PPM-type phosphatase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HE10_LEIBR

TriTrypDb:

LbrM.25.0630 , LBRM2903_250015200

Length:

406

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 7

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4HE10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE10

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0035970	peptidyl-threonine dephosphorylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0004721	phosphoprotein phosphatase activity	3	23
GO:0004722	protein serine/threonine phosphatase activity	4	23
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	23
GO:0016788	hydrolase activity, acting on ester bonds	3	23
GO:0016791	phosphatase activity	5	23
GO:0042578	phosphoric ester hydrolase activity	4	23
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	23
GO:0017018	myosin phosphatase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.648
CLV_C14_Caspase3-7	96	100	PF00656	0.352
CLV_NRD_NRD_1	301	303	PF00675	0.414
CLV_PCSK_KEX2_1	322	324	PF00082	0.363
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.363
CLV_PCSK_SKI1_1	206	210	PF00082	0.458
DEG_SCF_FBW7_1	333	338	PF00400	0.445
DOC_CYCLIN_RxL_1	84	94	PF00134	0.381
DOC_MAPK_gen_1	85	93	PF00069	0.321
DOC_MAPK_HePTP_8	112	124	PF00069	0.381
DOC_MAPK_MEF2A_6	115	124	PF00069	0.369
DOC_MAPK_MEF2A_6	85	93	PF00069	0.321
DOC_PP4_FxxP_1	293	296	PF00568	0.405
DOC_USP7_MATH_1	296	300	PF00917	0.534
DOC_USP7_MATH_1	304	308	PF00917	0.462
DOC_USP7_MATH_1	69	73	PF00917	0.456
DOC_USP7_UBL2_3	115	119	PF12436	0.458
DOC_WW_Pin1_4	331	336	PF00397	0.587
LIG_14-3-3_CanoR_1	382	387	PF00244	0.675
LIG_Actin_WH2_2	312	330	PF00022	0.550
LIG_BRCT_BRCA1_1	176	180	PF00533	0.318
LIG_BRCT_BRCA1_1	211	215	PF00533	0.341
LIG_BRCT_BRCA1_1	361	365	PF00533	0.475
LIG_BRCT_BRCA1_1	46	50	PF00533	0.413
LIG_BRCT_BRCA1_2	361	367	PF00533	0.537
LIG_deltaCOP1_diTrp_1	46	54	PF00928	0.415
LIG_FHA_1	107	113	PF00498	0.358
LIG_FHA_1	336	342	PF00498	0.549
LIG_FHA_2	241	247	PF00498	0.404
LIG_FHA_2	33	39	PF00498	0.382
LIG_FHA_2	332	338	PF00498	0.576
LIG_FHA_2	351	357	PF00498	0.547
LIG_LIR_Gen_1	109	116	PF02991	0.372
LIG_LIR_Gen_1	212	223	PF02991	0.373
LIG_LIR_Gen_1	321	332	PF02991	0.447
LIG_LIR_Gen_1	362	371	PF02991	0.466
LIG_LIR_Nem_3	109	114	PF02991	0.361
LIG_LIR_Nem_3	212	218	PF02991	0.373
LIG_LIR_Nem_3	321	327	PF02991	0.426
LIG_LIR_Nem_3	362	368	PF02991	0.435
LIG_LIR_Nem_3	45	51	PF02991	0.413
LIG_MLH1_MIPbox_1	361	365	PF16413	0.520
LIG_PCNA_yPIPBox_3	230	238	PF02747	0.279
LIG_PCNA_yPIPBox_3	311	320	PF02747	0.543
LIG_Pex14_1	360	364	PF04695	0.524
LIG_Pex14_2	224	228	PF04695	0.318
LIG_Pex14_2	361	365	PF04695	0.475
LIG_Pex14_2	50	54	PF04695	0.321
LIG_PTB_Apo_2	16	23	PF02174	0.358
