Protein TSSC4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein TSSC4

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE03_LEIBR

TriTrypDb:

LbrM.25.0560 , LBRM2903_250014700

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.559
CLV_PCSK_FUR_1	260	264	PF00082	0.539
CLV_PCSK_KEX2_1	209	211	PF00082	0.539
CLV_PCSK_KEX2_1	262	264	PF00082	0.654
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.539
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.654
CLV_PCSK_SKI1_1	276	280	PF00082	0.792
DOC_ANK_TNKS_1	181	188	PF00023	0.658
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.382
DOC_MAPK_MEF2A_6	135	143	PF00069	0.440
DOC_MAPK_MEF2A_6	157	166	PF00069	0.554
DOC_PP2B_LxvP_1	141	144	PF13499	0.471
DOC_PP2B_LxvP_1	166	169	PF13499	0.515
DOC_PP4_FxxP_1	202	205	PF00568	0.447
DOC_USP7_MATH_1	144	148	PF00917	0.474
DOC_USP7_MATH_1	221	225	PF00917	0.708
DOC_USP7_UBL2_3	232	236	PF12436	0.567
DOC_USP7_UBL2_3	270	274	PF12436	0.637
DOC_USP7_UBL2_3	276	280	PF12436	0.641
DOC_WW_Pin1_4	180	185	PF00397	0.569
DOC_WW_Pin1_4	22	27	PF00397	0.573
LIG_14-3-3_CanoR_1	263	267	PF00244	0.690
LIG_14-3-3_CanoR_1	81	87	PF00244	0.477
LIG_BRCT_BRCA1_1	59	63	PF00533	0.390
LIG_EH_1	60	64	PF12763	0.379
LIG_FHA_1	196	202	PF00498	0.710
LIG_FHA_2	181	187	PF00498	0.579
LIG_FHA_2	32	38	PF00498	0.687
LIG_LIR_Apic_2	224	228	PF02991	0.712
LIG_LIR_Gen_1	12	20	PF02991	0.734
LIG_LIR_Gen_1	186	194	PF02991	0.606
LIG_LIR_Gen_1	73	83	PF02991	0.554
LIG_LIR_Nem_3	117	121	PF02991	0.601
LIG_LIR_Nem_3	12	17	PF02991	0.517
LIG_LIR_Nem_3	186	192	PF02991	0.593
LIG_LIR_Nem_3	73	79	PF02991	0.549
LIG_MYND_1	165	169	PF01753	0.527
LIG_PTB_Apo_2	188	195	PF02174	0.692
LIG_PTB_Phospho_1	188	194	PF10480	0.691
LIG_RPA_C_Fungi	251	263	PF08784	0.508
LIG_SH2_CRK	189	193	PF00017	0.591
LIG_SH2_CRK	225	229	PF00017	0.720
LIG_SH2_CRK	76	80	PF00017	0.588
LIG_SH2_GRB2like	189	192	PF00017	0.694
LIG_SH2_PTP2	159	162	PF00017	0.629
LIG_SH2_SRC	159	162	PF00017	0.629
LIG_SH2_STAP1	14	18	PF00017	0.519
LIG_SH2_STAT5	118	121	PF00017	0.492
LIG_SH2_STAT5	159	162	PF00017	0.587
LIG_SH2_STAT5	229	232	PF00017	0.680
LIG_SH3_1	159	165	PF00018	0.626
LIG_SH3_3	159	165	PF00018	0.540
LIG_SH3_3	227	233	PF00018	0.669
LIG_SH3_3	23	29	PF00018	0.617
LIG_SH3_4	232	239	PF00018	0.586
LIG_SH3_4	268	275	PF00018	0.749
LIG_SUMO_SIM_par_1	103	108	PF11976	0.456
LIG_TRAF2_1	19	22	PF00917	0.746
LIG_TRAF2_1	39	42	PF00917	0.752
LIG_WRC_WIRS_1	83	88	PF05994	0.567
MOD_CK1_1	110	116	PF00069	0.567
MOD_CK1_1	117	123	PF00069	0.525
MOD_CK1_1	147	153	PF00069	0.585
MOD_CK2_1	180	186	PF00069	0.580
MOD_GlcNHglycan	123	126	PF01048	0.484
MOD_GlcNHglycan	14	17	PF01048	0.552
MOD_GlcNHglycan	146	149	PF01048	0.712
MOD_GlcNHglycan	202	205	PF01048	0.713
MOD_GlcNHglycan	256	259	PF01048	0.610
MOD_GSK3_1	110	117	PF00069	0.565
MOD_GSK3_1	252	259	PF00069	0.606
MOD_N-GLC_1	133	138	PF02516	0.478
MOD_N-GLC_1	22	27	PF02516	0.675
MOD_N-GLC_1	31	36	PF02516	0.739
MOD_NEK2_1	264	269	PF00069	0.666
MOD_PIKK_1	195	201	PF00454	0.714
MOD_PKA_1	262	268	PF00069	0.690
MOD_PKA_2	262	268	PF00069	0.689
MOD_Plk_1	107	113	PF00069	0.580
MOD_Plk_1	133	139	PF00069	0.484
MOD_Plk_1	31	37	PF00069	0.761
MOD_Plk_4	107	113	PF00069	0.550
MOD_Plk_4	114	120	PF00069	0.556
MOD_Plk_4	31	37	PF00069	0.551
MOD_Plk_4	75	81	PF00069	0.547
MOD_ProDKin_1	180	186	PF00069	0.575
MOD_ProDKin_1	22	28	PF00069	0.573
MOD_SUMO_for_1	175	178	PF00179	0.659
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.522
TRG_ENDOCYTIC_2	14	17	PF00928	0.520
TRG_ENDOCYTIC_2	189	192	PF00928	0.548
TRG_ENDOCYTIC_2	76	79	PF00928	0.592
TRG_NLS_Bipartite_1	262	278	PF00514	0.706
TRG_NLS_MonoExtC_3	208	214	PF00514	0.652
TRG_NLS_MonoExtN_4	206	213	PF00514	0.445
TRG_NLS_MonoExtN_4	271	278	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P685	Leptomonas seymouri	52%	94%
A0A3Q8IC96	Leishmania donovani	71%	100%
A0A422NX50	Trypanosoma rangeli	31%	100%
A4I1B3	Leishmania infantum	71%	100%
D0A5K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QA23	Leishmania major	69%	100%
V5BN56	Trypanosoma cruzi	29%	100%