Beta-lactamase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE00_LEIBR

TriTrypDb:

LbrM.25.0530 , LBRM2903_250014100

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.519
CLV_NRD_NRD_1	210	212	PF00675	0.598
CLV_NRD_NRD_1	303	305	PF00675	0.604
CLV_NRD_NRD_1	33	35	PF00675	0.406
CLV_PCSK_FUR_1	301	305	PF00082	0.678
CLV_PCSK_KEX2_1	121	123	PF00082	0.537
CLV_PCSK_KEX2_1	210	212	PF00082	0.594
CLV_PCSK_KEX2_1	303	305	PF00082	0.675
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.502
CLV_PCSK_SKI1_1	124	128	PF00082	0.536
CLV_PCSK_SKI1_1	139	143	PF00082	0.577
CLV_PCSK_SKI1_1	14	18	PF00082	0.389
CLV_PCSK_SKI1_1	185	189	PF00082	0.556
CLV_PCSK_SKI1_1	324	328	PF00082	0.626
CLV_PCSK_SKI1_1	34	38	PF00082	0.259
DEG_APCC_DBOX_1	184	192	PF00400	0.528
DEG_SCF_FBW7_1	393	400	PF00400	0.537
DEG_SPOP_SBC_1	126	130	PF00917	0.503
DOC_CDC14_PxL_1	270	278	PF14671	0.469
DOC_CKS1_1	394	399	PF01111	0.620
DOC_MAPK_MEF2A_6	324	331	PF00069	0.556
DOC_USP7_MATH_1	126	130	PF00917	0.660
DOC_USP7_MATH_1	133	137	PF00917	0.628
DOC_USP7_MATH_1	141	145	PF00917	0.549
DOC_USP7_MATH_1	171	175	PF00917	0.548
DOC_USP7_MATH_1	197	201	PF00917	0.581
DOC_USP7_MATH_1	206	210	PF00917	0.618
DOC_USP7_MATH_1	228	232	PF00917	0.681
DOC_USP7_MATH_1	286	290	PF00917	0.551
DOC_USP7_MATH_1	322	326	PF00917	0.477
DOC_USP7_MATH_1	402	406	PF00917	0.592
DOC_USP7_MATH_1	420	424	PF00917	0.772
DOC_USP7_MATH_1	47	51	PF00917	0.471
DOC_USP7_MATH_1	470	474	PF00917	0.565
DOC_USP7_UBL2_3	117	121	PF12436	0.555
DOC_WW_Pin1_4	167	172	PF00397	0.544
DOC_WW_Pin1_4	198	203	PF00397	0.578
DOC_WW_Pin1_4	249	254	PF00397	0.669
DOC_WW_Pin1_4	331	336	PF00397	0.479
DOC_WW_Pin1_4	384	389	PF00397	0.641
DOC_WW_Pin1_4	393	398	PF00397	0.659
DOC_WW_Pin1_4	403	408	PF00397	0.804
LIG_14-3-3_CanoR_1	14	20	PF00244	0.435
LIG_14-3-3_CanoR_1	224	230	PF00244	0.620
LIG_14-3-3_CanoR_1	296	300	PF00244	0.621
LIG_14-3-3_CanoR_1	34	40	PF00244	0.333
LIG_14-3-3_CanoR_1	49	55	PF00244	0.415
LIG_Actin_WH2_2	256	271	PF00022	0.491
LIG_Actin_WH2_2	72	88	PF00022	0.485
LIG_AP2alpha_1	433	437	PF02296	0.420
LIG_BIR_III_2	227	231	PF00653	0.602
LIG_BIR_III_4	204	208	PF00653	0.551
LIG_BRCT_BRCA1_1	230	234	PF00533	0.626
LIG_BRCT_BRCA1_1	433	437	PF00533	0.505
LIG_EVH1_1	394	398	PF00568	0.532
LIG_FHA_1	216	222	PF00498	0.635
LIG_FHA_1	282	288	PF00498	0.550
LIG_FHA_1	315	321	PF00498	0.645
LIG_FHA_1	389	395	PF00498	0.626
LIG_FHA_1	94	100	PF00498	0.385
LIG_FHA_2	199	205	PF00498	0.760
LIG_FHA_2	250	256	PF00498	0.389
LIG_FHA_2	332	338	PF00498	0.513
LIG_HCF-1_HBM_1	466	469	PF13415	0.499
LIG_LIR_Gen_1	37	48	PF02991	0.353
LIG_LIR_Gen_1	430	440	PF02991	0.554
LIG_LIR_LC3C_4	6	11	PF02991	0.313
LIG_LIR_Nem_3	110	115	PF02991	0.426
LIG_LIR_Nem_3	170	175	PF02991	0.602
LIG_LIR_Nem_3	37	43	PF02991	0.395
LIG_LIR_Nem_3	430	436	PF02991	0.566
LIG_LRP6_Inhibitor_1	22	28	PF00058	0.317
LIG_MLH1_MIPbox_1	433	437	PF16413	0.502
LIG_Pex14_2	338	342	PF04695	0.535
LIG_Pex14_2	433	437	PF04695	0.577
LIG_PTAP_UEV_1	389	394	PF05743	0.546
LIG_PTAP_UEV_1	398	403	PF05743	0.523
LIG_SH2_NCK_1	367	371	PF00017	0.590
LIG_SH2_SRC	103	106	PF00017	0.387
LIG_SH2_STAT5	103	106	PF00017	0.465
LIG_SH2_STAT5	225	228	PF00017	0.485
LIG_SH2_STAT5	293	296	PF00017	0.614
LIG_SH2_STAT5	40	43	PF00017	0.381
LIG_SH2_STAT5	452	455	PF00017	0.719
LIG_SH2_STAT5	91	94	PF00017	0.383
LIG_SH3_3	161	167	PF00018	0.538
