RNA-binding protein, putative, UPB1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein UBP1, putative

Species:

Leishmania braziliensis

UniProt:

A4HDZ2_LEIBR

TriTrypDb:

LbrM.25.0450 , LBRM2903_250011000

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HDZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003723	RNA binding	4	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	98	100	PF00082	0.351
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.351
CLV_PCSK_SKI1_1	46	50	PF00082	0.351
CLV_PCSK_SKI1_1	98	102	PF00082	0.351
DOC_CYCLIN_RxL_1	43	50	PF00134	0.551
DOC_MAPK_gen_1	98	104	PF00069	0.551
DOC_PP4_MxPP_1	5	8	PF00568	0.663
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_FHA_1	55	61	PF00498	0.480
LIG_FHA_2	36	42	PF00498	0.551
LIG_IBAR_NPY_1	144	146	PF08397	0.653
LIG_LIR_Nem_3	50	55	PF02991	0.542
LIG_LIR_Nem_3	69	75	PF02991	0.537
LIG_SH2_CRK	72	76	PF00017	0.592
LIG_SH2_NCK_1	115	119	PF00017	0.577
LIG_SH2_STAT3	146	149	PF00017	0.603
LIG_SH2_STAT3	158	161	PF00017	0.742
LIG_SH2_STAT5	35	38	PF00017	0.539
LIG_SH2_STAT5	77	80	PF00017	0.632
LIG_SH3_3	17	23	PF00018	0.771
MOD_CK1_1	79	85	PF00069	0.551
MOD_CK2_1	36	42	PF00069	0.551
MOD_GlcNHglycan	106	109	PF01048	0.673
MOD_GlcNHglycan	162	165	PF01048	0.759
MOD_GlcNHglycan	78	81	PF01048	0.339
MOD_NEK2_1	104	109	PF00069	0.659
MOD_NEK2_1	160	165	PF00069	0.623
MOD_NEK2_2	54	59	PF00069	0.514
MOD_PIKK_1	13	19	PF00454	0.700
MOD_PKA_2	63	69	PF00069	0.544
TRG_ENDOCYTIC_2	52	55	PF00928	0.467
TRG_ENDOCYTIC_2	72	75	PF00928	0.587
TRG_ER_diArg_1	111	114	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4G4	Trypanosomatidae	66%	81%
A0A1X0P4M7	Trypanosomatidae	67%	97%
A0A3Q8ID53	Leishmania donovani	87%	100%
A0A3S7WYY4	Leishmania donovani	91%	100%
A0A422NWY7	Trypanosoma rangeli	69%	100%
A4HDZ1	Leishmania braziliensis	100%	100%
A4I191	Leishmania infantum	87%	100%
D0A986	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	78%
E9AH94	Leishmania infantum	90%	73%
E9AXC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	97%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QA45	Leishmania major	86%	100%
Q4QA46	Leishmania major	90%	100%
V5BNA6	Trypanosoma cruzi	69%	100%