Putative DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HE09_LEIBR

TriTrypDb:

LbrM.25.0620 , LBRM2903_250015100

Length:

1099

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A4HE09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE09

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006289	nucleotide-excision repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0008270	zinc ion binding	6	7
GO:0016491	oxidoreductase activity	2	7
GO:0016787	hydrolase activity	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.748
CLV_C14_Caspase3-7	825	829	PF00656	0.543
CLV_C14_Caspase3-7	931	935	PF00656	0.322
CLV_MEL_PAP_1	605	611	PF00089	0.314
CLV_NRD_NRD_1	291	293	PF00675	0.402
CLV_NRD_NRD_1	321	323	PF00675	0.602
CLV_NRD_NRD_1	353	355	PF00675	0.693
CLV_NRD_NRD_1	357	359	PF00675	0.654
CLV_NRD_NRD_1	43	45	PF00675	0.314
CLV_NRD_NRD_1	462	464	PF00675	0.729

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE7	Leptomonas seymouri	72%	100%
A0A3S7WYX7	Leishmania donovani	88%	100%
A4I1B6	Leishmania infantum	88%	100%
E9AXF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8J3	Leishmania major	28%	100%
Q4QA20	Leishmania major	87%	99%

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