Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HDZ9_LEIBR

TriTrypDb:

LbrM.25.0520 , LBRM2903_250014000

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.615
CLV_C14_Caspase3-7	438	442	PF00656	0.375
CLV_C14_Caspase3-7	523	527	PF00656	0.620
CLV_C14_Caspase3-7	604	608	PF00656	0.536
CLV_NRD_NRD_1	260	262	PF00675	0.526
CLV_NRD_NRD_1	263	265	PF00675	0.567
CLV_NRD_NRD_1	450	452	PF00675	0.562
CLV_NRD_NRD_1	464	466	PF00675	0.521
CLV_NRD_NRD_1	694	696	PF00675	0.562
CLV_NRD_NRD_1	825	827	PF00675	0.586
CLV_PCSK_FUR_1	261	265	PF00082	0.637
CLV_PCSK_KEX2_1	260	262	PF00082	0.500
CLV_PCSK_KEX2_1	263	265	PF00082	0.567
CLV_PCSK_KEX2_1	449	451	PF00082	0.537
CLV_PCSK_KEX2_1	464	466	PF00082	0.565
CLV_PCSK_KEX2_1	825	827	PF00082	0.586
CLV_PCSK_PC7_1	446	452	PF00082	0.487
CLV_PCSK_PC7_1	821	827	PF00082	0.577
CLV_PCSK_SKI1_1	139	143	PF00082	0.440
CLV_PCSK_SKI1_1	374	378	PF00082	0.482
CLV_PCSK_SKI1_1	411	415	PF00082	0.417
CLV_PCSK_SKI1_1	505	509	PF00082	0.535
CLV_PCSK_SKI1_1	665	669	PF00082	0.470
CLV_PCSK_SKI1_1	687	691	PF00082	0.577
CLV_PCSK_SKI1_1	734	738	PF00082	0.467
CLV_PCSK_SKI1_1	78	82	PF00082	0.639
DEG_APCC_DBOX_1	664	672	PF00400	0.426
DEG_SCF_FBW7_1	140	147	PF00400	0.401
DEG_SPOP_SBC_1	243	247	PF00917	0.594
DEG_SPOP_SBC_1	480	484	PF00917	0.678
DEG_SPOP_SBC_1	530	534	PF00917	0.553
DOC_CKS1_1	721	726	PF01111	0.433
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.357
DOC_MAPK_DCC_7	263	273	PF00069	0.527
DOC_MAPK_gen_1	260	268	PF00069	0.629
DOC_MAPK_JIP1_4	165	171	PF00069	0.337
DOC_MAPK_MEF2A_6	264	273	PF00069	0.522
DOC_PP1_RVXF_1	824	831	PF00149	0.635
DOC_PP2B_LxvP_1	159	162	PF13499	0.521
DOC_PP2B_LxvP_1	564	567	PF13499	0.597
DOC_PP2B_LxvP_1	573	576	PF13499	0.617
DOC_PP2B_LxvP_1	671	674	PF13499	0.447
DOC_SPAK_OSR1_1	430	434	PF12202	0.482
DOC_USP7_MATH_1	154	158	PF00917	0.440
DOC_USP7_MATH_1	243	247	PF00917	0.595
DOC_USP7_MATH_1	25	29	PF00917	0.494
DOC_USP7_MATH_1	435	439	PF00917	0.444
DOC_USP7_MATH_1	481	485	PF00917	0.686
DOC_USP7_MATH_1	530	534	PF00917	0.643
DOC_USP7_MATH_1	576	580	PF00917	0.604
DOC_USP7_MATH_1	595	599	PF00917	0.697
DOC_USP7_MATH_1	704	708	PF00917	0.538
DOC_USP7_MATH_1	779	783	PF00917	0.620
DOC_USP7_MATH_1	785	789	PF00917	0.543
DOC_USP7_MATH_1	80	84	PF00917	0.555
DOC_USP7_MATH_1	815	819	PF00917	0.534
DOC_USP7_MATH_1	820	824	PF00917	0.494
DOC_USP7_MATH_2	771	777	PF00917	0.503
DOC_WW_Pin1_4	140	145	PF00397	0.531
DOC_WW_Pin1_4	244	249	PF00397	0.649
DOC_WW_Pin1_4	293	298	PF00397	0.534
DOC_WW_Pin1_4	306	311	PF00397	0.667
DOC_WW_Pin1_4	532	537	PF00397	0.562
DOC_WW_Pin1_4	568	573	PF00397	0.691
DOC_WW_Pin1_4	700	705	PF00397	0.620
DOC_WW_Pin1_4	710	715	PF00397	0.550
DOC_WW_Pin1_4	720	725	PF00397	0.600
DOC_WW_Pin1_4	767	772	PF00397	0.740
