Putative epsin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative epsin

Gene product:

epsin, putative

Species:

Leishmania braziliensis

UniProt:

A4HDZ7_LEIBR

TriTrypDb:

LbrM.25.0500 , LBRM2903_250013800

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030117	membrane coat	3	1
GO:0030118	clathrin coat	4	1
GO:0030120	vesicle coat	4	1
GO:0030125	clathrin vesicle coat	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HDZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDZ7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0030276	clathrin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.616
CLV_NRD_NRD_1	278	280	PF00675	0.480
CLV_PCSK_KEX2_1	238	240	PF00082	0.647
CLV_PCSK_KEX2_1	278	280	PF00082	0.480
CLV_PCSK_PC7_1	234	240	PF00082	0.599
CLV_PCSK_SKI1_1	77	81	PF00082	0.317
DEG_Nend_UBRbox_3	1	3	PF02207	0.581
DEG_SPOP_SBC_1	496	500	PF00917	0.535
DEG_SPOP_SBC_1	533	537	PF00917	0.548
DOC_CKS1_1	335	340	PF01111	0.607
DOC_CYCLIN_RxL_1	73	83	PF00134	0.300
DOC_MAPK_gen_1	287	295	PF00069	0.674
DOC_MAPK_MEF2A_6	223	232	PF00069	0.586
DOC_MAPK_NFAT4_5	223	231	PF00069	0.464
DOC_PP2B_LxvP_1	293	296	PF13499	0.511
DOC_PP4_FxxP_1	336	339	PF00568	0.647
DOC_USP7_MATH_1	18	22	PF00917	0.476
DOC_USP7_MATH_1	198	202	PF00917	0.748
DOC_USP7_MATH_1	437	441	PF00917	0.719
DOC_USP7_MATH_1	446	450	PF00917	0.646
DOC_USP7_MATH_1	496	500	PF00917	0.781
DOC_WW_Pin1_4	202	207	PF00397	0.686
DOC_WW_Pin1_4	303	308	PF00397	0.637
DOC_WW_Pin1_4	309	314	PF00397	0.647
DOC_WW_Pin1_4	334	339	PF00397	0.715
DOC_WW_Pin1_4	373	378	PF00397	0.543
DOC_WW_Pin1_4	489	494	PF00397	0.637
LIG_14-3-3_CanoR_1	105	113	PF00244	0.305
LIG_14-3-3_CanoR_1	239	249	PF00244	0.540
LIG_14-3-3_CanoR_1	266	270	PF00244	0.530
LIG_14-3-3_CanoR_1	287	296	PF00244	0.655
LIG_14-3-3_CanoR_1	52	61	PF00244	0.223
LIG_14-3-3_CanoR_1	68	73	PF00244	0.299
LIG_AP2alpha_2	358	360	PF02296	0.450
LIG_AP2alpha_2	484	486	PF02296	0.541
LIG_BRCT_BRCA1_1	107	111	PF00533	0.300
LIG_Clathr_ClatBox_1	79	83	PF01394	0.300
LIG_deltaCOP1_diTrp_1	549	557	PF00928	0.640
LIG_FHA_1	2	8	PF00498	0.544
LIG_FHA_1	303	309	PF00498	0.564
LIG_FHA_2	266	272	PF00498	0.671
LIG_FHA_2	29	35	PF00498	0.235
LIG_GBD_Chelix_1	132	140	PF00786	0.417
LIG_LIR_Apic_2	110	116	PF02991	0.417
LIG_LIR_Apic_2	333	339	PF02991	0.607
LIG_LIR_Apic_2	399	405	PF02991	0.794