LIG_SH3_3	360	366	PF00018	0.670
LIG_SH3_3	387	393	PF00018	0.666
LIG_SH3_3	396	402	PF00018	0.583
LIG_SH3_3	410	416	PF00018	0.688
LIG_SUMO_SIM_par_1	357	364	PF11976	0.542
LIG_TRAF2_1	53	56	PF00917	0.292
MOD_CDK_SPK_2	384	389	PF00069	0.632
MOD_CK1_1	125	131	PF00069	0.566
MOD_CK1_1	18	24	PF00069	0.321
MOD_CK1_1	198	204	PF00069	0.610
MOD_CK1_1	249	255	PF00069	0.674
MOD_CK1_1	3	9	PF00069	0.591
MOD_CK1_1	38	44	PF00069	0.288
MOD_CK1_1	400	406	PF00069	0.663
MOD_CK1_1	448	454	PF00069	0.614
MOD_CK1_1	50	56	PF00069	0.370
MOD_CK1_1	97	103	PF00069	0.314
MOD_CK2_1	107	113	PF00069	0.460
MOD_CK2_1	269	275	PF00069	0.452
MOD_CK2_1	322	328	PF00069	0.567
MOD_CK2_1	331	337	PF00069	0.467
MOD_CK2_1	460	466	PF00069	0.563
MOD_CK2_1	50	56	PF00069	0.351
MOD_GlcNHglycan	109	112	PF01048	0.345
MOD_GlcNHglycan	123	127	PF01048	0.469
MOD_GlcNHglycan	129	132	PF01048	0.641
MOD_GlcNHglycan	197	200	PF01048	0.541
MOD_GlcNHglycan	20	23	PF01048	0.284
MOD_GlcNHglycan	230	233	PF01048	0.545
MOD_GlcNHglycan	242	245	PF01048	0.521
MOD_GlcNHglycan	289	292	PF01048	0.539
MOD_GlcNHglycan	308	311	PF01048	0.766
MOD_GlcNHglycan	324	327	PF01048	0.521
MOD_GlcNHglycan	357	360	PF01048	0.578
MOD_GlcNHglycan	363	366	PF01048	0.530
MOD_GlcNHglycan	399	402	PF01048	0.608
MOD_GlcNHglycan	422	425	PF01048	0.669
MOD_GlcNHglycan	45	48	PF01048	0.343
MOD_GlcNHglycan	5	8	PF01048	0.529
MOD_GlcNHglycan	96	99	PF01048	0.436
MOD_GSK3_1	122	129	PF00069	0.534
MOD_GSK3_1	167	174	PF00069	0.601
MOD_GSK3_1	245	252	PF00069	0.702
MOD_GSK3_1	306	313	PF00069	0.633
MOD_GSK3_1	34	41	PF00069	0.531
MOD_GSK3_1	355	362	PF00069	0.543
MOD_GSK3_1	380	387	PF00069	0.668
MOD_GSK3_1	393	400	PF00069	0.664
MOD_GSK3_1	427	434	PF00069	0.618
MOD_GSK3_1	43	50	PF00069	0.386
MOD_GSK3_1	444	451	PF00069	0.719
MOD_GSK3_1	93	100	PF00069	0.305
MOD_N-GLC_1	255	260	PF02516	0.567
MOD_N-GLC_1	306	311	PF02516	0.679
MOD_N-GLC_1	403	408	PF02516	0.646
MOD_N-GLC_1	455	460	PF02516	0.647
MOD_NEK2_1	1	6	PF00069	0.498
MOD_NEK2_1	15	20	PF00069	0.404
MOD_NEK2_1	268	273	PF00069	0.443
MOD_NEK2_1	43	48	PF00069	0.379
MOD_NEK2_1	444	449	PF00069	0.724
MOD_NEK2_1	471	476	PF00069	0.758
MOD_NEK2_2	180	185	PF00069	0.522
MOD_NMyristoyl	1	7	PF02799	0.372
MOD_PIKK_1	29	35	PF00454	0.414
MOD_PK_1	269	275	PF00069	0.452
MOD_PKA_1	34	40	PF00069	0.376
MOD_PKA_2	223	229	PF00069	0.622
MOD_PKA_2	27	33	PF00069	0.450
MOD_PKA_2	295	301	PF00069	0.596
MOD_PKA_2	388	394	PF00069	0.625
MOD_PKA_2	420	426	PF00069	0.676
MOD_PKB_1	120	128	PF00069	0.526
MOD_Plk_1	255	261	PF00069	0.376
MOD_Plk_1	455	461	PF00069	0.655
MOD_Plk_2-3	295	301	PF00069	0.574
MOD_Plk_4	15	21	PF00069	0.365
MOD_Plk_4	35	41	PF00069	0.392
MOD_Plk_4	427	433	PF00069	0.447
MOD_Plk_4	448	454	PF00069	0.653
MOD_ProDKin_1	167	173	PF00069	0.543
MOD_ProDKin_1	198	204	PF00069	0.583
MOD_ProDKin_1	249	255	PF00069	0.674
MOD_ProDKin_1	331	337	PF00069	0.476
MOD_ProDKin_1	384	390	PF00069	0.640
MOD_ProDKin_1	393	399	PF00069	0.661
MOD_ProDKin_1	403	409	PF00069	0.802
MOD_SUMO_rev_2	262	271	PF00179	0.381
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.357
TRG_ENDOCYTIC_2	40	43	PF00928	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM3	Leptomonas seymouri	48%	86%
A0A3Q8ID86	Leishmania donovani	78%	88%
A4I1B1	Leishmania infantum	78%	88%
E9AXE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	88%
Q4QA25	Leishmania major	79%	100%