DOC_WW_Pin1_4	96	101	PF00397	0.570
LIG_14-3-3_CanoR_1	11	19	PF00244	0.574
LIG_14-3-3_CanoR_1	139	144	PF00244	0.521
LIG_14-3-3_CanoR_1	24	34	PF00244	0.602
LIG_14-3-3_CanoR_1	277	282	PF00244	0.530
LIG_14-3-3_CanoR_1	434	444	PF00244	0.465
LIG_14-3-3_CanoR_1	597	605	PF00244	0.640
LIG_14-3-3_CanoR_1	687	694	PF00244	0.577
LIG_14-3-3_CanoR_1	695	701	PF00244	0.433
LIG_14-3-3_CanoR_1	708	717	PF00244	0.455
LIG_14-3-3_CanoR_1	763	767	PF00244	0.639
LIG_14-3-3_CanoR_1	82	89	PF00244	0.656
LIG_Actin_WH2_2	152	167	PF00022	0.508
LIG_APCC_ABBA_1	357	362	PF00400	0.397
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BIR_III_2	409	413	PF00653	0.504
LIG_BIR_III_3	1	5	PF00653	0.503
LIG_BRCT_BRCA1_1	578	582	PF00533	0.639
LIG_CSL_BTD_1	307	310	PF09270	0.542
LIG_CSL_BTD_1	715	718	PF09270	0.486
LIG_CtBP_PxDLS_1	228	232	PF00389	0.640
LIG_eIF4E_1	662	668	PF01652	0.602
LIG_EVH1_1	564	568	PF00568	0.541
LIG_EVH1_2	634	638	PF00568	0.589
LIG_FHA_1	156	162	PF00498	0.388
LIG_FHA_1	49	55	PF00498	0.444
LIG_FHA_1	506	512	PF00498	0.493
LIG_FHA_1	523	529	PF00498	0.641
LIG_FHA_1	550	556	PF00498	0.645
LIG_FHA_1	801	807	PF00498	0.611
LIG_FHA_1	97	103	PF00498	0.567
LIG_FHA_2	602	608	PF00498	0.688
LIG_FHA_2	650	656	PF00498	0.406
LIG_FHA_2	681	687	PF00498	0.525
LIG_FHA_2	751	757	PF00498	0.596
LIG_LIR_Apic_2	239	243	PF02991	0.464
LIG_LIR_Apic_2	762	767	PF02991	0.427
LIG_LIR_Apic_2	827	832	PF02991	0.468
LIG_LIR_Gen_1	104	115	PF02991	0.363
LIG_LIR_Gen_1	134	144	PF02991	0.462
LIG_LIR_Gen_1	172	181	PF02991	0.413
LIG_LIR_Gen_1	355	364	PF02991	0.306
LIG_LIR_Gen_1	383	392	PF02991	0.422
LIG_LIR_Gen_1	515	521	PF02991	0.564
LIG_LIR_Gen_1	739	745	PF02991	0.485
LIG_LIR_Gen_1	755	764	PF02991	0.613
LIG_LIR_Gen_1	780	791	PF02991	0.540
LIG_LIR_Nem_3	104	110	PF02991	0.367
LIG_LIR_Nem_3	134	140	PF02991	0.498
LIG_LIR_Nem_3	172	177	PF02991	0.405
LIG_LIR_Nem_3	305	311	PF02991	0.392
LIG_LIR_Nem_3	35	41	PF02991	0.560
LIG_LIR_Nem_3	355	360	PF02991	0.336
LIG_LIR_Nem_3	383	388	PF02991	0.384
LIG_LIR_Nem_3	515	520	PF02991	0.567
LIG_LIR_Nem_3	739	743	PF02991	0.489
LIG_LIR_Nem_3	755	761	PF02991	0.614
LIG_LIR_Nem_3	780	786	PF02991	0.543
LIG_LIR_Nem_3	788	793	PF02991	0.567
LIG_LIR_Nem_3	827	833	PF02991	0.465
LIG_MYND_1	162	166	PF01753	0.511
LIG_Pex14_1	170	174	PF04695	0.360
LIG_Pex14_2	44	48	PF04695	0.501
LIG_SH2_NCK_1	506	510	PF00017	0.593
LIG_SH2_NCK_1	764	768	PF00017	0.603
LIG_SH2_SRC	479	482	PF00017	0.669
LIG_SH2_SRC	658	661	PF00017	0.523
LIG_SH2_STAP1	103	107	PF00017	0.367
LIG_SH2_STAP1	506	510	PF00017	0.611
LIG_SH2_STAT5	103	106	PF00017	0.373
LIG_SH2_STAT5	115	118	PF00017	0.385
LIG_SH2_STAT5	444	447	PF00017	0.397
LIG_SH2_STAT5	46	49	PF00017	0.572
LIG_SH2_STAT5	517	520	PF00017	0.538
