RNA-binding protein, putative, UPB2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein UBP1, putative

Species:

Leishmania braziliensis

UniProt:

A4HDZ1_LEIBR

TriTrypDb:

LbrM.25.0450 , LBRM2903_250011000

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HDZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HDZ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003723	RNA binding	4	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	97	99	PF00082	0.351
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.334
CLV_PCSK_SKI1_1	45	49	PF00082	0.334
CLV_PCSK_SKI1_1	97	101	PF00082	0.348
DOC_CKS1_1	4	9	PF01111	0.613
DOC_CYCLIN_RxL_1	42	49	PF00134	0.534
DOC_MAPK_gen_1	97	103	PF00069	0.551
DOC_PP4_MxPP_1	5	8	PF00568	0.635
DOC_WW_Pin1_4	3	8	PF00397	0.634
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_FHA_1	54	60	PF00498	0.465
LIG_FHA_2	35	41	PF00498	0.534
LIG_IBAR_NPY_1	143	145	PF08397	0.633
LIG_LIR_Nem_3	49	54	PF02991	0.525
LIG_LIR_Nem_3	68	74	PF02991	0.520
LIG_SH2_CRK	71	75	PF00017	0.552
LIG_SH2_NCK_1	114	118	PF00017	0.550
LIG_SH2_STAT3	145	148	PF00017	0.586
LIG_SH2_STAT3	157	160	PF00017	0.724
LIG_SH2_STAT5	34	37	PF00017	0.522
LIG_SH2_STAT5	76	79	PF00017	0.633
LIG_SH3_3	16	22	PF00018	0.721
MOD_CK1_1	78	84	PF00069	0.534
MOD_CK2_1	35	41	PF00069	0.536
MOD_GlcNHglycan	105	108	PF01048	0.673
MOD_GlcNHglycan	161	164	PF01048	0.806
MOD_GlcNHglycan	77	80	PF01048	0.329
MOD_NEK2_1	103	108	PF00069	0.638
MOD_NEK2_1	159	164	PF00069	0.669
MOD_NEK2_2	53	58	PF00069	0.498
MOD_PIKK_1	12	18	PF00454	0.736
MOD_PKA_2	62	68	PF00069	0.528
MOD_ProDKin_1	3	9	PF00069	0.635
TRG_ENDOCYTIC_2	51	54	PF00928	0.457
TRG_ENDOCYTIC_2	71	74	PF00928	0.552
TRG_ER_diArg_1	110	113	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P4G4	Trypanosomatidae	66%	80%
A0A1X0P4M7	Trypanosomatidae	67%	97%
A0A3Q8ID53	Leishmania donovani	90%	100%
A0A3S7WYY4	Leishmania donovani	91%	100%
A0A422NWY7	Trypanosoma rangeli	69%	100%
A4HDZ2	Leishmania braziliensis	100%	99%
A4I191	Leishmania infantum	90%	100%
D0A986	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	77%
E9AH94	Leishmania infantum	90%	72%
E9AXC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	97%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA45	Leishmania major	90%	100%
Q4QA46	Leishmania major	90%	100%
V5BNA6	Trypanosoma cruzi	69%	100%