LIG_SH2_CRK	324	328	PF00017	0.421
LIG_SH2_STAP1	305	309	PF00017	0.431
LIG_SH2_STAT3	236	239	PF00017	0.301
LIG_SH2_STAT5	236	239	PF00017	0.458
LIG_SH2_STAT5	364	367	PF00017	0.502
LIG_SH2_STAT5	43	46	PF00017	0.364
LIG_SH2_STAT5	65	68	PF00017	0.294
LIG_SH3_3	286	292	PF00018	0.448
LIG_SUMO_SIM_par_1	196	202	PF11976	0.326
LIG_TRAF2_1	229	232	PF00917	0.287
LIG_TRAF2_1	334	337	PF00917	0.599
MOD_CK1_1	106	112	PF00069	0.296
MOD_CK2_1	331	337	PF00069	0.564
MOD_CK2_1	339	345	PF00069	0.599
MOD_CK2_1	350	356	PF00069	0.552
MOD_CK2_1	69	75	PF00069	0.434
MOD_CK2_1	97	103	PF00069	0.435
MOD_GlcNHglycan	161	164	PF01048	0.278
MOD_GlcNHglycan	293	296	PF01048	0.542
MOD_GlcNHglycan	298	301	PF01048	0.533
MOD_GlcNHglycan	71	74	PF01048	0.431
MOD_GlcNHglycan	99	102	PF01048	0.345
MOD_GSK3_1	170	177	PF00069	0.292
MOD_GSK3_1	331	338	PF00069	0.599
MOD_GSK3_1	392	399	PF00069	0.617
MOD_N-GLC_1	159	164	PF02516	0.202
MOD_N-GLC_1	265	270	PF02516	0.352
MOD_N-GLC_1	312	317	PF02516	0.575
MOD_NEK2_1	174	179	PF00069	0.318
MOD_NEK2_1	44	49	PF00069	0.458
MOD_PIKK_1	339	345	PF00454	0.650
MOD_PIKK_1	60	66	PF00454	0.379
MOD_PIKK_1	8	14	PF00454	0.441
MOD_PKA_2	260	266	PF00069	0.279
MOD_PKA_2	296	302	PF00069	0.388
MOD_PKA_2	32	38	PF00069	0.318
MOD_Plk_1	206	212	PF00069	0.363
MOD_Plk_1	265	271	PF00069	0.370
MOD_Plk_1	312	318	PF00069	0.538
MOD_Plk_1	339	345	PF00069	0.594
MOD_Plk_4	106	112	PF00069	0.338
MOD_Plk_4	284	290	PF00069	0.492
MOD_Plk_4	39	45	PF00069	0.379
MOD_Plk_4	392	398	PF00069	0.494
MOD_ProDKin_1	331	337	PF00069	0.583
MOD_SUMO_rev_2	145	149	PF00179	0.326
MOD_SUMO_rev_2	182	187	PF00179	0.317
MOD_SUMO_rev_2	345	353	PF00179	0.581
TRG_DiLeu_BaEn_1	213	218	PF01217	0.202
TRG_DiLeu_BaEn_4	336	342	PF01217	0.602
TRG_ENDOCYTIC_2	305	308	PF00928	0.407
TRG_ENDOCYTIC_2	324	327	PF00928	0.404
TRG_ER_diArg_1	155	158	PF00400	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	31%	100%
A0A0N0P8F8	Leptomonas seymouri	28%	100%
A0A0N1I0H9	Leptomonas seymouri	29%	100%
A0A0N1IHU6	Leptomonas seymouri	87%	100%
A0A0N1PAL8	Leptomonas seymouri	46%	100%
A0A0N1PET0	Leptomonas seymouri	30%	70%
A0A0S4IY95	Bodo saltans	33%	100%
A0A0S4J0A6	Bodo saltans	65%	100%
A0A0S4J8Y7	Bodo saltans	34%	79%
A0A0S4JHB4	Bodo saltans	42%	100%
A0A0S4JPC3	Bodo saltans	31%	100%
A0A0S4KIS4	Bodo saltans	29%	89%
A0A0S4KJV9	Bodo saltans	31%	94%
A0A1X0NRG3	Trypanosomatidae	32%	100%
A0A1X0NUB7	Trypanosomatidae	32%	85%
A0A1X0NVC4	Trypanosomatidae	31%	99%
A0A1X0P2A0	Trypanosomatidae	39%	100%
A0A1X0P568	Trypanosomatidae	64%	100%
A0A1X0P991	Trypanosomatidae	32%	100%
A0A1X0PAN4	Trypanosomatidae	30%	100%
A0A3Q8IEK6	Leishmania donovani	29%	100%
A0A3Q8IFG7	Leishmania donovani	44%	100%
A0A3Q8IGS1	Leishmania donovani	31%	72%
A0A3Q8IK65	Leishmania donovani	30%	100%
