Myosin heavy chain kinase c-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myosin heavy chain kinase c-like protein

Species:

Leishmania braziliensis

UniProt:

A4HDZ8_LEIBR

TriTrypDb:

LbrM.25.0510 , LBRM2903_250013900

Length:

1723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HDZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	1
GO:0016310	phosphorylation	5	6

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0004683	calmodulin-dependent protein kinase activity	5	5
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.645
CLV_C14_Caspase3-7	243	247	PF00656	0.638
CLV_C14_Caspase3-7	998	1002	PF00656	0.506
CLV_MEL_PAP_1	1470	1476	PF00089	0.648
CLV_NRD_NRD_1	1051	1053	PF00675	0.403
CLV_NRD_NRD_1	1067	1069	PF00675	0.517
CLV_NRD_NRD_1	1071	1073	PF00675	0.457
CLV_NRD_NRD_1	1186	1188	PF00675	0.447
CLV_NRD_NRD_1	1274	1276	PF00675	0.438
CLV_NRD_NRD_1	1407	1409	PF00675	0.698

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID65	Leishmania donovani	65%	100%
A4I1A9	Leishmania infantum	65%	100%
E9AXE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QA27	Leishmania major	63%	99%

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