LIG_LIR_Apic_2	438	444	PF02991	0.782
LIG_LIR_Apic_2	472	477	PF02991	0.630
LIG_LIR_Gen_1	21	30	PF02991	0.305
LIG_LIR_Gen_1	358	368	PF02991	0.468
LIG_LIR_Gen_1	512	520	PF02991	0.825
LIG_LIR_Nem_3	12	16	PF02991	0.470
LIG_LIR_Nem_3	186	191	PF02991	0.618
LIG_LIR_Nem_3	21	26	PF02991	0.222
LIG_LIR_Nem_3	358	363	PF02991	0.452
LIG_LIR_Nem_3	427	432	PF02991	0.548
LIG_LIR_Nem_3	449	455	PF02991	0.547
LIG_LIR_Nem_3	498	504	PF02991	0.688
LIG_LIR_Nem_3	512	516	PF02991	0.830
LIG_LIR_Nem_3	549	554	PF02991	0.691
LIG_MAD2	330	338	PF02301	0.523
LIG_NRBOX	131	137	PF00104	0.277
LIG_Pex14_1	72	76	PF04695	0.339
LIG_SH2_CRK	113	117	PF00017	0.417
LIG_SH2_CRK	76	80	PF00017	0.303
LIG_SH2_GRB2like	113	116	PF00017	0.417
LIG_SH2_GRB2like	251	254	PF00017	0.485
LIG_SH2_PTP2	23	26	PF00017	0.359
LIG_SH2_STAP1	251	255	PF00017	0.610
LIG_SH2_STAT5	113	116	PF00017	0.206
LIG_SH2_STAT5	23	26	PF00017	0.407
LIG_SH2_STAT5	50	53	PF00017	0.315
LIG_SH2_STAT5	84	87	PF00017	0.344
LIG_SH2_STAT5	93	96	PF00017	0.381
LIG_SH3_1	35	41	PF00018	0.365
LIG_SH3_3	201	207	PF00018	0.596
LIG_SH3_3	304	310	PF00018	0.659
LIG_SH3_3	321	327	PF00018	0.567
LIG_SH3_3	337	343	PF00018	0.773
LIG_SH3_3	35	41	PF00018	0.338
LIG_SH3_3	350	356	PF00018	0.683
LIG_SH3_3	366	372	PF00018	0.651
LIG_SH3_3	374	380	PF00018	0.641
LIG_SH3_3	392	398	PF00018	0.613
LIG_SH3_3	404	410	PF00018	0.580
LIG_SH3_3	412	418	PF00018	0.640
LIG_SH3_3	420	426	PF00018	0.543
LIG_SH3_3	490	496	PF00018	0.570
LIG_SH3_3	513	519	PF00018	0.818
LIG_SUMO_SIM_anti_2	21	29	PF11976	0.278
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.300
LIG_SUMO_SIM_par_1	78	83	PF11976	0.301
LIG_TRAF2_1	217	220	PF00917	0.489
LIG_TRAF2_1	268	271	PF00917	0.469
LIG_TRAF2_2	195	200	PF00917	0.527
MOD_CDK_SPK_2	309	314	PF00069	0.592
MOD_CDK_SPxK_1	303	309	PF00069	0.742
MOD_CK1_1	106	112	PF00069	0.342
MOD_CK1_1	240	246	PF00069	0.610
MOD_CK1_1	294	300	PF00069	0.634
MOD_CK1_1	301	307	PF00069	0.627
MOD_CK1_1	367	373	PF00069	0.577
MOD_CK1_1	469	475	PF00069	0.746
MOD_CK1_1	489	495	PF00069	0.746
MOD_CK2_1	121	127	PF00069	0.300
MOD_CK2_1	16	22	PF00069	0.361
MOD_CK2_1	214	220	PF00069	0.524
MOD_CK2_1	265	271	PF00069	0.531
MOD_CK2_1	28	34	PF00069	0.300
MOD_CK2_1	322	328	PF00069	0.716
MOD_CK2_1	6	12	PF00069	0.452
MOD_DYRK1A_RPxSP_1	309	313	PF00069	0.547
MOD_GlcNHglycan	175	178	PF01048	0.564