A0A3Q8IL63	Leishmania donovani	29%	100%
A0A3S7WTA2	Leishmania donovani	29%	100%
A0A3S7WZ14	Leishmania donovani	95%	100%
A0A422N8D7	Trypanosoma rangeli	28%	100%
A0A422NAJ1	Trypanosoma rangeli	33%	100%
A0A422NBV9	Trypanosoma rangeli	65%	100%
A0A422NL94	Trypanosoma rangeli	31%	93%
A0A422NML6	Trypanosoma rangeli	41%	100%
A0A422NS77	Trypanosoma rangeli	31%	98%
A0A422P293	Trypanosoma rangeli	33%	100%
A0BQL0	Paramecium tetraurelia	32%	100%
A0CUB5	Paramecium tetraurelia	29%	100%
A0DSB3	Paramecium tetraurelia	29%	100%
A0DTY1	Paramecium tetraurelia	31%	100%
A3A8W2	Oryza sativa subsp. japonica	28%	100%
A3A8W6	Oryza sativa subsp. japonica	23%	70%
A4H7Y6	Leishmania braziliensis	29%	100%
A4HG10	Leishmania braziliensis	28%	100%
A4HHY5	Leishmania braziliensis	44%	100%
A4HKF6	Leishmania braziliensis	30%	72%
A4HNR1	Leishmania braziliensis	29%	100%
A4HWB4	Leishmania infantum	29%	100%
A4I1B7	Leishmania infantum	94%	100%
A4I329	Leishmania infantum	29%	100%
A4I565	Leishmania infantum	44%	100%
A4I7Y4	Leishmania infantum	31%	72%
A4IA25	Leishmania infantum	29%	100%
A4ICT4	Leishmania infantum	30%	100%
A5PJZ2	Bos taurus	32%	100%
C9ZJK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZMJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZNW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
C9ZQJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A2L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A2U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	68%
D0A5L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ACV0	Leishmania major	28%	100%
E9AQ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ASH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AXF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AZD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B2U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	72%
E9B540	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B541	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O62829	Bos taurus	32%	100%
O62830	Bos taurus	33%	84%
O64583	Arabidopsis thaliana	28%	100%
O75688	Homo sapiens	33%	85%
O80871	Arabidopsis thaliana	29%	100%
O81716	Arabidopsis thaliana	29%	100%
P20650	Rattus norvegicus	32%	100%
P34221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	87%
P35813	Homo sapiens	32%	100%
P35814	Oryctolagus cuniculus	32%	100%
P35815	Rattus norvegicus	34%	100%
P36982	Leishmania chagasi	94%	100%
P36993	Mus musculus	34%	100%
P38089	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P39966	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	88%
P40371	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P49443	Mus musculus	32%	100%
P49444	Paramecium tetraurelia	31%	100%
P49596	Caenorhabditis elegans	34%	100%
P49597	Arabidopsis thaliana	29%	94%
