2_1	296	301	PF00069	0.359
MOD_NEK2_1	316	321	PF00069	0.384
MOD_NEK2_2	289	294	PF00069	0.264
MOD_PIKK_1	211	217	PF00454	0.432
MOD_PIKK_1	241	247	PF00454	0.646
MOD_PIKK_1	256	262	PF00454	0.285
MOD_PKA_2	27	33	PF00069	0.651
MOD_PKB_1	271	279	PF00069	0.441
MOD_Plk_1	153	159	PF00069	0.373
MOD_Plk_1	211	217	PF00069	0.482
MOD_Plk_4	142	148	PF00069	0.225
MOD_Plk_4	39	45	PF00069	0.637
MOD_Plk_4	5	11	PF00069	0.469
MOD_ProDKin_1	122	128	PF00069	0.660
MOD_ProDKin_1	168	174	PF00069	0.709
MOD_ProDKin_1	177	183	PF00069	0.375
MOD_ProDKin_1	22	28	PF00069	0.486
MOD_ProDKin_1	61	67	PF00069	0.655
MOD_SUMO_for_1	240	243	PF00179	0.570
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.406
TRG_ENDOCYTIC_2	202	205	PF00928	0.448
TRG_ER_diArg_1	184	186	PF00400	0.407
TRG_ER_diArg_1	271	273	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T2	Leptomonas seymouri	38%	98%
A0A3Q8IF78	Leishmania donovani	70%	99%
A0A3R7K7C7	Trypanosoma rangeli	30%	100%
A4I1B8	Leishmania infantum	71%	100%
D0A5L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QA18	Leishmania major	71%	99%