PPM-type phosphatase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HE10_LEIBR

TriTrypDb:

LbrM.25.0630 , LBRM2903_250015200

Length:

406

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 7

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HE10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE10

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0035970	peptidyl-threonine dephosphorylation	6	2
GO:0036211	protein modification process	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0004721	phosphoprotein phosphatase activity	3	23
GO:0004722	protein serine/threonine phosphatase activity	4	23
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	23
GO:0016788	hydrolase activity, acting on ester bonds	3	23
GO:0016791	phosphatase activity	5	23
GO:0017018	myosin phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	23
GO:0043167	ion binding	2	12

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.648
CLV_C14_Caspase3-7	96	100	PF00656	0.352
CLV_NRD_NRD_1	301	303	PF00675	0.414
CLV_PCSK_KEX2_1	322	324	PF00082	0.363
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.363
CLV_PCSK_SKI1_1	206	210	PF00082	0.458
DEG_SCF_FBW7_1	333	338	PF00400	0.445
DOC_CYCLIN_RxL_1	84	94	PF00134	0.381
DOC_MAPK_gen_1	85	93	PF00069	0.321
DOC_MAPK_HePTP_8	112	124	PF00069	0.381

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	31%	100%
A0A0N0P8F8	Leptomonas seymouri	28%	100%
A0A0N1I0H9	Leptomonas seymouri	29%	100%
A0A0N1IHU6	Leptomonas seymouri	87%	100%
A0A0N1PAL8	Leptomonas seymouri	46%	100%
A0A0N1PET0	Leptomonas seymouri	30%	70%
A0A0S4IY95	Bodo saltans	33%	100%
A0A0S4J0A6	Bodo saltans	65%	100%
A0A0S4J8Y7	Bodo saltans	34%	79%
A0A0S4JHB4	Bodo saltans	42%	100%

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