P49599	Arabidopsis thaliana	27%	100%
Q09172	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q09173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	98%
Q0IIF0	Bos taurus	29%	100%
Q0J2L7	Oryza sativa subsp. japonica	32%	100%
Q0J2R1	Oryza sativa subsp. japonica	27%	100%
Q0JLP9	Oryza sativa subsp. japonica	28%	87%
Q19775	Caenorhabditis elegans	35%	87%
Q2PC20	Bos taurus	29%	100%
Q2QWE3	Oryza sativa subsp. japonica	29%	96%
Q3EAF9	Arabidopsis thaliana	30%	100%
Q4Q225	Leishmania major	29%	100%
Q4Q2U6	Leishmania major	29%	100%
Q4Q5B1	Leishmania major	32%	72%
Q4Q7S1	Leishmania major	44%	100%
Q4QA19	Leishmania major	94%	100%
Q4QFG7	Leishmania major	29%	100%
Q53Q11	Oryza sativa subsp. japonica	28%	100%
Q5JKN1	Oryza sativa subsp. japonica	29%	100%
Q5N9N2	Oryza sativa subsp. japonica	28%	98%
Q5SGD2	Homo sapiens	32%	100%
Q5SMK6	Oryza sativa subsp. japonica	27%	100%
Q653S3	Oryza sativa subsp. japonica	28%	100%
Q65XK7	Oryza sativa subsp. japonica	28%	100%
Q67UX7	Oryza sativa subsp. japonica	34%	100%
Q69QZ0	Oryza sativa subsp. japonica	30%	100%
Q69VD9	Oryza sativa subsp. japonica	28%	100%
Q6AUQ4	Oryza sativa subsp. japonica	26%	100%
Q6EN45	Oryza sativa subsp. japonica	37%	100%
Q6ETK3	Oryza sativa subsp. japonica	27%	100%
Q6ING9	Xenopus laevis	27%	100%
Q6K1U4	Oryza sativa subsp. japonica	27%	78%
Q6K5I0	Oryza sativa subsp. japonica	26%	79%
Q6L482	Oryza sativa subsp. japonica	30%	100%
Q6L4R7	Oryza sativa subsp. japonica	27%	91%
Q6L5C4	Oryza sativa subsp. japonica	36%	83%
Q6L5H6	Oryza sativa subsp. japonica	29%	100%
Q6YTI2	Oryza sativa subsp. japonica	23%	92%
Q6ZKL8	Oryza sativa subsp. japonica	27%	76%
Q7XQU7	Oryza sativa subsp. japonica	33%	100%
Q7XU84	Oryza sativa subsp. japonica	29%	100%
Q8BHN0	Mus musculus	32%	100%
Q8BXN7	Mus musculus	30%	100%
Q8CGA0	Mus musculus	32%	90%
Q8L7I4	Arabidopsis thaliana	33%	100%
Q8N3J5	Homo sapiens	30%	100%
Q8N819	Homo sapiens	28%	94%
Q8R0F6	Mus musculus	29%	100%
Q8RX37	Arabidopsis thaliana	29%	100%
Q9CAJ0	Arabidopsis thaliana	28%	79%
Q9FIF5	Arabidopsis thaliana	30%	98%
Q9FYN7	Oryza sativa subsp. japonica	27%	100%
Q9H0C8	Homo sapiens	28%	100%
Q9LME4	Arabidopsis thaliana	31%	100%
Q9LMT1	Arabidopsis thaliana	26%	100%
Q9LNF4	Arabidopsis thaliana	28%	100%
Q9LNP9	Arabidopsis thaliana	27%	79%
Q9LNW3	Arabidopsis thaliana	30%	92%
Q9LUU7	Arabidopsis thaliana	32%	96%
Q9M9W9	Arabidopsis thaliana	27%	100%
Q9SZ53	Arabidopsis thaliana	26%	100%
Q9WVR7	Rattus norvegicus	32%	90%
Q9XEE8	Arabidopsis thaliana	30%	100%
Q9Z1Z6	Rattus norvegicus	29%	100%
Q9ZW21	Arabidopsis thaliana	28%	100%
V5BA03	Trypanosoma cruzi	33%	100%
V5BCX6	Trypanosoma cruzi	32%	100%
V5BH00	Trypanosoma cruzi	43%	100%
V5BSS7	Trypanosoma cruzi	64%	100%
V5DCR6	Trypanosoma cruzi	34%	99%