Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HDZ4_LEIBR

TriTrypDb:

LbrM.25.0470 , LBRM2903_250012100

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

A4HDZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.354
CLV_PCSK_KEX2_1	133	135	PF00082	0.354
CLV_PCSK_SKI1_1	113	117	PF00082	0.305
DEG_SPOP_SBC_1	168	172	PF00917	0.445
DEG_SPOP_SBC_1	220	224	PF00917	0.516
DOC_MAPK_gen_1	133	141	PF00069	0.355
DOC_MAPK_MEF2A_6	133	141	PF00069	0.440
DOC_MAPK_NFAT4_5	134	142	PF00069	0.352
DOC_SPAK_OSR1_1	107	111	PF12202	0.448
DOC_USP7_MATH_1	14	18	PF00917	0.545
DOC_USP7_MATH_1	168	172	PF00917	0.516
DOC_USP7_MATH_1	220	224	PF00917	0.606
DOC_WW_Pin1_4	228	233	PF00397	0.539
DOC_WW_Pin1_4	5	10	PF00397	0.612
LIG_14-3-3_CanoR_1	133	138	PF00244	0.419
LIG_14-3-3_CanoR_1	227	231	PF00244	0.501
LIG_14-3-3_CanoR_1	7	13	PF00244	0.524
LIG_14-3-3_CanoR_1	93	102	PF00244	0.406
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_FHA_1	134	140	PF00498	0.355
LIG_FHA_1	97	103	PF00498	0.455
LIG_LIR_Gen_1	127	137	PF02991	0.429
LIG_LIR_Gen_1	149	157	PF02991	0.401
LIG_LIR_Gen_1	182	192	PF02991	0.427
LIG_LIR_Nem_3	127	132	PF02991	0.414
LIG_LIR_Nem_3	180	184	PF02991	0.523
LIG_LIR_Nem_3	62	67	PF02991	0.502
LIG_LIR_Nem_3	84	90	PF02991	0.493
LIG_LYPXL_S_1	207	211	PF13949	0.526
LIG_LYPXL_yS_3	208	211	PF13949	0.522
LIG_PDZ_Class_2	234	239	PF00595	0.512
LIG_SH2_CRK	119	123	PF00017	0.404
LIG_SH2_CRK	129	133	PF00017	0.443
LIG_SH2_CRK	77	81	PF00017	0.456
LIG_SH2_CRK	87	91	PF00017	0.576
LIG_SH2_GRB2like	119	122	PF00017	0.397
LIG_SH2_GRB2like	151	154	PF00017	0.341
LIG_SH2_GRB2like	184	187	PF00017	0.518
LIG_SH2_NCK_1	119	123	PF00017	0.385
LIG_SH2_NCK_1	77	81	PF00017	0.448
LIG_SH2_SRC	119	122	PF00017	0.397
LIG_SH2_SRC	50	53	PF00017	0.449
LIG_SH2_STAT3	151	154	PF00017	0.434
LIG_SH2_STAT3	202	205	PF00017	0.457
LIG_SH2_STAT5	50	53	PF00017	0.497
LIG_SH2_STAT5	95	98	PF00017	0.458
LIG_TYR_ITIM	117	122	PF00017	0.345
LIG_TYR_ITIM	75	80	PF00017	0.452
MOD_CDK_SPxxK_3	9	16	PF00069	0.490
MOD_CK1_1	171	177	PF00069	0.482
MOD_CK1_1	8	14	PF00069	0.547
MOD_CK2_1	132	138	PF00069	0.354
MOD_CK2_1	14	20	PF00069	0.537
MOD_Cter_Amidation	111	114	PF01082	0.248
MOD_GlcNHglycan	163	166	PF01048	0.497
MOD_GlcNHglycan	171	174	PF01048	0.569
MOD_GlcNHglycan	96	99	PF01048	0.294
MOD_GSK3_1	1	8	PF00069	0.549
MOD_GSK3_1	14	21	PF00069	0.589
MOD_GSK3_1	155	162	PF00069	0.455
MOD_GSK3_1	167	174	PF00069	0.551
MOD_GSK3_1	222	229	PF00069	0.593
MOD_GSK3_1	96	103	PF00069	0.467
MOD_NEK2_1	1	6	PF00069	0.511
MOD_NEK2_1	132	137	PF00069	0.434
MOD_NEK2_1	169	174	PF00069	0.446
MOD_NEK2_1	187	192	PF00069	0.427
MOD_NEK2_1	94	99	PF00069	0.461
MOD_NEK2_2	146	151	PF00069	0.383
MOD_PIKK_1	1	7	PF00454	0.482
MOD_PIKK_1	155	161	PF00454	0.370
MOD_PK_1	69	75	PF00069	0.448
MOD_PKA_1	133	139	PF00069	0.361
MOD_PKA_2	132	138	PF00069	0.412
MOD_PKA_2	226	232	PF00069	0.496
MOD_PKB_1	195	203	PF00069	0.445
MOD_Plk_4	146	152	PF00069	0.387
MOD_Plk_4	18	24	PF00069	0.456
MOD_Plk_4	230	236	PF00069	0.455
MOD_ProDKin_1	228	234	PF00069	0.541
MOD_ProDKin_1	5	11	PF00069	0.613
TRG_ENDOCYTIC_2	119	122	PF00928	0.432
TRG_ENDOCYTIC_2	129	132	PF00928	0.404
TRG_ENDOCYTIC_2	152	155	PF00928	0.433
TRG_ENDOCYTIC_2	184	187	PF00928	0.433
TRG_ENDOCYTIC_2	208	211	PF00928	0.522
TRG_ENDOCYTIC_2	77	80	PF00928	0.426
TRG_ENDOCYTIC_2	87	90	PF00928	0.576
TRG_ER_diArg_1	132	134	PF00400	0.381
TRG_ER_diArg_1	194	197	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P674	Leptomonas seymouri	59%	100%
A0A3Q8IBN4	Leishmania donovani	70%	100%
A4I193	Leishmania infantum	69%	100%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AXC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QA43	Leishmania major	68%	100%
Q4QA45	Leishmania major	44%	100%