LIG_SH2_STAT5	722	725	PF00017	0.595
LIG_SH2_STAT5	764	767	PF00017	0.588
LIG_SH2_STAT5	790	793	PF00017	0.514
LIG_SH2_STAT5	829	832	PF00017	0.632
LIG_SH3_2	565	570	PF14604	0.545
LIG_SH3_3	121	127	PF00018	0.663
LIG_SH3_3	212	218	PF00018	0.490
LIG_SH3_3	263	269	PF00018	0.554
LIG_SH3_3	304	310	PF00018	0.386
LIG_SH3_3	545	551	PF00018	0.588
LIG_SH3_3	562	568	PF00018	0.618
LIG_SH3_3	569	575	PF00018	0.608
LIG_SH3_3	631	637	PF00018	0.525
LIG_SH3_3	718	724	PF00018	0.482
LIG_SH3_3	83	89	PF00018	0.478
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.497
LIG_SUMO_SIM_par_1	187	194	PF11976	0.483
LIG_SUMO_SIM_par_1	226	233	PF11976	0.635
LIG_SUMO_SIM_par_1	411	417	PF11976	0.420
LIG_TRAF2_1	652	655	PF00917	0.429
LIG_TRAF2_1	757	760	PF00917	0.415
MOD_CK1_1	118	124	PF00069	0.500
MOD_CK1_1	135	141	PF00069	0.686
MOD_CK1_1	230	236	PF00069	0.656
MOD_CK1_1	244	250	PF00069	0.628
MOD_CK1_1	27	33	PF00069	0.454
MOD_CK1_1	483	489	PF00069	0.698
MOD_CK1_1	501	507	PF00069	0.572
MOD_CK1_1	531	537	PF00069	0.633
MOD_CK1_1	541	547	PF00069	0.701
MOD_CK1_1	571	577	PF00069	0.636
MOD_CK1_1	586	592	PF00069	0.731
MOD_CK1_1	598	604	PF00069	0.602
MOD_CK1_1	606	612	PF00069	0.618
MOD_CK2_1	176	182	PF00069	0.440
MOD_CK2_1	315	321	PF00069	0.459
MOD_CK2_1	649	655	PF00069	0.417
MOD_CK2_1	680	686	PF00069	0.533
MOD_CK2_1	750	756	PF00069	0.604
MOD_CK2_1	767	773	PF00069	0.513
MOD_GlcNHglycan	120	123	PF01048	0.559
MOD_GlcNHglycan	134	137	PF01048	0.650
MOD_GlcNHglycan	27	30	PF01048	0.599
MOD_GlcNHglycan	285	288	PF01048	0.629
MOD_GlcNHglycan	326	329	PF01048	0.688
MOD_GlcNHglycan	343	346	PF01048	0.566
MOD_GlcNHglycan	416	419	PF01048	0.430
MOD_GlcNHglycan	437	440	PF01048	0.534
MOD_GlcNHglycan	455	458	PF01048	0.482
MOD_GlcNHglycan	485	488	PF01048	0.703
MOD_GlcNHglycan	600	603	PF01048	0.823
MOD_GlcNHglycan	683	686	PF01048	0.587
MOD_GlcNHglycan	710	713	PF01048	0.622
MOD_GlcNHglycan	787	790	PF01048	0.525
MOD_GlcNHglycan	812	816	PF01048	0.698
MOD_GlcNHglycan	822	825	PF01048	0.601
MOD_GSK3_1	126	133	PF00069	0.567
MOD_GSK3_1	135	142	PF00069	0.691
MOD_GSK3_1	269	276	PF00069	0.518
MOD_GSK3_1	283	290	PF00069	0.570
MOD_GSK3_1	302	309	PF00069	0.591
MOD_GSK3_1	401	408	PF00069	0.512
MOD_GSK3_1	479	486	PF00069	0.640
MOD_GSK3_1	501	508	PF00069	0.568
MOD_GSK3_1	528	535	PF00069	0.661
MOD_GSK3_1	583	590	PF00069	0.728
MOD_GSK3_1	596	603	PF00069	0.532
MOD_GSK3_1	696	703	PF00069	0.661
MOD_GSK3_1	704	711	PF00069	0.543
MOD_GSK3_1	716	723	PF00069	0.440
MOD_GSK3_1	750	757	PF00069	0.697
MOD_GSK3_1	762	769	PF00069	0.551
MOD_GSK3_1	773	780	PF00069	0.534
MOD_GSK3_1	811	818	PF00069	0.587
MOD_GSK3_1	87	94	PF00069	0.672
MOD_LATS_1	503	509	PF00433	0.602
MOD_N-GLC_1	435	440	PF02516	0.518
MOD_N-GLC_1	767	772	PF02516	0.482
