Scamp family-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SCAMP family, putative

Species:

Leishmania braziliensis

UniProt:

A4HE02_LEIBR

TriTrypDb:

LbrM.25.0550 , LBRM2903_250014500

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0032588	trans-Golgi network membrane	4	2
GO:0055038	recycling endosome membrane	6	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A4HE02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE02

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008104	protein localization	4	16
GO:0009987	cellular process	1	16
GO:0015031	protein transport	4	16
GO:0033036	macromolecule localization	2	16
GO:0045184	establishment of protein localization	3	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0051641	cellular localization	2	16
GO:0070727	cellular macromolecule localization	3	16
GO:0071702	organic substance transport	4	16
GO:0071705	nitrogen compound transport	4	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	28	34	PF00089	0.294
CLV_NRD_NRD_1	225	227	PF00675	0.362
CLV_NRD_NRD_1	231	233	PF00675	0.428
CLV_NRD_NRD_1	235	237	PF00675	0.468
CLV_NRD_NRD_1	49	51	PF00675	0.245
CLV_PCSK_KEX2_1	225	227	PF00082	0.276
CLV_PCSK_KEX2_1	231	233	PF00082	0.310
CLV_PCSK_KEX2_1	235	237	PF00082	0.318
CLV_PCSK_PC7_1	231	237	PF00082	0.351
CLV_PCSK_SKI1_1	50	54	PF00082	0.245
CLV_PCSK_SKI1_1	70	74	PF00082	0.354
CLV_PCSK_SKI1_1	75	79	PF00082	0.343
DOC_MAPK_DCC_7	191	201	PF00069	0.245
DOC_MAPK_gen_1	231	241	PF00069	0.605
DOC_MAPK_MEF2A_6	191	199	PF00069	0.352
DOC_PIKK_1	21	28	PF02985	0.569
DOC_USP7_MATH_1	102	106	PF00917	0.280
LIG_14-3-3_CanoR_1	142	150	PF00244	0.487
LIG_EH1_1	175	183	PF00400	0.187
LIG_FHA_1	191	197	PF00498	0.307
LIG_LIR_Gen_1	80	89	PF02991	0.330
LIG_LIR_Nem_3	218	224	PF02991	0.552
LIG_LIR_Nem_3	80	84	PF02991	0.330
LIG_PCNA_yPIPBox_3	104	117	PF02747	0.187
LIG_Pex14_2	48	52	PF04695	0.468
LIG_RPA_C_Fungi	221	233	PF08784	0.380
LIG_SH2_CRK	60	64	PF00017	0.344
LIG_SH2_SRC	125	128	PF00017	0.196
LIG_SH2_STAT5	125	128	PF00017	0.294
LIG_SH3_2	46	51	PF14604	0.368
LIG_SH3_3	192	198	PF00018	0.326
LIG_SH3_3	43	49	PF00018	0.360
LIG_SUMO_SIM_anti_2	62	68	PF11976	0.196
LIG_TYR_ITIM	135	140	PF00017	0.351
LIG_TYR_ITIM	58	63	PF00017	0.448
MOD_CK2_1	30	36	PF00069	0.463
MOD_GlcNHglycan	99	102	PF01048	0.451
MOD_NEK2_2	210	215	PF00069	0.335
MOD_PKA_2	190	196	PF00069	0.422
MOD_PKA_2	30	36	PF00069	0.536
MOD_Plk_4	129	135	PF00069	0.359
MOD_SUMO_rev_2	3	8	PF00179	0.587
TRG_ENDOCYTIC_2	137	140	PF00928	0.358
TRG_ENDOCYTIC_2	60	63	PF00928	0.351
TRG_ER_diArg_1	224	226	PF00400	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P960	Leptomonas seymouri	28%	100%
A0A0S4J7Y6	Bodo saltans	35%	97%
A0A1X0P4W4	Trypanosomatidae	29%	100%
A0A3Q8IBN8	Leishmania donovani	79%	67%
A0A3Q8IN09	Leishmania donovani	28%	100%
A0A3R7KQ76	Trypanosoma rangeli	28%	100%
A4HNE3	Leishmania braziliensis	30%	100%
A4I1B2	Leishmania infantum	79%	67%
A4IC16	Leishmania infantum	28%	100%
C9ZYI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFV4	Leishmania major	29%	100%
E9AXE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	68%
E9B707	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4QA24	Leishmania major	78%	100%