MOD_GlcNHglycan	239	242	PF01048	0.520
MOD_GlcNHglycan	317	320	PF01048	0.613
MOD_GlcNHglycan	369	372	PF01048	0.778
MOD_GlcNHglycan	398	401	PF01048	0.643
MOD_GlcNHglycan	433	436	PF01048	0.638
MOD_GlcNHglycan	469	472	PF01048	0.680
MOD_GlcNHglycan	516	519	PF01048	0.748
MOD_GSK3_1	103	110	PF00069	0.343
MOD_GSK3_1	18	25	PF00069	0.310
MOD_GSK3_1	198	205	PF00069	0.681
MOD_GSK3_1	287	294	PF00069	0.665
MOD_GSK3_1	297	304	PF00069	0.680
MOD_GSK3_1	431	438	PF00069	0.741
MOD_GSK3_1	465	472	PF00069	0.676
MOD_GSK3_1	475	482	PF00069	0.642
MOD_GSK3_1	48	55	PF00069	0.376
MOD_GSK3_1	531	538	PF00069	0.697
MOD_N-GLC_1	1	6	PF02516	0.562
MOD_N-GLC_1	298	303	PF02516	0.625
MOD_N-GLC_1	364	369	PF02516	0.445
MOD_N-GLC_1	466	471	PF02516	0.669
MOD_N-GLC_1	539	544	PF02516	0.578
MOD_N-GLC_1	68	73	PF02516	0.223
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	103	108	PF00069	0.320
MOD_NEK2_1	111	116	PF00069	0.283
MOD_NEK2_1	298	303	PF00069	0.544
MOD_NEK2_1	364	369	PF00069	0.523
MOD_NEK2_1	465	470	PF00069	0.555
MOD_PIKK_1	1	7	PF00454	0.559
MOD_PIKK_1	287	293	PF00454	0.607
MOD_PIKK_1	322	328	PF00454	0.559
MOD_PIKK_1	457	463	PF00454	0.663
MOD_PIKK_1	486	492	PF00454	0.633
MOD_PKA_2	237	243	PF00069	0.544
MOD_PKA_2	265	271	PF00069	0.561
MOD_PKA_2	51	57	PF00069	0.229
MOD_Plk_1	364	370	PF00069	0.456
MOD_Plk_1	68	74	PF00069	0.387
MOD_Plk_4	107	113	PF00069	0.345
MOD_Plk_4	22	28	PF00069	0.437
MOD_Plk_4	364	370	PF00069	0.562
MOD_Plk_4	424	430	PF00069	0.546
MOD_Plk_4	75	81	PF00069	0.300
MOD_ProDKin_1	202	208	PF00069	0.687
MOD_ProDKin_1	303	309	PF00069	0.640
MOD_ProDKin_1	334	340	PF00069	0.716
MOD_ProDKin_1	373	379	PF00069	0.543
MOD_ProDKin_1	489	495	PF00069	0.629
MOD_SUMO_rev_2	322	332	PF00179	0.538
TRG_DiLeu_BaEn_1	22	27	PF01217	0.229
TRG_DiLeu_BaEn_1	96	101	PF01217	0.417
TRG_ENDOCYTIC_2	23	26	PF00928	0.390
TRG_ENDOCYTIC_2	76	79	PF00928	0.312
TRG_ER_diArg_1	278	280	PF00400	0.488
TRG_ER_diArg_1	61	64	PF00400	0.417
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI1	Leptomonas seymouri	49%	100%
A0A1X0P4K8	Trypanosomatidae	39%	100%
A0A3Q8IDD0	Leishmania donovani	61%	100%
A0A422NX91	Trypanosoma rangeli	44%	100%
A4I1A8	Leishmania infantum	60%	100%
E9AXE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	89%
O95208	Homo sapiens	26%	88%
Q4QA28	Leishmania major	62%	100%
V5BXH3	Trypanosoma cruzi	44%	100%