MOD_N-GLC_1	815	820	PF02516	0.530
MOD_NEK2_1	101	106	PF00069	0.436
MOD_NEK2_1	236	241	PF00069	0.553
MOD_NEK2_1	324	329	PF00069	0.568
MOD_NEK2_1	339	344	PF00069	0.501
MOD_NEK2_1	414	419	PF00069	0.444
MOD_NEK2_1	7	12	PF00069	0.536
MOD_NEK2_1	754	759	PF00069	0.566
MOD_NEK2_1	800	805	PF00069	0.566
MOD_NEK2_1	81	86	PF00069	0.581
MOD_NEK2_2	127	132	PF00069	0.502
MOD_NEK2_2	145	150	PF00069	0.525
MOD_NEK2_2	576	581	PF00069	0.609
MOD_PIKK_1	182	188	PF00454	0.655
MOD_PIKK_1	312	318	PF00454	0.536
MOD_PIKK_1	395	401	PF00454	0.389
MOD_PIKK_1	649	655	PF00454	0.417
MOD_PK_1	696	702	PF00069	0.398
MOD_PKA_2	116	122	PF00069	0.450
MOD_PKA_2	501	507	PF00069	0.522
MOD_PKA_2	596	602	PF00069	0.551
MOD_PKA_2	649	655	PF00069	0.417
MOD_PKA_2	762	768	PF00069	0.662
MOD_PKA_2	81	87	PF00069	0.653
MOD_PKA_2	820	826	PF00069	0.594
MOD_PKB_1	451	459	PF00069	0.572
MOD_Plk_1	127	133	PF00069	0.572
MOD_Plk_1	402	408	PF00069	0.498
MOD_Plk_1	754	760	PF00069	0.595
MOD_Plk_1	91	97	PF00069	0.497
MOD_Plk_2-3	750	756	PF00069	0.604
MOD_Plk_4	101	107	PF00069	0.484
MOD_Plk_4	109	115	PF00069	0.481
MOD_Plk_4	145	151	PF00069	0.588
MOD_Plk_4	236	242	PF00069	0.589
MOD_Plk_4	551	557	PF00069	0.535
MOD_Plk_4	639	645	PF00069	0.569
MOD_Plk_4	696	702	PF00069	0.593
MOD_Plk_4	717	723	PF00069	0.485
MOD_Plk_4	779	785	PF00069	0.527
MOD_Plk_4	800	806	PF00069	0.642
MOD_ProDKin_1	140	146	PF00069	0.528
MOD_ProDKin_1	244	250	PF00069	0.649
MOD_ProDKin_1	293	299	PF00069	0.534
MOD_ProDKin_1	306	312	PF00069	0.670
MOD_ProDKin_1	532	538	PF00069	0.561
MOD_ProDKin_1	568	574	PF00069	0.689
MOD_ProDKin_1	700	706	PF00069	0.627
MOD_ProDKin_1	710	716	PF00069	0.552
MOD_ProDKin_1	720	726	PF00069	0.597
MOD_ProDKin_1	767	773	PF00069	0.747
MOD_ProDKin_1	96	102	PF00069	0.562
MOD_SUMO_for_1	539	542	PF00179	0.566
TRG_DiLeu_BaEn_2	514	520	PF01217	0.500
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.507
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.432
TRG_ENDOCYTIC_2	103	106	PF00928	0.390
TRG_ENDOCYTIC_2	41	44	PF00928	0.573
TRG_ENDOCYTIC_2	46	49	PF00928	0.528
TRG_ENDOCYTIC_2	517	520	PF00928	0.557
TRG_ENDOCYTIC_2	740	743	PF00928	0.461
TRG_ENDOCYTIC_2	790	793	PF00928	0.514
TRG_ER_diArg_1	259	261	PF00400	0.580
TRG_ER_diArg_1	448	451	PF00400	0.571
TRG_ER_diArg_1	75	78	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	450	455	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	665	670	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	752	756	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX0	Leptomonas seymouri	36%	76%
A0A3S7WYX4	Leishmania donovani	74%	79%
A4I1B0	Leishmania infantum	74%	79%
E9AXE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	79%
Q4QA26	Leishmania major	72%	100%